Clinical effects of nonconvulsive electrotherapy combined with mindfulness-based stress reduction and changes of serum inflammatory factors in depression

BACKGROUND Depression is a common and serious psychological condition,which seriously affects individual well-being and functional ability.Traditional treatment methods include drug therapy and psychological counseling;however,these methods have different degrees of side effects and limitations.In recent years,nonconvulsive electrotherapy(NET)has attracted increasing attention as a noninvasive treatment method.However,the clinical efficacy and potential mechanism of NET on depression are still unclear.We hypothesized that NET has a positive clinical effect in the treatment of depression,and may have a regulatory effect on serum inflammatory factors during treatment.AIM To assess the effects of NET on depression and analyze changes in serum inflammatory factors.METHODS This retrospective study enrolled 140 patients undergoing treatment for depression between May 2017 and June 2022,the observation group that received a combination of mindfulness-based stress reduction(MBSR)and NET treatment(n=70)and the control group that only received MBSR therapy(n=70).The clinical effectiveness of the treatment was evaluated by assessing various factors,including the Hamilton Depression Scale(HAMD)-17,self-rating idea of suicide scale(SSIOS),Pittsburgh Sleep Quality Index(PSQI),and levels of serum inflammatory factors before and after 8 wk of treatment.The quality of life scores between the two groups were compared.Comparisons were made using t and χ^(2) tests.RESULTS After 8 wk of treatment,the observation group exhibited a 91.43%overall effectiveness rate which was higher than that of the control group which was 74.29%(64 vs 52,χ^(2)=7.241;P<0.05).The HAMD,SSIOS,and PSQI scores showed a significant decrease in both groups.Moreover,the observation group had lower scores than the control group(10.37±2.04 vs 14.02±2.16,t=10.280;1.67±0.28 vs 0.87±0.12,t=21.970;5.29±1.33 vs 7.94±1.35,t=11.700;P both<0.001).Additionally,there was a notable decrease in the IL-2,IL-1β,and IL-6 in both groups after treatment.Furthermore,the observation group exhibited superior serum inflammatory factors compared to the control group(70.12±10.32 vs 102.24±20.21,t=11.840;19.35±2.46 vs 22.27±2.13,t=7.508;32.25±4.6 vs 39.42±4.23,t=9.565;P both<0.001).Moreover,the observation group exhibited significantly improved quality of life scores compared to the control group(Social function:19.25±2.76 vs 16.23±2.34;Emotions:18.54±2.83 vs 12.28±2.16;Environment:18.49±2.48 vs 16.56±3.44;Physical health:19.53±2.39 vs 16.62±3.46;P both<0.001)after treatment.CONCLUSION MBSR combined with NET effectively alleviates depression,lowers inflammation(IL-2,IL-1β,and IL-6),reduces suicidal thoughts,enhances sleep,and improves the quality of life of individuals with depression.

Intervention effect of mindfulness-based stress reduction for psychological health among nurses:A meta-analysis

Objective:To systematically evaluate the effects of MBSR on psychological health intervention in nurses.Methods:The randomized controlled trial(RCT)and self-controlled trial(SC)investigating the application of mindfulness-based stress reduction in nursing staff were retrieved from CNKI,WanFang,VIP,PubMed,Cochrane Library,Web of Science,EMBASE databases.The retrieval time was set from the establishment of the database to April 2020.The Review Manager 5.3 software were used for meta-analysis.Result:9 RCTs and 5 self-control trails were included with 1421,712 subjects in the experimental group and 709 subjects in the control group.The results of the meta-analysis showed that compared with the control group,mindfulness-based stress reduction therapy can effectively reduce the psychological symptoms of clinical nurses[SMD=-0.96,95%CI(-1.51,-0.38),P=0.001],reduces nurses'anxiety levels[SMD=-1.28,95%CI(-2.18,-0.38),P=0.005],relieve the nurse's depression[SMD=-1.08,95%CI(-2.15,-0.02),P=0.005],improve the mental resilience of nurse[SMD=7.05,95%CI(3.93,10.17),P=0.03],showing a statistical meaning.Conclusion:The mental health of nurses is often neglected by themselves and there is insufficient awareness that MBSR can improve mental health.There has been a debate about whether MBSR actually improves the mental health of nurses,so it is necessary to further explore this issue and seek better methods and opportunities for practice.

Effects of mindfulness-based stress reduction therapy on anxiety and depression in patients with maintenance hemodialysis:a meta analysis

Objective:This study aimed to evaluate the effects of mindfulness-based stress reduction therapy on anxiety and depression in patients with maintenance hemodialysis.Methods:CNKI,VIP,WanFang,CBM,Embase,the Cochrane Library and PubMed databases were retrieved.Randomized controlled trials of intervention effects of mindfulness-based stress reduction combined with conventional hemodialysis education compared with conventional hemodialysis education on maintenance hemodialysis patients were collected.The retrieval period was from the establishment of the database to December 2019.Two researchers independently screened the literatures,extracted the data and evaluated the risk of bias in the included studies.RevMan 5.3 software was used for analysis.Results:A total of 9 studies,which comprised a total of 664 participants were included in the final meta analysis.The results showed that mindfulness-based stress reduction could reduce the anxiety of patients(SMD=?1.65,95%CI:?2.29 to?1.01),reduce the depression(SMD=?1.44,95%CI:?1.85 to?1.03).Conclusion:Mindfulness-based stress reduction therapy has positive effects on depression,anxiety in patients with maintenance hemodialysis.

Mindfulness-based stress reduction training and supplemented Jinshui Liujun decoction promote recovery in patients with nonsmall cell lung cancer

BACKGROUND Conventional chemotherapy(CC)administered to patients with non-small cell lung cancer(NSCLC)often causes adverse effects,such as cardiopulmonary dysfunction and immune system imbalance.Patients may experience anxiety and depression during the perioperative period due to various factors,such as treatment costs and cancer recurrence risks,thereby compromising the overall quality of life.Consequently,we hypothesized that integrating mindfulness-based stress reduction training(MSRT)with Jinshui Liujun decoction may mitigate negative emotions and promote recovery in patients with NSCLC.AIM To explore the effects of MSRT and Jinshui Liujun decoction on the immune function and emotional state of NSCLC patients.METHODS A retrospective clinical study was conducted involving 92 patients with stage IIIb-IV NSCLC;35 patients in the control group(CG)received CC therapy(combination of pemetrexed and carboplatin),and 57 patients in the treatment group(TG)received MSRT-assisted flavored Jinshui Liujun decoction(FJLD)in addition to CC.We evaluated the survival time,Karnofsky performance status,treatment efficacy,traditional Chinese medicine syndrome score,immune function,negative emotional level,and adverse reactions of the CG and TG.RESULTS Median progression-free survival,Karnofsky performance status,and clinical efficacy of the TG were superior to those of the CG(P<0.05).Symptoms of cough,weakness,bloody sputum,shortness of breath,and chest pain significantly decreased in the TG compared to that in the CG(P<0.05).In the TG,MSRT+FJLD treatment increased the numbers of CD3^(+)and CD4^(+)immune cells,effectively reduced the number of CD8^(+)cells,and enhanced the CD4^(+)/CD8^(+)ratio,thereby restoring the immune function of patients.In the TG,the self-rating anxiety scale and self-rating depression scale scores decreased significantly.There was no statistically significant difference in the incidence of adverse reactions between the CG and TG(P>0.05).CONCLUSION MSRT+FJLD proved to be an effective treatment for patients with NSCLC.

Simulation of thermal and sodium expansion stress in aluminum reduction cells

Two finite element(FE) models were built up for analysis of stress field in the lining of aluminum electrolysis cells.Distribution of sodium concentration in cathode carbon blocks was calculated by one FE model of a cathode block.Thermal stress field was calculated by the other slice model of the cell at the end of the heating-up.Then stresses coupling thermal and sodium expansion were considered after 30 d start-up.The results indicate that sodium penetrates to the bottom of the cathode block after 30 d start-up.The semi-graphitic carbon block has the largest stress at the thermal stage.After 30 d start-up the anthracitic carbon has the greatest sodium expansion stress and the graphitized carbon has the lowest sodium expansion stress.Sodium penetration can cause larger deformation and stress in the cathode carbon block than thermal expansion.

Influence of standardized nursing intervention combined with mindfulness stress reduction training on the curative effect in patients with acute pancreatitis

BACKGROUND Acute pancreatitis(AP)is a common inflammatory disease of the pancreas with high mortality rates.It is of great significance to take scientific intervention measures for patients with AP in time.AIM To explore the effect of standardized nursing combined with mindfulness stress reduction training on the curative effect,negative emotion,and quality of life in patients with acute pancreatitis.METHODS A total of 80 patients with acute pancreatitis admitted to The First People's Hospital of Jiangxia District Hospital from May 2021 to May 2023 were randomly divided into control group and observation group(n=40).Patients in control group were given the standardized nursing intervention,and the observation group were given standardized nursing plus mindfulness stress reduction training intervention.The time of clinical symptom disappeared or improved,complication occurrence rate,emotional state,and quality of life score of the two groups were observed and compared.RESULTS In comparison with the control group,the bowel sound recovery time,ventosity and abdominal pain improvement time,and venting and cacation time in observation group were shorter,and the total incidence rate of complications was reduced,showing statistically significant difference(P<0.05).The scores of anxiety and depression in observation group were lower than those in control group(P<0.05).Serum levels of tumour necrosis factor alpha,interleukin(IL)-6,IL-1βand IL-8 in observation group were lower than those in control group(P<0.05).The scores of life quality in physiology,psychology,environment and social relations in observation group were higher than those in control group,and the differences were statistically significant(P<0.05).CONCLUSION The application of standardized nursing intervention combined with mindfulness stress reduction training in patients with acute pancreatitis has a definite effect,which can help to ameliorate the clinical symptoms,anxiety and depression of patients,reduce the incidence rate of complications,and improve the prognosis of patients.

Properties and appropriate conditions of stress reduction factor and thermal shock resistance parameters for ceramics

Through introducing the analytical problem of the plate with convection into the solution of the transient heat conduction thermal stress field model of the elastic plate, the stress reduction factor is presented explicitly in its dimensionless form. A new stress reduction factor is introduced for the purpose of comparison. The proper- ties and appropriate conditions of the stress reduction factor, the first and second ther- mal shock resistance （TSR） parameters for the high and low Biot numbers, respectively, and the approximation formulas for the intermediate Blot number-interval are discussed. To investigate the TSR of ceramics more accurately, it is recommended to combine the heat transfer theory with the theory of thermoelasticity or fracture mechanics or use a numerical method. The critical rupture temperature difference and the critical rup- ture dimensionless time can be used to characterize the TSR of ceramics intuitively and legibly.

Research progress on the effects of positive stress reduction on positive awareness and psychosocial functioning in patients with depressive disorders

To review the current research status of positive thought stress reduction therapy(PTSRT),psychosocial functioning of patients with depressive disorders,the shortcomings and outlook of the influence of PTSRT on positive thought awareness,and psychosocial functioning of patients with depressive disorders.This review has the objective to provide clinical healthcare personnel with essential information about the use of PTSRT to improve the level of positive thought and psychosocial functioning of patients with depressive disorders.

Reduction and compensation of lattice stress in high energy P^+ and P+Sb implanted silicon

The relations of variation of lattice stress to shape, peak concentrations of the P atom depth profile and Sb doses of P+Sb dual implantation were studied in high energy P implantation silicon. The experimental results show that the lattice stress in P-implanted silicon obviously increases with increasing ion dose. The stress of P-implanted silicon with the dose of 2×1013/cm2 is 2.2 times greater than at a dose of 3.6×1012/cm2. The stress decreases rapidly as the annealing time increases.It is very interesting that the stress has a negative value when the concentration of P atoms in the implanted layer is below 6×1016/cm3, whereas the stress becomes positive when the concentration is greater than 6×16/cm3. The stress increases rapidly with increasing Sb ion dose after P implantation. The stress has a positive value before annealing. If the Sb dose is below 1 ×1016/cm2, the stress is negative after annealing,and it is positive when the Sb dose is higher than 1×1016/cm2. The stress is close to zero for a Sb implantation dose of 1×1016/cm2. The best compensation dose of Sb to P implantation dose of 3×1016/cm2 is 1×1016/cm2.

Mindfulness-based cognitive therapy in the intervention of psychiatric disorders: A review

Mindfulness-based cognitive therapy(MBCT)is frequently used for psychiatric disorders.Despite MBCT’s considerable potential for improving psychological health for patients,there is little empirical evidence to support its practical application in Chinese.This review will define meditation and mindfulness,provide an overview of the development of MBCT,identify the evidence for the effectiveness of MBCT,and offer recommendations to medical personnels on how to provide support for patients receiving mindfulness intervention.

Characteristics and mechanism investigation on drag reduction of oblique riblets

This work primarily focuses on the drag reduction characteristics and mechanism investigation of oblique riblets. First, a calculation model of the oblique riblets surface is established, and Reynolds stress model(RSM) turbulence model is used for numerical simulation of the oblique riblets flow field. Subsequently, the influence of inclination angle between flow direction and arrangement direction of riblets on friction resistance and drag reduction rate is further analyzed. Through the investigation of the distribution of shear stress, pressure stress and velocity in oblique riblets boundary layer, the oblique riblets drag reduction mechanism is finally revealed. Results show that, with increase of velocity and inclination angle, the pressure resistance increases obviously, along with the decreasing of the viscous resistance distinctly. The maximum drag reduction rate of the oblique riblets is 7.33%. Moreover, when the inclination angle increases, the wall shear stress reduces on oblique riblets surface; while differential pressure increases at both sides of oblique riblets tips. In addition, when inclination angle is small, the secondary vortex at oblique riblets tips will disappear soon. New vortices will be formed inside the oblique riblets and cause the decrease of viscosity resistance. Thus, oblique riblets show a better drag reduction effect and have an effective control on boundary layer.

Research Findings Using Mindfulness-Based Interventions for Chronic Pain

Chronic pain is a complex condition that is very detrimental to physical and psychological wellbeing. It carries a significant level of disability and economic burden. Pain patients frequently experience comorbid mental illness (e.g. depression, anxiety, PTSD, insomnia) and often require psychotherapeutic interventions in addition to medication management. Mindfulness-based interventions (MBIs) have emerged as a means to treat several chronic conditions (e.g. chronic pain, depression, anxiety, substance abuse, stress, insomnia). The objective of this review is to evaluate the current research on the use of MBIs in chronic pain managment. Although there are several controlled trials on the use of MBIs in chronic pain management, only a few studies were found that demonstrated significant effects on pain intensity, quality of life, as well as physical and psychological functioning. Therefore, the current evidence is mixed and there are insufficient data to definitively confirm the full impact of the use of MBIs in chronic pain conditions such as fibromyalgia, chronic low back pain, rheumatoid arthritis, and chronic musculoskeletal pain. The lack of compelling evidence at this time signals a demand for higher quality investigations in this area. Research examining MBIs and concomitant CBT may be of great value in order to synergize and strengthen patient outcomes.

Drag reduction by linear viscosity model in turbulent channel flow of polymer solution

A further numerical study of the theory that the drag reduction in the turbulence is related to the viscosity profile growing linearly with the distance from the wall was performed.The constant viscosity in the Navier-Stokes equations was replaced using this viscosity model.Some drag reduction characteristics were shown comparing with Virk's phenomenology.The mean velocity and Reynolds stress profiles are consistent with the experimental and direct numerical simulation results.A drag reduction level of 45% was obtained.It is reasonable for this linear viscosity model to explain the mechanism of turbulence drag reduction in some aspects.

Antioxidant-induced reductive stress has untoward consequences on the brain microvasculature

All cells in the body metabolize oxygen in a series of reactions in the mitochondria to generate energy.A by-product of these reactions is the production of highly reactive oxygen radicals which have the potential to cause irreparable damage to cellular components,and have been linked to mutagenic and neurotoxicity of the nervous system.Under normal conditions,innate molecular systems,glutathione,superoxide dismutases,

Bayesian partial pooling to reduce uncertainty in overcoring rock stress estimation

The state of in situ stress is a crucial parameter in subsurface engineering,especially for critical projects like nuclear waste repository.As one of the two ISRM suggested methods,the overcoring(OC)method is widely used to estimate the full stress tensors in rocks by independent regression analysis of the data from each OC test.However,such customary independent analysis of individual OC tests,known as no pooling,is liable to yield unreliable test-specific stress estimates due to various uncertainty sources involved in the OC method.To address this problem,a practical and no-cost solution is considered by incorporating into OC data analysis additional information implied within adjacent OC tests,which are usually available in OC measurement campaigns.Hence,this paper presents a Bayesian partial pooling(hierarchical)model for combined analysis of adjacent OC tests.We performed five case studies using OC test data made at a nuclear waste repository research site of Sweden.The results demonstrate that partial pooling of adjacent OC tests indeed allows borrowing of information across adjacent tests,and yields improved stress tensor estimates with reduced uncertainties simultaneously for all individual tests than they are independently analysed as no pooling,particularly for those unreliable no pooling stress estimates.A further model comparison shows that the partial pooling model also gives better predictive performance,and thus confirms that the information borrowed across adjacent OC tests is relevant and effective.

Finite element analysis of slope stability by expanding the mobilized principal stress Mohr's circles-Development, encoding and validation

In recent years,finite element analysis is increasingly being proposed in slope stability problems as a competitive method to traditional limit equilibrium methods(LEMs)which are known for their inherent deficiencies.However,the application of finite element method(FEM)to slope stability as a strength reduction method(SRM)or as finite element limit analysis(FELA)is not always a success for the drawbacks that characterize both methods.To increase the performance of finite element analysis in this problem,a new approach is proposed in this paper.It consists in gradually expanding the mobilized stress Mohr’s circles until the soil failure occurs according to a prescribed non-convergence criterion.The present approach called stress deviator increasing method(SDIM)is considered rigorous for three main reasons.Firstly,it preserves the definition of the factor of safety(FOS)as the ratio of soil shear strength to the mobilized shear stress.Secondly,it maintains the progressive development of shear stress resulting from the increase in the principal stress deviator on the same plane,on which the shear strength takes place.Thirdly,by introducing the concept of equivalent stress loading,the resulting trial stresses are checked against the violation of the actual yield criterion formed with the real strength parameters rather than those reduced by a trial factor.The new numerical procedure was encoded in a Fortran computer code called S^(4)DINA and verified by several examples.Comparisons with other numerical methods such as the SRM,gravity increasing method(GIM)or even FELA by assessing both the FOS and contours of equivalent plastic strains showed promising results.

Experimental and Numerical Investigation of Stress Condition in Unstable Soil

In unstable soils, a special erosion process termed suffusion can occur under the effect of relatively low hydraulic gradient. The critical hydraulic gradient of an unstable soil is smaller than in stable soils, which is described by a reduction factor α. According to a theory of Skempton and Brogan (1994) [1], this reduction factor is related to the stress conditions in the soil. In an unstable soil, the average stresses acting in the fine portion are believed to be smaller than the average stresses in the coarse portion. It is assumed that the stress ratio and the reduction factor for the hydraulic gradient are almost equal. In order to prove this theory, laboratory tests and discrete element modelings are carried out. Models of stable and unstable soils are established, and the stresses inside the sample are analysed. It is found that indeed in unstable soils the coarse grains are subject to larger stresses. The stress ratios in stable soils are almost unity, whereas in unstable soils smaller stress ratios, which are dependent on the soil composition and on the relative density of the soil, are obtained. A comparison between the results of erosion tests and numerical modeling shows that the stress ratios and the reduction factors are strongly related, as assumed by Skempton and Brogan (1994) [1].

Interrelations Between Psychological Stress and Cancer-Deciphering Molecular Signals in the Tumor Microenvironment

Current research has revealed some links between psychological stress and cellular mutation,neoplastic proliferation and metastasis in patients with cancer.In stressful situations,the stress-related neuroendocrine mediators(e.g.,catecholamines,and glucocorticoids(GSs))are being secreted,via stimulation of the sympathetic nervous system(SNS),and the hypothalamic-pituitaryadrenocortical(HPA)axis.Catecholamine may affect the malignant progression,since they can regulate various cellular signaling pathways,via adrenergic receptors(ARs)that are expressed by different types of neoplastic cells.The ARs increase the proliferation and invasive potential of such cells,and change their“behavior”in the tumor microenvironment.Similarly,cortisol and its glucocorticoid receptors(GRs)can promote stress-induced malignant growth and metastasis.Maladaptation to stressful situations,often relevant to the cancer diagnosis and treatment,may accelerate tumor growth and spread(e.g.,via inflammation,angiogenesis,and migration).Studies have shown that psychological interventions can be helpful for adaptation to adverse circumstances during the therapeutic process in patients with cancer.This mini-review will address some interrelations between psychological stress and cancer.It will discuss how the receptor-mediated signaling pathways may lead to cancer initiation,propagation,and spread.In addition,it will describe a supportive role of the stress reduction strategies,for example,in patients with breast cancer(BC).

Developing the Online Course in Stress Crises and Coping:A Low Stress Curriculum Design Model

Professional students are increasingly bombarded with numerous forms of negative stress or distress in their pursuit of graduate studies and studies in general.In addition to rigorous course learning expectations and educational institutional stress,students have numerous situational and external stressors.Creating curricula and online delivery mechanisms that maintain the focus on educational pursuit and the achievement of advanced professional competencies,skills,and behaviors is more a matter of curricular design and forethought than a naturally occurring condition within the course.This manuscript is about curricular design intended to reduce negative stress on students engaged in graduate professional education.Developing course delivery to ease learning related stress does not occur,using traditional curricular development approaches.What follows is a student informed approach to creating a low stress online course on Stress Crisis and Coping as an essential skill set needed to function in most aspects of professional work and in human service delivery.

“互联网+”知信行居家护理模式联合正念减压对糖尿病视网膜病变患者的干预研究

目的探究“互联网+”知信行居家护理模式联合正念减压对糖尿病视网膜病变(DR)患者的干预效果。方法选取2022年1月至2023年1月就诊的DR患者100例,采用随机数字表法均分为对照组和观察组,对照组进行“互联网+”知信行居家护理模式,观察组联合正念减压护理,对比血糖控制率、视功能评分、自我管理能力、治疗依从性、护理满意度、生活质量评分、心理状态评分。结果观察组血糖控制率、视功能评分、自我管理能力、治疗依从性、护理满意度、生活质量评分心理状态评分高于对照组(P<0.05),心理状态评分低于对照组(P<0.05)。结论“互联网+”知信行居家护理模式联合正念减压护理可以提高DR患者自我管理能力、治疗依从性,从而提高血糖控制率,改善视功能和生活质量,缓解焦虑、抑郁情绪,护理满意度高。