BACKGROUND Treatment for severe acute severe pancreatitis(SAP)can significantly affect Health-related quality of life(HR-QoL).The effects of different treatment strategies such as endoscopic and surgical necrosectomy ...BACKGROUND Treatment for severe acute severe pancreatitis(SAP)can significantly affect Health-related quality of life(HR-QoL).The effects of different treatment strategies such as endoscopic and surgical necrosectomy on HR-QoL in patients with SAP remain poorly investigated.AIM To critically appraise the available evidence on HR-QoL following surgical or endoscopic necrosectomy in patient with SAP.METHODS A literature search was performed on PubMed,Google^(TM) Scholar,the Cochrane Library,MEDLINE and Reference Citation Analysis databases for studies that investigated HR-QoL following surgical or endoscopic necrosectomy in patients with SAP.Data collected included patient characteristics,outcomes of interventions and HR-QoL-related details.RESULTS Eleven studies were found to have evaluated HR-QoL following treatment for severe acute pancreatitis including 756 patients.Three studies were randomized trials,four were prospective cohort studies and four were retrospective cohort studies with prospective follow-up.Four studies compared HR-QoL following surgical and endoscopic necrosectomy.Several metrics of HR-QoL were used including Short Form(SF)-36 and EuroQol.One randomized trial and one cohort study demonstrated significantly improved physical scores at three months in patients who underwent endoscopic necrosectomy compared to surgical necrosectomy.One prospective study that examined HR-QoL following surgical necrosectomy reported some deterioration in the functional status of the patients.On the other hand,a cohort study that assessed the long-term HR-QoL following sequential surgical necrosectomy stated that all patients had SF-36>60%.In the only study that examined patients following endoscopic necrosectomy,the HR-QoL was also very good.Three studies investigated the quality adjusted life years suggesting that endoscopic and surgical approaches to management of pancreatic necrosis were comparable in cost effectiveness.Finally,regarding HR-QoL between open necrosectomy and minimally invasive approaches,patients who underwent the later had a significantly better overall quality of life,vitality and mental health.CONCLUSION This review would suggest that the endoscopic approach might offer better HR-QoL compared to surgical necrosectomy.However,the available comparative literature was very limited.More randomized trials powered to detect differences in HR-QoL are required.展开更多
目的:探讨横窦骑跨性硬膜外血肿的手术治疗效果。方法:98例创伤性横窦骑跨性硬膜外血肿患者分为开颅组(40例)与微创引流组(58例)。开颅组全麻下骨窗开颅血肿清除,微创引流组局麻CT定位下以软通道引流管穿刺血肿腔,并以尿激酶5～6万IU冲...目的:探讨横窦骑跨性硬膜外血肿的手术治疗效果。方法:98例创伤性横窦骑跨性硬膜外血肿患者分为开颅组(40例)与微创引流组(58例)。开颅组全麻下骨窗开颅血肿清除,微创引流组局麻CT定位下以软通道引流管穿刺血肿腔,并以尿激酶5～6万IU冲洗引流。比较两组不同时间点的血肿体积,并发症发生率以及3月后GOS评分。结果:微创引流组术后1 d CT显示血肿量较术前显著减少(P<0.05),3～5 d血肿完全清除。术后7 dGCS评分较术前显著提高(P<0.05)。两组并发症发生率及术后三月GOS评分差异均无统计学意义。结论:微创软通道血肿引流术对横窦骑跨性硬膜外血肿疗效显著,并有方便快捷,创伤小等优点。展开更多
文摘BACKGROUND Treatment for severe acute severe pancreatitis(SAP)can significantly affect Health-related quality of life(HR-QoL).The effects of different treatment strategies such as endoscopic and surgical necrosectomy on HR-QoL in patients with SAP remain poorly investigated.AIM To critically appraise the available evidence on HR-QoL following surgical or endoscopic necrosectomy in patient with SAP.METHODS A literature search was performed on PubMed,Google^(TM) Scholar,the Cochrane Library,MEDLINE and Reference Citation Analysis databases for studies that investigated HR-QoL following surgical or endoscopic necrosectomy in patients with SAP.Data collected included patient characteristics,outcomes of interventions and HR-QoL-related details.RESULTS Eleven studies were found to have evaluated HR-QoL following treatment for severe acute pancreatitis including 756 patients.Three studies were randomized trials,four were prospective cohort studies and four were retrospective cohort studies with prospective follow-up.Four studies compared HR-QoL following surgical and endoscopic necrosectomy.Several metrics of HR-QoL were used including Short Form(SF)-36 and EuroQol.One randomized trial and one cohort study demonstrated significantly improved physical scores at three months in patients who underwent endoscopic necrosectomy compared to surgical necrosectomy.One prospective study that examined HR-QoL following surgical necrosectomy reported some deterioration in the functional status of the patients.On the other hand,a cohort study that assessed the long-term HR-QoL following sequential surgical necrosectomy stated that all patients had SF-36>60%.In the only study that examined patients following endoscopic necrosectomy,the HR-QoL was also very good.Three studies investigated the quality adjusted life years suggesting that endoscopic and surgical approaches to management of pancreatic necrosis were comparable in cost effectiveness.Finally,regarding HR-QoL between open necrosectomy and minimally invasive approaches,patients who underwent the later had a significantly better overall quality of life,vitality and mental health.CONCLUSION This review would suggest that the endoscopic approach might offer better HR-QoL compared to surgical necrosectomy.However,the available comparative literature was very limited.More randomized trials powered to detect differences in HR-QoL are required.
文摘目的:探讨横窦骑跨性硬膜外血肿的手术治疗效果。方法:98例创伤性横窦骑跨性硬膜外血肿患者分为开颅组(40例)与微创引流组(58例)。开颅组全麻下骨窗开颅血肿清除,微创引流组局麻CT定位下以软通道引流管穿刺血肿腔,并以尿激酶5～6万IU冲洗引流。比较两组不同时间点的血肿体积,并发症发生率以及3月后GOS评分。结果:微创引流组术后1 d CT显示血肿量较术前显著减少(P<0.05),3～5 d血肿完全清除。术后7 dGCS评分较术前显著提高(P<0.05)。两组并发症发生率及术后三月GOS评分差异均无统计学意义。结论:微创软通道血肿引流术对横窦骑跨性硬膜外血肿疗效显著,并有方便快捷,创伤小等优点。
