Dermatofibrosarcoma protuberans(DFSP), the most common dermal sarcoma, is a low-grade, slow growing fibroblastic malignant neoplasm that most frequently affects middle aged adults and is characterized by a high local ...Dermatofibrosarcoma protuberans(DFSP), the most common dermal sarcoma, is a low-grade, slow growing fibroblastic malignant neoplasm that most frequently affects middle aged adults and is characterized by a high local recurrence rate and a low propensity for metastasis. Wide surgical resection or Mohs micrographic surgery(MMS) are the preferred approaches for localized disease, while radiation therapy is warranted for inoperable disease or for cases with positive margins where re-excision is not possible. DFSP is generally regarded as refractory to conventional chemotherapy. Treatment options for systemic disease were limited until the discovery of a unique translocation, t(17;22)(q22;q13)(COL1A1;PDGFB) found in a majority of cases. In recent years, imatinib, a PDGFβR, ABL and KIT inhibitor, has revolutionized systemic therapy in DFSP. In this review, we summarize the epidemiological, clinical, histological and genetic characteristics of DFSP and update the readers on its current management.展开更多
Reconstruction of defects on the chin represents a challenge given the functional, multidirectional movement of the chin subunit. In this article, we describe the surgical technique of a bilateral O to Z rotation flap...Reconstruction of defects on the chin represents a challenge given the functional, multidirectional movement of the chin subunit. In this article, we describe the surgical technique of a bilateral O to Z rotation flap on the chin, as well as complications, cosmetic outcome, and patient satisfaction. A retrospective chart review from January 2009-June 2011 identified twelve patients where an O to Z flap was used to repair a surgical defect. Of the twelve patients identified, one patient had a presumed post-operative infection, and one patient required additional corrections. There were no complications of hematomas or flap necrosis. Overall patient cosmetic outcome was excellent. An O to Z closure is an option for chin reconstruction of small to medium defects that offers a satisfactory cosmetic outcome, high patient satisfaction and low complication rate.展开更多
基金support from the NIHR Royal Marsden/ICR Biomedical Research Center
文摘Dermatofibrosarcoma protuberans(DFSP), the most common dermal sarcoma, is a low-grade, slow growing fibroblastic malignant neoplasm that most frequently affects middle aged adults and is characterized by a high local recurrence rate and a low propensity for metastasis. Wide surgical resection or Mohs micrographic surgery(MMS) are the preferred approaches for localized disease, while radiation therapy is warranted for inoperable disease or for cases with positive margins where re-excision is not possible. DFSP is generally regarded as refractory to conventional chemotherapy. Treatment options for systemic disease were limited until the discovery of a unique translocation, t(17;22)(q22;q13)(COL1A1;PDGFB) found in a majority of cases. In recent years, imatinib, a PDGFβR, ABL and KIT inhibitor, has revolutionized systemic therapy in DFSP. In this review, we summarize the epidemiological, clinical, histological and genetic characteristics of DFSP and update the readers on its current management.
文摘Reconstruction of defects on the chin represents a challenge given the functional, multidirectional movement of the chin subunit. In this article, we describe the surgical technique of a bilateral O to Z rotation flap on the chin, as well as complications, cosmetic outcome, and patient satisfaction. A retrospective chart review from January 2009-June 2011 identified twelve patients where an O to Z flap was used to repair a surgical defect. Of the twelve patients identified, one patient had a presumed post-operative infection, and one patient required additional corrections. There were no complications of hematomas or flap necrosis. Overall patient cosmetic outcome was excellent. An O to Z closure is an option for chin reconstruction of small to medium defects that offers a satisfactory cosmetic outcome, high patient satisfaction and low complication rate.
