Comparative Study of the Widal Test against Stool Culture in the Diagnosis of Suspected Cases of Typhoid Fever in Some Low Income Communities in the Adamawa Region of Cameroon

Introduction: Infectious diseases constitute a major concern of public health in developing countries. Facilities and well trained staff have been shown to be one of the major obstacles in the rapid and quality diagnosis of these diseases. As such, we carried out an analysis to compare the Widal test and stool culture to identify febrile patients with Salmonella infection. Method: A cross sectional study was conducted to diagnose salmonella infection with out-patients who demonstrated signs of salmonella infection. Serum was harvested from blood collected from 368 (Vina = 234, Mayo Banyo 65, and Djerem = 69) patients accompanied by stool, Widal test was conducted on the spot and stool was taken to a reference laboratory for culture using standard microbiological methods, sociological set up was calculated in percentages, prevalence was calculated using excel while statistical difference was calculated using SPSS. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated to compare the Widal test against stool culture. Results: A total of 368 (50.8% females and 49.2% males) participants took part in the survey. Salmonella prevalence (66.24%) in stool culture in the Vina division was significantly different (p 0.05). The sensitivity,specificity, PPV, and NPV of slide agglutination test against stool culture varied from different areas (Vina: 51.6%, 73.62%, 79.21% and 43.61%;Mayo Banyo: 60.53%, 77.78%, 79.31% and 58.33%;Djerem: 53.18%, 83.73% 73.91% and 67.39%) respectively. Slide agglutination test has a fair agreement with the stool culture (kappa, Vina = 0.202;Mayo Banyo = 0.37 and Djerem = 0.38). Conclusion: Generally, in the three areas of study, the Widal test had a fair correlation with the stool culture;This means the Widal test should not be used alone but in combination with stool culture in the detection of salmonella infections.

FLNG船舶STOOL安装的可行性研究

STOOL作为FLNG船舶TOPSIDE模块的重要支撑结构,其施工方案的优劣将直接影响液化装置各单元模块安装的可行性。本文重点介绍了STOOL施工方案的可行性研究及建造过程的难点控制。在清洁能源概念被各领域日益渗透的今天,作为其配套装置在设计及建造过程中的优化、迭代也必将推动清洁能源领域上下游产业链的可持续发展。本文作为指导性文件,可为FLNG船舶STOOL的施工与工艺研究提供宝贵的参考与借鉴。

Fecal microbial biomarkers combined with multi-target stool DNA test improve diagnostic accuracy for colorectal cancer

BACKGROUND Colorectal cancer(CRC)is a major global health burden.The current diagnostic tests have shortcomings of being invasive and low accuracy.AIM To explore the combination of intestinal microbiome composition and multi-target stool DNA(MT-sDNA)test in the diagnosis of CRC.METHODS We assessed the performance of the MT-sDNA test based on a hospital clinical trial.The intestinal microbiota was tested using 16S rRNA gene sequencing.This case-control study enrolled 54 CRC patients and 51 healthy controls.We identified biomarkers of bacterial structure,analyzed the relationship between different tumor markers and the relative abundance of related flora components,and distinguished CRC patients from healthy subjects by the linear discriminant analysis effect size,redundancy analysis,and random forest analysis.RESULTS MT-sDNA was associated with Bacteroides.MT-sDNA and carcinoembryonic antigen(CEA)were positively correlated with the existence of Parabacteroides,and alpha-fetoprotein(AFP)was positively associated with Faecalibacterium and Megamonas.In the random forest model,the existence of Streptococcus,Escherichia,Chitinophaga,Parasutterella,Lachnospira,and Romboutsia can distinguish CRC from health controls.The diagnostic accuracy of MT-sDNA combined with the six genera and CEA in the diagnosis of CRC was 97.1%,with a sensitivity and specificity of 98.1%and 92.3%,respectively.CONCLUSION There is a positive correlation of MT-sDNA,CEA,and AFP with intestinal microbiome.Eight biomarkers including six genera of gut microbiota,MT-sDNA,and CEA showed a prominent sensitivity and specificity for CRC prediction,which could be used as a non-invasive method for improving the diagnostic accuracy for this malignancy.

自动粪便分析仪与人工复核法检测粪便结果的比较分析

目的比较自动粪便分析仪与人工复核法两种粪便检测方法的检验效果。方法收集2022年9月—2023年8月三明市第二医院就诊患者的9402份新鲜粪便标本,分别使用FA160自动粪便分析仪和人工复核法检测粪便有形成分(白细胞、红细胞、脂肪球、真菌)和隐血,记录两种方法的检测结果并进行统计学分析。结果自动粪便分析仪检测白细胞、红细胞、脂肪球、真菌和隐血的阳性检出率分别为4.90%、2.67%、6.31%、4.54%、25.34%,人工复核法阳性检出率分别为4.17%、2.22%、5.55%、5.29%、25.23%,自动粪便分析仪对粪便有形成分的阳性检出率除真菌略低于人工复核外,其他各项指标均高于人工复核,且差异均有统计学意义(均P<0.05),而粪便隐血试验的阳性检出率比较差异无统计学意义(P>0.05)。以人工复核法为标准,自动粪便分析仪检测白细胞、红细胞、脂肪球、真菌、隐血的阳性符合率分别为91.07%、96.17%、94.83%、78.07%、98.19%;阴性符合率分别为98.85%、99.46%、98.90%、99.56%、99.25%;阳性预测值分别为77.44%、80.08%、83.47%、90.87%、97.77%;阴性预测值分别为99.61%、99.91%、99.69%、98.79%、99.39%。结论自动粪便分析仪与人工复核法的检测结果虽然符合率较高,但还存在漏检和误检。因此对自动分析结果必须进行人工复核,提高检测结果的准确性,为临床提供可靠的参考依据。

南海深水FPSO模块支墩设计与分析

针对中国南海海况恶劣,浮式生产储卸油装置(Floating Production Storage and Offloading,FPSO)在南海服役多年后,少数支墩由于建造工艺出现裂纹问题,以南海某深水FPSO为研究对象,对常用箱式支墩形式进行改进优化设计。运用有限元方法对箱式模块支墩和改进后的丰字形模块支墩与十字交叉带裙边支墩进行评估,对不同支墩形式进行强度分析、变形分析和疲劳分析,并对不同支墩的工艺进行综合对比,结合工程实践和有限元计算,给出支墩推荐设计方案。结果表明,优化后的十字交叉带裙边支墩结构强度和疲劳均优于箱式支墩,同时还具有便于加工组装的特点,最终选定十字交叉带裙边支墩方案。

腰凳型婴幼儿背带压力测试与分析

为改善腰凳型婴幼儿背带的服装压力分布不均现象,采用自行研发的服装压力测量系统,在人台肩部、背部和腰部共12个测量点分别植入薄膜型压力传感器并测量压力值。结果表明,穿着腰凳型背带时肩部压力最大、腰部次之、背部最小,各部位压力随婴儿体重增加而增加,总压力超出婴儿体重;同一负重水平下,穿着摩擦因数较大的服装面料时,背带在人体各部位上造成的压力较小;在同一人体部位、不同测量点上,随负重水平上升而出现压力分化现象。在各个部位的分化点添加高密度海绵垫片,各部位压力不匀得到有效缓解,对于相关产品的改进设计与研究具有重要启发意义。

《神农本草经》与经方应用之黄芩篇

《神农本草经》记载黄芩:“味苦平,主诸热黄疸,肠澼泄痢,逐水,下血闭,恶疮,疽蚀,火疡。”以《神农本草经》中黄芩主治作用为线索,分析经方中黄芩的应用。黄芩主治诸热黄疸时,多配伍柴胡、半夏等,以小柴胡汤类方为代表方;治疗肠澼泄痢时,常配伍黄连、芍药等,如葛根黄芩黄连汤、黄芩汤、泻心汤类方等;下血闭时,多配伍芍药、桃仁及虫类药等,如大黄䗪虫丸、鳖甲煎丸;治疗恶疮、疽蚀、火疡时,多与王不留行、花椒、芍药、桑白皮等配伍,代表方为王不留行散。张仲景临证又拓展了黄芩主治作用,将黄芩与不同药物配伍发挥不同作用,如黄芩配伍半夏、黄连、干姜等治疗心下痞;配伍阿胶、黄连等治疗心中烦;配伍白术、附子等治疗出血;配伍当归、白术等治疗内热扰胎。

体检人群幽门螺杆菌感染检测意愿调查

目的探讨体检人群对H.pylori感染检测的主动性及其对检测方式的倾向性。方法于2022年9月至2022年12月在国内两家综合性三甲医院的体检人员中发放电子调查问卷,问卷内容包括受访者对H.pylori感染及检测方式的了解情况,主动给自己及家中老人、儿童(<14岁)检测的意愿,及其对尿素呼气试验(urea breath test,UBT)和H.pylori粪便抗原试验(H.pylori stool antigen test,HpSAT)的比较与选择等。结果共回收488份有效问卷。消化道症状或疾病在体检人群(57.0%)及其家庭成员(35.5%)中普遍存在。体检人群对H.pylori感染的熟悉率仅为11.9%。43.0%受访者会在体检时主动检测,36.9%的受访者在医师建议下才会进行检测,而20.1%不会主动检测。影响检测主动性的因素主要是对H.pylori感染的了解程度。对于家中老人和儿童的检测,大部分体检人员需要医师建议才会进行检测。体检人员选择检测方式时,主要看其重准确性、方便性、安全性,超过80%体检人员会选择UBT。结论体检人群对H.pylori感染的认知水平较低,但检测意愿性较强,在检测时倾向于选择传统的UBT,对新兴的快速HpSAT缺乏了解。

从伏邪致病辨治腹泻型肠易激综合征

腹泻型肠易激综合征(diarrhea-predominant irritable bowel syndrome,IBS-D)是临床常见的功能性胃肠病,其易受激惹、反复发作的临床特点及中医病机演变过程与伏邪致病有诸多相似之处。基于IBS-D “湿邪内伏”“气郁内伏”及“瘀血内伏”的中医病机演变特点,可通过区分患者大便性状、腹部切诊和舌下络脉表现以进行IBS-D“湿、滞、瘀”伏邪病机的分类和病情的分级,并提出了疏利内伏之湿邪、条畅内伏之郁气、疏通内伏之瘀血的治则。基于伏邪致病辨治IBS-D,为完善中医治疗IBS-D的理论和拓展伏邪学说的临床应用提供了思路。

基于Bristol粪便性状分型的肠道准备方案对结肠镜检查效率的影响研究

目的研究基于Bristol粪便性状分型的肠道准备方案对结肠镜检查效率的影响。方法选取西安医学院第二附属医院于2020年10月至2022年9月收治的88例拟行结肠镜检查患者进行随机对照试验,按照随机数字表法分为观察组和对照组,每组44例。对照组男22例、女22例,年龄(48.71±3.44)岁,实施常规肠道准备方案;观察组男21例、女23例,年龄(48.55±3.40)岁,实施基于Bristol粪便性状分型的肠道准备方案。对比两组患者接受不同肠道准备方案后肠道准备成功率、结肠清洁度[Boston肠道准备量表(BBPS)]、结肠进镜时间、整体检查时间。采用t检验、χ^(2)检验。结果观察组肠道准备合格率高于对照组[79.55%(35/44)比47.73%(21/44)],差异有统计学意义(χ^(2)=9.625,P=0.002);观察组的右侧、中间、左侧BBPS评分均高于对照组[(2.11±0.69)分比(1.71±0.52)分、(2.31±0.48)分比(1.95±0.57)分、(2.29±0.47)分比(1.99±0.67)分],结肠进镜时间、整体检查时间均短于对照组[(11.20±0.85)min比(11.62±1.05)min、(15.17±1.24)min比(16.28±1.73)min],差异均有统计学意义(t=3.071、P=0.003,t=3.205、P=0.002,t=2.432、P=0.017,t=2.062、P=0.042,t=3.459、P=0.001)。结论基于Bristol粪便性状分型的肠道准备方案能提高肠道准备成功率和结肠清洁度,缩短结肠进镜和整体检查时间,显著优化了结肠镜检查的效率和质量,为临床提供了一种更有效的肠道准备方法。

Exploring non-invasive diagnostics for metabolic dysfunctionassociated fatty liver disease

The population with metabolic dysfunction-associated fatty liver disease(MAFLD)is increasingly common worldwide.Identification of people at risk of progression to advanced stages is necessary to timely offer interventions and appropriate care.Liver biopsy is currently considered the gold standard for the diagnosis and staging of MAFLD,but it has associated risks and limitations.This has spurred the exploration of non-invasive diagnostics for MAFLD,especially for steatohepatitis and fibrosis.These non-invasive approaches mostly include biomarkers and algorithms derived from anthropometric measurements,serum tests,imaging or stool metagenome profiling.However,they still need rigorous and widespread clinical validation for the diagnostic performance.

When the vermiform appendix resembles a polyp: Be cautious of an intussuscepted appendix polypectomy

This article discusses a recently published case report on a rare instance of type IV appendiceal intussusception with a concurrent mucinous adenocarcinoma of the cecum in a young individual.The report highlights challenges in diagnosing ap-pendiceal intussusception,emphasizing the importance of endoscopic expertise in preventing impulsive decisions such as inappropriate polypectomies.The rarity of the concurrent intussuscepted appendix and mucinous cecal cancer is under-scored,prompting consideration of malignancy in appendiceal intussusception cases.Additionally,the report addresses the increasing incidence of early-onset colorectal cancer and the need for a revaluation of diagnostic paradigms in the context of evolving epidemiological trends.The awareness of potential misinter-pretations and the imperative for further investigation into this rare condition are emphasized.

Retrospective analysis of discordant results between histology and other clinical diagnostic tests on helicobacter pylori infection

BACKGROUND A reliable test is essential for diagnosing Helicobacter pylori(H.pylori)infection,and crucial for managing H.pylori-related diseases.Serving as an excellent method for detecting H.pylori infection,histologic examination is a test that clinicians heavily rely on,especially when complemented with immunohistochemistry(IHC).Additionally,other diagnostic tests for H.pylori,such as the rapid urease test(CLO test)and stool antigen test(SA),are also highly sensitive and specific.Typically,the results of histology and other tests align with each other.However,on rare occasions,discrepancy between histopathology and other H.pylori diagnostic tests occurs.AIM To investigate the discordance between histology and other H.pylori tests,the underlying causes,and the impact on clinical management.METHODS Pathology reports of gastric biopsies were retrieved spanning August 2013 and July 2018.Reports were included in the study only if there were other H.pylori tests within seven days of the biopsy.These additional tests include CLO test,SA,and H.pylori culture.Concordance between histopathology and other tests was determined based on the consistency of results.In instances where histology results were negative while other tests were positive,the slides were retrieved for re-assessment,and the clinical chart was reviewed.RESULTS Of 1396 pathology reports were identified,each accompanied by one additional H.pylori test.The concordance rates in detecting H.pylori infection between biopsy and other tests did not exhibit significant differences based on the number of biopsy fragments.117 discrepant cases were identified.Only 20 cases(9 with CLO test and 11 with SA)had negative biopsy but positive results in other tests.Four cases initially stained with Warthin-Starry turned out to be positive for H.pylori with subsequent IHC staining.Among the remaining 16 true discrepant cases,10 patients were on proton pump inhibitors before the biopsy and/or other tests.Most patients underwent treatment,except for two who were untreated,and two patients who were lost to follow-up.CONCLUSION There are rare discrepant cases with negative biopsy but positive in SA or CLO test.Various factors may contribute to this inconsistency.Most patients in such cases had undergone treatment.

结肠毛细血管扩张症伴出血1例并文献复习

目的探讨结肠毛细血管扩张症的临床特点及诊疗思路。方法回顾分析因反复消化道出血伴贫血就诊的结肠毛细血管扩张症1例患者的临床资料,并复习相关文献。结果患者,女,56岁,因“反复黑便、鲜血便交替”就诊,肠镜检查示盲肠至降结肠范围内环周黏膜多处见广泛大小不等的网状、树枝状、蜘蛛痣样毛细血管扩张,最大约5 mm×5 mm,诊断为结肠毛细血管扩张症。结论结肠毛细血管扩张症又称“结肠血管发育不良”,多见于老年患者,大多无症状,少数可表现为消化道出血,电子结肠镜检查是诊断本病的重要手段,病变多见于右半结肠,无症状者无需治疗,合并出血者可考虑药物治疗或内镜下局部止血。

127例疑似细菌性腹泻者粪便标本中病原微生物检测及药敏试验结果调查

目的探讨分析疑似细菌性腹泻者粪便标本中病原微生物检测及药敏试验结果。方法在我院开展为期1年的调查,选取2023年1月至2023年10月我院收治的127例疑似细菌性腹泻患者,采集粪便标本8mL进行病原微生物检测,记录菌株检出情况及分布情况,并采用微生物药敏试纸扩散法行药敏试验分析病原菌的耐药性。结果(1)127例疑似细菌性腹泻患者中,进行细菌初筛125例,其中阴性82例,阳性43例,包括副溶血弧菌7例,沙门菌11例,沙门菌并其他细菌3例,致病性大肠埃希菌2例,致病性大肠埃希菌并其他细菌1例,其他细菌19例。后续经区、市确认结果有一定出入,市确诊结果最终经复核无误,共计检出菌株42株。(2)127例疑似细菌性腹泻患者剔除24例空白,病毒检出阴性64例,阳性39例,共计检出病毒41株。(3)季节分布结果显示,6~8月细菌检出率最高,3~5月次之;9~10月病毒检出率最高,1~2月次之,不同季节细菌、病毒检出率差异有统计学意义(P<0.05)。(4)不同性别细菌、病毒检出率对比差异无统计学意义(P>0.05)。(5)年龄阶段分布结果显示,细菌、病毒均在儿童及老年群体中检出率较高,不同年龄阶段细菌、病毒检出率差异有统计学意义(P<0.05)。(6)药敏试验结果显示,沙门菌对环丙沙星耐药率最高,达50.00%,其次是头孢他啶为42.86%;副溶血弧菌对头孢唑林耐药率最高,达71.43%,其次为头孢他啶、头孢曲松、庆大霉素、头孢呋辛,均为57.14%;致病性大肠埃希菌对环丙沙星耐药率最高,达100.00%;其他细菌对头孢呋辛、头孢唑林耐药率最高,达30.00%,其次是庆大霉素为25.00%。结论通过检测发现127例疑似细菌性腹泻患者中,细菌以沙门菌、病毒以诺如病毒较为多见,且细菌感染多发夏季、病毒感染多发秋冬季,以儿童及老年为主要发病群体,临床应加以重视,针对细菌性腹泻可结合药敏试验给予敏感药物治疗以增强疗效。

Efficacy and tolerability of chitin-glucan combined with simethicone(GASTRAP^(■)DIRECT)in irritable bowel syndrome:A prospective,open-label,multicenter study

BACKGROUND Irritable bowel syndrome(IBS),defined according to the Rome IV diagnostic criteria,is a chronic functional gastrointestinal disorder characterized by recurrent abdominal pain related to altered bowel habits.First-line recommended treatments are limited to combining drugs targeting predominant symptoms,particularly pain(antispasmodics),constipation(laxatives),and diarrhea(loperamide),yielding only a limited therapeutic gain.GASTRAP^(■)DIRECT is a class IIa medical formulation composed of a combination of chitin-glucan and simethicone indicated for the symptomatic treatment of gas-related gastrointestinal disorders by combining different mechanisms of action.AIM To evaluate the efficacy,tolerability,and safety of 4-week GASTRAP^(■)DIRECT treatment in patients with IBS.METHODS In this prospective,multicenter,open-label trial,120 patients with IBS received three sticks of GASTRAP^(■)DIRECT(1.5 g/d of chitin-glucan and 0.75 mg/d of simethicone)per day for 4 weeks.The primary endpoint was the responder rate,defined as the number of patients whose abdominal pain score decreased by≥30%from baseline to week(W)4.The analysis was performed using the per-protocol set.Cardinal symptoms,impact of global symptoms on daily life,change in stool consistency,and improvement in defecatory disorders were evaluated.RESULTS Overall,100 patients were evaluated.At W4,67%(95%CI:57-75)showed improvement in abdominal pain(score:5.8±2.4 vs 2.9±2.0,P<0.0001).Similar improvements were observed for bloating[8.0±1.7 vs 4.7±2.9,P<0.0001;60%(95%CI:50-70)responders],abdominal distension[7.2±2.1 vs 4.4±3.1,P<0.0001;53%(95%CI:43-63)responders],and impact of global symptoms on daily life[7.1±2.0 vs 4.6±2.9,P<0.0001;54%(95%CI:44-64)responders].Stool consistency improved in most patients(90%and 57%for patients with liquid and hard stools,respectively).Overall,42%of patients with defecatory disorders reported very much/considerable improvements by W2.No severe adverse event occurred,and tolerability was rated“good”or“very good”by 93%of patients.CONCLUSION GASTRAP^(■)DIRECT is safe and well tolerated,alleviating IBS symptoms rapidly in 2 weeks.This open-label study suggests that the combination of chitin-glucan and simethicone could be beneficial in patients with IBS.

从调肝论治二便、汗液、白带、乳汁的排出异常

人体内有多种需要排出的物质,诸物质之通畅外泄需借助秉木疏泄之性的肝脏之功,如胆汁、月经、精液、二便、汗液、白带、乳汁的排出均离不开肝的调节,肝气条达,疏泄有度,体内精气、浊废各循其道,顺时适度溢泄而出。肝失疏泄,气机郁结,脏腑气机不畅,诸窍失于疏启,则可见汗出不畅、癃闭、便秘、白带、乳汁不下之弊,应辨证采用养血柔肝或疏肝理气之法以恢复肝疏泄之功,常用到小柴胡汤、柴胡疏肝散等。肝疏泄太过,气机亢逆,诸窍不当启而启,可致大汗、遗溺、泄泻、赤带、漏乳等症,则应清肝、平肝、柔肝,常用龙胆泻肝汤、痛泻要方、丹栀逍遥散等方。

七味止痢散联合双歧杆菌四联活菌对腹腔镜胆囊切除术后腹泻患者大便性状及菌群的影响

目的:探讨七味止痢散联合双歧杆菌四联活菌对腹腔镜胆囊切除术(LC)后腹泻患者大便性状及菌群的影响。方法:选取我院2020年6月~2022年6月106例LC术后腹泻患者,随机数字表法分为观察组(n=53)及对照组(n=53)。对照组予以双歧杆菌四联活菌,观察组在此基础联合七味止痢散。比较两组临床疗效、治疗前后大便性状、大便频率、肠道菌群、胃肠激素、炎症因子、不良反应。结果:观察组总有效率为94.33%(50/53),高于对照组的81.13%(43/53)(P<0.05);观察组治疗后大便性状评分及频率低于对照组(P<0.05);观察组治疗后肠球菌、大肠埃希菌数量低于对照组,乳酸杆菌、双歧杆菌数量高于对照组(P<0.05);观察组治疗后血清胃动素(MTL)、胃泌素(GAS)、血管活性肠肽(VIP)低于对照组(P<0.05);观察组治疗后血清白细胞介素(IL)-8、肿瘤坏死因子(TNF)-α、IL-6低于对照组(P<0.05)。结论:七味止痢散联合双歧杆菌四联活菌治疗LC术后腹泻的疗效确切,能改善患者的大便性状,降低大便频率,调节肠道菌群及胃肠激素,降低炎症因子水平。

基于“相火在位”理论探讨藏肾疏肝法治疗溃疡性结肠炎

溃疡性结肠炎属于炎症性肠病,其发病机制与肠道免疫紊乱相关。近年来有学者根据相火生理病理特点提出“相火免疫”学说。通过梳理“相火在位”的理论内涵,认为相火在位与肾精封藏、肝气疏泄具有生理相关性,结合溃疡性结肠炎临床症状及病理基础,认为“肾失封藏、相火妄动”是溃疡性结肠炎发病的根本病机,并提出藏肾疏肝的治疗大法,以填补下焦,封髓藏肾固其根本,配合清遏余邪、疏肝敛阳以治其标,分予清热疏肝、利湿化浊、散瘀解毒以“消、敛、降”妄火,标本兼治,为中医辨治溃疡性结肠炎提供新思路。

妈咪爱和蒙脱石散联合治疗对腹泻患儿大便、血常规恢复正常时间的影响分析

目的分析枯草杆菌二联活菌颗粒(商品名:妈咪爱)和蒙脱石散联合治疗对腹泻患儿大便、血常规恢复正常时间的影响。方法87例腹泻患儿,根据治疗方法的不同分为研究组(44例)与参考组(43例)。研究组采用妈咪爱和蒙脱石散联合治疗,参考组采用蒙脱石散治疗。比较两组患儿临床疗效,大便(大便次数、大便性状恢)、血常规恢复正常时间及症状(腹痛、呕吐、发热)消退时间,炎症因子、免疫指标改善情况。结果研究组患儿大便次数、大便性状、血常规恢复正常时间以及腹痛、呕吐、发热消退时间分别为(2.23±0.13)、(3.28±0.18)、(2.58±0.22)、(1.07±0.05)、(1.18±0.08)、(1.91±0.11)d,均显著短于参考组的(3.24±0.17)、(4.44±0.29)、(4.99±0.45)、(2.24±0.09)、(2.75±0.17)、(2.92±0.24)d(P<0.05)。治疗后,两组患儿白细胞介素-2、白细胞介素-10、免疫球蛋白G、免疫球蛋白A水平均较治疗前显著改善,且研究组患儿白细胞介素-2(41.65±3.64)pg/ml、白细胞介素-10(75.64±6.87)pg/ml、免疫球蛋白G(16.88±2.18)g/L、免疫球蛋白A(1.69±0.34)g/L均显著优于参考组的(59.92±5.09)pg/ml、(54.35±5.24)pg/ml、(11.86±1.26)g/L、(1.28±0.22)g/L(P<0.05)。研究组患儿总有效率97.73%显著高于参考组的83.72%(P<0.05)。结论妈咪爱和蒙脱石散联合治疗腹泻患儿能有效缩短大便、血常规恢复正常时间及各项症状消退时间,提升总体疗效,改善患儿炎症因子和免疫功能。