Clinical effects of nonconvulsive electrotherapy combined with mindfulness-based stress reduction and changes of serum inflammatory factors in depression

BACKGROUND Depression is a common and serious psychological condition,which seriously affects individual well-being and functional ability.Traditional treatment methods include drug therapy and psychological counseling;however,these methods have different degrees of side effects and limitations.In recent years,nonconvulsive electrotherapy(NET)has attracted increasing attention as a noninvasive treatment method.However,the clinical efficacy and potential mechanism of NET on depression are still unclear.We hypothesized that NET has a positive clinical effect in the treatment of depression,and may have a regulatory effect on serum inflammatory factors during treatment.AIM To assess the effects of NET on depression and analyze changes in serum inflammatory factors.METHODS This retrospective study enrolled 140 patients undergoing treatment for depression between May 2017 and June 2022,the observation group that received a combination of mindfulness-based stress reduction(MBSR)and NET treatment(n=70)and the control group that only received MBSR therapy(n=70).The clinical effectiveness of the treatment was evaluated by assessing various factors,including the Hamilton Depression Scale(HAMD)-17,self-rating idea of suicide scale(SSIOS),Pittsburgh Sleep Quality Index(PSQI),and levels of serum inflammatory factors before and after 8 wk of treatment.The quality of life scores between the two groups were compared.Comparisons were made using t and χ^(2) tests.RESULTS After 8 wk of treatment,the observation group exhibited a 91.43%overall effectiveness rate which was higher than that of the control group which was 74.29%(64 vs 52,χ^(2)=7.241;P<0.05).The HAMD,SSIOS,and PSQI scores showed a significant decrease in both groups.Moreover,the observation group had lower scores than the control group(10.37±2.04 vs 14.02±2.16,t=10.280;1.67±0.28 vs 0.87±0.12,t=21.970;5.29±1.33 vs 7.94±1.35,t=11.700;P both<0.001).Additionally,there was a notable decrease in the IL-2,IL-1β,and IL-6 in both groups after treatment.Furthermore,the observation group exhibited superior serum inflammatory factors compared to the control group(70.12±10.32 vs 102.24±20.21,t=11.840;19.35±2.46 vs 22.27±2.13,t=7.508;32.25±4.6 vs 39.42±4.23,t=9.565;P both<0.001).Moreover,the observation group exhibited significantly improved quality of life scores compared to the control group(Social function:19.25±2.76 vs 16.23±2.34;Emotions:18.54±2.83 vs 12.28±2.16;Environment:18.49±2.48 vs 16.56±3.44;Physical health:19.53±2.39 vs 16.62±3.46;P both<0.001)after treatment.CONCLUSION MBSR combined with NET effectively alleviates depression,lowers inflammation(IL-2,IL-1β,and IL-6),reduces suicidal thoughts,enhances sleep,and improves the quality of life of individuals with depression.

Mindfulness-based stress reduction training and supplemented Jinshui Liujun decoction promote recovery in patients with nonsmall cell lung cancer

BACKGROUND Conventional chemotherapy(CC)administered to patients with non-small cell lung cancer(NSCLC)often causes adverse effects,such as cardiopulmonary dysfunction and immune system imbalance.Patients may experience anxiety and depression during the perioperative period due to various factors,such as treatment costs and cancer recurrence risks,thereby compromising the overall quality of life.Consequently,we hypothesized that integrating mindfulness-based stress reduction training(MSRT)with Jinshui Liujun decoction may mitigate negative emotions and promote recovery in patients with NSCLC.AIM To explore the effects of MSRT and Jinshui Liujun decoction on the immune function and emotional state of NSCLC patients.METHODS A retrospective clinical study was conducted involving 92 patients with stage IIIb-IV NSCLC;35 patients in the control group(CG)received CC therapy(combination of pemetrexed and carboplatin),and 57 patients in the treatment group(TG)received MSRT-assisted flavored Jinshui Liujun decoction(FJLD)in addition to CC.We evaluated the survival time,Karnofsky performance status,treatment efficacy,traditional Chinese medicine syndrome score,immune function,negative emotional level,and adverse reactions of the CG and TG.RESULTS Median progression-free survival,Karnofsky performance status,and clinical efficacy of the TG were superior to those of the CG(P<0.05).Symptoms of cough,weakness,bloody sputum,shortness of breath,and chest pain significantly decreased in the TG compared to that in the CG(P<0.05).In the TG,MSRT+FJLD treatment increased the numbers of CD3^(+)and CD4^(+)immune cells,effectively reduced the number of CD8^(+)cells,and enhanced the CD4^(+)/CD8^(+)ratio,thereby restoring the immune function of patients.In the TG,the self-rating anxiety scale and self-rating depression scale scores decreased significantly.There was no statistically significant difference in the incidence of adverse reactions between the CG and TG(P>0.05).CONCLUSION MSRT+FJLD proved to be an effective treatment for patients with NSCLC.

Study on the Effect of Mindfulness-Based Stress Reduction Combined with Preemptive Sedation on Postoperative Sleep Improvement in Patients Undergoing Gynecological Laparoscopic Surgery

Objective:To explore the effects of mindfulness-based stress reduction(MBSR)training combined with dexmedetomidine hydrochloride preemptive sedation on postoperative sleep quality in patients undergoing laparoscopic ovarian tumor resection.By comparing postoperative sleep quality,pain scores,anxiety scores,and adverse reactions among three groups of patients,the clinical efficacy of this combined treatment was evaluated.Methods:A total of 123 patients undergoing laparoscopic ovarian tumor resection in the hospital from January 2022 to December 2023 were included.Based on the interventions,patients were randomly divided into three groups:Group I received dexmedetomidine hydrochloride preemptive sedation,Group II received MBSR training,and Group III received a combination of MBSR training and dexmedetomidine hydrochloride preemptive sedation.Preoperative SAS anxiety scores,postoperative adverse reactions(nausea,vomiting,respiratory depression,skin itching,etc.),VAS pain scores,Ramsay sedation scores,AIS sleep scores,and postoperative SAS anxiety scores were recorded and analyzed.Results:The results showed that Group III demonstrated significantly better postoperative sleep quality(first-day postoperative AIS score:7.975±1.98),pain relief(first-day postoperative VAS score:2.97±0.85),and anxiety improvement(first-day postoperative SAS score:40.46±2.12)compared to Groups I and II(P<0.05).Additionally,Group III exhibited a lower incidence of adverse reactions,particularly in terms of nausea,vomiting,and respiratory depression.Conclusion:MBSR training combined with dexmedetomidine hydrochloride preemptive sedation effectively reduces perioperative stress responses,improves postoperative sleep quality,alleviates pain,and relieves anxiety in patients undergoing laparoscopic ovarian tumor resection,with good safety and tolerability.This study provides a novel intervention strategy for the postoperative rehabilitation of patients undergoing laparoscopic surgery,meriting further clinical application.

Intervention effect of mindfulness-based stress reduction for psychological health among nurses:A meta-analysis

Objective:To systematically evaluate the effects of MBSR on psychological health intervention in nurses.Methods:The randomized controlled trial(RCT)and self-controlled trial(SC)investigating the application of mindfulness-based stress reduction in nursing staff were retrieved from CNKI,WanFang,VIP,PubMed,Cochrane Library,Web of Science,EMBASE databases.The retrieval time was set from the establishment of the database to April 2020.The Review Manager 5.3 software were used for meta-analysis.Result:9 RCTs and 5 self-control trails were included with 1421,712 subjects in the experimental group and 709 subjects in the control group.The results of the meta-analysis showed that compared with the control group,mindfulness-based stress reduction therapy can effectively reduce the psychological symptoms of clinical nurses[SMD=-0.96,95%CI(-1.51,-0.38),P=0.001],reduces nurses'anxiety levels[SMD=-1.28,95%CI(-2.18,-0.38),P=0.005],relieve the nurse's depression[SMD=-1.08,95%CI(-2.15,-0.02),P=0.005],improve the mental resilience of nurse[SMD=7.05,95%CI(3.93,10.17),P=0.03],showing a statistical meaning.Conclusion:The mental health of nurses is often neglected by themselves and there is insufficient awareness that MBSR can improve mental health.There has been a debate about whether MBSR actually improves the mental health of nurses,so it is necessary to further explore this issue and seek better methods and opportunities for practice.

Effects of mindfulness-based stress reduction therapy on anxiety and depression in patients with maintenance hemodialysis:a meta analysis

Objective:This study aimed to evaluate the effects of mindfulness-based stress reduction therapy on anxiety and depression in patients with maintenance hemodialysis.Methods:CNKI,VIP,WanFang,CBM,Embase,the Cochrane Library and PubMed databases were retrieved.Randomized controlled trials of intervention effects of mindfulness-based stress reduction combined with conventional hemodialysis education compared with conventional hemodialysis education on maintenance hemodialysis patients were collected.The retrieval period was from the establishment of the database to December 2019.Two researchers independently screened the literatures,extracted the data and evaluated the risk of bias in the included studies.RevMan 5.3 software was used for analysis.Results:A total of 9 studies,which comprised a total of 664 participants were included in the final meta analysis.The results showed that mindfulness-based stress reduction could reduce the anxiety of patients(SMD=?1.65,95%CI:?2.29 to?1.01),reduce the depression(SMD=?1.44,95%CI:?1.85 to?1.03).Conclusion:Mindfulness-based stress reduction therapy has positive effects on depression,anxiety in patients with maintenance hemodialysis.

Simulation of thermal and sodium expansion stress in aluminum reduction cells

Two finite element(FE) models were built up for analysis of stress field in the lining of aluminum electrolysis cells.Distribution of sodium concentration in cathode carbon blocks was calculated by one FE model of a cathode block.Thermal stress field was calculated by the other slice model of the cell at the end of the heating-up.Then stresses coupling thermal and sodium expansion were considered after 30 d start-up.The results indicate that sodium penetrates to the bottom of the cathode block after 30 d start-up.The semi-graphitic carbon block has the largest stress at the thermal stage.After 30 d start-up the anthracitic carbon has the greatest sodium expansion stress and the graphitized carbon has the lowest sodium expansion stress.Sodium penetration can cause larger deformation and stress in the cathode carbon block than thermal expansion.

Influence of standardized nursing intervention combined with mindfulness stress reduction training on the curative effect in patients with acute pancreatitis

BACKGROUND Acute pancreatitis(AP)is a common inflammatory disease of the pancreas with high mortality rates.It is of great significance to take scientific intervention measures for patients with AP in time.AIM To explore the effect of standardized nursing combined with mindfulness stress reduction training on the curative effect,negative emotion,and quality of life in patients with acute pancreatitis.METHODS A total of 80 patients with acute pancreatitis admitted to The First People's Hospital of Jiangxia District Hospital from May 2021 to May 2023 were randomly divided into control group and observation group(n=40).Patients in control group were given the standardized nursing intervention,and the observation group were given standardized nursing plus mindfulness stress reduction training intervention.The time of clinical symptom disappeared or improved,complication occurrence rate,emotional state,and quality of life score of the two groups were observed and compared.RESULTS In comparison with the control group,the bowel sound recovery time,ventosity and abdominal pain improvement time,and venting and cacation time in observation group were shorter,and the total incidence rate of complications was reduced,showing statistically significant difference(P<0.05).The scores of anxiety and depression in observation group were lower than those in control group(P<0.05).Serum levels of tumour necrosis factor alpha,interleukin(IL)-6,IL-1βand IL-8 in observation group were lower than those in control group(P<0.05).The scores of life quality in physiology,psychology,environment and social relations in observation group were higher than those in control group,and the differences were statistically significant(P<0.05).CONCLUSION The application of standardized nursing intervention combined with mindfulness stress reduction training in patients with acute pancreatitis has a definite effect,which can help to ameliorate the clinical symptoms,anxiety and depression of patients,reduce the incidence rate of complications,and improve the prognosis of patients.

Properties and appropriate conditions of stress reduction factor and thermal shock resistance parameters for ceramics

Through introducing the analytical problem of the plate with convection into the solution of the transient heat conduction thermal stress field model of the elastic plate, the stress reduction factor is presented explicitly in its dimensionless form. A new stress reduction factor is introduced for the purpose of comparison. The proper- ties and appropriate conditions of the stress reduction factor, the first and second ther- mal shock resistance （TSR） parameters for the high and low Biot numbers, respectively, and the approximation formulas for the intermediate Blot number-interval are discussed. To investigate the TSR of ceramics more accurately, it is recommended to combine the heat transfer theory with the theory of thermoelasticity or fracture mechanics or use a numerical method. The critical rupture temperature difference and the critical rup- ture dimensionless time can be used to characterize the TSR of ceramics intuitively and legibly.

Research progress on the effects of positive stress reduction on positive awareness and psychosocial functioning in patients with depressive disorders

To review the current research status of positive thought stress reduction therapy(PTSRT),psychosocial functioning of patients with depressive disorders,the shortcomings and outlook of the influence of PTSRT on positive thought awareness,and psychosocial functioning of patients with depressive disorders.This review has the objective to provide clinical healthcare personnel with essential information about the use of PTSRT to improve the level of positive thought and psychosocial functioning of patients with depressive disorders.

Reduction and compensation of lattice stress in high energy P^+ and P+Sb implanted silicon

The relations of variation of lattice stress to shape, peak concentrations of the P atom depth profile and Sb doses of P+Sb dual implantation were studied in high energy P implantation silicon. The experimental results show that the lattice stress in P-implanted silicon obviously increases with increasing ion dose. The stress of P-implanted silicon with the dose of 2×1013/cm2 is 2.2 times greater than at a dose of 3.6×1012/cm2. The stress decreases rapidly as the annealing time increases.It is very interesting that the stress has a negative value when the concentration of P atoms in the implanted layer is below 6×1016/cm3, whereas the stress becomes positive when the concentration is greater than 6×16/cm3. The stress increases rapidly with increasing Sb ion dose after P implantation. The stress has a positive value before annealing. If the Sb dose is below 1 ×1016/cm2, the stress is negative after annealing,and it is positive when the Sb dose is higher than 1×1016/cm2. The stress is close to zero for a Sb implantation dose of 1×1016/cm2. The best compensation dose of Sb to P implantation dose of 3×1016/cm2 is 1×1016/cm2.

Mindfulness-based cognitive therapy in the intervention of psychiatric disorders: A review

Mindfulness-based cognitive therapy(MBCT)is frequently used for psychiatric disorders.Despite MBCT’s considerable potential for improving psychological health for patients,there is little empirical evidence to support its practical application in Chinese.This review will define meditation and mindfulness,provide an overview of the development of MBCT,identify the evidence for the effectiveness of MBCT,and offer recommendations to medical personnels on how to provide support for patients receiving mindfulness intervention.

Characteristics and mechanism investigation on drag reduction of oblique riblets

This work primarily focuses on the drag reduction characteristics and mechanism investigation of oblique riblets. First, a calculation model of the oblique riblets surface is established, and Reynolds stress model(RSM) turbulence model is used for numerical simulation of the oblique riblets flow field. Subsequently, the influence of inclination angle between flow direction and arrangement direction of riblets on friction resistance and drag reduction rate is further analyzed. Through the investigation of the distribution of shear stress, pressure stress and velocity in oblique riblets boundary layer, the oblique riblets drag reduction mechanism is finally revealed. Results show that, with increase of velocity and inclination angle, the pressure resistance increases obviously, along with the decreasing of the viscous resistance distinctly. The maximum drag reduction rate of the oblique riblets is 7.33%. Moreover, when the inclination angle increases, the wall shear stress reduces on oblique riblets surface; while differential pressure increases at both sides of oblique riblets tips. In addition, when inclination angle is small, the secondary vortex at oblique riblets tips will disappear soon. New vortices will be formed inside the oblique riblets and cause the decrease of viscosity resistance. Thus, oblique riblets show a better drag reduction effect and have an effective control on boundary layer.

Research Findings Using Mindfulness-Based Interventions for Chronic Pain

Chronic pain is a complex condition that is very detrimental to physical and psychological wellbeing. It carries a significant level of disability and economic burden. Pain patients frequently experience comorbid mental illness (e.g. depression, anxiety, PTSD, insomnia) and often require psychotherapeutic interventions in addition to medication management. Mindfulness-based interventions (MBIs) have emerged as a means to treat several chronic conditions (e.g. chronic pain, depression, anxiety, substance abuse, stress, insomnia). The objective of this review is to evaluate the current research on the use of MBIs in chronic pain managment. Although there are several controlled trials on the use of MBIs in chronic pain management, only a few studies were found that demonstrated significant effects on pain intensity, quality of life, as well as physical and psychological functioning. Therefore, the current evidence is mixed and there are insufficient data to definitively confirm the full impact of the use of MBIs in chronic pain conditions such as fibromyalgia, chronic low back pain, rheumatoid arthritis, and chronic musculoskeletal pain. The lack of compelling evidence at this time signals a demand for higher quality investigations in this area. Research examining MBIs and concomitant CBT may be of great value in order to synergize and strengthen patient outcomes.

Drag reduction by linear viscosity model in turbulent channel flow of polymer solution

A further numerical study of the theory that the drag reduction in the turbulence is related to the viscosity profile growing linearly with the distance from the wall was performed.The constant viscosity in the Navier-Stokes equations was replaced using this viscosity model.Some drag reduction characteristics were shown comparing with Virk's phenomenology.The mean velocity and Reynolds stress profiles are consistent with the experimental and direct numerical simulation results.A drag reduction level of 45% was obtained.It is reasonable for this linear viscosity model to explain the mechanism of turbulence drag reduction in some aspects.

Antioxidant-induced reductive stress has untoward consequences on the brain microvasculature

All cells in the body metabolize oxygen in a series of reactions in the mitochondria to generate energy.A by-product of these reactions is the production of highly reactive oxygen radicals which have the potential to cause irreparable damage to cellular components,and have been linked to mutagenic and neurotoxicity of the nervous system.Under normal conditions,innate molecular systems,glutathione,superoxide dismutases,

Bayesian partial pooling to reduce uncertainty in overcoring rock stress estimation

The state of in situ stress is a crucial parameter in subsurface engineering,especially for critical projects like nuclear waste repository.As one of the two ISRM suggested methods,the overcoring(OC)method is widely used to estimate the full stress tensors in rocks by independent regression analysis of the data from each OC test.However,such customary independent analysis of individual OC tests,known as no pooling,is liable to yield unreliable test-specific stress estimates due to various uncertainty sources involved in the OC method.To address this problem,a practical and no-cost solution is considered by incorporating into OC data analysis additional information implied within adjacent OC tests,which are usually available in OC measurement campaigns.Hence,this paper presents a Bayesian partial pooling(hierarchical)model for combined analysis of adjacent OC tests.We performed five case studies using OC test data made at a nuclear waste repository research site of Sweden.The results demonstrate that partial pooling of adjacent OC tests indeed allows borrowing of information across adjacent tests,and yields improved stress tensor estimates with reduced uncertainties simultaneously for all individual tests than they are independently analysed as no pooling,particularly for those unreliable no pooling stress estimates.A further model comparison shows that the partial pooling model also gives better predictive performance,and thus confirms that the information borrowed across adjacent OC tests is relevant and effective.

正念减压课程对甲状腺癌手术患者知觉压力及焦虑抑郁水平的影响

目的构建正念减压课程并评价其对甲状腺癌手术患者知觉压力及焦虑抑郁状况的干预效果。方法将该院甲状腺外二科2023年3-11月行手术治疗的90例甲状腺癌患者随机数字表法分为干预组和对照组,各45例。2组患者均进行标准的健康教育,干预组在此基础上开展5次正念减压课程。干预前后使用感知压力测量表(CPSS)、焦虑自我评估测量表(SAS)及抑郁自我评估测量表(SDS)对2组进行评估。结果干预后,干预组CPSS得分为(34.534±6.452)分、SAS得分为(44.243±3.684)分、SDS得分为(42.854±3.215)分,均明显低于对照组[(39.824±5.243)、(47.621±3.583)、(45.964±3.265)分],差异均有统计学意义(P<0.05)。结论正念减压课程能有效降低甲状腺癌手术患者的知觉压力水平,改善其焦虑和抑郁状况。

基于互联网的正念减压疗法对维持性血液透析患者睡眠质量的影响研究

目的探讨基于互联网的正念减压(MBSR)疗法对维持性血液透析(MHD)患者睡眠质量及正念注意觉知的影响。方法从湘潭市某综合医院的血透室选取84例正在进行MHD治疗的患者作为研究对象,将其随机分成试验组和对照组,每组42例。对照组采用医院血透室的常规护理措施,试验组则实施常规护理+基于互联网的正念减压疗法。在干预前后分别使用匹兹堡睡眠质量指数量表(PSQI)和正念注意觉知量表(MAAS)对两组患者的睡眠质量和正念水平进行对比分析。结果干预后试验组的MAAS评分显著高于对照组及本组干预前(P<0.05),PSQI总分以及睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍、日间功能障碍6个维度的得分明显低于对照组(P<0.05)。结论基于互联网的MBSR疗法可以改善MHD患者的睡眠质量,可以提高MHD患者的正念注意觉知水平,对缓解患者身心压力、改善患者心境状态有积极作用。

参芪增液活血汤治疗妊娠晚期未足月羊水偏少患者的临床效果

目的观察参芪增液活血汤联合静脉补液治疗妊娠晚期未足月羊水偏少患者的临床效果及对母体氧化应激相关指标的影响。方法将2022年6月至2024年3月在宜兴市中医医院住院的孕龄28~35周、诊断为羊水偏少的80例患者,按随机数字表法分为对照组和试验组,每组各40例。对照组静脉补液治疗,试验组用参芪增液活血汤联合静脉补液治疗。观察两组羊水指数(AFI)、分娩时实际羊水量、母儿结局、不良反应及母血中天然硫醇(-SH)、动态二硫化物(-SS)、缺血修饰白蛋白(IMA)水平。结果治疗后试验组AFI高于对照组,分娩时实际羊水量多于对照组,剖宫产率、早产率、胎儿窘迫发生率均低于对照组,差异有统计学意义(P<0.05)。试验组治疗后-SH高于对照组,-SS、IMA低于对照组,差异有统计学意义(P<0.05)。结论参芪增液活血汤联合静脉补液治疗妊娠晚期未足月羊水偏少患者,能降低母体氧化应激指标-SS、IMA水平,升高抗氧化标志物-SH水平,恢复硫醇/二硫化物动态平衡,增加围产期羊水量,减少早产、剖宫产、胎儿窘迫等母儿不良结局。

小切口插入闭合复位经皮微创钢板内固定术治疗胫腓骨骨折患者的效果

目的:观察小切口插入闭合复位经皮微创钢板内固定术(MIPPO)治疗胫腓骨骨折患者的效果。方法:选取2021年8月至2023年8月该院收治的94例胫腓骨骨折患者进行前瞻性研究,按随机数字表法将其分为对照组与观察组各47例。对照组行切开复位钢板内固定术(ORIF)治疗,观察组行MIPPO治疗。比较两组围术期指标水平,手术前后应激指标[皮质醇(Cor)、去甲肾上腺素(NE)]水平、踝关节功能[美国足踝外科学协会踝-后足评分(AOFAS-AH)]评分、膝关节功能[美国特种外科医院膝关节(HSS)]评分,以及并发症发生率。结果:观察组术中出血量少于对照组,早期自主活动时间、完全负重时间、住院时间均短于对照组,差异有统计学意义(P<0.05);术后3 d,两组Cor、NE水平均高于术前,但观察组低于对照组,差异有统计学意义(P<0.05);术后3个月,两组AOFAS-AH、HSS评分均高于术前,且观察组高于对照组,差异有统计学意义(P<0.05);观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论:MIPPO治疗胫腓骨骨折患者可提高踝关节功能和膝关节功能评分,降低应激指标水平、并发症发生率,改善围术期指标水平,其效果优于ORIF治疗。