BACKGROUND Primary hepatic carcinoma(PHC)has an insidious onset and is usually diagnosed in the middle and late stages.Although transcatheter arterial chemoembolization(TACE)is the preferred option for treating middle...BACKGROUND Primary hepatic carcinoma(PHC)has an insidious onset and is usually diagnosed in the middle and late stages.Although transcatheter arterial chemoembolization(TACE)is the preferred option for treating middle-and advanced-stage PHC,it has limited efficacy in killing tumor cells and poor long-term efficacy.TACE plus percutaneous microwave coagulation therapy(PMCT)is more effective than interventional therapy alone and can improve survival time.However,there are few reports on the effects of TACE and PMCT on serum marker levels and the prognosis of patients with advanced PHC.AIM To investigate the effect of PMCT+TACE on serum tumor markers and the prognosis of middle-late PHC.METHODS This retrospective study included 150 patients with middle-late PHC admitted to Zhongshan People’s Hospital between March 2018 and February 2021.Patients were divided into a single group(treated with TACE,n=75)and a combined group(treated with TACE+PMCT,n=75).Before and after treatment,the clinical efficacy and serum tumor marker levels[carbohydrate antigen 19-9(CA19-9),alpha-fetoprotein(AFP),and carcinoembryonic antigen(CEA)]of both groups were observed.The 1-year survival rates and prognostic factors of the two groups were analyzed.RESULTS The combined group had 21 and 35 cases of complete remission(CR)and partial remission(PR),respectively.The single group had 13 and 25 cases of CR and PR,decreased,with the decrease in the combined group being more significant(P<0.05).The 1-year survival rate of the combined group(80.00%)was higher than that of the single group(60.00%)(P<0.05).The average survival time within 1 year in the combined group was 299.38±61.13 d,longer than that in the single group(214.41±72.97 d,P<0.05).COX analysis revealed that tumor diameter,tumor number,and the treatment method were prognostic factors for patients with middle-late PHC(P<0.05).CONCLUSION TACE+PMCT is effective in treating patients with mid-late PHC.It reduces the levels of tumor markers,prolongs survival,and improves prognosis.展开更多
The northeastern Chinese Yanliao Biota （sometimes called the Daohugou Biota） comprises numerous, frequently spectacular fossils of non-marine organisms, occurring in Middle-Upper Jurassic strata in western Liaoning,...The northeastern Chinese Yanliao Biota （sometimes called the Daohugou Biota） comprises numerous, frequently spectacular fossils of non-marine organisms, occurring in Middle-Upper Jurassic strata in western Liaoning, northern Hebei, and southeastern Inner Mongolia. The biota lasted for about 10 million years, divided into two phases： the Bathonian-Callovian Daohugou phase （about 168-164 million years ago） and the Oxfordian Linglongta phase （164-159 million years ago）. The Yanliao fossils are often taphonomically exceptional （many vertebrate skeletons, for example, are complete and accompanied by preserved integumentary features）, and not only are taxonomically diverse but also include the oldest known representatives of many groups of plants, invertebrates, and vertebrates. These fossils have provided significant new information regarding the origins and early evolution of such clades as fleas, birds, and mammals, in addition to the evolution of some major biological structures such as feathers, and have demonstrated the existence of a complex terrestrial ecosystem in northeast China around the time of the Middle-Late Jurassic boundary.展开更多
[Objective]The paper was to study optimum chemical agents and control periods against rice false smut( Ustilaginoidea virens) in single cropping middle-late rice. [Method]Taking chemical agents( triadimefon,armure,Jin...[Objective]The paper was to study optimum chemical agents and control periods against rice false smut( Ustilaginoidea virens) in single cropping middle-late rice. [Method]Taking chemical agents( triadimefon,armure,Jinggangmycin) as main treatments and spraying periods( within 7 d before initial heading stage,within 7 d before initial heading stage + initial heading stage,initial heading stage) as assisted treatments,the field efficacy trial and optimum control period of U. virens in single cropping middle-late rice were studied using Huanghuazhan and Jinnongsimiao as experimental materials in 2013. [Result] Three chemical agents,triadimefon,armure,Jinggangmycin,extremely reduced diseased panicle rate and disease index of U. virens,but there was no significant difference among three chemical agents. Spraying period did not have significant impact on diseased panicle rate and disease index of U. virens,whereas spraying within7 d before initial heading stage and during initial heading stage had relatively good control effect. Yield increased significantly after application of three chemical agents,and armure led to greater increase. The reason for yield increase was that seed setting rate was significantly increased,and the number of filled grains per panicle was significantly increased. Although spraying period influenced yield,the difference was not significant. [Conclusion] Triadimefon,armure and Jinggangmycin had good control effects against U. virens in single cropping middle-late rice,of which armure had better control effects. Spraying chemical agents increased seed setting rate,and further increased the number of filled grains per panicle and yield. Spraying within 7 d before initial heading stage and during initial heading stage had relatively better control effect against U. virens.展开更多
The Middle-Late Jurassic transition period is a critical period for the evolution of terrestrial vertebrates,but the global fossil record from this time is relatively poor.The Shishugou Fauna of this period has recent...The Middle-Late Jurassic transition period is a critical period for the evolution of terrestrial vertebrates,but the global fossil record from this time is relatively poor.The Shishugou Fauna of this period has recently produced significant fossil remains of dinosaurs and other vertebrate groups,some representing the earliest known members of several dinosaurian groups and other vertebrate groups and some representing the best-known specimens of their group.These discoveries are significant for our understanding of the origin and evolution of several vertebrate lineages.Radiometric dating indicates that the fauna is aged approximately 159-164 Ma.Comparisons with other similarly-aged terrestrial faunas such as Shaximiao and Yanliao show both taxonomic similarities and differences between these faunas and indicate that the Junggar deposits might have preserved the most complete vertebrate fossil record for a Middle-Late Jurassic Laurasian terrestrial fauna.展开更多
The Late Devonian-early Carboniferous deposits of the Anarak section in northeastern Isfahan,Central Iran,evaluated based on conodont biostratigraphy,sedimentary environment and sequence stratigraphy.According to the ...The Late Devonian-early Carboniferous deposits of the Anarak section in northeastern Isfahan,Central Iran,evaluated based on conodont biostratigraphy,sedimentary environment and sequence stratigraphy.According to the field observations,five lithological units were identified.Investigating the conodont fauna of the Late Devonian-Carboniferous(Mississippian-Pennsylvanian)deposits of Bahram,Shishtu,and Qaleh(Sardar 1)formations in Anarak section led to the identification of 67 species of 18 conodont genera,and accordingly 22 conodont biozones were differentiated.The correlation of sea-level change curves,regarding to the conodont biofacies with the global sea-level curve,demonstrates the relative correlation in the mentioned times due to the shallow condition of the central Iran basin compared to the European and American basins.The microfacies analysis led to the identification of 12 microfacies related to the open sea,bioclastic barrier,lagoon and tidal flat sub-sedimentary environments in a homoclinal carbonate ramp environment.Based on sequence stratigraphy studies,three 3rd order sequences were identified.The first sequence,which is of the Late Devonian(upper part of the Bahram Formation,32.5 m),the second sequence(12.5 m)is the Late Devonian(uppermost part of the Bahram Formation),and the third sequence(68 m)is the early Carboniferous(the Shishtu I Formation).展开更多
The current paper is focused on the facies, sedimentary environment and depositional cycles study of the Middle-Late Permian sediments in the South Fars Zireh Gas Field, the subsurface section of well ZH-A. Four hundr...The current paper is focused on the facies, sedimentary environment and depositional cycles study of the Middle-Late Permian sediments in the South Fars Zireh Gas Field, the subsurface section of well ZH-A. Four hundred thin-sections obtained from cores and cuttings were examined under standard petrographic microscope. For this study research, Corel Draw X6, Corel Photo-Paint, DN2 Microscopy Image Processing System, Scope Photo, Autodesk Map, Geocalc and Auto Cad 2014 were utilized. Based on microfacies analysis and significant founa and flora, fourteen major facies in four facies associations comprising tidal flat (A), lagoon (B), shoal (C) and open marine (D) identified in the well ZH-A. This formation was deposited in inner part of a homoclinal ramp. Based on depositional cycles, seven main 3rd order sequences were revealed in the Well ZH-A. The ooid grainstone facies with interparticle and oomoldic porosity has high reservoir potential. The diagenetic processes like dolomitization and dissolution have significant effect in the reservoir quality. Based on research results, a major framework can be weaved and used to correlate reservoir layering.展开更多
文摘BACKGROUND Primary hepatic carcinoma(PHC)has an insidious onset and is usually diagnosed in the middle and late stages.Although transcatheter arterial chemoembolization(TACE)is the preferred option for treating middle-and advanced-stage PHC,it has limited efficacy in killing tumor cells and poor long-term efficacy.TACE plus percutaneous microwave coagulation therapy(PMCT)is more effective than interventional therapy alone and can improve survival time.However,there are few reports on the effects of TACE and PMCT on serum marker levels and the prognosis of patients with advanced PHC.AIM To investigate the effect of PMCT+TACE on serum tumor markers and the prognosis of middle-late PHC.METHODS This retrospective study included 150 patients with middle-late PHC admitted to Zhongshan People’s Hospital between March 2018 and February 2021.Patients were divided into a single group(treated with TACE,n=75)and a combined group(treated with TACE+PMCT,n=75).Before and after treatment,the clinical efficacy and serum tumor marker levels[carbohydrate antigen 19-9(CA19-9),alpha-fetoprotein(AFP),and carcinoembryonic antigen(CEA)]of both groups were observed.The 1-year survival rates and prognostic factors of the two groups were analyzed.RESULTS The combined group had 21 and 35 cases of complete remission(CR)and partial remission(PR),respectively.The single group had 13 and 25 cases of CR and PR,decreased,with the decrease in the combined group being more significant(P<0.05).The 1-year survival rate of the combined group(80.00%)was higher than that of the single group(60.00%)(P<0.05).The average survival time within 1 year in the combined group was 299.38±61.13 d,longer than that in the single group(214.41±72.97 d,P<0.05).COX analysis revealed that tumor diameter,tumor number,and the treatment method were prognostic factors for patients with middle-late PHC(P<0.05).CONCLUSION TACE+PMCT is effective in treating patients with mid-late PHC.It reduces the levels of tumor markers,prolongs survival,and improves prognosis.
基金supported by the National Natural Science Foundation of China(41120124002)the National Basic Research Program of China(2012CB821900)
文摘The northeastern Chinese Yanliao Biota （sometimes called the Daohugou Biota） comprises numerous, frequently spectacular fossils of non-marine organisms, occurring in Middle-Upper Jurassic strata in western Liaoning, northern Hebei, and southeastern Inner Mongolia. The biota lasted for about 10 million years, divided into two phases： the Bathonian-Callovian Daohugou phase （about 168-164 million years ago） and the Oxfordian Linglongta phase （164-159 million years ago）. The Yanliao fossils are often taphonomically exceptional （many vertebrate skeletons, for example, are complete and accompanied by preserved integumentary features）, and not only are taxonomically diverse but also include the oldest known representatives of many groups of plants, invertebrates, and vertebrates. These fossils have provided significant new information regarding the origins and early evolution of such clades as fleas, birds, and mammals, in addition to the evolution of some major biological structures such as feathers, and have demonstrated the existence of a complex terrestrial ecosystem in northeast China around the time of the Middle-Late Jurassic boundary.
基金Supported by National Science and Technology Support Program(2007BAD89B14)Special Fund for Agro-scientific Research in the Public Interest(00803028)+3 种基金Major Technical Research Project of Ministry of Agriculture for Agricultural Structure Adjustment(06-03-07B)Project of Guangdong Provincial Finance Department(YCY[2005]No.11,YCJ[2006]No.187)Agricultural Research Project of Guangdong Provincial Science and Technology Department(2005B20101001)Special Fund for Agro-scientific Research in the Public Interest(201103001)
文摘[Objective]The paper was to study optimum chemical agents and control periods against rice false smut( Ustilaginoidea virens) in single cropping middle-late rice. [Method]Taking chemical agents( triadimefon,armure,Jinggangmycin) as main treatments and spraying periods( within 7 d before initial heading stage,within 7 d before initial heading stage + initial heading stage,initial heading stage) as assisted treatments,the field efficacy trial and optimum control period of U. virens in single cropping middle-late rice were studied using Huanghuazhan and Jinnongsimiao as experimental materials in 2013. [Result] Three chemical agents,triadimefon,armure,Jinggangmycin,extremely reduced diseased panicle rate and disease index of U. virens,but there was no significant difference among three chemical agents. Spraying period did not have significant impact on diseased panicle rate and disease index of U. virens,whereas spraying within7 d before initial heading stage and during initial heading stage had relatively good control effect. Yield increased significantly after application of three chemical agents,and armure led to greater increase. The reason for yield increase was that seed setting rate was significantly increased,and the number of filled grains per panicle was significantly increased. Although spraying period influenced yield,the difference was not significant. [Conclusion] Triadimefon,armure and Jinggangmycin had good control effects against U. virens in single cropping middle-late rice,of which armure had better control effects. Spraying chemical agents increased seed setting rate,and further increased the number of filled grains per panicle and yield. Spraying within 7 d before initial heading stage and during initial heading stage had relatively better control effect against U. virens.
基金supported by the National Natural Science Foundation of China(42288201,41688103,40830210,41120124002)the National Science Foundation Division of Earth Sciences(NSF EAR 0310217,0922187,1636753)the National Geographic Society。
文摘The Middle-Late Jurassic transition period is a critical period for the evolution of terrestrial vertebrates,but the global fossil record from this time is relatively poor.The Shishugou Fauna of this period has recently produced significant fossil remains of dinosaurs and other vertebrate groups,some representing the earliest known members of several dinosaurian groups and other vertebrate groups and some representing the best-known specimens of their group.These discoveries are significant for our understanding of the origin and evolution of several vertebrate lineages.Radiometric dating indicates that the fauna is aged approximately 159-164 Ma.Comparisons with other similarly-aged terrestrial faunas such as Shaximiao and Yanliao show both taxonomic similarities and differences between these faunas and indicate that the Junggar deposits might have preserved the most complete vertebrate fossil record for a Middle-Late Jurassic Laurasian terrestrial fauna.
文摘The Late Devonian-early Carboniferous deposits of the Anarak section in northeastern Isfahan,Central Iran,evaluated based on conodont biostratigraphy,sedimentary environment and sequence stratigraphy.According to the field observations,five lithological units were identified.Investigating the conodont fauna of the Late Devonian-Carboniferous(Mississippian-Pennsylvanian)deposits of Bahram,Shishtu,and Qaleh(Sardar 1)formations in Anarak section led to the identification of 67 species of 18 conodont genera,and accordingly 22 conodont biozones were differentiated.The correlation of sea-level change curves,regarding to the conodont biofacies with the global sea-level curve,demonstrates the relative correlation in the mentioned times due to the shallow condition of the central Iran basin compared to the European and American basins.The microfacies analysis led to the identification of 12 microfacies related to the open sea,bioclastic barrier,lagoon and tidal flat sub-sedimentary environments in a homoclinal carbonate ramp environment.Based on sequence stratigraphy studies,three 3rd order sequences were identified.The first sequence,which is of the Late Devonian(upper part of the Bahram Formation,32.5 m),the second sequence(12.5 m)is the Late Devonian(uppermost part of the Bahram Formation),and the third sequence(68 m)is the early Carboniferous(the Shishtu I Formation).
文摘The current paper is focused on the facies, sedimentary environment and depositional cycles study of the Middle-Late Permian sediments in the South Fars Zireh Gas Field, the subsurface section of well ZH-A. Four hundred thin-sections obtained from cores and cuttings were examined under standard petrographic microscope. For this study research, Corel Draw X6, Corel Photo-Paint, DN2 Microscopy Image Processing System, Scope Photo, Autodesk Map, Geocalc and Auto Cad 2014 were utilized. Based on microfacies analysis and significant founa and flora, fourteen major facies in four facies associations comprising tidal flat (A), lagoon (B), shoal (C) and open marine (D) identified in the well ZH-A. This formation was deposited in inner part of a homoclinal ramp. Based on depositional cycles, seven main 3rd order sequences were revealed in the Well ZH-A. The ooid grainstone facies with interparticle and oomoldic porosity has high reservoir potential. The diagenetic processes like dolomitization and dissolution have significant effect in the reservoir quality. Based on research results, a major framework can be weaved and used to correlate reservoir layering.
基金funded by National Natural Science Foundation of China(42272028,42130209)one hundred talents project from the Chinese Academy of Sciences(E0CQ010103)。
