Objective:To evaluate the therapeutic efficacy of acupuncture plus Dang Gui Bu Xue Qu Feng Tang for benign essential blepharospasm(BEB).Methods:A prospective randomized controlled trial was performed.A total of 105 pa...Objective:To evaluate the therapeutic efficacy of acupuncture plus Dang Gui Bu Xue Qu Feng Tang for benign essential blepharospasm(BEB).Methods:A prospective randomized controlled trial was performed.A total of 105 participants were randomized 1:1:1 into an acupuncture group,a herbal medicine group and an acupuncture plus herbal medicine group.Participants in the acupuncture group received manual acupuncture treatment,twice a week.Participants in the herbal medicine group received Dang Gui Bu Xue Qu Feng Tang,oral administration,once a day.Participants in the acupuncture plus herbal medicine group received both treatments.The therapeutic effects of the three groups were evaluated after four weeks of treatment.The primary outcome was the Jankovic rating scale(JRS)score,and the secondary outcome was the blepharospasm disability index(BSDI)score.Results:After four weeks of treatment,the JRS total scores significantly decreased in all three groups versus baseline(P<0.05).A greater reduction in the JRS total score was reported in participants in the acupuncture plus herbal medicine group(P<0.05),but there was no significant difference between the acupuncture group and the herbal medicine group(P>0.05).The acupuncture plus herbal medicine group had a greater decrease in the JRS severity score than the herbal medicine group(P<0.05).The reduction in the JRS frequency score was not significantly different among the three groups(P>0.05).The BSDI scores significantly decreased in all three groups versus baseline(P<0.05),but the reduction in the BSDI score was insignificantly different among the three groups(P>0.05).Conclusion:It is effective in the treatment of BEB either to use acupuncture and Dang Gui Bu Xue Qu Feng Tang alone or in combination.The combination therapy shows a more significant effect than either of the treatment alone.展开更多
Traditional Chinese medicine (TCM) is a great treasure of China, the analysis of which is an arduous task. The viewpoint that all chemical constituents of Chinese herbal complex prescription should be analyzed as a bl...Traditional Chinese medicine (TCM) is a great treasure of China, the analysis of which is an arduous task. The viewpoint that all chemical constituents of Chinese herbal complex prescription should be analyzed as a black box is elucidated for the first time. Intelligent multi-mode multi-column chromatographic system (IMMCC) with its hybrids is the basic method and HPLC Unified Method is the breakthrough for the black box analysis. Dang-Gui-Bu-Xue-Tang was selected as a typical TCM and a systematic separation method from non-aqueous mobile phase to pure water mobile phase was put forward in order to convert unknown sample to known sample. The a, c values and UV spectra of 66 components of Astragalus, 78 components of Angelica and 71 components of Dang-Gui-Bu-Xue-Tang were obtained. Intelligent optimization and peak identification method and software for complex samples were developed and the optimum multi-step multi-binary gradient curve of mobile phase for Astragalus was ascertained.The maximum error展开更多
文摘Objective:To evaluate the therapeutic efficacy of acupuncture plus Dang Gui Bu Xue Qu Feng Tang for benign essential blepharospasm(BEB).Methods:A prospective randomized controlled trial was performed.A total of 105 participants were randomized 1:1:1 into an acupuncture group,a herbal medicine group and an acupuncture plus herbal medicine group.Participants in the acupuncture group received manual acupuncture treatment,twice a week.Participants in the herbal medicine group received Dang Gui Bu Xue Qu Feng Tang,oral administration,once a day.Participants in the acupuncture plus herbal medicine group received both treatments.The therapeutic effects of the three groups were evaluated after four weeks of treatment.The primary outcome was the Jankovic rating scale(JRS)score,and the secondary outcome was the blepharospasm disability index(BSDI)score.Results:After four weeks of treatment,the JRS total scores significantly decreased in all three groups versus baseline(P<0.05).A greater reduction in the JRS total score was reported in participants in the acupuncture plus herbal medicine group(P<0.05),but there was no significant difference between the acupuncture group and the herbal medicine group(P>0.05).The acupuncture plus herbal medicine group had a greater decrease in the JRS severity score than the herbal medicine group(P<0.05).The reduction in the JRS frequency score was not significantly different among the three groups(P>0.05).The BSDI scores significantly decreased in all three groups versus baseline(P<0.05),but the reduction in the BSDI score was insignificantly different among the three groups(P>0.05).Conclusion:It is effective in the treatment of BEB either to use acupuncture and Dang Gui Bu Xue Qu Feng Tang alone or in combination.The combination therapy shows a more significant effect than either of the treatment alone.
文摘Traditional Chinese medicine (TCM) is a great treasure of China, the analysis of which is an arduous task. The viewpoint that all chemical constituents of Chinese herbal complex prescription should be analyzed as a black box is elucidated for the first time. Intelligent multi-mode multi-column chromatographic system (IMMCC) with its hybrids is the basic method and HPLC Unified Method is the breakthrough for the black box analysis. Dang-Gui-Bu-Xue-Tang was selected as a typical TCM and a systematic separation method from non-aqueous mobile phase to pure water mobile phase was put forward in order to convert unknown sample to known sample. The a, c values and UV spectra of 66 components of Astragalus, 78 components of Angelica and 71 components of Dang-Gui-Bu-Xue-Tang were obtained. Intelligent optimization and peak identification method and software for complex samples were developed and the optimum multi-step multi-binary gradient curve of mobile phase for Astragalus was ascertained.The maximum error