Development of a new cerebral ischemia reperfusion model of Mongolian gerbils and standardized evaluation system

Background:The Mongolian gerbil is an excellent laboratory animal for preparing the cerebral ischemia model due to its inherent deficiency in the circle of Willis.However,the low incidence and unpredictability of symptoms are caused by numerous complex variant types of the circle.Additionally,the lack of an evaluation system for the cer-ebral ischemia/reperfusion(I/R)model of gerbils has shackled the application of this model.Methods:We created a symptom-oriented principle and detailed neurobehavioral scoring criteria.At different time points of reperfusion,we analyzed the alteration in locomotion by rotarod test and grip force score,infarct volume by triphenyltetrazo-lium chloride(TTC)staining,neuron loss using Nissl staining,and histological charac-teristics using hematoxylin-eosin(H&E)straining.Results:With a successful model rate of 56%,32 of the 57 gerbils operated by our method harbored typical features of cerebral I/R injury,and the mortality rate in the male gerbils was significantly higher than that in the female gerbils.The suc-cessfully prepared I/R gerbils demonstrated a significant reduction in motility and grip strength at 1 day after reperfusion;formed obvious infarction;exhibited typi-cal pathological features,such as tissue edema,neuronal atrophy and death,and vacuolated structures;and were partially recovered with the extension of reperfu-sion time.Conclusion:This study developed a new method for the unilateral common carotid artery ligation I/R model of gerbil and established a standardized evaluation system for this model,which could provide a new cerebral I/R model of gerbils with more practical applications.

Towards 6D Little String Theory of Particles

A model for particles based on preons in chiral, vector and tensor/graviton supermultiplets of unbroken global supersymmetry is engineered. The framework of the model is little string theory. Phenomenological predictions are discussed.

Structural Foundation and Geometry of the Material Singularity (and Its Quantum Entanglement)

In this paper we develop and study, as the second part of one more general development, the energy transmutation equation for the material singularity, previously obtained through the symmetrisation of a wave packet, that is, we develop the correlation between the terms of this equation, which accounts for the formation of matter from a previous vibrational state, and the different possible energy species. These energetic species are ascribed, in a simplified form, to the equation E¯ω=E¯k+E¯f, which allows us, through its associated phase factor, to gain an insight into the wave character of the kinetic energy and thus to attain the basis of the matter-wave, and all sorts of related phenomenologies, including that concerning quantum entanglement. The formation of the matter was previously identified as an energetic process, analogous to the kinetic one, in which finally the inertial mass is consolidated as a mass in a different phase, now, in addition, the mass of the material singularity is identified as a volumetric density of waves of toroidal geometry created in the process of singularisation or energy transfer between species, which makes it possible to establish the real relation or correspondence between the corpuscular and photonic energy equation (E=mc2=hν), i.e. to explain through m the intimate sense of the first equivalence, which explains what νis in the second one.

Non-Uniform Pion Tetrahedron Aether and Electron Tetrahedron Model

We propose that the QCD vacuum pion tetrahedron condensate density vary in space and drops to extremely low values in the Kennan, Barger and Cowie (KBC) void in analogy to earth’s atmospheric density drop with elevation from earth. We propose a formula for the gravitation acceleration based on the non-uniform pion tetrahedron condensate. Gravity may be due to the underlying microscopic attraction between quarks and antiquarks, which are part of the vacuum pion tetrahedron condensate. We propose an electron tetrahedron model, where electrons are comprised of tetraquark tetrahedrons, and . The quarks determine the negative electron charge and the or quarks determine the electron two spin states. The electron tetrahedron may perform a high frequency quark exchange reactions with the pion tetrahedron condensate by tunneling through the condensation gap creating a delocalized electron cloud with a fixed spin. The pion tetrahedron may act as a QCD glue bonding electron pairs in atoms and molecules and protons to neutrons in the nuclei. Conservation of valence quarks and antiquarks is proposed.

Constraints on Asymmetric Dark Matter in Quintessence Model

The modified cosmology like quintessence model with kination phase predicted the Hubble expansion rate of the universe before Big Bang Nucleosynthesis is different from the standard cosmological scenario. The modified expansion rate leaves its imprint on the relic density of asymmetric dark matter. In this work, we review the calculation of relic density of asymmetric WIMP dark matter in the standard cosmological scenario and quintessence model with kination phase. Then we use the Planck data to find constraints on the annihilation cross section and the mass of the asymmetric dark matter in those models.

Calculation of Particle Decay Times in the Standard Model

We present here a two-step method of classification and calculation for decay rates in the Standard Model. The first step is a phenomenological classification method, which is an extended and improved schematic experimental formula for decay width originally introduced by Chang. This schematic formula separates decays into seven classes. Furthermore, from it is derived a process-specific interaction energy mX. The second step is a numerical calculation method, which calculates this interaction energy mX numerically by minimization of action from the Lagrangian of the process, from which follows the decay width via the phenomenological formula. The Lagrangian is based on an extension of the Standard Model, the extended SU(4)-preon-model. A comparison of numerically calculated and observed decay widths for a large selection of decays shows a good agreement.

Calculation of the Standard Model Parameters and Particles Based on a SU(4) Preon Model

This paper describes an extension and a new foundation of the Standard Model of particle physics based on a SU(4)-force called hyper-color, and on preon subparticles. The hyper-color force is a generalization of the SU(2)-based weak interaction and the SU(1)-based right-chiral self-interaction, in which the W-and the Z-bosons are Yukawa residual-field-carriers of the hyper-color force, in the same sense as the pions are the residual-field-carriers of the color SU(3) interaction. Using the method of numerical minimization of the SU(4)-action based on this model, the masses and the inner structure of leptons, quarks and weak bosons are calculated: the mass results are very close to the experimental values. We calculate also precisely the value of the Cabibbo angle, so the mixing matrices of the Standard model, CKM matrix for quarks and PMNS matrix for neutrinos can also be calculated. In total, we reduce the 29 parameters of the Standard Model to a total of 7 parameters.

Refined Aerodynamic Test of Wide-Bodied Aircraft and Its Application

The large dual-channel wide-bodied aircraft has a long range and a high cruise Mach number.Therefore,its aerodynamic design requires a high level ofwind tunnel test refinement.Based on the requirements of aerodynamic design for the future wide-bodied aircraft and the characteristics of high-speed wind tunnel tests,the error theory is introduced to analyze the factors affecting the accuracy of the test data.This study carries out a series of research on the improvement of refined aerodynamic test technology in an FL-26 wind tunnel,including design and optimization of the support system of wide-bodied aircraft,model attitude angle measurement,Mach number control accuracy,measurement and control system stability,test data correction and perfection,high-precision force balance and standard model development.In addition,the effect of the standard specification of the refined aerodynamic test is investigated to improve the data quality.The research findings have been applied in the standard model test and subsequent models of wide-bodied aircraft.The results show that whenMach numbers are less than 0.9,the control accuracy of Mach numbers in the FL-26 wind tunnel is smaller than 0.001 and the measurement error of attack angle is smaller than 0.01°.Therefore,it has the ability to correct the data influenced by factors,such as support/wall interference,model deformation,floating resistance and airflow deflection angle.The repeatability accuracy of the standard model’s comparison test shows that the lift coefficient is less than or equal to 0.0012,the drag coefficient is less than or equal to 0.00004,pitching moment coefficient is less than or equal to 0.0004.The bending resolution of the model’s deformation measurement is less than 0.2 mm,and the tensional deformation is smaller than 0.04°.The revised aerodynamic data and model deformation measurement results have good agreement with that of the ETW wind tunnel.The results demonstrate that the improved technology presented in this paper can significantly enhance the refined aerodynamic test of wide-bodied aircraft.

Nonlocal stress gradient formulation for damping vibration analysis of viscoelastic microbeam in thermal environment

An integral nonlocal stress gradient viscoelastic model is proposed on the basis of the integral nonlocal stress gradient model and the standard viscoelastic model,and is utilized to investigate the free damping vibration analysis of the viscoelastic BernoulliEuler microbeams in thermal environment.Hamilton's principle is used to derive the differential governing equations and corresponding boundary conditions.The integral relations between the strain and the nonlocal stress are converted into a differential form with constitutive constraints.The size-dependent axial thermal stress due to the variation of the environmental temperature is derived explicitly.The Laplace transformation is utilized to obtain the explicit expression for the bending deflection and moment.Considering the boundary conditions and constitutive constraints,one can get a nonlinear equation with complex coefficients,from which the complex characteristic frequency can be determined.A two-step numerical method is proposed to solve the elastic vibration frequency and the damping ratio.The effects of length scale parameters,viscous coefficient,thermal stress,vibration order on the vibration frequencies,and critical viscous coefficient are investigated numerically for the viscoelastic Bernoulli-Euler microbeams under different boundary conditions.

Particles Composition and Interactions Using the Nuon Model

The Standard Model in Particle Physics has been able to make many predictions confirmed later with a flow of experimental results. With the discovery of the Higgs boson at the LHC, one is full of admiration for the people contributing to this model fifty years ago and its predictions that have been confirmed gradually. The original particle quark constituent model has evolved with the deep inelastic experiments to a quark and gluons system, then to a more general system with virtual quarks. This work is the result of observations while working at CERN in Geneva with many different experiments at the ISR, SPS, LEP, LHC colliders. A new model based on nuons is introduced, that allows accurate evaluations of the particle masses (mesons and baryons) and magnetic moment, computes very accurately the kinematics distributions for particles and jets observed in the p-p collisions at the LHC (elastic and inelastic) and at lower energy machines. This new model looks at a first glance in contradiction with the quark model because it can build the elementary particles with nuons only, i.e. electrons and neutrinos. However, all the existing physics involved in electron, positron and neutrino interactions may be used to explain interactions between composite particles such as protons or heavy ions.

The Complex Field Theory and Mass Formation—An Alternative Model to Higgs Mechanism

The electromagnetic force, strong nuclear force, weak nuclear force, and gravitational force are the four fundamental forces of nature. The Standard Model (SM) succeeded in combining the first three forces to describe the most basic building blocks of matter and govern the universe. Despite the model’s great success in resolving many issues in particle physics but still has several setbacks and limitations. The model failed to incorporate the fourth force of gravity. It infers that all fermions and bosons are massless contrary to experimental facts. In addition, the model addresses neither the 95% of the universe’s energy of Dark Matter (DM) and Dark Energy (DE) nor the universe’s expansion. The Complex Field Theory (CFT) identifies DM and DE as complex fields of complex masses and charges that encompasses the whole universe, and pervade all matter. This presumption resolves the issue of failing to detect DM and DE for the last five decades. The theory also presents a model for the universe’s expansion and presumes that every material object carries a fraction of this complex field proportional to its mass. These premises clearly explain the physical nature of the gravitational force and its complex field and pave the way for gravity into the SM. On the other hand, to solve the issue of massless bosons and fermions in the SM, Higgs mechanism introduces a pure and abstractive theoretical model of unimaginable four potentials to generate fictitious bosons as mass donors to fermions and W± and Z bosons. The CFT in this paper introduces, for the first time, a physical explanation to the mystery of the mass formation of particles rather than Higgs’ pure mathematical derivations. The analyses lead to uncovering the mystery of electron-positron production near heavy nuclei and never in a vacuum. In addition, it puts a constraint on Einstein’s mass-energy equation that energy can never be converted to mass without the presence of dense dark matter and cannot be true in a vacuum. Furthermore, CFT provides different perspectives and resolves real-world physics concepts such as the nuclear force, Casimir force, Lamb’s shift, and the anomalous magnetic moment to be published elsewhere.

Part I: Explaining the “Muon g - 2” Results with Probabilistic Spacetime

A recent experimental finding replicated an earlier research result, both of which demonstrated conflict with a specific Standard Model prediction. The “Muon g - 2” studies have indicated that the degree of muon precession predicted by the Model is not the same as observed. The researchers offer many posteriori atheoretical hypotheses as possible explanations of their findings, but no fundamental theoretical understanding of the near discovery is among them. This article describes both an explication for the unexpected result and describes its underlying mechanism based on an existing cosmological theory, the Probabilistic Spacetime Theory. The paper also discusses the potential value of this theory.

The Standard Model Theory [May Be] a Wrong Theory

The Standard Model is the theory of Physics that describes the elementary particles of matter and the strong, weak and electromagnetic interactions, between them. The theory of the Standard Model does not include the description of the gravitational interactions. It is a very well founded theory that has predicted many experimental results, such as the existence of many particles and has withstood many experimental tests. The key missing piece of the theory to fill in was the Higgs boson, whose existence was reasonably suspected and confirmed by CERN’s ATLAS and CMS experiments in 2012. The current synthesis of the theory was completed in the mid-1970s, after the experimental confirmation of the existence of the quarks, and then confirmed, with the discovery of the Higgs boson, in 2012. All these, are according to the established views of science. But according to the opinions of many scientists, opinions with which I as the author of this paper agree, the theory of the Standard Model is a wrong theory because, while it makes some successful predictions, it does not answer to a number of many other questions that it should answer for its final establishment. Specifically and according to established views, the theory cannot explain the existence of dark matter and dark energy, the behavior of neutrinos and the existence of particles with very different masses. It is also questionable whether the Higgs boson, discovered in the ATLAS experiment is actually the particle that contributes to the creation of the mass of the elementary particles of matter, and whether the Higgs mechanism is theoretically a correct mechanism. There is doubt if the interactions, actually be created by the exchange of bosons? If bosons are really exist? And not any convincing explanation is given by the theory, for the case that, the bosons exist as particles, where were they found? And how do they work? For replace, or fill the void will be left by the theory of the Standard Model, which I believe sooner or later will be renewed or retired, I propose a New Model that more convincingly describes the elementary components of matter and the interactions between them. The New Model also addresses all the weak points of the theory of the Standard Model, including the interaction of gravity. But the main feature of the New Model, which will surprise you! Is its reliability, correctness, logic and simplicity. But this is something you will judge after studying the New Model.

A Scenario for Asymmetric Genesis of Matter

A previous preon scenario for the standard model particles, based on unbroken supersymmetry, is applied to the problem of matter-antimatter asymmetry. Attention is paid to the fact that the asymmetric hydrogen atom—like all atoms—can be described in terms of symmetric preons. Preons are created in the early universe. The matter-antimatter asymmetry is caused by stochastic correlations in charge density fluctuations of preons and antipreons and by the subsequent preon combinatorial mechanism to form quarks and leptons, and finally the three lightest elements. A tentative gravitino mass estimate is given based on minimal interference with nucleosynthesis. With local supersymmetry the scenario can be extended to supergravity.

Van der Waals interactions and Photoelectric Effect in Noncommutative Quantum Mechanics

We calculate the long-range Van der Waals force and the photoelectric cross section in a noncommutative setup. It is argued that non-commutativity effects could not be discerned for the Van der Waals interactions. The result for the photoelectric effect shows deviation from the usual commutative one, which in principle can be used to put bounds on the space-space non-commutativity parameter.

A late Holocene winter monsoon record inferred from the palaeo-aeolian sand dune in the southeastern Mu Us Desert, northern China

The variation of the Asian winter monsoonal strength has seriously affected the climate and environmental conditions in the Asian monsoonal region, and even in marginal islands and the ocean in the East Asian region. However, relevant under-standing remains unclear due to the lack of suitable geological materials and effective proxies in the key study areas. Here, we present a grain-size record derived from the palaeo-aeolian sand dune in the southeastern Mu Us Desert, together with other proxies and OSL dating, which reflect a relatively detailed history of the winter monsoon and abrupt environmental events during the past 4.2 ka. Our grain-size standard deviation model indicated that 〉224 μm content can be considered as an indicator of the intensity of Asian winter monsoon, and it shows declined around 4.2–2.1 ka, enhanced but unstable in 2.1–0.9 ka, and obviously stronger since then. In addition, several typical climate events were also documented, forced by the periodic variation of winter monsoonal intensity. These include the cold intervals of 4.2, 2.8, 1.4 ka, and the Little Ice Age （LIA）, and relatively warm sub-phases around 3.0, 2.1, 1.8 ka, and the Medieval Warm Period （MWP）, which were roughly accordant with the records of the aeolian materials, peat, stalagmites, ice cores, and sea sediments in various latitudes of the Northern Hemisphere. Combined with the previous progresses of the Asian summer monsoon, we prelimi-narily confirmed a millennial-scale anti-correlation of Asian winter and summer monsoons in the Late Holocene epoch. This study suggests that the evolution of the palaeo-aeolian sand dune has the potential for comprehending the history of Asian monsoon across the desert regions of the modern Asian monsoonal margin in northern China.

Attribute-Based Re-Encryption Scheme in the Standard Model

In this paper, we propose a new attribute-based proxy re-encryption scheme, where a semi-trusted proxy, with some additional information, can transform a ciphertext under a set of attributes into a new ciphertext under another set of attributes on the same message, but not vice versa, furthermore, its security was proved in the standard model based on decisional bilinear Diffie-Hellman assumption. This scheme can be used to realize fine-grained selectively sharing of encrypted data, but the general proxy rencryption scheme severely can not do it, so the proposed schemecan be thought as an improvement of general traditional proxy re-encryption scheme.

Cryptanalysis and Improvement of a New Certificateless Signature Scheme in the Standard Model

Digital signature,as an important cryptographic primitive,has been widely used in many application scenarios,such as e-commerce,authentication,cloud computing,and so on.Certificateless Public Key Cryptography(PKC)can get rid of the certificate management problem in the traditional Public Key Infrastructure(PKI)and eliminate the key-escrow problem in the identity-based PKC.Lately,a new Certificateless Signature(CLS)scheme has been proposed by Kyung-Ah Shim(IEEE SYSTEMS JOURNAL,2018,13(2)),which claimed to achieve provable security in the standard model.Unfortunately,we present a concrete attack to demonstrate that the scheme cannot defend against the Type I adversary.In this type of attack,the adversary can replace the public key of the signer,and then he plays the role of the signer to forge a legal certificateless signature on any message.Furthermore,we give an improved CLS scheme to resist such an attack.In terms of the efficiency and the signature length,the improved CLS is preferable to the original scheme and some recently proposed CLS schemes in the case of precomputation.

OPEN ARCHITECTURE CNC SYSTEM HITCNC AND KEY TECHNOLOGY

Aiming at the characteristics of modularity and reconfigurable in open architecture computer numerical control （CNC） system, the open architecture CNC system, Harbin Institute of Tech- nology computer numerical control （HITCNC）, is researched and manufactured based on the interface standards. The system＇s external interfaces are coincident with the corresponding international standards, and the internal interfaces follow the open modular architecture controller （OMAC） agreement. In the research and manufacturing process, object-oriented technology is used to ensure the openness of the HITCNC, and static programming is applied in the CNC system according to the idea of modularization disassembly. The HITCNC also actualizes real-time and unreal-time modules adopting real-time dynamical linked library （RTDLL） and component object model （COM）. Finite state ma- chine （FSM） is adopted to do dynamically modeling of HITCNC. The complete separation between the software and the hardware is achieved in the HITCNC by applying the SoftSERCANS technique. The application of the above key techniques decreases the programming workload greatly, and uses software programs replacing hardware functions, which offers plenty technique ensures for the openness of HITCNC. Finally, based on the HITCNC, a three-dimensional milling system is established. On the system, series experiments are done to validate the expandability and interchangeability of HITCNC. The results of the experiments show that the established open architecture CNC system HITCNC is correct and feasible, and has good openness.