Six novel monacolin analogs, monacolins V_1–V_6(1–6), together with seven known ones(7–13), were isolated from the ethyl acetate extract of red yeast rice. Their structures and absolute configurations were determin...Six novel monacolin analogs, monacolins V_1–V_6(1–6), together with seven known ones(7–13), were isolated from the ethyl acetate extract of red yeast rice. Their structures and absolute configurations were determined by spectroscopic methods,especially 2D NMR(~1H-~1HCOSY, HSQC, HMBC, and NOESY/ROESY) and CD spectroscopic analyses as well as chemical derivation.Monacolins V_2(2) and V_3(3) represent the first examples of monacolins with 3-hydroxybutyrate substitute. The anti-inflammatory inhibitory activities against the lipopolysaccharide(LPS) induced NO production in BV-2 cells as well as antioxidant activities against rat liver microsomal lipid peroxidation were evaluated.展开更多
In the 1970's, a Japanese scientist discoveredthat some strains of Monascus spp. when theygrew on rice might produce a certain secondary me-tabolite, known collectively as Monacolin K,which could effectively inhib...In the 1970's, a Japanese scientist discoveredthat some strains of Monascus spp. when theygrew on rice might produce a certain secondary me-tabolite, known collectively as Monacolin K,which could effectively inhibit HMG-CoA reduc-tase and had many bio-activities such as展开更多
基金supported financially by CAMS Initiative for Innovative Medicine(No.2017-I2M-4-004)the Drug Innovation Major Project(No.2018ZX09711001-006)
文摘Six novel monacolin analogs, monacolins V_1–V_6(1–6), together with seven known ones(7–13), were isolated from the ethyl acetate extract of red yeast rice. Their structures and absolute configurations were determined by spectroscopic methods,especially 2D NMR(~1H-~1HCOSY, HSQC, HMBC, and NOESY/ROESY) and CD spectroscopic analyses as well as chemical derivation.Monacolins V_2(2) and V_3(3) represent the first examples of monacolins with 3-hydroxybutyrate substitute. The anti-inflammatory inhibitory activities against the lipopolysaccharide(LPS) induced NO production in BV-2 cells as well as antioxidant activities against rat liver microsomal lipid peroxidation were evaluated.
文摘In the 1970's, a Japanese scientist discoveredthat some strains of Monascus spp. when theygrew on rice might produce a certain secondary me-tabolite, known collectively as Monacolin K,which could effectively inhibit HMG-CoA reduc-tase and had many bio-activities such as
