The phenomenon of electrical attraction and repulsion between charged particles is well known, and described mathematically by Coulomb’s Law, yet until now there has been no explanation for why this occurs. There has...The phenomenon of electrical attraction and repulsion between charged particles is well known, and described mathematically by Coulomb’s Law, yet until now there has been no explanation for why this occurs. There has been no mechanistic explanation that reveals what causes the charged particles to accelerate, either towards or away from each other. This paper gives a detailed explanation of the phenomena of electrical attraction and repulsion based on my previous work that determined the exact wave-function solutions for both the Electron and the Positron. It is revealed that the effects are caused by wave interactions between the wave functions that result in Electromagnetic reflections of parts of the particle’s wave functions, causing a change in their momenta.展开更多
Sea ice drift is mainly controlled by ocean currents, local wind, and internal ice stress. Information on sea ice motion, especially in situ synchronous observation of an ice velocity, a current velocity, and a wind s...Sea ice drift is mainly controlled by ocean currents, local wind, and internal ice stress. Information on sea ice motion, especially in situ synchronous observation of an ice velocity, a current velocity, and a wind speed, is of great significance to identify ice drift characteristics. A sea ice substitute, the so-called "modelled ice", which is made by polypropylene material with a density similar to Bohai Sea ice, is used to complete a free drift experiment in the open sea. The trajectories of isolated modelled ice, currents and wind in the Bohai Sea during non-frozen and frozen periods are obtained. The results show that the currents play a major role while the wind plays a minor role in the free drift of isolated modelled ice when the wind is mild in the Bohai Sea. The modelled ice drift is significantly affected by the ocean current and wind based on the ice–current–wind relationship established by a multiple linear regression. The modelled ice velocity calculated by the multiple linear regression is close to that of the in situ observation, the magnitude of the error between the calculated and observed ice velocities is less than12.05%, and the velocity direction error is less than 6.21°. Thus, the ice velocity can be estimated based on the observed current velocity and wind speed when the in situ observed ice velocity is missing. And the modelled ice of same thickness with a smaller density is more sensitive to the current velocity and the wind speed changes. In addition, the modelled ice drift characteristics are shown to be close to those of the real sea ice, which indicates that the modelled ice can be used as a good substitute of real ice for in situ observation of the free ice drift in the open sea, which helps solve time availability, safety and logistics problems related to in situ observation on real ice.展开更多
Wind speed extremes in the sub-Arctic realm of the North-East Pacific region were investigated through extreme value analysis of wind speed obtained from wind simulations of the COSMO-CLM (Consortium for Small-scale M...Wind speed extremes in the sub-Arctic realm of the North-East Pacific region were investigated through extreme value analysis of wind speed obtained from wind simulations of the COSMO-CLM (Consortium for Small-scale Modelling, climate version) mesoscale model, as well as using observed data. The analysis showed that the set of wind speed extremes obtained from observations is a mixture of two different subsets each neatly described by the Weibull distribution. Using special metaphoric terminology, they are labelled as “Black Swans” and “Dragons”. The “Dragons” are responsible for strongest extremes. It has been shown that both reanalysis and GCM (general circulation model) data have no “Dragons”. This means that such models underestimate wind speed maxima, and the important circulation process generating the anomalies is not simulated. The COSMO-CLM data have both “Black Swans” and “Dragons”. This evidence provides a clue that an atmospheric model with a detailed spatial resolution (we used in this work the data from domain with 13.2 km spatial resolution) does reproduce the special mechanism responsible for the generation of the largest wind speed extremes. However, a more thorough analysis shows that the differences in the parameters of the cumulative distribution functions are still significant. The ratio between the modelled Dragons and Black Swans can reach up to only 10%. It is much less than 30%, which was the level established for observations.展开更多
A beam approximation method for dynamic analysis of launch vehicles modelled as stiffened cylindrical shells is proposed.Firstly,an initial beam model of the stiffened cylindrical shell is established based on the cro...A beam approximation method for dynamic analysis of launch vehicles modelled as stiffened cylindrical shells is proposed.Firstly,an initial beam model of the stiffened cylindrical shell is established based on the cross-sectional area equivalence principle that represents the shell skin and its longitudinal ribs as a beam with annular cross-section,and the circumferential ribs as lumped masses at the nodes of the beam elements.Then,a fine finite element model(FE model)of the stiffened cylindrical shell is constructed and a modal analysis is carried out.Finally,the initial beam model is improved through model updating against the natural frequencies and mode shapes of the fine FE model of the shell.To facilitate the comparison between the mode shapes of the fine FE model of the stiffened shell and the equivalent beam model,a weighted nodal displacement coupling relationship is introduced.To prevent the design parameters used in model updating from converging to incorrect values,a pre-model updating procedure is added before the proper model updating.The results of two examples demonstrate that the beam approximation method presented in this paper can build equivalent beam models of stiffened cylindrical shells which can reflect the global longitudinal,lateral and torsional vibration characteristics very well in terms of the natural frequencies.展开更多
Detailed information on the spatio-temporal changes of cropland soil organic carbon(SOC) can significantly contribute to the improvement of soil fertility and mitigate climate change. Nonetheless, information and know...Detailed information on the spatio-temporal changes of cropland soil organic carbon(SOC) can significantly contribute to the improvement of soil fertility and mitigate climate change. Nonetheless, information and knowledge on the national scale spatio-temporal changes and the corresponding uncertainties of SOC in Chinese upland soils remain limited. The CENTURY model was used to estimate the SOC storages and their changes in Chinese uplands from 1980 to 2010. With the Monte Carlo method, the uncertainties of CENTURY-modelled SOC dynamics associated with the spatial heterogeneous model inputs were quantified. Results revealed that the SOC storage in Chinese uplands increased from 3.03(1.59 to 4.78) Pg C in 1980 to 3.40(2.39 to 4.62) Pg C in 2010. Increment of SOC storage during this period was 370 Tg C, with an uncertainty interval of –440 to 1110 Tg C. The regional disparities of SOC changes reached a significant level, with considerable SOC accumulation in the Huang-Huai-Hai Plain of China and SOC loss in the northeastern China. The SOC lost from Meadow soils, Black soils and Chernozems was most severe, whilst SOC accumulation in Fluvo-aquic soils, Cinnamon soils and Purplish soils was most significant. In modelling large-scale SOC dynamics, the initial soil properties were major sources of uncertainty. Hence, more detailed information concerning the soil properties must be collected. The SOC stock of Chinese uplands in 2010 was still relatively low, manifesting that recommended agricultural management practices in conjunction with effectively economic and policy incentives to farmers for soil fertility improvement were indispensable for future carbon sequestration in these regions.展开更多
The focus of this paper is on determination of the dynamic parameters of structural systems with viscoelastic (VE) dampers described by Maxwell rheological models. Such parameters could be obtained after solving the a...The focus of this paper is on determination of the dynamic parameters of structural systems with viscoelastic (VE) dampers described by Maxwell rheological models. Such parameters could be obtained after solving the appropriately defined nonlinear eigenvalue problem for frames with VE dampers. The solution to the nonlinear eigenvalue problem is obtained by equating to zero the determinant of the considered system of equations. Apart from complex conjugate eigenvalues, the real ones occurred when dampers that are described by the classic Maxwell model, are also determined.展开更多
安全生产事故往往由多组织交互、多因素耦合造成,事故原因涉及多个组织。为预防和遏制多组织生产安全事故的发生,基于系统理论事故建模与过程模型(Systems-Theory Accident Modeling and Process,STAMP)、24Model,构建一种用于多组织事...安全生产事故往往由多组织交互、多因素耦合造成,事故原因涉及多个组织。为预防和遏制多组织生产安全事故的发生,基于系统理论事故建模与过程模型(Systems-Theory Accident Modeling and Process,STAMP)、24Model,构建一种用于多组织事故分析的方法,并以青岛石油爆炸事故为例进行事故原因分析。结果显示:STAMP-24Model可以分组织,分层次且有效、全面、详细地分析涉及多个组织的事故原因,探究多组织之间的交互关系;对事故进行动态演化分析,可得到各组织不安全动作耦合关系与形成的事故失效链及管控失效路径,进而为预防多组织事故提供思路和参考。展开更多
随着隔震技术的推广应用以及建筑业信息化水平的持续提升,在隔震工程中对隔震层建筑信息模型(building information modeling, BIM)建模的需求逐渐增长,然而针对性的研究工作相对较少。为此,围绕隔震支座BIM模型的高效建模方法和应用模...随着隔震技术的推广应用以及建筑业信息化水平的持续提升,在隔震工程中对隔震层建筑信息模型(building information modeling, BIM)建模的需求逐渐增长,然而针对性的研究工作相对较少。为此,围绕隔震支座BIM模型的高效建模方法和应用模块开展了研究。首先,综合隔震支座应用情况和力学特性,可将其分为橡胶隔震支座、滑移摩擦隔震支座和其他类型隔震支座,据此提出了隔震支座BIM快速建模模块基本架构;随后,基于Revit和Visual Studio平台开发了三类隔震支座BIM模型的快速建模功能,并实现了连接节点参数化建模和支座批量/手动布置的操作功能;最后,开展了某化工公司的库房隔震加固项目的隔震层BIM模型建模实践,结果表明:利用快速建模模块可将隔震层BIM建模操作从7个步骤降低至2个步骤,且使用过程中对隔震支座构造细节的认知要求相对较低。同时,建成后的BIM模型与实际工程在建筑信息的多个方面具有较好的一致性。相关研究可为建筑和桥梁隔震工程的BIM建模提供参考和借鉴。展开更多
Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse ...Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse the disease itself.Stem cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of Parkinson’s disease.Mesenchymal stem cells are considered a promising option due to fewer ethical concerns,a lower risk of immune rejection,and a lower risk of teratogenicity.We performed a meta-analysis to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function,memory,and preservation of dopamine rgic neurons in a Parkinson’s disease animal model.We searched bibliographic databases(PubMed/MEDLINE,Embase,CENTRAL,Scopus,and Web of Science)to identify articles and included only pee r-reviewed in vivo interve ntional animal studies published in any language through J une 28,2023.The study utilized the random-effect model to estimate the 95%confidence intervals(CI)of the standard mean differences(SMD)between the treatment and control groups.We use the systematic review center for laboratory animal expe rimentation’s risk of bias tool and the collaborative approach to meta-analysis and review of animal studies checklist for study quality assessment.A total of 33studies with data from 840 Parkinson’s disease model animals were included in the meta-analysis.Treatment with mesenchymal stem cells significantly improved motor function as assessed by the amphetamine-induced rotational test.Among the stem cell types,the bone marrow MSCs with neurotrophic factor group showed la rgest effect size(SMD[95%CI]=-6.21[-9.50 to-2.93],P=0.0001,I^(2)=0.0%).The stem cell treatment group had significantly more tyrosine hydroxylase positive dopamine rgic neurons in the striatum([95%CI]=1.04[0.59 to 1.49],P=0.0001,I^(2)=65.1%)and substantia nigra(SMD[95%CI]=1.38[0.89 to 1.87],P=0.0001,I^(2)=75.3%),indicating a protective effect on dopaminergic neurons.Subgroup analysis of the amphetamine-induced rotation test showed a significant reduction only in the intracranial-striatum route(SMD[95%CI]=-2.59[-3.25 to-1.94],P=0.0001,I^(2)=74.4%).The memory test showed significant improvement only in the intravenous route(SMD[95%CI]=4.80[1.84 to 7.76],P=0.027,I^(2)=79.6%).Mesenchymal stem cells have been shown to positively impact motor function and memory function and protect dopaminergic neurons in preclinical models of Parkinson’s disease.Further research is required to determine the optimal stem cell types,modifications,transplanted cell numbe rs,and delivery methods for these protocols.展开更多
Parkinson’s disease is typically characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta.Many studies have been performed based on the supplementation of lost dopaminergic ...Parkinson’s disease is typically characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta.Many studies have been performed based on the supplementation of lost dopaminergic neurons to treat Parkinson’s disease.The initial strategy for cell replacement therapy used human fetal ventral midbrain and human embryonic stem cells to treat Parkinson’s disease,which could substantially alleviate the symptoms of Parkinson’s disease in clinical practice.However,ethical issues and tumor formation were limitations of its clinical application.Induced pluripotent stem cells can be acquired without sacrificing human embryos,which eliminates the huge ethical barriers of human stem cell therapy.Another widely considered neuronal regeneration strategy is to directly reprogram fibroblasts and astrocytes into neurons,without the need for intermediate proliferation states,thus avoiding issues of immune rejection and tumor formation.Both induced pluripotent stem cells and direct reprogramming of lineage cells have shown promising results in the treatment of Parkinson’s disease.However,there are also ethical concerns and the risk of tumor formation that need to be addressed.This review highlights the current application status of cell reprogramming in the treatment of Parkinson’s disease,focusing on the use of induced pluripotent stem cells in cell replacement therapy,including preclinical animal models and progress in clinical research.The review also discusses the advancements in direct reprogramming of lineage cells in the treatment of Parkinson’s disease,as well as the controversy surrounding in vivo reprogramming.These findings suggest that cell reprogramming may hold great promise as a potential strategy for treating Parkinson’s disease.展开更多
基于IEEE及国际系统工程协会(International Council on Systems Engineering,INCOSE)社区会刊,提取与基于模型的系统工程(model based systems engineering,MBSE)领域相关的167篇顶刊的关键词和摘要。采用Python及其第三方库WordCloud...基于IEEE及国际系统工程协会(International Council on Systems Engineering,INCOSE)社区会刊,提取与基于模型的系统工程(model based systems engineering,MBSE)领域相关的167篇顶刊的关键词和摘要。采用Python及其第三方库WordCloud技术,以可视化形式展示MBSE领域研究内容并对MBSE发展态势进行研究。研究结果表明,MBSE在产品研发全生命周期,应用建模技术来支持系统需求、设计、分析、验证与确认等活动,在系统架构设计方面具有重要作用,将MBSE与安全性分析、可靠性分析方法结合也是MBSE的重要研究内容;系统建模语言(system modeling language,SysML)和对象过程方法(object process method,OPM)分别是目前MBSE研究领域中最受欢迎的建模语言和建模方法;将MBSE方法与本体进行结合是规范MBSE模型表达的重要手段,将MBSE与信息物理系统、数字孪生、并行工程领域进行融合研究是MBSE的重要发展方向。所提研究为使用WordCloud文本分析技术来探索当前的MBSE研究提供了技术路线参考,有助于对MBSE的未来发展态势进行预测。展开更多
Spatial heterogeneity or“patchiness”of plankton distributions in the ocean has always been an attractive and challenging scientific issue to oceanographers.We focused on the accumulation and dynamic mechanism of the...Spatial heterogeneity or“patchiness”of plankton distributions in the ocean has always been an attractive and challenging scientific issue to oceanographers.We focused on the accumulation and dynamic mechanism of the Acetes chinensis in the Lianyungang nearshore licensed fishing area.The Lagrangian frame approaches including the Lagrangian coherent structures theory,Lagrangian residual current,and Lagrangian particle-tracking model were applied to find the transport pathways and aggregation characteristics of Acetes chinensis.There exist some material transport pathways for Acetes chinensis passing through the licensed fishing area,and Acetes chinensis is easy to accumulate in the licensed fishing area.The main mechanism forming this distribution pattern is the local circulation induced by the nonlinear interaction of topography and tidal flow.Both the Lagrangian coherent structure analysis and the particle trajectory tracking indicate that Acetes chinensis in the licensed fishing area come from the nearshore estuary.This work contributed to the adjustment of licensed fishing area and the efficient utilization of fishery resources.展开更多
Powered by advanced information technology,more and more complex systems are exhibiting characteristics of the cyber-physical-social systems(CPSS).In this context,computational experiments method has emerged as a nove...Powered by advanced information technology,more and more complex systems are exhibiting characteristics of the cyber-physical-social systems(CPSS).In this context,computational experiments method has emerged as a novel approach for the design,analysis,management,control,and integration of CPSS,which can realize the causal analysis of complex systems by means of“algorithmization”of“counterfactuals”.However,because CPSS involve human and social factors(e.g.,autonomy,initiative,and sociality),it is difficult for traditional design of experiment(DOE)methods to achieve the generative explanation of system emergence.To address this challenge,this paper proposes an integrated approach to the design of computational experiments,incorporating three key modules:1)Descriptive module:Determining the influencing factors and response variables of the system by means of the modeling of an artificial society;2)Interpretative module:Selecting factorial experimental design solution to identify the relationship between influencing factors and macro phenomena;3)Predictive module:Building a meta-model that is equivalent to artificial society to explore its operating laws.Finally,a case study of crowd-sourcing platforms is presented to illustrate the application process and effectiveness of the proposed approach,which can reveal the social impact of algorithmic behavior on“rider race”.展开更多
Solar wind charge exchange produces emissions in the soft X-ray energy range which can enable the study of near-Earth space regions such as the magnetopause,the magnetosheath and the polar cusps by remote sensing tech...Solar wind charge exchange produces emissions in the soft X-ray energy range which can enable the study of near-Earth space regions such as the magnetopause,the magnetosheath and the polar cusps by remote sensing techniques.The Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)and Lunar Environment heliospheric X-ray Imager(LEXI)missions aim to obtain soft Xray images of near-Earth space thanks to their Soft X-ray Imager(SXI)instruments.While earlier modeling works have already simulated soft X-ray images as might be obtained by SMILE SXI during its mission,the numerical models used so far are all based on the magnetohydrodynamics description of the space plasma.To investigate the possible signatures of ion-kinetic-scale processes in soft Xray images,we use for the first time a global hybrid-Vlasov simulation of the geospace from the Vlasiator model.The simulation is driven by fast and tenuous solar wind conditions and purely southward interplanetary magnetic field.We first produce global X-ray images of the dayside near-Earth space by placing a virtual imaging satellite at two different locations,providing meridional and equatorial views.We then analyze regional features present in the images and show that they correspond to signatures in soft X-ray emissions of mirrormode wave structures in the magnetosheath and flux transfer events(FTEs)at the magnetopause.Our results suggest that,although the time scales associated with the motion of those transient phenomena will likely be significantly smaller than the integration time of the SMILE and LEXI imagers,mirror-mode structures and FTEs can cumulatively produce detectable signatures in the soft X-ray images.For instance,a local increase by 30%in the proton density at the dayside magnetopause resulting from the transit of multiple FTEs leads to a 12%enhancement in the line-of-sight-and time-integrated soft X-ray emissivity originating from this region.Likewise,a proton density increase by 14%in the magnetosheath associated with mirror-mode structures can result in an enhancement in the soft X-ray signal by 4%.These are likely conservative estimates,given that the solar wind conditions used in the Vlasiator run can be expected to generate weaker soft X-ray emissions than the more common denser solar wind.These results will contribute to the preparatory work for the SMILE and LEXI missions by providing the community with quantitative estimates of the effects of small-scale,transient phenomena occurring on the dayside.展开更多
Both the attribution of historical change and future projections of droughts rely heavily on climate modeling. However,reasonable drought simulations have remained a challenge, and the related performances of the curr...Both the attribution of historical change and future projections of droughts rely heavily on climate modeling. However,reasonable drought simulations have remained a challenge, and the related performances of the current state-of-the-art Coupled Model Intercomparison Project phase 6(CMIP6) models remain unknown. Here, both the strengths and weaknesses of CMIP6 models in simulating droughts and corresponding hydrothermal conditions in drylands are assessed.While the general patterns of simulated meteorological elements in drylands resemble the observations, the annual precipitation is overestimated by ~33%(with a model spread of 2.3%–77.2%), along with an underestimation of potential evapotranspiration(PET) by ~32%(17.5%–47.2%). The water deficit condition, measured by the difference between precipitation and PET, is 50%(29.1%–71.7%) weaker than observations. The CMIP6 models show weaknesses in capturing the climate mean drought characteristics in drylands, particularly with the occurrence and duration largely underestimated in the hyperarid Afro-Asian areas. Nonetheless, the drought-associated meteorological anomalies, including reduced precipitation, warmer temperatures, higher evaporative demand, and increased water deficit conditions, are reasonably reproduced. The simulated magnitude of precipitation(water deficit) associated with dryland droughts is overestimated by 28%(24%) compared to observations. The observed increasing trends in drought fractional area,occurrence, and corresponding meteorological anomalies during 1980–2014 are reasonably reproduced. Still, the increase in drought characteristics, associated precipitation and water deficit are obviously underestimated after the late 1990s,especially for mild and moderate droughts, indicative of a weaker response of dryland drought changes to global warming in CMIP6 models. Our results suggest that it is imperative to employ bias correction approaches in drought-related studies over drylands by using CMIP6 outputs.展开更多
文摘The phenomenon of electrical attraction and repulsion between charged particles is well known, and described mathematically by Coulomb’s Law, yet until now there has been no explanation for why this occurs. There has been no mechanistic explanation that reveals what causes the charged particles to accelerate, either towards or away from each other. This paper gives a detailed explanation of the phenomena of electrical attraction and repulsion based on my previous work that determined the exact wave-function solutions for both the Electron and the Positron. It is revealed that the effects are caused by wave interactions between the wave functions that result in Electromagnetic reflections of parts of the particle’s wave functions, causing a change in their momenta.
基金The National Natural Science Foundation of China under contract No.41571510the Fundamental Research Funds for the Central Universities of China under contract No.2014KJJCB02
文摘Sea ice drift is mainly controlled by ocean currents, local wind, and internal ice stress. Information on sea ice motion, especially in situ synchronous observation of an ice velocity, a current velocity, and a wind speed, is of great significance to identify ice drift characteristics. A sea ice substitute, the so-called "modelled ice", which is made by polypropylene material with a density similar to Bohai Sea ice, is used to complete a free drift experiment in the open sea. The trajectories of isolated modelled ice, currents and wind in the Bohai Sea during non-frozen and frozen periods are obtained. The results show that the currents play a major role while the wind plays a minor role in the free drift of isolated modelled ice when the wind is mild in the Bohai Sea. The modelled ice drift is significantly affected by the ocean current and wind based on the ice–current–wind relationship established by a multiple linear regression. The modelled ice velocity calculated by the multiple linear regression is close to that of the in situ observation, the magnitude of the error between the calculated and observed ice velocities is less than12.05%, and the velocity direction error is less than 6.21°. Thus, the ice velocity can be estimated based on the observed current velocity and wind speed when the in situ observed ice velocity is missing. And the modelled ice of same thickness with a smaller density is more sensitive to the current velocity and the wind speed changes. In addition, the modelled ice drift characteristics are shown to be close to those of the real sea ice, which indicates that the modelled ice can be used as a good substitute of real ice for in situ observation of the free ice drift in the open sea, which helps solve time availability, safety and logistics problems related to in situ observation on real ice.
文摘Wind speed extremes in the sub-Arctic realm of the North-East Pacific region were investigated through extreme value analysis of wind speed obtained from wind simulations of the COSMO-CLM (Consortium for Small-scale Modelling, climate version) mesoscale model, as well as using observed data. The analysis showed that the set of wind speed extremes obtained from observations is a mixture of two different subsets each neatly described by the Weibull distribution. Using special metaphoric terminology, they are labelled as “Black Swans” and “Dragons”. The “Dragons” are responsible for strongest extremes. It has been shown that both reanalysis and GCM (general circulation model) data have no “Dragons”. This means that such models underestimate wind speed maxima, and the important circulation process generating the anomalies is not simulated. The COSMO-CLM data have both “Black Swans” and “Dragons”. This evidence provides a clue that an atmospheric model with a detailed spatial resolution (we used in this work the data from domain with 13.2 km spatial resolution) does reproduce the special mechanism responsible for the generation of the largest wind speed extremes. However, a more thorough analysis shows that the differences in the parameters of the cumulative distribution functions are still significant. The ratio between the modelled Dragons and Black Swans can reach up to only 10%. It is much less than 30%, which was the level established for observations.
基金the National Natural Science Foundation of China(11672060,11672052).
文摘A beam approximation method for dynamic analysis of launch vehicles modelled as stiffened cylindrical shells is proposed.Firstly,an initial beam model of the stiffened cylindrical shell is established based on the cross-sectional area equivalence principle that represents the shell skin and its longitudinal ribs as a beam with annular cross-section,and the circumferential ribs as lumped masses at the nodes of the beam elements.Then,a fine finite element model(FE model)of the stiffened cylindrical shell is constructed and a modal analysis is carried out.Finally,the initial beam model is improved through model updating against the natural frequencies and mode shapes of the fine FE model of the shell.To facilitate the comparison between the mode shapes of the fine FE model of the stiffened shell and the equivalent beam model,a weighted nodal displacement coupling relationship is introduced.To prevent the design parameters used in model updating from converging to incorrect values,a pre-model updating procedure is added before the proper model updating.The results of two examples demonstrate that the beam approximation method presented in this paper can build equivalent beam models of stiffened cylindrical shells which can reflect the global longitudinal,lateral and torsional vibration characteristics very well in terms of the natural frequencies.
基金Under the auspices of National Key Research and Development Program of China(No.2017YFA0603002)National Natural Science Foundation of China(No.31800358,31700369)+1 种基金Jiangsu Agricultural Science and Technology Innovation Fund(No.CX(19)3099)the Foundation of Jiangsu Vocational College of Agriculture and Forestry(No.2019kj014)。
文摘Detailed information on the spatio-temporal changes of cropland soil organic carbon(SOC) can significantly contribute to the improvement of soil fertility and mitigate climate change. Nonetheless, information and knowledge on the national scale spatio-temporal changes and the corresponding uncertainties of SOC in Chinese upland soils remain limited. The CENTURY model was used to estimate the SOC storages and their changes in Chinese uplands from 1980 to 2010. With the Monte Carlo method, the uncertainties of CENTURY-modelled SOC dynamics associated with the spatial heterogeneous model inputs were quantified. Results revealed that the SOC storage in Chinese uplands increased from 3.03(1.59 to 4.78) Pg C in 1980 to 3.40(2.39 to 4.62) Pg C in 2010. Increment of SOC storage during this period was 370 Tg C, with an uncertainty interval of –440 to 1110 Tg C. The regional disparities of SOC changes reached a significant level, with considerable SOC accumulation in the Huang-Huai-Hai Plain of China and SOC loss in the northeastern China. The SOC lost from Meadow soils, Black soils and Chernozems was most severe, whilst SOC accumulation in Fluvo-aquic soils, Cinnamon soils and Purplish soils was most significant. In modelling large-scale SOC dynamics, the initial soil properties were major sources of uncertainty. Hence, more detailed information concerning the soil properties must be collected. The SOC stock of Chinese uplands in 2010 was still relatively low, manifesting that recommended agricultural management practices in conjunction with effectively economic and policy incentives to farmers for soil fertility improvement were indispensable for future carbon sequestration in these regions.
基金the financial support received from the Poznan University of Technology(Grant No.DS 11-088/12)in connection with this work.
文摘The focus of this paper is on determination of the dynamic parameters of structural systems with viscoelastic (VE) dampers described by Maxwell rheological models. Such parameters could be obtained after solving the appropriately defined nonlinear eigenvalue problem for frames with VE dampers. The solution to the nonlinear eigenvalue problem is obtained by equating to zero the determinant of the considered system of equations. Apart from complex conjugate eigenvalues, the real ones occurred when dampers that are described by the classic Maxwell model, are also determined.
文摘安全生产事故往往由多组织交互、多因素耦合造成,事故原因涉及多个组织。为预防和遏制多组织生产安全事故的发生,基于系统理论事故建模与过程模型(Systems-Theory Accident Modeling and Process,STAMP)、24Model,构建一种用于多组织事故分析的方法,并以青岛石油爆炸事故为例进行事故原因分析。结果显示:STAMP-24Model可以分组织,分层次且有效、全面、详细地分析涉及多个组织的事故原因,探究多组织之间的交互关系;对事故进行动态演化分析,可得到各组织不安全动作耦合关系与形成的事故失效链及管控失效路径,进而为预防多组织事故提供思路和参考。
文摘随着隔震技术的推广应用以及建筑业信息化水平的持续提升,在隔震工程中对隔震层建筑信息模型(building information modeling, BIM)建模的需求逐渐增长,然而针对性的研究工作相对较少。为此,围绕隔震支座BIM模型的高效建模方法和应用模块开展了研究。首先,综合隔震支座应用情况和力学特性,可将其分为橡胶隔震支座、滑移摩擦隔震支座和其他类型隔震支座,据此提出了隔震支座BIM快速建模模块基本架构;随后,基于Revit和Visual Studio平台开发了三类隔震支座BIM模型的快速建模功能,并实现了连接节点参数化建模和支座批量/手动布置的操作功能;最后,开展了某化工公司的库房隔震加固项目的隔震层BIM模型建模实践,结果表明:利用快速建模模块可将隔震层BIM建模操作从7个步骤降低至2个步骤,且使用过程中对隔震支座构造细节的认知要求相对较低。同时,建成后的BIM模型与实际工程在建筑信息的多个方面具有较好的一致性。相关研究可为建筑和桥梁隔震工程的BIM建模提供参考和借鉴。
文摘Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse the disease itself.Stem cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of Parkinson’s disease.Mesenchymal stem cells are considered a promising option due to fewer ethical concerns,a lower risk of immune rejection,and a lower risk of teratogenicity.We performed a meta-analysis to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function,memory,and preservation of dopamine rgic neurons in a Parkinson’s disease animal model.We searched bibliographic databases(PubMed/MEDLINE,Embase,CENTRAL,Scopus,and Web of Science)to identify articles and included only pee r-reviewed in vivo interve ntional animal studies published in any language through J une 28,2023.The study utilized the random-effect model to estimate the 95%confidence intervals(CI)of the standard mean differences(SMD)between the treatment and control groups.We use the systematic review center for laboratory animal expe rimentation’s risk of bias tool and the collaborative approach to meta-analysis and review of animal studies checklist for study quality assessment.A total of 33studies with data from 840 Parkinson’s disease model animals were included in the meta-analysis.Treatment with mesenchymal stem cells significantly improved motor function as assessed by the amphetamine-induced rotational test.Among the stem cell types,the bone marrow MSCs with neurotrophic factor group showed la rgest effect size(SMD[95%CI]=-6.21[-9.50 to-2.93],P=0.0001,I^(2)=0.0%).The stem cell treatment group had significantly more tyrosine hydroxylase positive dopamine rgic neurons in the striatum([95%CI]=1.04[0.59 to 1.49],P=0.0001,I^(2)=65.1%)and substantia nigra(SMD[95%CI]=1.38[0.89 to 1.87],P=0.0001,I^(2)=75.3%),indicating a protective effect on dopaminergic neurons.Subgroup analysis of the amphetamine-induced rotation test showed a significant reduction only in the intracranial-striatum route(SMD[95%CI]=-2.59[-3.25 to-1.94],P=0.0001,I^(2)=74.4%).The memory test showed significant improvement only in the intravenous route(SMD[95%CI]=4.80[1.84 to 7.76],P=0.027,I^(2)=79.6%).Mesenchymal stem cells have been shown to positively impact motor function and memory function and protect dopaminergic neurons in preclinical models of Parkinson’s disease.Further research is required to determine the optimal stem cell types,modifications,transplanted cell numbe rs,and delivery methods for these protocols.
基金supported by the National Natural Science Foundation of China,No.31960120Yunnan Science and Technology Talent and Platform Plan,No.202105AC160041(both to ZW).
文摘Parkinson’s disease is typically characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta.Many studies have been performed based on the supplementation of lost dopaminergic neurons to treat Parkinson’s disease.The initial strategy for cell replacement therapy used human fetal ventral midbrain and human embryonic stem cells to treat Parkinson’s disease,which could substantially alleviate the symptoms of Parkinson’s disease in clinical practice.However,ethical issues and tumor formation were limitations of its clinical application.Induced pluripotent stem cells can be acquired without sacrificing human embryos,which eliminates the huge ethical barriers of human stem cell therapy.Another widely considered neuronal regeneration strategy is to directly reprogram fibroblasts and astrocytes into neurons,without the need for intermediate proliferation states,thus avoiding issues of immune rejection and tumor formation.Both induced pluripotent stem cells and direct reprogramming of lineage cells have shown promising results in the treatment of Parkinson’s disease.However,there are also ethical concerns and the risk of tumor formation that need to be addressed.This review highlights the current application status of cell reprogramming in the treatment of Parkinson’s disease,focusing on the use of induced pluripotent stem cells in cell replacement therapy,including preclinical animal models and progress in clinical research.The review also discusses the advancements in direct reprogramming of lineage cells in the treatment of Parkinson’s disease,as well as the controversy surrounding in vivo reprogramming.These findings suggest that cell reprogramming may hold great promise as a potential strategy for treating Parkinson’s disease.
文摘基于IEEE及国际系统工程协会(International Council on Systems Engineering,INCOSE)社区会刊,提取与基于模型的系统工程(model based systems engineering,MBSE)领域相关的167篇顶刊的关键词和摘要。采用Python及其第三方库WordCloud技术,以可视化形式展示MBSE领域研究内容并对MBSE发展态势进行研究。研究结果表明,MBSE在产品研发全生命周期,应用建模技术来支持系统需求、设计、分析、验证与确认等活动,在系统架构设计方面具有重要作用,将MBSE与安全性分析、可靠性分析方法结合也是MBSE的重要研究内容;系统建模语言(system modeling language,SysML)和对象过程方法(object process method,OPM)分别是目前MBSE研究领域中最受欢迎的建模语言和建模方法;将MBSE方法与本体进行结合是规范MBSE模型表达的重要手段,将MBSE与信息物理系统、数字孪生、并行工程领域进行融合研究是MBSE的重要发展方向。所提研究为使用WordCloud文本分析技术来探索当前的MBSE研究提供了技术路线参考,有助于对MBSE的未来发展态势进行预测。
基金the National Natural Science Foundation of China(No.31802297)。
文摘Spatial heterogeneity or“patchiness”of plankton distributions in the ocean has always been an attractive and challenging scientific issue to oceanographers.We focused on the accumulation and dynamic mechanism of the Acetes chinensis in the Lianyungang nearshore licensed fishing area.The Lagrangian frame approaches including the Lagrangian coherent structures theory,Lagrangian residual current,and Lagrangian particle-tracking model were applied to find the transport pathways and aggregation characteristics of Acetes chinensis.There exist some material transport pathways for Acetes chinensis passing through the licensed fishing area,and Acetes chinensis is easy to accumulate in the licensed fishing area.The main mechanism forming this distribution pattern is the local circulation induced by the nonlinear interaction of topography and tidal flow.Both the Lagrangian coherent structure analysis and the particle trajectory tracking indicate that Acetes chinensis in the licensed fishing area come from the nearshore estuary.This work contributed to the adjustment of licensed fishing area and the efficient utilization of fishery resources.
基金the National Key Research and Development Program of China(2021YFF0900800)the National Natural Science Foundation of China(61972276,62206116,62032016)+2 种基金the New Liberal Arts Reform and Practice Project of National Ministry of Education(2021170002)the Open Research Fund of the State Key Laboratory for Management and Control of Complex Systems(20210101)Tianjin University Talent Innovation Reward Program for Literature and Science Graduate Student(C1-2022-010)。
文摘Powered by advanced information technology,more and more complex systems are exhibiting characteristics of the cyber-physical-social systems(CPSS).In this context,computational experiments method has emerged as a novel approach for the design,analysis,management,control,and integration of CPSS,which can realize the causal analysis of complex systems by means of“algorithmization”of“counterfactuals”.However,because CPSS involve human and social factors(e.g.,autonomy,initiative,and sociality),it is difficult for traditional design of experiment(DOE)methods to achieve the generative explanation of system emergence.To address this challenge,this paper proposes an integrated approach to the design of computational experiments,incorporating three key modules:1)Descriptive module:Determining the influencing factors and response variables of the system by means of the modeling of an artificial society;2)Interpretative module:Selecting factorial experimental design solution to identify the relationship between influencing factors and macro phenomena;3)Predictive module:Building a meta-model that is equivalent to artificial society to explore its operating laws.Finally,a case study of crowd-sourcing platforms is presented to illustrate the application process and effectiveness of the proposed approach,which can reveal the social impact of algorithmic behavior on“rider race”.
基金the European Research Council for starting grant 200141-QuESpace,with which the Vlasiator model was developedconsolidator grant 682068-PRESTISSIMO awarded for further development of Vlasiator and its use in scientific investigations+4 种基金Academy of Finland grant numbers 338629-AERGELC’H,339756-KIMCHI,336805-FORESAIL,and 335554-ICT-SUNVACThe Academy of Finland also supported this work through the PROFI4 grant(grant number 3189131)support from the NASA grants,80NSSC20K1670 and 80MSFC20C0019the NASA GSFC FY23 IRADHIF funds。
文摘Solar wind charge exchange produces emissions in the soft X-ray energy range which can enable the study of near-Earth space regions such as the magnetopause,the magnetosheath and the polar cusps by remote sensing techniques.The Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)and Lunar Environment heliospheric X-ray Imager(LEXI)missions aim to obtain soft Xray images of near-Earth space thanks to their Soft X-ray Imager(SXI)instruments.While earlier modeling works have already simulated soft X-ray images as might be obtained by SMILE SXI during its mission,the numerical models used so far are all based on the magnetohydrodynamics description of the space plasma.To investigate the possible signatures of ion-kinetic-scale processes in soft Xray images,we use for the first time a global hybrid-Vlasov simulation of the geospace from the Vlasiator model.The simulation is driven by fast and tenuous solar wind conditions and purely southward interplanetary magnetic field.We first produce global X-ray images of the dayside near-Earth space by placing a virtual imaging satellite at two different locations,providing meridional and equatorial views.We then analyze regional features present in the images and show that they correspond to signatures in soft X-ray emissions of mirrormode wave structures in the magnetosheath and flux transfer events(FTEs)at the magnetopause.Our results suggest that,although the time scales associated with the motion of those transient phenomena will likely be significantly smaller than the integration time of the SMILE and LEXI imagers,mirror-mode structures and FTEs can cumulatively produce detectable signatures in the soft X-ray images.For instance,a local increase by 30%in the proton density at the dayside magnetopause resulting from the transit of multiple FTEs leads to a 12%enhancement in the line-of-sight-and time-integrated soft X-ray emissivity originating from this region.Likewise,a proton density increase by 14%in the magnetosheath associated with mirror-mode structures can result in an enhancement in the soft X-ray signal by 4%.These are likely conservative estimates,given that the solar wind conditions used in the Vlasiator run can be expected to generate weaker soft X-ray emissions than the more common denser solar wind.These results will contribute to the preparatory work for the SMILE and LEXI missions by providing the community with quantitative estimates of the effects of small-scale,transient phenomena occurring on the dayside.
基金supported by Ministry of Science and Technology of China (Grant No. 2018YFA0606501)National Natural Science Foundation of China (Grant No. 42075037)+1 种基金Key Laboratory Open Research Program of Xinjiang Science and Technology Department (Grant No. 2022D04009)the National Key Scientific and Technological Infrastructure project “Earth System Numerical Simulation Facility” (EarthLab)。
文摘Both the attribution of historical change and future projections of droughts rely heavily on climate modeling. However,reasonable drought simulations have remained a challenge, and the related performances of the current state-of-the-art Coupled Model Intercomparison Project phase 6(CMIP6) models remain unknown. Here, both the strengths and weaknesses of CMIP6 models in simulating droughts and corresponding hydrothermal conditions in drylands are assessed.While the general patterns of simulated meteorological elements in drylands resemble the observations, the annual precipitation is overestimated by ~33%(with a model spread of 2.3%–77.2%), along with an underestimation of potential evapotranspiration(PET) by ~32%(17.5%–47.2%). The water deficit condition, measured by the difference between precipitation and PET, is 50%(29.1%–71.7%) weaker than observations. The CMIP6 models show weaknesses in capturing the climate mean drought characteristics in drylands, particularly with the occurrence and duration largely underestimated in the hyperarid Afro-Asian areas. Nonetheless, the drought-associated meteorological anomalies, including reduced precipitation, warmer temperatures, higher evaporative demand, and increased water deficit conditions, are reasonably reproduced. The simulated magnitude of precipitation(water deficit) associated with dryland droughts is overestimated by 28%(24%) compared to observations. The observed increasing trends in drought fractional area,occurrence, and corresponding meteorological anomalies during 1980–2014 are reasonably reproduced. Still, the increase in drought characteristics, associated precipitation and water deficit are obviously underestimated after the late 1990s,especially for mild and moderate droughts, indicative of a weaker response of dryland drought changes to global warming in CMIP6 models. Our results suggest that it is imperative to employ bias correction approaches in drought-related studies over drylands by using CMIP6 outputs.