Objective:To evaluate the effects of the modified Linggui Zhugan Decoction(加味苓桂术甘汤) combined with short-term very low calorie diets(VLCDs) on glycemic control in newly diagnosed type 2 diabetes mellitus(T2DM) p...Objective:To evaluate the effects of the modified Linggui Zhugan Decoction(加味苓桂术甘汤) combined with short-term very low calorie diets(VLCDs) on glycemic control in newly diagnosed type 2 diabetes mellitus(T2DM) patients.Methods:A total of 20 subjects with newly diagnosed T2DM were treated with the modified Linggui Zhugan Decoction(one-month administration) combined with short-term VLCDs(5 days),and 3-months follow-up.A standard 75-g oral-glucose-tolerance test(OGTT) indexes fasting plasma glucose(FPG),post-prandial 0.5 h and 2 h plasma glucose(P0.5hPG,P2hPG),glycated hemoglobin A1C(GHbA1C),body weight,body mass index(BMI),insulin function,insulin resistance index,incidence of hypoglycemia,and the liver and renal functions were evaluated before and after treatment.Correlations of BMI with insulin function and insulin resistance were also assessed.Results:After the treatment,the patients' plasma glucose decreased steadily,FPG decreased from 5.8±0.9 mmol/L at pre-treatment to 5.0±0.6 mmol/L at 3-months follow-up(P<0.05),and P2hPG decreased from 11.7±3.8 mmol/L at pre-treatment to 6.9±0.9 mmol/L at 3-months follow-up(P<0.01).The level of GHbA1C declined from(6.47±1.24)% at pre-treatment to(6.14±0.99)% at 3-months follow-up(P<0.01).Body weight and BMI also declined significantly.Insulin resistance index was improved obviously and no event of hypoglycemia occurred.Part of the patients companied with fatty liver had a transient increase in hepatic transaminase during the treatment,but it turned to normal after the treatment.Conclusions:The modified Linggui Zhugan Decoction combined with short-term VLCDs can be safely implemented for steady glycemic control in newly diagnosed T2DM patients.展开更多
目的探讨加味苓桂术甘汤治疗老年椎基底动脉供血不足性的临床疗效。方法回顾性选取我院确诊并治疗的椎基底动脉供血不足性老年患者128例作为研究对象,按随机数字表法分为对照组(64例)与治疗组(64例),前者予以西医常规治疗,后者在常规治...目的探讨加味苓桂术甘汤治疗老年椎基底动脉供血不足性的临床疗效。方法回顾性选取我院确诊并治疗的椎基底动脉供血不足性老年患者128例作为研究对象,按随机数字表法分为对照组(64例)与治疗组(64例),前者予以西医常规治疗,后者在常规治疗基础上予以加味苓桂术甘汤治疗,治疗前后测定椎-基底动脉平均血流速度:即左椎动脉(LVA)和右椎动脉(RVA)以及基底动脉(VB)三者的平均血流速度、血液流变学指标(全血高切黏度、全血低切黏度、血浆黏度、红细胞压积)变化情况,空腹采静脉血测定血清C反应蛋白(C-reactionprotein,CRP)、内皮素(endothelin,ET-1)及降钙素基因相关肽(Calcitonin gene related peptide,CGRP)水平,同时对比临床疗效。结果对照组总有效率76.56%低于治疗组总有效率90.63%,差异有统计学意义(P<0.05);与对照组比较,治疗组治疗后椎-基底动脉平均血流速度显著升高,治疗后血清CRP、ET-1水平降低,CGRP水平升高,血液黏度指标及红细胞压积降低,差异有统计学意义(P<0.05),两组间不良反应差异无统计学意义(P>0.05)。结论采用加味苓桂术甘汤能降低椎-基底动脉供血不足性老年患者血液黏度,提高血流速度,效果显著。展开更多
基金supported by International Science and Technology Cooperation Program of Guangdong Province (No. 2009B050700022)
文摘Objective:To evaluate the effects of the modified Linggui Zhugan Decoction(加味苓桂术甘汤) combined with short-term very low calorie diets(VLCDs) on glycemic control in newly diagnosed type 2 diabetes mellitus(T2DM) patients.Methods:A total of 20 subjects with newly diagnosed T2DM were treated with the modified Linggui Zhugan Decoction(one-month administration) combined with short-term VLCDs(5 days),and 3-months follow-up.A standard 75-g oral-glucose-tolerance test(OGTT) indexes fasting plasma glucose(FPG),post-prandial 0.5 h and 2 h plasma glucose(P0.5hPG,P2hPG),glycated hemoglobin A1C(GHbA1C),body weight,body mass index(BMI),insulin function,insulin resistance index,incidence of hypoglycemia,and the liver and renal functions were evaluated before and after treatment.Correlations of BMI with insulin function and insulin resistance were also assessed.Results:After the treatment,the patients' plasma glucose decreased steadily,FPG decreased from 5.8±0.9 mmol/L at pre-treatment to 5.0±0.6 mmol/L at 3-months follow-up(P<0.05),and P2hPG decreased from 11.7±3.8 mmol/L at pre-treatment to 6.9±0.9 mmol/L at 3-months follow-up(P<0.01).The level of GHbA1C declined from(6.47±1.24)% at pre-treatment to(6.14±0.99)% at 3-months follow-up(P<0.01).Body weight and BMI also declined significantly.Insulin resistance index was improved obviously and no event of hypoglycemia occurred.Part of the patients companied with fatty liver had a transient increase in hepatic transaminase during the treatment,but it turned to normal after the treatment.Conclusions:The modified Linggui Zhugan Decoction combined with short-term VLCDs can be safely implemented for steady glycemic control in newly diagnosed T2DM patients.
文摘目的探讨加味苓桂术甘汤治疗老年椎基底动脉供血不足性的临床疗效。方法回顾性选取我院确诊并治疗的椎基底动脉供血不足性老年患者128例作为研究对象,按随机数字表法分为对照组(64例)与治疗组(64例),前者予以西医常规治疗,后者在常规治疗基础上予以加味苓桂术甘汤治疗,治疗前后测定椎-基底动脉平均血流速度:即左椎动脉(LVA)和右椎动脉(RVA)以及基底动脉(VB)三者的平均血流速度、血液流变学指标(全血高切黏度、全血低切黏度、血浆黏度、红细胞压积)变化情况,空腹采静脉血测定血清C反应蛋白(C-reactionprotein,CRP)、内皮素(endothelin,ET-1)及降钙素基因相关肽(Calcitonin gene related peptide,CGRP)水平,同时对比临床疗效。结果对照组总有效率76.56%低于治疗组总有效率90.63%,差异有统计学意义(P<0.05);与对照组比较,治疗组治疗后椎-基底动脉平均血流速度显著升高,治疗后血清CRP、ET-1水平降低,CGRP水平升高,血液黏度指标及红细胞压积降低,差异有统计学意义(P<0.05),两组间不良反应差异无统计学意义(P>0.05)。结论采用加味苓桂术甘汤能降低椎-基底动脉供血不足性老年患者血液黏度,提高血流速度,效果显著。
