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Current Problems of the Diagnostics and Treatment of Sepsis and Burn Injuries: The Modified Pathogenetic Concept
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作者 Olga Kovalenko Lesia Ostapiuk Anatoliy Voloshinovskii 《International Journal of Clinical Medicine》 CAS 2023年第1期20-33,共14页
Background: The deep understanding of pathogenesis is a key moment in the formation of the modern strategy of modern medicine. We conducted the thorough analysis of the microscopic processes occurring in the bodies of... Background: The deep understanding of pathogenesis is a key moment in the formation of the modern strategy of modern medicine. We conducted the thorough analysis of the microscopic processes occurring in the bodies of patients with purulent-septic complications. The modified pathogenetic concept of the diagnostic and treatment model of diseases with septic complications is presented. The obtained information about the mechanisms of origin and development of these diseases is fundamentally important for finding the modern effective methods of treating patients. The aim of the research is to modify treatment tactics for patients with sepsis and burn injuries based on the modified pathogenetic concept using modern diagnostics, i.e. the method of fluorescence spectroscopy (MFS) and biomarkers. Materials and Methods: The proposed modified pathogenetic concept of the diagnostic and treatment model of diseases with purulent-septic complications along with standard methods was used successfully for effective treatment of 15 patients with sepsis and 25 with burn injuries. Results: 3 main scenarios of behaviour of spectral-fluorescence characteristics of patients with sepsis are illustrated. Spectral-fluorescence markers of sepsis were studied, which are informative 24 to 48 hours before the appearance of obvious clinical and laboratory signs of significant changes in the general somatic status of patients. Conclusions: The proposed diagnostic and therapeutic approach is new and fundamentally important for diagnostics and monitoring of the process of treatment of patients with purulent-septic diseases and burn injuries. An in-depth understanding of the dynamics of septic complications and the corresponding changes of the main markers of these diseases during treatment is especially relevant. The use of infusion therapy with solutions of donor albumin as an effective pathogenetic treatment is scientifically justified. 展开更多
关键词 Purulent-Inflammatory Diseases SEPSIS modified Pathogenetic Diagnostic and treatment Model Method of Fluorescent Spectroscopy Biomarkers Albumin Infusion
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Fretting Wear Behavior of Medium Carbon Steel Modified by Low Temperature Gas Multi-component Thermo-chemical Treatment 被引量:3
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作者 LUO Jun ZHENG Jianfeng PENG Jinfang HE Liping ZHU Minhao 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2010年第3期288-296,共9页
The introduction of surface engineering is expected to be an effective strategy against fretting damage. A large number of studies show that the low gas multi-component (such as carbon, nitrogen, sulphur and oxygen, ... The introduction of surface engineering is expected to be an effective strategy against fretting damage. A large number of studies show that the low gas multi-component (such as carbon, nitrogen, sulphur and oxygen, etc) thermo-chemical treatment(LTGMTT) can overcome the brittleness of nitriding process, and upgrade the surface hardness and improve the wear resistance and fatigue properties of the work-pieces significantly. However, there are few reports on the anti-fretting properties of the LTGMTT modified layer up to now, which limits the applications of fretting. So this paper discusses the fretting wear behavior of modified layer on the surface of LZ50 (0.48%C) steel prepared by low temperature gas multi-component thermo-chemical treatment (LTGMTT) technology. The fretting wear tests of the modified layer flat specimens and its substrate (LZ50 steel) against 52100 steel balls with diameter of 40 mm are carried out under normal load of 150 N and displacement amplitudes varied from 2 μm to 40 μm. Characterization of the modified layer and dynamic analyses in combination with microscopic examinations were performed through the means of scanning electron microscope(SEM), optical microscope(OM), X-ray diffraction(XRD) and surface profilometer. The experimental results showed that the modified layer with a total thickness of 60 μm was consisted of three parts, i.e., loose layer, compound layer and diffusion layer. Compared with the substrate, the range of the mixed fretting regime(MFR) of the LTGMTT modified layer diminished, and the slip regime(SR) of the modified layer shifted to the direction of smaller displacement amplitude. The coefficient of friction(COF) of the modified layer was lower than that of the substrate in the initial stage. For the modified layer, the damage in partial slip regime(PSR) was very slight. The fretting wear mechanism of the modified layer both in MFR and SR was abrasive wear and delamination. The modified layer presented better wear resistance than the substrate in PSR and MFR; however, in SR, the wear resistance of the modified layer decreased with the increase of the displacement amplitudes. The experimental results can provide some experimental bases for promoting industrial application of LTGMTT modified layer in anti-fretting wear. 展开更多
关键词 fretting wear fretting regimes low temperature gas multi-component thermo-chemical treatment(LTGMTT) modified layer medium carbon steel
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Genetically modified human umbilical cord blood cells as a promising strategy for treatment of spinal cord injury 被引量:2
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作者 Yana O. Mukhamedshina Albert A. Rizvanov 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第9期1420-1421,共2页
Spinal cord injury (SCI) continues to be a pressing health and social problem. The injury leads to neuronal and glial cell death accompanied by degeneration of nerve fibers. There are currently no particularly effec... Spinal cord injury (SCI) continues to be a pressing health and social problem. The injury leads to neuronal and glial cell death accompanied by degeneration of nerve fibers. There are currently no particularly effective treatments. SCI causes profound disabil- ity of people affected and has attracted increased attention in the international field of neuroregeneration. For the past two decades, much hope has been placed in cell therapies for the restoration of both structure and function of the injured spinal cord. Embryonic and neural stem cells, olfactory ensheathing cells, microglia-like cells, Schwann cells, mesenchymal stem cells. 展开更多
关键词 gene cell VEGF GDNF Genetically modified human umbilical cord blood cells as a promising strategy for treatment of spinal cord injury SCI
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Evaluation of modified hemodilution combined therapy in the treatment of acute ischemic stroke in the elderly 被引量:1
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作者 Yue Chen Guangbai Xie 《Neural Regeneration Research》 SCIE CAS CSCD 2006年第2期184-187,共4页
BACKGROUND: Thrombolysis therapy is not suitable for the elderly patients with acute ischemic stroke who delayed to be diagnosed for more than 3 hours, but traditional medicine is also not very ideal. OBJECTIVE: To ... BACKGROUND: Thrombolysis therapy is not suitable for the elderly patients with acute ischemic stroke who delayed to be diagnosed for more than 3 hours, but traditional medicine is also not very ideal. OBJECTIVE: To observe the clinical therapeutic effect of modified hemodilution combined therapy applied in elderly patients with acute cerebral thrombosis and analyze the mechanism of this therapeutic method. DESIGN: 1:1 paired grouping according to gender and controlled observation SETTING: Department of Internal Medicine, Chengzhanyuan District, First Hospital Affiliated to Zhejiang University. PARTICIPANTS: Totally 90 elderly patients with acute ischemic stroke who received the treatment in the Cadre Ward and Mental Ward, Department of Internal Medicine, Chengzhanyuan District, First Hospital Affiliated to Zhejiang University from March 1996 to June 2004 were recruited. They all met the diagnosis criteria revised by the Fourth Academic Conference of National Cerebrovascular Diseases in 1995 and were diagnosed as acute ischemic stroke by skull CT. They were informed of therapeutic plan and detected items. According to 1:1 paired principle in gender, 90 enrolled patients were assigned into treated group (n=45) and control group (n=45). There were 39 male and 6 female in the treatment group, and they were aged (76±6)years, ranging from 71 to 84 years, and hospitalized at the 14^th to 76^th hours after onset. There were 39 male and 6 female in the control group, and they were aged (76±6)years , ranging from 70 to 82 years, and hospitalized at the 16^th to 72^th hours after onset. METHODS: Therapeutic method: Patients of treated group received modified hemodilution combined therapy. 200 mL whole blood of patients was exchanged with 500 mL dextran-40 (including 20 mL danshen parenteral solution and 32 mg heparin) at the beginning of therapy; From the 2^nd day, compound huangqi tea bag (Huangqi mainly, including danshen, honghua, chuanxiong, shishao and a little acetyl salicylic acid) was made, twice a day, 1 bag once. At the same time, the above-mentioned dextran-40 liquid of 500 mL was intravenously injected, once a day, 14 days in total; On the 6^th day after therapy, the above-mentioned aseptic autoblood stored in refrigerator at 4℃ was transfused back into the patients following pre-treatment of high-concentration oxygenation and ultraviolet irradiation by light quantum instrument. Patients of control group were intravenously injected of 0.4 g venoruton(Traditional Chinese medicine compound parenteral solution for promoting blood circulation and removing blood stasis ) and 50 g/L glucose of 500 mL, 75 mg acetosal was taken orally, once a day, 14 days in total. ② Measurement and observation of index: Blood coagulation index, change of platelet aggregation rate and change of hemorrheology of patients in two groups were monitored before and after therapy. The level of blood lipid of patients in two groups was measured with American Beckman automatic biochemistry analyzer. Blood flow rate of middle cerebral artery of resting electrocardiogram were measured with American HP SONOS 2500 sonoscope. Neuro-dysfunction score revised in the national conference (1995) was used to evaluate the recovery of neurological function of the patients in two groups at the 3rd, 5^th, 7^th and 14^th days after therapy. ③Therapeutic effect and adverse effect were observed at the same time. MAIN OUTCOME MEASURES : ① Changes of coagulation index, blood lipid level and hemorheology; ② Blood flow rate of middle cerebral artery and NDS of patients with acute ischemic stroke in two groups; ③Adverse effect of drug. RESULTS: Totally 90 patients were enrolled in the experiment. One patient from treated group died of hyperosmolar nonketotic diabetic coma of complicated diabetes mellitus. One patient from control group died of severe pulmonary infection. The rest 88 patients entered the stage of result analysis. ① Change of coagulation index and platelet aggregation rate: prothrombin time (PT), activated partial thromboplastin time (APTT) and thrombin time (TT) of patients after therapy were significantly longer than those before therapy in the treated group and those after therapy in control group [After therapy in treated group: (18.4±1.9), (41.8±2.1), (19.7±1.7) s, Before therapy in treated group: (13.4±1.3), (35.8±1.3), (12.5±0.9) s, After therapy in control group: (16.9±1.5), (39.1±1.1), (11.9±2.1) s, P〈 0.05]:Concentration of fibrinogen (Fbg) after therapy was significantly lower than that before therapy in the treated group and that after therapy in control group[After therapy in treated group: (3.4±0.4) g/L; Before therapy in treated group: (4.3±0.7) g/L; After therapy in control group:(4.0±0.6) g/L; P 〈 0.05]. Platelet aggregation rate decreased from (37.92 ±0.85)% before therapy to (26.42±1.01)% after therapy (P 〈 0.01). ②Change of blood lipid level: Levels of total cholesterol (TC), triacylglycerol(TG) and low density lipoprotein cholesterol (LDL-C) of patients after therapy were significantly lower than those before therapy in treated group and those after therapy in control group [After therapy in treated group: (5.2±0.9), (1.9±0.9), (2.08±1.1) mmol/L, before therapy in treated group: (5.9±1.2), (2.8±0.9), (3.94±0.5) mmol/L, After therapy in control group: (6.0±1.1), (2.6±0.8), (3.84±0.9) mmol/L, P 〈 0.05]. ③Change of hemorheology index: Hematocrit of patients of treated group was significantly lower after therapy than before therapy [Before therapy: (43.84±4.55)% ;After therapy: (40.48±4.02)%;P 〈 0.05]. Blood flow rate of middle cerebral artery of patients of treated group was significantly lower before therapy than after therapy [(90±1.2), (97±2.1) cm/s,P〈 0.01]. ⑤NDS of patients in treated group was significantly lower than of control group 14 days after therapy. The total effective rate after therapy was significantly higher in the treated group than in the control group (93%,78%, P 〈 0.05). ⑥There was no obvious adverse effect. CONCLUSION: Modified hemodilution combined therapy can improve hemorheology, decrease hematocrit, increase blood flow rate of middle cerebral artery, so as to improve the impaired clinical neurological function of elderly patients with acute cerebral thrombosis through anticoagulation and antiplatelet aggregative activity as well as regulating blood lipid. 展开更多
关键词 ab Evaluation of modified hemodilution combined therapy in the treatment of acute ischemic stroke in the elderly
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APPLICATION OF MODIFIED POLYACYLAMIDE IN TREATMENT OF PAPERMAKING DEINKING WASTEWATER 被引量:1
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作者 FushanChen HongjieZhang HuirenHu LijuanQin 《天津科技大学学报》 CAS 2004年第A02期187-190,共4页
In this paper, the application of modified polyacylamide is discussed and the complex systems of PAC/modified PAM are used to treat the papermaking wastewater. The results showed that when cationic polyacylamide (CPAM... In this paper, the application of modified polyacylamide is discussed and the complex systems of PAC/modified PAM are used to treat the papermaking wastewater. The results showed that when cationic polyacylamide (CPAM) and amphoteric polyacylamide (AmPAM) were used at the dosage of 0.75ppm with PAC, of which the optimum dosage was 100ppm, the removed rate of CODcr was above 80% . 展开更多
关键词 脱墨废水 水处理化学 改性聚丙烯酰胺 废水处理 絮凝作用
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Process optimization for treatment of methyltin mercaptide effluents using modified semi-coke 被引量:1
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作者 王欣 C.Srinivasakannan +4 位作者 曲雯雯 彭金辉 张利波 段昕辉 卢帅丹 《Journal of Central South University》 SCIE EI CAS 2013年第12期3633-3640,共8页
The central composite process optimization was performed by response surface methodology technique using a design for the treatment of methyltin mercaptide with modified semi-coke. The semi-coke from the coal industry... The central composite process optimization was performed by response surface methodology technique using a design for the treatment of methyltin mercaptide with modified semi-coke. The semi-coke from the coal industry was suitably modified by treating it with phosphoric acid, with a thermal activation process. The objective of the process optimization is to reduce the chemical oxygen demand(COD) and 4NH—N in the methyltin mercaptide industrial effluent. The process variables considered for process optimization are the semi-coke dosage, adsorption time and effluent pH. The optimized process conditions are identified to be a semi-coke dosage of 80 g/L, adsorption time of 90 min and a pH value of 8.34. The ANOVA results indicate that the adsorbent dosage and pH are the significant parameters, while the adsorption time is insignificant, possibly owing to the large range of adsorption time chosen. The textural characteristics of modified semi-coke were analyzed using scanning electron microscopy and nitrogen adsorption isotherm. The average BET surface area of modified semi-coke is estimated to be 915 m2/g, with the average pore volume of 0.71 cm3/g and a average pore diameter of 3.09 nm, with micropore volume contributing to 52.36%. 展开更多
关键词 流程优化 工业废水 甲基锡 改性 硫醇 半焦 吸附时间 平均孔径
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Development of a novel modified EGSB reactor for municipal sewage treatment at ambient temperatures 被引量:1
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作者 周雪飞 张亚雷 +2 位作者 张选军 强志民 赵建夫 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2009年第4期554-560,共7页
A novel modified expanded granular sludge bed(EGSBm) reactor was developed for anaerobic treatment of municipal sewage with mixed liquid recirculation instead of effluent recirculation commonly adopted by a convention... A novel modified expanded granular sludge bed(EGSBm) reactor was developed for anaerobic treatment of municipal sewage with mixed liquid recirculation instead of effluent recirculation commonly adopted by a conventional EGSB(EGSBc) reactor.Performances of these two reactors were compared in treating municipal sewage at ambient temperatures ranging from 8 to 26 ℃.At an upflow liquid velocity(Vup) of 10.3 m/h,the mean concentrations of filtrated COD(CODfilt) and COD of the EGSBm effluent were determined to be 59.4 and 95.9 mg/L,respectively,which were significantly lower than those of the EGSBc effluent operated under identical experimental conditions.When the organic loading rate was suddenly increased from 1.2 to 7.2 kg COD/(m3·d),the EGSBm regained the removal efficiency of previous operation phase in 10 d.Hydrodynamic characteristics of the reactors were compared using the residence time distribution(RTD) model.It was found that the treatment efficiency of EGSBm kept increasing as the Vup increased.The polymerase Chain Reaction-Denaturing Gradient Gel Electrophoresis(PCR-DGGE) technique was used to analyze the microbial diversity in EGSBm.Fingerprinting pattern indicated that some species in the inoculating sludge were still reserved in the granular sludge of EGSBm,moreover,several new species occurred. 展开更多
关键词 EGSB反应器 城市污水处理 改性处理 膨胀颗粒污泥床 变性梯度凝胶电泳 化学需氧量 PCR技术 小说
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Modified Foerster-Dandy 's operation for treatment of spasmodic torticollis under endoscope-assisting
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作者 刘江 《外科研究与新技术》 2011年第3期218-218,共1页
Objective To study microsurgical effectiveness Foerster-Dandy’s endoscope-assisted operation for treatment of spasmodic torticollis. Methods 183 cases of spasmodic torticollis patients were treated by microsurgical m... Objective To study microsurgical effectiveness Foerster-Dandy’s endoscope-assisted operation for treatment of spasmodic torticollis. Methods 183 cases of spasmodic torticollis patients were treated by microsurgical modified Foerster-Dandy’s operation from July 2001 to June 2009,which was randomly 展开更多
关键词 modified Foerster-Dandy s operation for treatment of spasmodic torticollis under endoscope-assisting
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The clinical study of modified total aortic arch replacement and stent elephant trunk technique treatment for patients with DeBakey Ⅰ thoracic aortic dissection
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作者 吴智勇 《外科研究与新技术》 2011年第3期176-176,共1页
Objective To summarize the clinical study of modified total aortic arch replacement and stent elephant trunk technique treatment to patients with DeBakey Ⅰ thoracic aortic dissection. Methods From January 2006 to Oct... Objective To summarize the clinical study of modified total aortic arch replacement and stent elephant trunk technique treatment to patients with DeBakey Ⅰ thoracic aortic dissection. Methods From January 2006 to October 2010,101 cases of DeBakeyⅠaortic dissection were treated by modified total arch replacement and stent elephant trunk technique,in which emergencey surgery were performed on 73 cases. There were 76 male and 25 展开更多
关键词 The clinical study of modified total aortic arch replacement and stent elephant trunk technique treatment for patients with DeBakey thoracic aortic dissection
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<i>In-Vitro</i>Fermentation by Human Fecal Bacteria and Bile Salts Binding Capacity of Physical Modified Defatted Rice Bran Dietary Fiber 被引量:9
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作者 Cheickna Daou Hui Zhang +1 位作者 Camel Lagnika Oumarou Hama Moutaleb 《Food and Nutrition Sciences》 2014年第12期1114-1120,共7页
Defatted rice bran dietary fiber (DRBDF) was modified by micronization, ultrasound, microwave and extrusion cooking. We investigated the impacts of these physical treatments on the fermentation ability and bile salts ... Defatted rice bran dietary fiber (DRBDF) was modified by micronization, ultrasound, microwave and extrusion cooking. We investigated the impacts of these physical treatments on the fermentation ability and bile salts binding capacity of DRBDF. In-vitro fermentation by human fecal bacteria of modified fibers showed that the major fermentation products were propionic, acetate and butyrate acid. Fermentation of extruded fiber gave the highest amounts of propionic and acetic acid 135.76 and 25.45 mmol/L respectively, while, the fermented product with microwaved fiber had the highest butyric acid content (10.75 mmol/L). The amount of short-chain fatty acid increased from 12 h to 24 h and propionic acid was the predominant. On the other hand,in-vitrobile salts binding showed that extruded fiber had higher affinity with sodium deoxycholate and sodium chenodeoxycholate (66.14% and 30.25% respectively) while microwaved fiber exhibited the highest affinity with sodium taurocholate (14.38%). In the light of obtained results we can affirmed that these physical treatments significantly improved the fermentation products and bile salts binding capacity of DRBDF. Extrusion compared to the other physical treatment methods used in this study has greatly and positively influenced the fermentation and bile binding capacity of DRBDF. 展开更多
关键词 Defatted Rice Bran DIETARY FIBER PHYSICAL treatments modified DIETARY FIBER FERMENTATION Bile Salts Binding
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Dynamic Elastic Modulus and Damping Ratio of Lignin-Modified Loess 被引量:1
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作者 Qian Wang Zhaozhao Liu +2 位作者 Xiumei Zhong Zhongnan Gao Fuqiang Liu 《Journal of Renewable Materials》 SCIE EI 2021年第3期523-540,共18页
To effectively improve the poor engineering properties of loess and enhance its seismic performance,the industrial by-product lignin is used as a modified material.Based on lots of dynamic triaxial tests,the dynamic e... To effectively improve the poor engineering properties of loess and enhance its seismic performance,the industrial by-product lignin is used as a modified material.Based on lots of dynamic triaxial tests,the dynamic elastic modulus and damping ratio of lignin-modified loess were tested.The effects of lignin content on the dynamic elastic modulus and damping ratio of lignin-modified loess were analyzed.Combined with scanning electron microscopy(SEM)and X-ray diffraction(XRD),the microscopic mechanism of lignin to improve the dynamic properties of loess was studied.The results show that lignin can effectively modify the dynamic deformation of loess under dynamic load.Under the same dynamic stress condition,the dynamic strain of lignin-modified loess is smaller than compacted loess.The dynamic elastic modulus of modified loess with different lignin content are quite different,but both decrease with the increase of dynamic strain.And the dynamic elastic modulus of modified loess is greater than compacted loess.The maximum dynamic elastic modulus of modified loess with a lignin content of 1%are significantly greater than others.Under the same dynamic strain condition,the damping ratio of lignin-modified loess is smaller than compacted loess.Lignin can effectively fill loess pores and cement loess particles.Compared with compacted loess,no new mineral components are generated in the lignin-modified loess.The optimum lignin content of dynamics characteristic of modified loess is present,and the optimum lignin content is 1%. 展开更多
关键词 LIGNIN modified treatment dynamic triaxial test SEM XRD
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Comparision of modified and conventional delta-shaped gastroduodenostomy in totally laparoscopic surgery 被引量:27
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作者 Chang-Ming Huang Mi Lin +5 位作者 Jian-Xian Lin Chao-Hui Zheng Ping Li Jian-Wei Xie Jia-Bin Wang Jun Lu 《World Journal of Gastroenterology》 SCIE CAS 2014年第30期10478-10485,共8页
AIM:To evaluate the safety and feasibility of a modified delta-shaped gastroduodenostomy(DSG)in totally laparoscopic distal gastrectomy(TLDG).METHODS:We performed a case-control study enrolling 63 patients with distal... AIM:To evaluate the safety and feasibility of a modified delta-shaped gastroduodenostomy(DSG)in totally laparoscopic distal gastrectomy(TLDG).METHODS:We performed a case-control study enrolling 63 patients with distal gastric cancer(GC)undergoing TLDG with a DSG from January 2013 to June 2013.Twenty-two patients underwent a conventional DSG(Con-Group),whereas the other 41 patients underwent a modified version of the DSG(Mod-Group).The modified procedure required only the instruments of the surgeon and assistant to complete the involution of the common stab incision and to completely resect the duodenal cutting edge,resulting in an anastomosis with an inverted T-shaped appearance.The clinicopathological characteristics,surgical outcomes,anastomosis time and complications of the two groups were retrospectively analyzed using a prospectively maintained comprehensive database.RESULTS:DSG procedures were successfully completed in all of the patients with histologically complete(R0)resections,and none of these patients required conversion to open surgery.The clinicopathological characteristics of the two groups were similar.There were no significant differences between the groups in the operative time,intraoperative blood loss,extension of the lymph node(LN)dissection and number of dissected LNs(150.8±21.6 min vs 143.4±23.4 min,P=0.225for the operative time;26.8±11.3 min vs 30.6±14.8mL,P=0.157 for the intraoperative blood loss;4/18 vs3/38,P=0.375 for the extension of the LN dissection;and 43.9±13.4 vs 39.5±11.5 per case,P=0.151 for the number of dissected LNs).The anastomosis time,however,was significantly shorter in the Mod-Group than in the Con-Group(13.9±2.8 min vs 23.9±5.6min,P=0.000).The postoperative outcomes,including the times to out-of-bed activities,first flatus,resumption of soft diet and postoperative hospital stay,as well as the anastomosis size,did not differ significantly(1.9±0.6 d vs 2.3±1.5 d,P=0.228 for the time to outof-bed activities;3.2±0.9 d vs 3.5±1.3 d,P=0.295for the first flatus time;7.5±0.8 d vs 8.1±4.3 d,P=0.489 for the resumption of a soft diet time;14.3±10.6 d vs 11.5±4.9 d,P=0.148 for the postoperative hospital stay;and 30.5±3.6 mm vs 30.1±4.0 mm,P=0.730 for the anastomosis size).One patient with minor anastomotic leakage in the Con-Group was managed conservatively;no other patients experienced any complications around the anastomosis.The operative complication rates were similar in the Con-and ModGroups(9.1%vs 7.3%,P=1.000).CONCLUSION:The modified DSG,an alternative reconstruction in TLDG for GC,is technically safe and feasible,with a simpler process that reduces the anastomosis time. 展开更多
关键词 STOMACH NEOPLASMS Totally LAPAROSCOPIC surgery DIG
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Modified Kugel补片修补腹股沟疝的治疗体会
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作者 盛建华 刘建平 +1 位作者 余璟 李国强 《实用临床医学(江西)》 CAS 2011年第6期55-56,60,共3页
目的探讨Modified Kugel补片修补腹股沟疝的的技术操作要点,并评价其治疗效果。方法对16例行开放性前入路腹膜前间隙置入Modified Kugel补片治疗的腹股沟疝患者的临床资料进行回顾性分析。结果 16例患者手术时间45~60 min,未留置导尿... 目的探讨Modified Kugel补片修补腹股沟疝的的技术操作要点,并评价其治疗效果。方法对16例行开放性前入路腹膜前间隙置入Modified Kugel补片治疗的腹股沟疝患者的临床资料进行回顾性分析。结果 16例患者手术时间45~60 min,未留置导尿管。所有患者术后6~24 h下床活动,均于手术当晚进食半流质,第2天进普食。切口疼痛轻微,切口均一期愈合。术后发生阴囊血肿、发热各1例,无尿潴留、切口感染等并发症。术后3~7 d均痊愈出院。术后随访3~20个月,无明显异物感,无一例术后复发。结论应用Modified Kugel补片治疗腹股沟疝安全有效,术后恢复快、并发症少。 展开更多
关键词 腹股沟疝 modified KUGEL补片 治疗
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EFFECT OF Ni CRYSTAL SIZE DISTRIBUTION ON THE ANTICOKING BEHAVIOR OF La-MODIFIED Ni/α-Al_2O_3 CATALYSTS
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作者 陈廷蕤 潘惠芳 +2 位作者 张在龙 王彪 王槐平 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 1993年第3期18-21,共4页
The crystal size distribution(CSD)was determined with small angle X-ray scattering technique.Theanticoking property of Ni-catalysts was investigated with the steam reforming of n-heptane in a TG-monitoredflow reacto... The crystal size distribution(CSD)was determined with small angle X-ray scattering technique.Theanticoking property of Ni-catalysts was investigated with the steam reforming of n-heptane in a TG-monitoredflow reactor.The results of this study show that the rate of coking on the supported Ni-catalysts depends main-ly on the percentage content of the large size fraction(25-70nm)of Ni-crystallites,and that the dispersion ofNi-crystallites and the anticoking property of the Ni/α-Al<sub>2</sub>O<sub>3</sub> catalysts were promoted obviously by theLa<sub>2</sub>O<sub>3</sub>-modification method.The variation of the Ni-CSD and the anticoking property of the catalysts were fur-ther tested through different periods of hydrothermal treatment.It is found that the content of the largeNi-crystal size fraction and the coking rate pass correspondingly through a maximum. 展开更多
关键词 anticoking BEHAVIOR crystal size distribution La-modified Ni/α-Al2O3 CATALYSTS period of HYDROTHERMAL treatment
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加味二陈汤治疗顽固性呃逆临床观察
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作者 任燕怡 李霞 +2 位作者 何俊余 宋帮丽 马悦 《实用中医药杂志》 2024年第6期1042-1043,共2页
目的:观察加味二陈汤治疗顽固性呃逆的临床效果。方法:126例按照随机数字表法分为试验组和对照组各63例。试验组用加味二陈汤治疗,对照组用甲氧氯普胺治疗。结果:试验组起效时间短于对照组,症状改善优于对照组,总有效率高于对照组,两组... 目的:观察加味二陈汤治疗顽固性呃逆的临床效果。方法:126例按照随机数字表法分为试验组和对照组各63例。试验组用加味二陈汤治疗,对照组用甲氧氯普胺治疗。结果:试验组起效时间短于对照组,症状改善优于对照组,总有效率高于对照组,两组比较差异均有统计学意义(P<0.05)。结论:加味二陈汤治疗顽固性呃逆效果较好。 展开更多
关键词 顽固性呃逆 加味二陈汤 对照治疗观察
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改良隔药脐灸联合敷贴序贯治疗小儿厌食症(脾气虚证)的临床观察
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作者 李茜 张萍 段保全 《中医药导报》 2024年第1期86-88,92,共4页
目的:探究与分析改良隔药脐灸联合敷贴序贯治疗小儿厌食症(脾气虚证)的临床疗效及对预后复发的影响。方法:选取我院2019年2月至2022年3月收治的小儿厌食症(脾气虚证)120例患儿,采取随机数字表法将其随机分为3组,每组各40例,对照组采用... 目的:探究与分析改良隔药脐灸联合敷贴序贯治疗小儿厌食症(脾气虚证)的临床疗效及对预后复发的影响。方法:选取我院2019年2月至2022年3月收治的小儿厌食症(脾气虚证)120例患儿,采取随机数字表法将其随机分为3组,每组各40例,对照组采用中药制剂厌食贴外敷治疗;治疗A组在对照组的基础上加用传统隔姜脐灸治疗;在对照组的基础上治疗B组加用改良隔药脐灸治疗,3组患儿均连续治疗4周,对比3组患儿的临床疗效、治疗前后主症积分和次症积分,同时对比3组治疗后4周、8周及12周的复发率。结果:治疗B组、治疗A组、对照组临床总有效率分别为95.00%(38/40)、80.00%(32/40)、62.5%(25/40),治疗B组临床总有效率均高于治疗A组和对照组(P<0.05)。3组患儿治疗后主症积分及次症积分均较治疗前降低,治疗B组患儿治疗后主症积分及次症积分均低于治疗A组、对照组,治疗A组患儿治疗后主症积分及次症积分均低于对照组,差异均有统计学意义(P<0.05)。随访8周时,治疗B组复发率[2.50%(1/40)]低于对照组[20.00%(8/40)],随访12周时,治疗B组复发率[2.50%(1/40)]低于治疗A组[17.50%(7/40)]和对照组[30.00%(12/40)],差异均有统计学意义(P<0.05)。结论:改良隔药脐灸与敷贴序贯联合治疗小儿厌食症(脾气虚证)可获得显著的临床疗效,促进改善患儿的临床症状及体征,同时在短期时间内有效避免了疾病的复发,具有较高的应用价值。 展开更多
关键词 改良隔药脐灸 穴位敷贴 隔姜脐灸 序贯治疗 小儿厌食症 脾气虚证 临床研究
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多发性硬化的治疗进展
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作者 王茜 陆正齐 李蕊 《重庆医科大学学报》 CAS CSCD 北大核心 2024年第5期597-602,共6页
多发性硬化(multiple sclerosis,MS)是一种慢性中枢神经系统炎症性脱髓鞘疾病,随着人们对MS发病机制了解的深入,MS的治疗手段也在不断更新。近年来,新上市的疾病修饰治疗(disease-modifying therapy,DMT)药物层出不穷,临床研究显示出良... 多发性硬化(multiple sclerosis,MS)是一种慢性中枢神经系统炎症性脱髓鞘疾病,随着人们对MS发病机制了解的深入,MS的治疗手段也在不断更新。近年来,新上市的疾病修饰治疗(disease-modifying therapy,DMT)药物层出不穷,临床研究显示出良好的疗效及安全性。治疗策略及目标也在更新。本文主要对近年来新上市的DMT药物的作用机制、疗效以及安全性进行综述,此外对治疗策略、治疗目标以及正在研发的新药也做了简要介绍,以期为临床决策的制定提供参考。 展开更多
关键词 多发性硬化 治疗 进展 疾病修饰治疗
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表面改性密网支架治疗合并系统性红斑狼疮多发颅内动脉瘤一例
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作者 丁前进 马永杰 张鸿祺 《中国脑血管病杂志》 CAS CSCD 北大核心 2024年第4期257-260,共4页
合并系统性红斑狼疮(SLE)的多发颅内动脉瘤病例临床较为罕见,尽管SLE与颅内多发动脉瘤发生之间的相关性暂不明确,但是对于合并SLE的颅内动脉瘤患者,其动脉瘤通常具有增长快速和极易破裂的特点,如何对其动脉瘤进行破裂风险评估并制定治... 合并系统性红斑狼疮(SLE)的多发颅内动脉瘤病例临床较为罕见,尽管SLE与颅内多发动脉瘤发生之间的相关性暂不明确,但是对于合并SLE的颅内动脉瘤患者,其动脉瘤通常具有增长快速和极易破裂的特点,如何对其动脉瘤进行破裂风险评估并制定治疗策略尤为重要。该文报道1例表面改性密网支架置入治疗合并SLE多发颅内动脉瘤患者,并进行相关文献复习,希望为临床医师诊疗该疾病提供帮助。 展开更多
关键词 颅内动脉瘤 系统性红斑狼疮 血管内治疗 表面改性密网支架
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强化混凝耦合改性沸石过滤处理微污染水
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作者 李砂 黄智研 +3 位作者 卢钒 孔艳丽 马江雅 聂勇 《水处理技术》 CAS CSCD 北大核心 2024年第4期111-116,123,共7页
针对南方某市微污染水源水(XJ)低温低浊及氨氮问题,采用烧杯实验及中试动态运行实验进行复合助凝剂强化混凝耦合改性沸石过滤处理低温低浊及氨氮效能研究。结果表明,配置的Fe/Si复合助凝剂在絮凝初期投加时明显提高了低温低浊水的出水... 针对南方某市微污染水源水(XJ)低温低浊及氨氮问题,采用烧杯实验及中试动态运行实验进行复合助凝剂强化混凝耦合改性沸石过滤处理低温低浊及氨氮效能研究。结果表明,配置的Fe/Si复合助凝剂在絮凝初期投加时明显提高了低温低浊水的出水水质。复合助凝剂的存在起到良好的吸附架桥作用,提高混凝效果。强化混凝对氨氮去除作用有限,不足10%。改性沸石颗粒(MZK)能够利用离子交换和化学吸附作用显著提高氨氮去除效果,去除率达到83.1%。在连续中试动态运行中,出水浊度基本控制在0.6 NTU;在240 h的运行周期内,MZK对氨氮的去除效果明显优于石英砂,氨氮的平均去除率为77.6%,出水处氨氮浓度均小于0.5 mg/L。强化混凝耦合改性沸石过滤为低温低浊及氨氮的水处理提供了理论基础和技术参考,具有较好的应用前景和推广价值。 展开更多
关键词 低温低浊 氨氮 助凝剂强化混凝 改性沸石过滤 耦合处理
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时效处理对Fe-Ni基奥氏体合金耐点蚀性能的影响
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作者 郑军宝 闫英杰 曹睿 《电焊机》 2024年第3期18-23,79,共7页
针对Fe-Ni基奥氏体合金在740℃时效处理后的析出相随时效时间的演变进行探究;并通过电化学腐蚀试验以及Mott-Schottky分析,研究了时效处理对合金耐腐蚀性能的影响。结果表明:740℃时效处理可以促进γ′沉淀强化相[Ni_(3)(Al,Ti)]在合金... 针对Fe-Ni基奥氏体合金在740℃时效处理后的析出相随时效时间的演变进行探究;并通过电化学腐蚀试验以及Mott-Schottky分析,研究了时效处理对合金耐腐蚀性能的影响。结果表明:740℃时效处理可以促进γ′沉淀强化相[Ni_(3)(Al,Ti)]在合金中的析出;随时效时间的增加,γ′析出相的密度和尺寸增加;同时,时效处理会增加合金表面点缺陷数量,降低合金钝化膜致密性,从而导致合金耐点蚀性降低;通过恒电位阳极极化处理能够有效降低合金表面点缺陷数量,提高合金耐点蚀性。 展开更多
关键词 Fe-Ni基奥氏体合金 时效处理 γ′析出相 耐点蚀性能 表面改性
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