Saccades of video head impulse test in Meniere's disease and Vestibular Migraine: What can we learn from?

Background:Saccades are often observed on video head impulse tests(vHIT)in patients with Meniere's Disease(MD)and Vestibular Migraine(VM).However,their saccadic features are not fully described.Objective:This study aims to identify the saccades characteristics of MD and VM.Methods:75 VM patients and 103 definite unilateral MD patients were enrolled in this study.First raw saccades were exported and analyzed.The VM patients were divided into left and right based on their ears,while the MD patients were separated into affected and unaffected subgroups based on their audiograms and symptoms.Results:The MD patients have more saccades on the affected side(85%vs.69%),and saccade velocity is more consistent than the contralateral side(shown by the coefficient of variation).The saccades occurrence rates on both sides are similar in VM(77%vs.76%),as are other saccadic parameters.The MD patients have more significant inter-aural differences than the VM patients,manifested in higher velocity(p-value 0.000),earlier arriving(p-value 0.010),and more time-domain gathered(p-value 0.003)on the affected side.Conclusions:Bilateral saccades are commonly observed in MD and VM.In contrast to MD,saccades on VM are subtle,scattered,and late-arrived.Furthermore,the MD patients showed inconsistent saccadic distribution with more velocity-uniform saccades on the affected side.

Exploration of the efficacy and mechanism of treating head wind disease with the combination change of ginger volatile oil and gingerol by using content-weighted network pharmacology technology

Background:Exploring the efficacy,potential components,and mechanism of the combination of ginger essential oil and gingerols in the treatment of head wind disease based on network pharmacology technology with content weight.Methods:The experimental groups were divided into:0:10,1:4,1:2,1:1,2:1,4:1,10:0.The relative content(Ri)of the chemical constituents of ginger's volatile oil was determined using gas chromatography-mass spectrometry(GC-MS).Additionally,the physicochemical and biological property parameters(LogP,MDCK,PPB,MW)of the components were considered.To assess the quantitative effect of the components,a grading score was performed,and the quantitative effect index(Ki)was calculated.Subsequently,the target effect index(Ti)was calculated by combining the component-target matching score(Fit score).Using these calculations,the target effect score A was determined under the influence of multiple components targeting different targets.Key targets with A≥1000 were identified.To predict the targets related to head wind disease,the Comparative Toxicogenomics Database(https://ctdbase.org/),Gene Cards(https://www.genecards.org/),and Disgenet database(https://www.disgenet.org/)were utilized.The key targets,obtained from different proportions of ginger's volatile oil and gingerol,were intersected with the predicted targets.This facilitated network pharmacological analysis and verification of the efficacy.Results:The content of volatile oil in ginger demonstrated an impact on key targets associated with the volatile oil group.Each specific combination of volatile oil consistently activated distinct pathways,with variations stemming from changes in content.Experimental testing revealed that different combinations of ginger's volatile oil and gingerol effectively alleviated migraine symptoms in rats.Conclusion:Through the application of content-weighted network pharmacology technology and pharmacodynamic verification,it was determined that altering the ratio between ginger's volatile oil and gingerol leads to variations in potential targets and pathways,consequently impacting its efficacy.

Analysis of video head impulse test saccades data in patients with vestibular migraine or probable vestibular migraine

Objective:Saccades accompanied by normal gain in video head impulse tests(vHIT)are often observed in patients with vestibular migraine(VM).However,they are not considered as an independent indicator,reducing their utility in diagnosing VM.To better understand clinical features of VM,it is necessary to understand raw saccades data.Methods:Fourteen patients with confirmed VM,45 patients with probable VM(p-VM)and 14 agematched healthy volunteers were included in this study.Clinical findings related to spontaneous nystagmus(SN),positional nystagmus(PN),head-shaking nystagmus(HSN),caloric test and vHIT were recorded.Raw saccades data were exported and numbered by their sequences,and their features analyzed.Results:VM patients showed no SN,PN or HSN,and less than half of them showed unilateral weakness(UW)on caloric test.The first saccades from lateral semicircular canal stimulation were the most predominant for both left and right sides.Neither velocity nor time parameters were significantly different when compared between the two sides.Most VM patients(86%)exhibited small saccades,around 35%of the head peak velocity,with a latency of 200e400 ms.Characteristics of saccades were similar in patients with p-VM.Only four normal subjects showed saccades,all unilateral and seemingly random.Conclusions:Small saccades involving bilateral semicircular canals with a scattered distribution pattern are common in patients with VM and p-VM.

Xiongzhi Dilong decoction interferes with calcitonin gene-related peptide(CGRP)-induced migraine in rats through the CGRP/iNOS pathway

Objective: To evaluate the effects of Xiongzhi Dilong decoction(XZDLD) and its wind medicine on calcitonin gene-related peptide(CGRP)-induced migraine and explore the mechanism through the CGRP/inducible nitric oxide synthase(iNOS) pathway.Methods: Rats were divided into control, model, XZDLD, XZDLD(external wind), XZDLD(internal wind),and olcegepant groups. CGRP was injected into the dura mater to induce a migraine. The frequency of head scratching, cage climbing, and facial grooming was observed. The pain threshold, the levels of CGRP,pituitary adenylate cyclase activating polypeptide(PACAP), substance P(SP), and the plasma protein extravasation(PPE) ratio were measured. The phosphorylation levels of p38, extracellular signalregulated kinase 1/2(ERK1/2), and expression of iNOS were detected by western blot.Results: Compared with the model group, the three modified XZDLD groups showed reduced frequency of head scratching and cage climbing in the first 30 min(all P <.05). Facial grooming frequency was reduced in XZDLD and XZDLD(external wind) groups(P =.0003 and P =.0131, respectively). External wind medicine played a more important role in increasing mechanical pain threshold than internal wind medicine. Moreover, compared with the model group, the three modified XZDLD groups demonstrated reduced plasma levels of CGRP and PACAP(all P <.05). No difference in the SP level was observed among the six groups. XZDLD reduced PPE ratio. XZDLD and XZDLD(external wind) groups suppressed the CGRP/iNOS pathway by inhibiting the p-p38/p38 ratio and the expression of iNOS. No difference in pERK1/2/ERK1/2 ratio was detected among the six groups.Conclusion: XZDLD increases pain threshold, downregulates the expression of CGRP and PACAP, and reduces PPE ratio by inhibiting the CGRP/iNOS pathway. External wind medicine is more effective than internal one on improving facial grooming and head scratching, increasing the mechanical pain threshold, and inhibiting the expression of iNOS.

Analysis on formula principles for“head wind”disease based on apriori and clustering algorithm

Objective:To explore the formula principles for“head wind”disease by data-mining and provide reference for the treatment of“head wind”disease.Methods:Prescriptions for headache from“Dictionary of Traditional Chinese Medicine Prescriptions”were collected,sorted and entered into the“Traditional Chinese Medicine Inheritance System”(V2.5)to analyze the composition principles by the methods of revised mutual information,complex system entropy cluster and unsupervised hierarchical cluster.Results:The herbs with high usage frequency in these prescriptions for“head wind”disease included Chuan-xiong,Bai-zhi,Xi-xin,Fang-feng,Gan-cao,Shi-Gao and Qiang-Huo.Three new prescriptions were obtained based on the composition principles and rules.The first new prescription is composed of Quan-xie,Xiong-huang,Jiang-can,Zhi-chuan-wu and Di-long.The second new prescription is composed of Du-huo,Rou-gui,Ku-shen;Fang-feng,Gao-ben,Qiang-huo.The third new prescription is composed of Fu-zi,Sheng-chuan-wu,Tian-nan-xing,Chuan-xiong,Bai-zhi,Shi-gao.Conclusion:We found that the most of herbs used to treat the“head wind”disease are warm and spicy,mainly belong to diaphoretic herbs,wind-expelling herbs,and dampness-dispelling herbs.In addition,the new prescriptions for infertility mainly focus on eliminating evil,with the characteristics of“eliminating phlegm and turbid”,“dredging the channels and collaterals”,“expelling wind-evil”and“promoting blood circulation”.

考虑激励幅值慢变的卷绕头转子系统动力学建模

卷绕头转子系统结构之间的耦合振动和时频变激励使振动问题十分复杂,为了更准确地研究其动力学特性,根据转子动力学理论,使用有限元方法建立了考虑多盘质量慢变的卷绕头非线性转子系统整机动力学模型,运用Newmark-β数值积分方法对其动力学特性求解,得到仅存在初始不平衡量以及卷装不良带来的激励频率、幅值慢变下的非线性动力学行为。通过分析轴心轨迹、时域波形和幅频特性曲线等结果,发现卷绕头转子系统对因卷装不良引起的激励幅值慢变较为敏感,出现新的频率成分。进一步对比分析了不同节点处的振动频谱,其结果可为卷绕头转子系统动力学设计和故障识别提供一定理论支持。

基于SHAP重要性排序和时空双流的多风场超短期功率预测

针对多风场风功率预测中时空特征提取不充分的问题,提出一种基于空间、时间双流特征提取的功率预测方法。采用沙普利加性解释(SHAP)方法分析原始高维数值天气预报(NWP)中各变量的重要性,选择贡献度高的变量子集作为预测模型输入,降低模型复杂度。构建基于自适应动态邻接矩阵的改进图注意力网络(IGAT)提取多风场的动态空间特征;同时将多头注意力机制(MHA)与时间卷积网络(TCN)结合,加强关键时序特征的学习。使用前馈神经网络输出多风场功率预测结果。以西北某十风场的数据进行案例研究,结果表明所提模型的预测效果优于其他模型。

基于MAGAT的风电场功率缺失数据填充方法

风电场功率数据质量对风电预测具有重要意义。然而,由于人为操作、传感器故障、网络故障或通信拥堵等原因,风电场功率数据容易出现大面积缺失问题。因此,结合多头注意力机制(multi-head attention,MA)和图注意力网络(graph attention network,GAT)构建了MAGAT模型,其中GAT层以异质图的方式刻画及提取风电场已知数据与缺失数据的关联关系,MA层挖掘风电场数据特征与缺失功率数据之间的映射关系,从而实现风电场功率缺失数据的高精度填充。在以我国江苏某风电场运行监测数据为对象的算例分析中,与其他先进填充算法相比,所提方法在不同缺失类型、不同缺失率等多个场景下均具有更好表现,表明所提方法在风电场缺失数据填充任务上的有效性及稳定性。

头穴丛刺长留针法治疗偏头痛的疗效观察

目的 观察头穴丛刺长留针法治疗偏头痛的临床疗效。方法 将88例偏头痛患者随机分为观察组(44例,脱落2例)和对照组(44例,脱落3例)。观察组采用常规针刺联合头穴丛刺长留针法治疗,对照组采用常规针刺方法治疗。比较两组临床疗效,观察两组治疗前后的视觉模拟量表(visual analog scale, VAS)评分、偏头痛特异性生活质量问卷(migraine-specific quality of life questionnaire, MSQ)、血清5-羟色胺(5-hydroxytryptamine, 5-HT)浓度。结果 观察组总有效率为92.9%,高于对照组的78.0%,差异有统计学意义(P>0.05)。两组治疗后VAS评分较治疗前降低(P<0.05),两组随访时VAS评分较治疗前和治疗后降低(P<0.05);观察组治疗后及随访时,VAS评分均低于对照组(P<0.05)。两组治疗后MSQ评分较治疗前升高(P<0.05),两组随访时MSQ评分较治疗前和治疗后升高(P<0.05);观察组治疗后及随访时,MSQ评分均高于对照组(P<0.05)。两组治疗后血清5-HT浓度均升高,且观察组高于对照组,差异有统计学意义(P<0.05)。结论 在常规针刺基础上,头穴丛刺长留针法治疗偏头痛临床疗效优于常规针刺方法,且在减轻偏头痛患者疼痛程度,改善其生活质量及提高5-HT浓度方面优于常规针刺方法。

基于数据挖掘对中药治疗头风病的用药规律分析

目的通过数据挖掘发现中药治疗头风病的用药特点并分析总结其规律,为头风病的治疗提供理论依据及用药参考。方法通过检索式检索知网等数据库中自建库至2022年3月有关于中医药治疗头风病的临床医案并提取相关处方建立Excel数据库,使用IBM SPSS Modeler 18对提取的中药做频数分析、关联规则分析及聚类分析。结果合格文献67篇,共统计处方99个,含87味中药,共使用1276次。川芎的使用率最高为84.85%,其他居于前5位的分别是白芍、甘草、当归、白芷,辛、苦,温为首要性味,归经首归肝经,解表类药物的利用度最高,其次是补虚类及活血化瘀类药物,关联程度较高的主要药对为当归—甘草—川芎、当归—白芷—川芎、柴胡—甘草—川芎、僵蚕—川芎、柴胡—白芷—川芎等。结论中医药治疗头风病,多以活血化瘀、益气养血、平肝熄风为主,主要药物包括川芎、白芍、甘草、当归、白芷、柴胡等。

电视剧《风起陇西》男子首服设计考

电视剧《风起陇西》的男子首服设计种类丰富,具有表意、象征、隐喻等功能,是串联全剧内容的重要线索,因其精良的制作水准而备受关注。文章以电视剧《风起陇西》的首服制作实物为研究对象,主要采用文献研究法,结合考古实物和其他艺术形式的图像,梳理、考辨、比对首服形态。研究认为电视剧《风起陇西》男子首服的结构、形制与运用基本符合历史依据,在追求历史之真的基础上进行了艺术化再创作,重视首服设计在视觉语言层面发挥的重要作用。

摇头倾斜抑制试验和视频头脉冲试验鉴别前庭性偏头痛和梅尼埃病的应用研究

背景 摇头倾斜抑制试验(HSTST)与前庭小脑介导的中枢储存机制有关,视频头脉冲试验(vHIT)对外周前庭疾病的诊断起重要作用。目的 探索HSTST及vHIT在诊断前庭性偏头痛(VM)和梅尼埃病(MD)中的临床应用价值。方法 选取2021年7月—2022年12月就诊于贵阳市第二人民医院神经内科以眩晕或头晕为主诉、诊断为VM及MD的患者。完成病史采集、床旁查体;有听力损害者完善纯音测听检查;所有患者进行前庭功能检查,包括摇头试验(HST)、HSTST、温度试验及vHIT,计算倾斜抑制指数(TSI)。比较HST阳性的VM及MD患者临床特征及检查结果,绘制TSI鉴别HST阳性的VM和MD患者的受试者工作特征(ROC)曲线。结果 研究共纳入VM患者50例,其中HST阳性22例(44.0%),包括水平眼震19例(86.4%),垂直眼震3例(13.6%);MD患者45例,其中HST阳性23例(51.1%),均为水平眼震。对HST阳性的VM及MD的患者分析显示:VM患者女∶男=4.5∶1,MD患者女∶男=1∶1.3,VM患者头痛家族史比例高于MD患者(P<0.05);VM患者伴随呕吐、耳鸣、耳闷感、听力下降症状的比例(31.8%、18.2%、13.6%、13.6%)低于MD患者(73.9%、100.0%、82.6%、100.0%),伴随头痛症状的比例(77.3%)高于MD患者(8.7%)(P<0.05);纯音测听结果显示MD患者听力下降比例高于VM患者(P<0.001);VM与MD患者vHIT结果比较,差异有统计学意义(P<0.05);VM与MD患者的TSI比较[(25.41±12.15)%与(78.71±13.76)%],差异有统计学意义(P<0.05),TSI鉴别HST阳性VM和MD的灵敏度为0.90,特异度为0.95,ROC曲线下面积为0.962(95%CI=0.91~1.00),最佳截断值为0.66。结论 VM主要是中枢机制,HSTST联合v HIT可以作为鉴别VM和MD的辅助检查工具。

自拟芎芷柴胡汤治疗无先兆偏头痛少阳邪郁证临床观察

目的 观察自拟芎芷柴胡汤治疗少阳邪郁型无先兆偏头痛的疗效。方法 将68例少阳邪郁型无先兆偏头痛的患者随机分为治疗组35例和对照组33例。对照组口服盐酸氟桂利嗪胶囊,治疗组口服芎芷柴胡汤。结果 治疗28 d后,治疗组VAS评分、每次发作持续时间、发作次数均低于对照组(P<0.05);治疗组的中医证候积分低于对照组(P<0.05);治疗组总有效率和愈显率均高于对照组(P<0.05)。结论 芎芷柴胡汤治疗少阳邪郁型无先兆偏头痛临床疗效满意,值得推广应用。

Revisiting Tashigang village

If you drive along the winding National Highway 318 for two hours,cross the Mon La Pass at an altitude of 4,742 meters,and keep heading south,past the Lhulang Town,Nyingchi City,surrounded by lush forests,you will arrive at Tashigang Village.From 2017 to 2023,I visited Tashigang three times,witnessing its steady development driven by the national strategy of rural revitalization.

考虑横向风浪干扰的舰船航向稳定性自动控制算法

考虑横向风浪干扰下,舰船进入横摇运动状态易偏离期望航向轨迹,为此,研究考虑横向风浪干扰的舰船航向稳定性自动控制算法。对舰船舵机、横向风浪干扰建模,基于所掌握的舰船舵机控制参数、干扰强度,将期望航向参数输入航向控制器,在基于改进BP-PID算法的航向稳定性自动控制方案下,由改进BP神经网络整定PID控制器参数,输出满足期望航向条件的舵角、舵速调节比例系数、微分系数以及积分系数,调节航向,实现航向稳定性自动控制。实验中,横向风浪干扰下,使用此算法控制舰船航向后,舰船航行时首摇角、横摇角、鳍角均方差明显变小,说明该算法可控制舰船按照期望航向稳定航行。

卷绕头横动拨叉机构对丝饼成型的影响分析

为进一步提升产品效能,分析FDY卷绕头横动拨叉机构的工作原理。根据卷绕头横动拨叉的结构特性的演变过程,分析了TMT卷绕机的两轴两叶型拨叉较其他类型拨叉存在的差异。结合拨叉的设计及运动特点,改变拨叉机构成型板、拔叉叶片及八字形瓷件的定位及尺寸,满足丝饼同卷径增质量的运行条件。生产实践结果表明:所使用的拨叉机构通过相关设计改造及调整相应工艺参数可以达到提升产品运输包装效率和节约能耗的目的。

考虑Miner线性累计损伤的卷绕头疲劳寿命预测

纺织机卷绕头长期振动会产生零件损伤,这种振动损伤会形成线性积累,当前方法对卷绕头的疲劳损伤以固定阈值为主,未考虑损伤积累问题,所以难以准确预测卷绕头的疲劳寿命。因此提出基于Miner线性累计损伤的纺织机卷绕头疲劳寿命预测方法。分析纺织卷绕头的主要结构,并从轴段单元、刚性盘、机匣、支承部件四方面出发,构建卷绕头整体的动力学方程。构建振动方程明确卷绕头的振动受力,结合Miner线性累计损伤理论,构建高速卷绕头的疲劳寿命预测函数,完成纺织机卷绕头疲劳寿命的预测。实验结果表明:这种估计方法的疲劳强度损失值与实际值更为接近,振动位移分析结果更加精准,且疲劳寿命预测误差降低,平均误差仅为1.475%。

Assessment of natural frequency of installed offshore wind turbines using nonlinear finite element model considering soil-monopile interaction

A nonlinear finite element model is developed to examine the lateral behaviors of monopiles, which support offshore wind turbines(OWTs) chosen from five different offshore wind farms in Europe. The simulation is using this model to accurately estimate the natural frequency of these slender structures, as a function of the interaction of the foundations with the subsoil. After a brief introduction to the wind power energy as a reliable alternative in comparison to fossil fuel, the paper focuses on concept of natural frequency as a primary indicator in designing the foundations of OWTs. Then the range of natural frequencies is provided for a safe design purpose. Next, an analytical expression of an OWT natural frequency is presented as a function of soil-monopile interaction through monopile head springs characterized by lateral stiffness KL, rotational stiffness KRand cross-coupling stiffness KLRof which the differences are discussed. The nonlinear pseudo three-dimensional finite element vertical slices model has been used to analyze the lateral behaviors of monopiles supporting the OWTs of different wind farm sites considered. Through the monopiles head movements(displacements and rotations), the values of KL, KRand KLRwere obtained and substituted in the analytical expression of natural frequency for comparison. The comparison results between computed and measured natural frequencies showed an excellent agreement for most cases. This confirms the convenience of the finite element model used for the accurate estimation of the monopile head stiffness.

Path planning for unmanned aerial vehicles in surveillance tasks under wind fields

The optimal path planning for fixed-wing unmanned aerial vehicles(UAVs) in multi-target surveillance tasks(MTST) in the presence of wind is concerned.To take into account the minimal turning radius of UAVs,the Dubins model is used to approximate the dynamics of UAVs.Based on the assumption,the path planning problem of UAVs in MTST can be formulated as a Dubins traveling salesman problem(DTSP).By considering its prohibitively high computational cost,the Dubins paths under terminal heading relaxation are introduced,which leads to significant reduction of the optimization scale and difficulty of the whole problem.Meanwhile,in view of the impact of wind on UAVs' paths,the notion of virtual target is proposed.The application of the idea successfully converts the Dubins path planning problem from an initial configuration to a target in wind into a problem of finding the minimal root of a transcendental equation.Then,the Dubins tour is derived by using differential evolution(DE) algorithm which employs random-key encoding technique to optimize the visiting sequence of waypoints.Finally,the effectiveness and efficiency of the proposed algorithm are demonstrated through computational experiments.Numerical results exhibit that the proposed algorithm can produce high quality solutions to the problem.

广西寒露风初日变化特征以及对双季晚稻抽穗安全期的影响

基于广西1961-2020年88个气象站观测资料,分析寒露风初日时空变化特征、50%及80%保证率初日,并结合水稻发育期资料对广西双季晚稻抽穗安全期进行分析。结果显示:(1)在时间上,广西寒露风初日以0.23 d/10a(P<0.05)的速率呈微弱提前趋势,呈不对称的“W”形特征;在空间上,广西寒露风初日呈高纬度早、低纬度晚,山区早、平地晚的“阶梯式”分布特征。(2)广西寒露风初日存在22年、12年、8年、3年4个周期变化,其中22年是广西寒露风初日的主要周期,未发生明显突变。(3)广西双季晚稻平均齐穗期以0.22 d/10a(P<0.05)的速率推迟,抽穗扬花期遭遇寒露风影响频率为21.9%。建议适当调整晚稻播种期,使其齐穗期提早3~7 d。桂中北地区应谨慎推广晚稻中晚熟品种,以避免受突发性的寒露风灾害影响。