To compare the effectiveness and side effects of various low dose of Mifepristone in combination with Misoprostol and low doses Mifepristone alone in emergency contraception Materials & Methods This is a multi ...To compare the effectiveness and side effects of various low dose of Mifepristone in combination with Misoprostol and low doses Mifepristone alone in emergency contraception Materials & Methods This is a multi center double blind randomized controlled clinical trial. A total of 899 healthy women were allocated into this study and were randomly divided into 3 groups. They were orally administrated with different emergency contraceptives with 120 h after unprotected intercourse. Group I (n=300) was given 25 mg Mifepristone plus 0.2 mg Misoprostol after 24 h. Group II (n=299) was given 10 mg Mifepristone plus 0.2 mg Misoprostol after 24 h. Group III (n=300) was administrated with 10 mg Mifepristone alone. The effective rates in different groups were calculated with Dixon method. Results Altogether 11 pregnancies occurred, among which 2 cases were in Group I, 2 cases in Group II, and 7 cases were in Group III. After correction with method failure, there was only one case in Group I, 0 case in Group II, and 5 cases in Group III. The contraceptive effectiveness in these groups was 95.5%, 100% and 76.9% respectively. The pregnancy rate was significantly lower in Group I and Group II than that of Group III (P<0.01). The side effects were slight and tolerable, and there was no significant difference between different groups (P>0.05). Conclusion Use of low dose Mifepristone (25 mg or 10 mg) in combination with 0.2 mg Misoprostol was an effective, low side effects and safe treatment regimen for emergency contraception.展开更多
Objective: Mifepristone, as a type of well-accepted emergency contraceptive drugs, is an optional progesterone receptor mod-ulator and widely used clinically. However, the effect of mifepristone on sperms is poorly st...Objective: Mifepristone, as a type of well-accepted emergency contraceptive drugs, is an optional progesterone receptor mod-ulator and widely used clinically. However, the effect of mifepristone on sperms is poorly studied. This research is intended to investigate the biological effect of mifepristone on human sperm function in vitro. Methods: Spermatozoa were incubated in the culture medium containing 0.04 μM, 0.4 μM, 4 μM and 40 μM of mifepristone for one hour after capacitation. It was required to measure sperm motility, viability, DNA integrity, acrosomal reaction, sperm hyperactivation, and the concentration of free calcium ions in spermatozoa. Results: After treating sperms with different concentrations of mifepristone in vitro, sperm viability, motility, morphology and DNA integrity were measured. The differences between the control group and the experimental group were of no statistical significance (p > .05). When the concentration of mifepristone was higher than 0.4 μM, the proportion of sperm hyperactivation was significantly reduced (p < .01). According to further examination on the rate of acrosomal reaction (AR rate) and the con-centration of free calcium ions in sperms, it was found that acrosomal reaction was significantly inhibited with the concentration of free calcium ions in sperms decreased when the concentration of mifepristone was higher than 0.4 μM. Conclusions: The in-vitro spermicidal mechanism of mifepristone is realized by inhibiting acrosomal reaction, hyperactivation and decreasing the concentration of free calcium ions.展开更多
Unintended pregnancy rates remain high throughout the World and increase the risk of poor maternal and infant outcomes.Most of unintended pregnancies occur in women who were not using contraceptionor who became pregna...Unintended pregnancy rates remain high throughout the World and increase the risk of poor maternal and infant outcomes.Most of unintended pregnancies occur in women who were not using contraceptionor who became pregnant despite the reported use of contraception.Women who have had recent unprotected intercourse including those who have had another form of contraception fail are potential candidates for this intervention.Currently used em-ergency contraceptive methods are pills that contain combined estrogen-progesterone,only progestin,antiprogestins and copper intrauterine devices.The most common form of this type of contraception is oral progestin-only pills(levonorgestrel).The most effective method is copper intrauterine devices followed by anti-progestins and oral progestin-only pills.The major pathogenesis of oral emergency contraceptives is the prevention or delay of ovulation.Although conception is possible on only a few days of the cycle,emergency contraception is offered when indicated without regard to the timing of the menstrual cycle because of uncertainty in the timing of the ovulation.Levonorgestrel and E/P regimes are most effective as soon as possible after unprotected sexual intercourse.A linear relationship has been shown between ef-fectiveness and the time of dose.The effectiveness continues for 120 h,but it is recommended to be used within 72 h after intercourse.Intrauterine devices may prevent pregnancy when 5 d after ovulation.展开更多
文摘To compare the effectiveness and side effects of various low dose of Mifepristone in combination with Misoprostol and low doses Mifepristone alone in emergency contraception Materials & Methods This is a multi center double blind randomized controlled clinical trial. A total of 899 healthy women were allocated into this study and were randomly divided into 3 groups. They were orally administrated with different emergency contraceptives with 120 h after unprotected intercourse. Group I (n=300) was given 25 mg Mifepristone plus 0.2 mg Misoprostol after 24 h. Group II (n=299) was given 10 mg Mifepristone plus 0.2 mg Misoprostol after 24 h. Group III (n=300) was administrated with 10 mg Mifepristone alone. The effective rates in different groups were calculated with Dixon method. Results Altogether 11 pregnancies occurred, among which 2 cases were in Group I, 2 cases in Group II, and 7 cases were in Group III. After correction with method failure, there was only one case in Group I, 0 case in Group II, and 5 cases in Group III. The contraceptive effectiveness in these groups was 95.5%, 100% and 76.9% respectively. The pregnancy rate was significantly lower in Group I and Group II than that of Group III (P<0.01). The side effects were slight and tolerable, and there was no significant difference between different groups (P>0.05). Conclusion Use of low dose Mifepristone (25 mg or 10 mg) in combination with 0.2 mg Misoprostol was an effective, low side effects and safe treatment regimen for emergency contraception.
文摘Objective: Mifepristone, as a type of well-accepted emergency contraceptive drugs, is an optional progesterone receptor mod-ulator and widely used clinically. However, the effect of mifepristone on sperms is poorly studied. This research is intended to investigate the biological effect of mifepristone on human sperm function in vitro. Methods: Spermatozoa were incubated in the culture medium containing 0.04 μM, 0.4 μM, 4 μM and 40 μM of mifepristone for one hour after capacitation. It was required to measure sperm motility, viability, DNA integrity, acrosomal reaction, sperm hyperactivation, and the concentration of free calcium ions in spermatozoa. Results: After treating sperms with different concentrations of mifepristone in vitro, sperm viability, motility, morphology and DNA integrity were measured. The differences between the control group and the experimental group were of no statistical significance (p > .05). When the concentration of mifepristone was higher than 0.4 μM, the proportion of sperm hyperactivation was significantly reduced (p < .01). According to further examination on the rate of acrosomal reaction (AR rate) and the con-centration of free calcium ions in sperms, it was found that acrosomal reaction was significantly inhibited with the concentration of free calcium ions in sperms decreased when the concentration of mifepristone was higher than 0.4 μM. Conclusions: The in-vitro spermicidal mechanism of mifepristone is realized by inhibiting acrosomal reaction, hyperactivation and decreasing the concentration of free calcium ions.
文摘Unintended pregnancy rates remain high throughout the World and increase the risk of poor maternal and infant outcomes.Most of unintended pregnancies occur in women who were not using contraceptionor who became pregnant despite the reported use of contraception.Women who have had recent unprotected intercourse including those who have had another form of contraception fail are potential candidates for this intervention.Currently used em-ergency contraceptive methods are pills that contain combined estrogen-progesterone,only progestin,antiprogestins and copper intrauterine devices.The most common form of this type of contraception is oral progestin-only pills(levonorgestrel).The most effective method is copper intrauterine devices followed by anti-progestins and oral progestin-only pills.The major pathogenesis of oral emergency contraceptives is the prevention or delay of ovulation.Although conception is possible on only a few days of the cycle,emergency contraception is offered when indicated without regard to the timing of the menstrual cycle because of uncertainty in the timing of the ovulation.Levonorgestrel and E/P regimes are most effective as soon as possible after unprotected sexual intercourse.A linear relationship has been shown between ef-fectiveness and the time of dose.The effectiveness continues for 120 h,but it is recommended to be used within 72 h after intercourse.Intrauterine devices may prevent pregnancy when 5 d after ovulation.
