The clinical effects of dosage during the period of treatment of Lithospermum Ruderale extract-a kind of Chinese traditional herbal medicine-on medicinal abortion induced by mifepristone and misoprostol were studied. ...The clinical effects of dosage during the period of treatment of Lithospermum Ruderale extract-a kind of Chinese traditional herbal medicine-on medicinal abortion induced by mifepristone and misoprostol were studied. Lithospermum Ruderale extract was administrated 3 d before, 3 d after or 3 d before plus 3 d after the administration of misoprostol respectively. The dose of Lithospermum Ruderale extract was 50 g, 75 g or 100 g respectively. Thus 1 350 women of early pregnancy were grouped into 9 groups and observed. The results showed that the effects of Lithospermum Ruderale used 3 d before, and 3 d before plus 3 d after (6 days misoprostol were significantly better than those only used 3 d after misoprostol both for complete abortion and bleeding (P<0.05). The dosage between 50 g and 100 g made no significant difference in clinical effects. Therefore it is reasonable to use 50 g Lithospermum Ruderale before misoprostol to improve medicinal abortion.展开更多
目的运用数据挖掘技术探索近10年文献中中医药治疗脑梗死患者的用药规律及其特点。方法通过检索2013年1月1日—2023年1月1日中国生物医学文献数据库(China Biology Medicine disc,CBMdisc)、中国知识网(China National Knowledge Intern...目的运用数据挖掘技术探索近10年文献中中医药治疗脑梗死患者的用药规律及其特点。方法通过检索2013年1月1日—2023年1月1日中国生物医学文献数据库(China Biology Medicine disc,CBMdisc)、中国知识网(China National Knowledge Internet,CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(维普网)中医药(含中西医结合)治疗脑梗死的相关文献。完成筛选、建立数据库,在中医传承辅助平台(V3.0)上运用频数统计、聚类分析、关联规则分析等方法,统计药物使用频率、性味归经分布情况,分析药物配伍规律及关联、聚类效果。结果纳入文献共143篇,共整理出161首方剂,222味中药。四气中温(41.51%)、寒(27.55%)、平(25.89%)为主;五味以苦(34.17%)、甘(28.82%)、辛(24.45%)为主;归经以肝(26.68%)、心(17.96%)、脾(16.14%)三经为主;药物频次≥35次的中药共有13味,以活血化瘀类药物为主;药物组合中频次≥45次的有18组;将整理后的222味中药可分为3个聚类。结论脑梗死的治疗药物以温寒平、归心肝经者为多,治疗方法以活血化瘀、补益肝肾、平肝熄风为主,可为临床治疗提供一定借鉴。展开更多
基金This study was funded by National Family Planning Commission of China
文摘The clinical effects of dosage during the period of treatment of Lithospermum Ruderale extract-a kind of Chinese traditional herbal medicine-on medicinal abortion induced by mifepristone and misoprostol were studied. Lithospermum Ruderale extract was administrated 3 d before, 3 d after or 3 d before plus 3 d after the administration of misoprostol respectively. The dose of Lithospermum Ruderale extract was 50 g, 75 g or 100 g respectively. Thus 1 350 women of early pregnancy were grouped into 9 groups and observed. The results showed that the effects of Lithospermum Ruderale used 3 d before, and 3 d before plus 3 d after (6 days misoprostol were significantly better than those only used 3 d after misoprostol both for complete abortion and bleeding (P<0.05). The dosage between 50 g and 100 g made no significant difference in clinical effects. Therefore it is reasonable to use 50 g Lithospermum Ruderale before misoprostol to improve medicinal abortion.
文摘目的运用数据挖掘技术探索近10年文献中中医药治疗脑梗死患者的用药规律及其特点。方法通过检索2013年1月1日—2023年1月1日中国生物医学文献数据库(China Biology Medicine disc,CBMdisc)、中国知识网(China National Knowledge Internet,CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(维普网)中医药(含中西医结合)治疗脑梗死的相关文献。完成筛选、建立数据库,在中医传承辅助平台(V3.0)上运用频数统计、聚类分析、关联规则分析等方法,统计药物使用频率、性味归经分布情况,分析药物配伍规律及关联、聚类效果。结果纳入文献共143篇,共整理出161首方剂,222味中药。四气中温(41.51%)、寒(27.55%)、平(25.89%)为主;五味以苦(34.17%)、甘(28.82%)、辛(24.45%)为主;归经以肝(26.68%)、心(17.96%)、脾(16.14%)三经为主;药物频次≥35次的中药共有13味,以活血化瘀类药物为主;药物组合中频次≥45次的有18组;将整理后的222味中药可分为3个聚类。结论脑梗死的治疗药物以温寒平、归心肝经者为多,治疗方法以活血化瘀、补益肝肾、平肝熄风为主,可为临床治疗提供一定借鉴。
