4-Aryl-3, 4-dihydropyrimidinones were synthesized using microwave-assisted,solvent-free protocol of the Biginelli reaction. The simple method provides the title compounds in78%―95% yields by the reaction of aromatic ...4-Aryl-3, 4-dihydropyrimidinones were synthesized using microwave-assisted,solvent-free protocol of the Biginelli reaction. The simple method provides the title compounds in78%―95% yields by the reaction of aromatic aldehydes with ethyl acetoac-etate and urea/thiourea inthe presence of a catalytic amount of cone. HCl. Lewis acids, such as ZnCl_2, SnCl_2, FeCl_3·6H_2O,and CuCl_2·2H_2O, were also found to be efficient catalysts for the synthesis ofdihydropyrimidinones.展开更多
文摘4-Aryl-3, 4-dihydropyrimidinones were synthesized using microwave-assisted,solvent-free protocol of the Biginelli reaction. The simple method provides the title compounds in78%―95% yields by the reaction of aromatic aldehydes with ethyl acetoac-etate and urea/thiourea inthe presence of a catalytic amount of cone. HCl. Lewis acids, such as ZnCl_2, SnCl_2, FeCl_3·6H_2O,and CuCl_2·2H_2O, were also found to be efficient catalysts for the synthesis ofdihydropyrimidinones.
