Drug resistance is one of the most intractable issues in targeted therapy for cancer diseases.It has also been demonstrated to be related to cancer heterogeneity,which promotes the emergence of treatment-refractory ca...Drug resistance is one of the most intractable issues in targeted therapy for cancer diseases.It has also been demonstrated to be related to cancer heterogeneity,which promotes the emergence of treatment-refractory cancer cell populations.Focusing on how cancer cells develop resistance during the encounter with targeted drugs and the immune system,we propose a mathematical model for studying the dynamics of drug resistance in a conjoint heterogeneous tumor-immune setting.We analyze the local geometric properties of the equilibria of the model.Numerical simulations show that the selectively targeted removal of sensitive cancer cells may cause the initially heterogeneous population to become a more resistant population.Moreover,the decline of immune recruitment is a stronger determinant of cancer escape from immune surveillance or targeted therapy than the decay in immune predation strength.Sensitivity analysis of model parameters provides insight into the roles of the immune system combined with targeted therapy in determining treatment outcomes.展开更多
The Kuqa fold-and-thrust belt exhibits apparent structural variation in the western and eastern zone.Two salt layer act as effective decollements and influence the varied deformation.In this study,detailed seismic int...The Kuqa fold-and-thrust belt exhibits apparent structural variation in the western and eastern zone.Two salt layer act as effective decollements and influence the varied deformation.In this study,detailed seismic interpretations and analog modeling are presented to construct the suprasalt and subsalt structures in the transfer zone of the middle Kuqa and investigate the influence of the two salt layers.The results reveal that the relationship of the two salt layers changes from separated to connected,and then overlapped toward the foreland in the transfer zone.Different structural models are formed in the suprasalt and subsalt units due to the interaction of the two salt layers.The imbricate thrust faults form two broom-like fault systems in the subsalt units.The suprasalt units develop detached folds terminating toward the east in the region near the orogenic belt.Whereas,two offset anticlines with different trends develop at the frontal edge of the lower salt layer and the trailing edge of the upper salt layer,respectively.According to exploration results in this region,the relationship between suprasalt and subsalt structures has an influence on hydrocarbon accumulation.We believe that the connected deformation contains high-risk plays while the decoupled deformation contains well-preserved plays.展开更多
基金supported by the National Natural Science Foundation of China(11871238,11931019,12371486)。
文摘Drug resistance is one of the most intractable issues in targeted therapy for cancer diseases.It has also been demonstrated to be related to cancer heterogeneity,which promotes the emergence of treatment-refractory cancer cell populations.Focusing on how cancer cells develop resistance during the encounter with targeted drugs and the immune system,we propose a mathematical model for studying the dynamics of drug resistance in a conjoint heterogeneous tumor-immune setting.We analyze the local geometric properties of the equilibria of the model.Numerical simulations show that the selectively targeted removal of sensitive cancer cells may cause the initially heterogeneous population to become a more resistant population.Moreover,the decline of immune recruitment is a stronger determinant of cancer escape from immune surveillance or targeted therapy than the decay in immune predation strength.Sensitivity analysis of model parameters provides insight into the roles of the immune system combined with targeted therapy in determining treatment outcomes.
基金supported by the National Natural Science Foundation of China(Grant Nos.41572187,41972219,41927802 and 42072320)the China Postdoctoral Science Foundation(Grant No.2020M671432)。
文摘The Kuqa fold-and-thrust belt exhibits apparent structural variation in the western and eastern zone.Two salt layer act as effective decollements and influence the varied deformation.In this study,detailed seismic interpretations and analog modeling are presented to construct the suprasalt and subsalt structures in the transfer zone of the middle Kuqa and investigate the influence of the two salt layers.The results reveal that the relationship of the two salt layers changes from separated to connected,and then overlapped toward the foreland in the transfer zone.Different structural models are formed in the suprasalt and subsalt units due to the interaction of the two salt layers.The imbricate thrust faults form two broom-like fault systems in the subsalt units.The suprasalt units develop detached folds terminating toward the east in the region near the orogenic belt.Whereas,two offset anticlines with different trends develop at the frontal edge of the lower salt layer and the trailing edge of the upper salt layer,respectively.According to exploration results in this region,the relationship between suprasalt and subsalt structures has an influence on hydrocarbon accumulation.We believe that the connected deformation contains high-risk plays while the decoupled deformation contains well-preserved plays.
