目的:构建针对脾肾亏虚型轻度认知障碍患者的经络拍打方案。方法:检索中国知网、万方数据库、维普数据库、PubMed、Web of Science、读秀学术搜索从建库至2022年12月,通过文献研究法确定脾肾亏虚型轻度认知障碍患者经络拍打方案的初稿,...目的:构建针对脾肾亏虚型轻度认知障碍患者的经络拍打方案。方法:检索中国知网、万方数据库、维普数据库、PubMed、Web of Science、读秀学术搜索从建库至2022年12月,通过文献研究法确定脾肾亏虚型轻度认知障碍患者经络拍打方案的初稿,遴选来自陕西省、广东省、广西壮族自治区、湖北省、福建省、山东省、湖南省、四川省的21名专家进行2轮问卷函询。结果:两轮专家积极系数分别为100.0%和95.2%,权威程度分别为0.89、0.90,协调系数分别为0.407、0.349,经χ2检验,差异均有统计学意义(P<0.001),同时运用成分分析法进行一致性检验,一致性比例均<0.1。最终形成脾肾亏虚型轻度认知障碍患者经络拍打方案,包括2个一级指标、7个二级指标、12个三级指标。结论:本研究构建的方案有一定科学性和实用性,可为脾肾亏虚型轻度认知障碍患者进行经络拍打治疗提供参考。展开更多
Epidemiological and biological evidences support a link between type 2 diabetes mellitus(DM2) and Alzheimer's disease(AD). Persons with diabetes have a higher incidence of cognitive decline and an increased risk o...Epidemiological and biological evidences support a link between type 2 diabetes mellitus(DM2) and Alzheimer's disease(AD). Persons with diabetes have a higher incidence of cognitive decline and an increased risk of developing all types of dementia. Cognitive deficits in persons with diabetes mainly affect the areas of psychomotor efficiency, attention, learning and memory, mental flexibility and speed, and executive function. The strong epidemiological association has suggested the existence of a physiopathological link. The determinants of the accelerated cognitive decline in DM2, however, are less clear. Increased cortical and subcortical atrophy have been evidenced after controlling for diabetic vascular disease and inadequate cerebral circulation. Most recent studies have focused on the role of insulin and insulin resistance as possible links between diabetes and AD. Disturbances in brain insulin signaling mechanisms may contribute to the molecular, biochemical, and histopathological lesions in AD. Hyperglycemia itself is a risk factor for cognitive dysfunction and dementia. Hypoglycemia may also have deleterious effects on cognitive function. Recurrent symptomatic and asymptomatic hypoglycemic episodes have been suggested to cause sub-clinical brain damage, and permanent cognitive impairment. Futuretrials are required to clarify the mechanistic link, to address the question whether cognitive decline may be prevented by an adequate metabolic control, and to elucidate the role of drugs that may cause hypoglycemic episodes.展开更多
文摘目的:构建针对脾肾亏虚型轻度认知障碍患者的经络拍打方案。方法:检索中国知网、万方数据库、维普数据库、PubMed、Web of Science、读秀学术搜索从建库至2022年12月,通过文献研究法确定脾肾亏虚型轻度认知障碍患者经络拍打方案的初稿,遴选来自陕西省、广东省、广西壮族自治区、湖北省、福建省、山东省、湖南省、四川省的21名专家进行2轮问卷函询。结果:两轮专家积极系数分别为100.0%和95.2%,权威程度分别为0.89、0.90,协调系数分别为0.407、0.349,经χ2检验,差异均有统计学意义(P<0.001),同时运用成分分析法进行一致性检验,一致性比例均<0.1。最终形成脾肾亏虚型轻度认知障碍患者经络拍打方案,包括2个一级指标、7个二级指标、12个三级指标。结论:本研究构建的方案有一定科学性和实用性,可为脾肾亏虚型轻度认知障碍患者进行经络拍打治疗提供参考。
文摘Epidemiological and biological evidences support a link between type 2 diabetes mellitus(DM2) and Alzheimer's disease(AD). Persons with diabetes have a higher incidence of cognitive decline and an increased risk of developing all types of dementia. Cognitive deficits in persons with diabetes mainly affect the areas of psychomotor efficiency, attention, learning and memory, mental flexibility and speed, and executive function. The strong epidemiological association has suggested the existence of a physiopathological link. The determinants of the accelerated cognitive decline in DM2, however, are less clear. Increased cortical and subcortical atrophy have been evidenced after controlling for diabetic vascular disease and inadequate cerebral circulation. Most recent studies have focused on the role of insulin and insulin resistance as possible links between diabetes and AD. Disturbances in brain insulin signaling mechanisms may contribute to the molecular, biochemical, and histopathological lesions in AD. Hyperglycemia itself is a risk factor for cognitive dysfunction and dementia. Hypoglycemia may also have deleterious effects on cognitive function. Recurrent symptomatic and asymptomatic hypoglycemic episodes have been suggested to cause sub-clinical brain damage, and permanent cognitive impairment. Futuretrials are required to clarify the mechanistic link, to address the question whether cognitive decline may be prevented by an adequate metabolic control, and to elucidate the role of drugs that may cause hypoglycemic episodes.
