AIM To explore the agreement between the mini-mental state examination(MMSE) and montreal cognitive assessment(Mo CA) within community dwelling older patients attending an old age psychiatry service and to derive and ...AIM To explore the agreement between the mini-mental state examination(MMSE) and montreal cognitive assessment(Mo CA) within community dwelling older patients attending an old age psychiatry service and to derive and test a conversion formula between the two scales.METHODS Prospective study of consecutive patients attending outpatient services.Both tests were administered by the same researcher on the same day in random order.RESULTS The total sample(n = 135) was randomly divided into two groups.One to derive a conversion rule(n = 70),and a second(n = 65) in which this rule was tested.The agreement(Pearson's r) of MMSE and Mo CA was 0.86(P < 0.001),and Lin's concordance correlation coefficient(CCC) was 0.57(95%CI:0.45-0.66).In the second sample Mo CA scores were converted to MMSE scores according to a conversion rule from the first sample which achieved agreement with the original MMSE scoresof 0.89(Pearson's r,P < 0.001) and CCC of 0.88(95%CI:0.82-0.92).CONCLUSION Although the two scales overlap considerably,the agreement is modest.The conversion rule derived herein demonstrated promising accuracy and warrants further testing in other populations.展开更多
BACKGROUND Syphilis is an infectious disease caused by Treponema pallidum that can invade the central nervous system,causing encephalitis.Few cases of anti-N-methyl-Daspartate receptor autoimmune encephalitis(AE)secon...BACKGROUND Syphilis is an infectious disease caused by Treponema pallidum that can invade the central nervous system,causing encephalitis.Few cases of anti-N-methyl-Daspartate receptor autoimmune encephalitis(AE)secondary to neurosyphilis have been reported.We report a neurosyphilis patient with anti-γ-aminobutyric acid-B receptor(GABABR)AE.CASE SUMMARY A young man in his 30s who presented with acute epileptic status was admitted to a local hospital.He was diagnosed with neurosyphilis,according to serum and cerebrospinal fluid(CSF)tests for syphilis.After 14 d of antiepileptic treatment and anti-Treponema pallidum therapy with penicillin,epilepsy was controlled but serious cognitive impairment,behavioral,and serious psychiatric symptoms were observed.He was then transferred to our hospital.The Mini-Mental State Examination(MMSE)crude test results showed only 2 points.Cranial magnetic resonance imaging revealed significant cerebral atrophy and multiple fluidattenuated inversion recovery high signals in the white matter surrounding both lateral ventricles,left amygdala and bilateral thalami.Anti-GABABR antibodies were discovered in CSF(1:3.2)and serum(1:100).The patient was diagnosed with neurosyphilis complicated by anti-GABABR AE,and received methylprednisolone and penicillin.Following treatment,his mental symptoms were alleviated.Cognitive impairment was significantly improved,with a MMSE of 8 points.Serum anti-GABABR antibody titer decreased to 1:32.The patient received methylprednisolone and penicillin after discharge.Three months later,the patient’s condition was stable,but the serum anti-GABABR antibody titer was 1:100.CONCLUSION This patient with neurosyphilis combined with anti-GABABR encephalitis benefited from immunotherapy.展开更多
目的通过评估老年性聋患者的认知功能,分析其相关影响因素。方法收集就诊于郑州大学第一附属医院耳科门诊的老年性聋患者112例,同期健康者112例。使用简易精神智能状态量表(mini-mental state examination,MMSE)评估认知功能,老年人听...目的通过评估老年性聋患者的认知功能,分析其相关影响因素。方法收集就诊于郑州大学第一附属医院耳科门诊的老年性聋患者112例,同期健康者112例。使用简易精神智能状态量表(mini-mental state examination,MMSE)评估认知功能,老年人听觉障碍筛查量表(the hearing handicap inventory for the elderly screening version,HHIE-S)和纯音听阈测定评估听力水平,并利用Logistic回归对老年性聋患者的认知功能行相关影响因素分析。结果老年性聋组MMSE评分27(24,28)分低于健康组28(27,29)分(Z=-4.371,P<0.001)。老年性聋患者不同年龄、学历、职业性质、耳聋病程、HHIE-S评分、纯音平均听阈、言语识别率的MMSE评分存在差异(P<0.05);学历(β=-7.151,P=0.012),耳聋病程(β=0.542,P=0.033)、HHIE-S评分(β=0.132,P=0.041)、纯音平均听阈(β=0.08,P=0.046)与老年性聋患者认知功能障碍显著相关。结论言语识别率、年龄对认知功能无直接影响,高学历是老年性聋患者认知功能的保护因素,耳聋病程长、听力损失程度重是老年性聋患者认知功能的危险因素。展开更多
目的探究椎管内麻醉对老年下肢骨折手术患者简易精神状态检查表(mini-mental state examination,MMSE)评分与不良事件发生情况的影响。方法选取2019年1月—2021年10月在吉林省前卫医院接受手术的老年下肢骨折患者,合计50例,对其以抽签...目的探究椎管内麻醉对老年下肢骨折手术患者简易精神状态检查表(mini-mental state examination,MMSE)评分与不良事件发生情况的影响。方法选取2019年1月—2021年10月在吉林省前卫医院接受手术的老年下肢骨折患者,合计50例,对其以抽签法进行随机分组,即对照组(n=25)与观察组(n=25),对照组实施全麻,观察组实施椎管内麻醉,对比两组患者的MMSE评分、不良事件发生率以及认知功能程度。结果观察组术后2 h精神状态评分明显高于对照组,差异有统计学意义(P<0.05);术后8、16 h,观察组与对照组的神经状态评分差异无统计学意义(P>0.05);观察组不良事件发生率低于对照组,差异有统计学意义(P<0.05);两组认知功能情况为:观察组正常21例、轻度4例、中度0例、重度0例,正常、轻度、中度、重度占比是84.00%、16.00%、0、0;对照组正常10例、轻度4例、中度6例、重度5例,正常、轻度、中度、重度占比是40.00%、16.00%、24.00%、20.00%。观察组认知功能正常率高于对照组,差异有统计学意义(P<0.05)。结论椎管内麻醉在骨科手术患者的应用,可以提升MMSE评分,减少重度以及重度认知功能问题的出现,并降低不良事件发生率。展开更多
文摘AIM To explore the agreement between the mini-mental state examination(MMSE) and montreal cognitive assessment(Mo CA) within community dwelling older patients attending an old age psychiatry service and to derive and test a conversion formula between the two scales.METHODS Prospective study of consecutive patients attending outpatient services.Both tests were administered by the same researcher on the same day in random order.RESULTS The total sample(n = 135) was randomly divided into two groups.One to derive a conversion rule(n = 70),and a second(n = 65) in which this rule was tested.The agreement(Pearson's r) of MMSE and Mo CA was 0.86(P < 0.001),and Lin's concordance correlation coefficient(CCC) was 0.57(95%CI:0.45-0.66).In the second sample Mo CA scores were converted to MMSE scores according to a conversion rule from the first sample which achieved agreement with the original MMSE scoresof 0.89(Pearson's r,P < 0.001) and CCC of 0.88(95%CI:0.82-0.92).CONCLUSION Although the two scales overlap considerably,the agreement is modest.The conversion rule derived herein demonstrated promising accuracy and warrants further testing in other populations.
文摘BACKGROUND Syphilis is an infectious disease caused by Treponema pallidum that can invade the central nervous system,causing encephalitis.Few cases of anti-N-methyl-Daspartate receptor autoimmune encephalitis(AE)secondary to neurosyphilis have been reported.We report a neurosyphilis patient with anti-γ-aminobutyric acid-B receptor(GABABR)AE.CASE SUMMARY A young man in his 30s who presented with acute epileptic status was admitted to a local hospital.He was diagnosed with neurosyphilis,according to serum and cerebrospinal fluid(CSF)tests for syphilis.After 14 d of antiepileptic treatment and anti-Treponema pallidum therapy with penicillin,epilepsy was controlled but serious cognitive impairment,behavioral,and serious psychiatric symptoms were observed.He was then transferred to our hospital.The Mini-Mental State Examination(MMSE)crude test results showed only 2 points.Cranial magnetic resonance imaging revealed significant cerebral atrophy and multiple fluidattenuated inversion recovery high signals in the white matter surrounding both lateral ventricles,left amygdala and bilateral thalami.Anti-GABABR antibodies were discovered in CSF(1:3.2)and serum(1:100).The patient was diagnosed with neurosyphilis complicated by anti-GABABR AE,and received methylprednisolone and penicillin.Following treatment,his mental symptoms were alleviated.Cognitive impairment was significantly improved,with a MMSE of 8 points.Serum anti-GABABR antibody titer decreased to 1:32.The patient received methylprednisolone and penicillin after discharge.Three months later,the patient’s condition was stable,but the serum anti-GABABR antibody titer was 1:100.CONCLUSION This patient with neurosyphilis combined with anti-GABABR encephalitis benefited from immunotherapy.
文摘目的通过评估老年性聋患者的认知功能,分析其相关影响因素。方法收集就诊于郑州大学第一附属医院耳科门诊的老年性聋患者112例,同期健康者112例。使用简易精神智能状态量表(mini-mental state examination,MMSE)评估认知功能,老年人听觉障碍筛查量表(the hearing handicap inventory for the elderly screening version,HHIE-S)和纯音听阈测定评估听力水平,并利用Logistic回归对老年性聋患者的认知功能行相关影响因素分析。结果老年性聋组MMSE评分27(24,28)分低于健康组28(27,29)分(Z=-4.371,P<0.001)。老年性聋患者不同年龄、学历、职业性质、耳聋病程、HHIE-S评分、纯音平均听阈、言语识别率的MMSE评分存在差异(P<0.05);学历(β=-7.151,P=0.012),耳聋病程(β=0.542,P=0.033)、HHIE-S评分(β=0.132,P=0.041)、纯音平均听阈(β=0.08,P=0.046)与老年性聋患者认知功能障碍显著相关。结论言语识别率、年龄对认知功能无直接影响,高学历是老年性聋患者认知功能的保护因素,耳聋病程长、听力损失程度重是老年性聋患者认知功能的危险因素。
文摘目的探究椎管内麻醉对老年下肢骨折手术患者简易精神状态检查表(mini-mental state examination,MMSE)评分与不良事件发生情况的影响。方法选取2019年1月—2021年10月在吉林省前卫医院接受手术的老年下肢骨折患者,合计50例,对其以抽签法进行随机分组,即对照组(n=25)与观察组(n=25),对照组实施全麻,观察组实施椎管内麻醉,对比两组患者的MMSE评分、不良事件发生率以及认知功能程度。结果观察组术后2 h精神状态评分明显高于对照组,差异有统计学意义(P<0.05);术后8、16 h,观察组与对照组的神经状态评分差异无统计学意义(P>0.05);观察组不良事件发生率低于对照组,差异有统计学意义(P<0.05);两组认知功能情况为:观察组正常21例、轻度4例、中度0例、重度0例,正常、轻度、中度、重度占比是84.00%、16.00%、0、0;对照组正常10例、轻度4例、中度6例、重度5例,正常、轻度、中度、重度占比是40.00%、16.00%、24.00%、20.00%。观察组认知功能正常率高于对照组,差异有统计学意义(P<0.05)。结论椎管内麻醉在骨科手术患者的应用,可以提升MMSE评分,减少重度以及重度认知功能问题的出现,并降低不良事件发生率。
