Multicenter Clinical Randomized Controlled Trial and Network Pharmacology Analysis of Zhenzhu Qingyuan Granules for the Treatment of Gastroesophageal Reflux Disease

Objective To evaluate the clinical efficacy and safety of Zhenzhu Qingyuan Granules through a clinical randomized controlled trial and to analyze the potential action targets and pathways of this formula using network pharmacology.Methods Patients with gastroesophageal reflux disease(GERD)of liver–stomach stagnant heat pattern who met the inclusion and exclusion criteria were randomly divided into the control group and the observation group.The control group received oral rabeprazole,whereas the observation group were given Zhenzhu Qingyuan Granules in addition to the rabeprazole.The treatment duration was 8 weeks.Clinical efficacy was observed in both groups after 8 weeks.Network pharmacology was used to analyze the action targets of ZhenzhuQingyuanGranules and the genes related to GERD,and core targets were inferred.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted to explore the potential mechanisms of this formula.Results The clinical research results showed that the total effective rate in the treatment group was 92.68%,compared with 70.00%in the control group,with a statistically significant difference(p<0.05).After treatment,both Chinese medicine syndrome score and endoscopic score improved in both groups compared with before treatment(p<0.05),and the treatment group showed greater improvement than the control group(p<0.05).Network pharmacology identified effective components of Zhenzhu Qingyuan Granules for treating GERD,including quercetin,luteolin,andβ-sitosterol,with potential action targets such as tumor protein 53(TP53),protein kinase B(AKT1),and tumor necrosis factor.Conclusion Zhenzhu Qingyuan Granules can significantly improve clinical symptoms in patients with GERD of liver–stomach stagnated heat pattern,enhance clinical efficacy,and have high safety.This formula may exert therapeutic effects through multiple targets and pathways.

Parameters Optimization of the Heating Furnace Control Systems Based on BP Neural Network Improved by Genetic Algorithm

The heating technological requirement of the conventional PID control is difficult to guarantee which based on the precise mathematical model,because the heating furnace for heating treatment with the big inertia,the pure time delay and nonlinear time-varying.Proposed one kind optimized variable method of PID controller based on the genetic algorithm with improved BP network that better realized the completely automatic intelligent control of the entire thermal process than the classics critical purporting(Z-N)method.A heating furnace for the object was simulated with MATLAB,simulation results show that the control system has the quicker response characteristic,the better dynamic characteristic and the quite stronger robustness,which has some promotional value for the control of industrial furnace.

Method for Incorporation of Controllability in Heat Exchanger Network Synthesis by Integrating Mathematical Programming and Knowledge Engineering

A method for incorporation of controlling the heat exchanger networks with or without splits is proposed by integrating mathemati-cal programming and knowledge engineering. The simultaneous optimal mathematical model is established. This method can be practically used in the integration of large-scale heat exchanger networks, not only to synthesize automatically but also to satisfy the requirement of struc-tural controllability with more objective human intervention.

Bypass Selection for Control of Heat Exchanger Network

Considering the flexibility and controllability of heat exchanger networks (HENs), bypasses are widely used for effective control of process stream target temperatures. However, the optimal location for the bypass is generally difficult to design with the trade-off between controllability and capital investments. In this paper, based on the steady-state model of heat exchanger networks the optimal bypass location was firstly selected by iteratively calculating the non-square Relative Gain Array (ns-RGA). To simplify the calculation process, rules of bypass selection were also proposed. In order to evaluate this method, then, the structural controllability of heat exchanger networks was analyzed. With both the consideration of the controllability and capital investments, the bypasses locations were finally selected. A case study on the HEN in Crude Distillation Unit was presented in which the ns-RGA and structural controllability were used to select bypasses and also to evaluate the results.

Control System of Neutral Beam Injection on HT-7

Neutral Beam Injection control system (NBICS) is constructed to measure the plasma current, Magnet current, vacuum pressure, cryopump temperature, control water cooling, filament voltage, and power supply, etc. The NBICS, consisting mainly of a Programmable Logic Controller (PLC) subsystem, data acquisition and processing subsystem and cryopump and vacuum pressure monitoring subsystem, has successfully been used on a NBI device. In this article, the design of NBICS on HT-7 is discussed and each subsystem is described in particular. In addition, some experimental results are reported which are very important data for further research related to the HT-7 tokamak.

Monitoring and control technology of solar photovoltaic power generation system

In view of characteristics of solar photovoltaic (PV) power station such as the decentralized layout and massive monitoring and control information, a solar PV power generation monitoring and control system has been designed. The system is designed into three layers namely the sensor and actuator layer, the PLC field monitoring and control layer and the remote network monitoring and control layer. Through ZigBee wireless network, PROFIBUS and GPRS wireless network, the system makes the three layers exchange information rapidly, and the system supervises not only various operational parameters of the power generating system but also weather changes as a way to change the solar tracking strategy of the PV power generating system and reduce the operating energy consumption of the system. Through the hardware redundant design of PLC central controller and the upper computer, the solar PV power station can be more secure and reliable when running.

Application of ArtificialNeural Network to Real-Time Condition Monitoring Control and Usual Trouble Diagnosis during Driling

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5-29 Establishment of HIRFL Control Network Monitoring Platform

There are a lot of equipments in HIRFL such as faraday cups, view screens power supplies, RF (radio frequency)equipment, vacuum equipment, and so on. A growing number of equipment support network interface in theseyears. Thus the control network system of HIRFL has become more and more big and complicated. So it is veryimportant to ensure that each device is online. We built a network monitoring platform. There are three functions.The first is monitoring the online or offline state of each switch. Second, the devices in the control network belongto different subsystem and are managed by subsystem managers. We cannot guarantee that each device is notdropped, but we can have a warning system which can warn device manager once the device dropped. Third, ifsome ports are abnormal, the information can be immediately reported to the administrator. Therefore, the controlnetwork monitoring platform has three subsystems, switch monitoring system, equipment offline warning systemand switch log analysis system, as shown in Fig. 1.

A Modification of SOM Network(SLFM) and Its Applications in Tool Wear Monitoring and Quality Control

In this paper, a Supervised Linear Feature Mapping(SLFM) algorithm, as a modification of the Kohonen Self Organizing Mapping (SOM),is proposed. The applications in cutting tool wear estimation and quality control and the comparison with a back propagation (BP) algorithm are discussed. The results show that the SLFM algorithm requires less training time and has higher accuracy compared with the BP algorithm. It might be a great potential approach to integrate multi sensor information in process control.

Heat exchanger network synthesis integrated with flexibility and controllability

Over the last three decades,flexibility and controllability considerations for heat exchanger networks(HENs)have received great attention,respectively.However,they should be simultaneously incorporated in HEN synthesis to allow the economic performance to be achievable in a practical operating environment.This paper proposes a method for simultaneous synthesis of flexible and controllable HEN by considering their coupling.The key idea is to add the bypasses with optimized initial fractions and positions to explore such coupling,and consequently enabling HENs to be operated successfully over a range of disturbance variations.These are implemented by identifying and quantifying disturbance propagations,and then examining the sensitivity of bypasses to the entire HEN.In this way,the superstructurebased mixed integer non-linear programming(MINLP)with objective function of minimizing the total annual cost is formulated.A case study is used to demonstrate the application of the proposed method.Quantitative measures and dynamic simulation show the ability to provide the satisfactory flexibility and controllability of the obtained HEN.

A Multi-Interface Remote Monitoring and Control System Architecture Based on Embedded Server

This paper presents a multi-interface embedded server architecture for remote real-time monitoring system and distributed monitoring applications. In the scheme,an embedded microprocessor( LPC3250 from NXP) is chosen as the CPU of the embedded server with a linux operation system( OS) environment. The embedded server provides multiple interfaces for supporting various application scenarios. The whole network is based on local area network and adopts the Browser / Server( B / S) model. The monitoring and control node is as a browser endpoint and the remote node with an embedded server is as a server endpoint. Users can easily acquire various sensors information through writing Internet protocol address of remote node on the computer browser. Compared with client / server( C / S) mode,B / S model needs less maintain and can be applicable to large user group. In addition,a simple network management protocol( SNMP) is used for management of devices in Internet protocol( IP) networks. The results of the demonstration experiment show that the proposed system gives good support to manage the network from different user terminals and allows the users to better interact with the ambient environment.

Burstiness-Aware Congestion Control Protocol for Wireless Sensor Networks

In monitoring Wireless Sensor Networks(WSNs),the traffic usually has bursty characteristics when an event occurs.Transient congestion would increase delay and packet loss rate severely,which greatly reduces network performance.To solve this problem,we propose a Burstiness-aware Congestion Control Protocol(BCCP) for wireless sensor networks.In BCCP,the backoff delay is adopted as a congestion indication.Normally,sensor nodes work on contention-based MAC protocol(such as CSMA/CA).However,when congestion occurs,localized TDMA instead of CSMA/CA is embedded into the nodes around the congestion area.Thus,the congestion nodes only deliver their data during their assigned slots to alleviate the contention-caused congestion.Finally,we implement BCCP in our sensor network testbed.The experiment results show that BCCP could detect area congestion in time,and improve the network performance significantly in terms of delay and packet loss rate.

Design and implementation of an expert system for remote fault diagnosis in ship lift

In this paper an expert system for remote fault diagnosis in the ship lift was developed by analysis of the fault tree and combination with VPN. The fault tree was constructed based on the operation condition of the ship lift. The diagnosis model was constructed by hierarchical classification of the fault tree structure, and the inference mechanism was given. Logical structure of the fault diagnosis in the ship lift was proposed. The implementation of the expert system for remote fault diagnosis in the ship lift was discussed, and the expert system developed was realized on the VPN virtual network. The system was applied to the Gaobaozhou ship lift project, and it ran successfully.

Two-tier control structure design methodology applied to heat exchanger networks

Because of its paramount importance in the successful industrial control strategy of a given heat exchanger network(HEN),the control structure designs for providing appropriate manipulated variable(MV)and controlled variable pairings have received considerable attention.However,quite frequently HENs with such control structures face the problem of hard constraints,typically holding the HENs at less controlled operating space.So both the MV pairings and the above control pairings should be considered to design a control structure.This paper investigates the systematic incorporation of the two pairings,and presents a methodology for designing such two-tier control structure.This is developed based on the sequential strategy,coupling an indirect-tier with direct-tier control structure design,wherein the intention is realized in the former stage and the latter is implemented for further optimization.The MV identification and pairing are achieved through variations in heat load of heat exchangers to design the indirect-tier control structure.Then the direct-tier control structure is followed the relative gain array pairing rules.With the proposed methodology,on the one hand,it generates an explicit connection between the MV pairings and the HEN configuration,and the quantitative interaction measure is improved to avoid the multiple solutions to break the relationship among all the control pairings into individuals;on the other hand,a two-tier control structure reveals control potentials and control system design requirements,this may avoid complex and economically unfavourable control and HEN structures.The application of proposed framework is illustrated with two cases involving the dynamic simulation analysis,the quantitative assessment and the random test.

Smart Street Lighting Control and Monitoring System for Electrical Power Saving by Using VANET

The huge amount of electrical power of many countries is consumed in lighting the streets. However, vehicles pass with very low rate in specific periods of time and parts of the streets are not occupied by vehicles over time. In this paper, we propose a system that automatically switches off the light for the parts of the streets having no vehicles and turns on the light for these parts once there are some vehicles that are going to come. Logically, this system may save a large amount of the electrical power. In addition, it may increase the lifetime of the lamps and reduce the pollutions. This system automatically controls and monitors the light of the streets. It can light only the parts that have vehicles and help on the maintenance of the lighting equipments. Vehicular Ad-Hoc Networks (VANET) make it possible to propose such system. VANET enables the possibility to know the presence of vehicles, their locations, their directions and their speeds in real time. These quantities are what are needed to develop this system. An advantage of using VANET is that there is no need to use specific network and equipments to design the system, but VANET infrastructure will be used. This decreases the cost and speed up the deployment of such system. This paper focuses on the proposal of different possible architectures of this system. Results show that the saved energy may reach up to 65% and an increase of the lifetime of the lamps of 53%.

A Realistic ICT Network Design and Implementation in the Neighbourhood Area of the Smart Grid

The Smart Grid has three main characteristics, which are to some degree antagonistic. These characteristics are: provision of good power quality, energy cost reduction and improvement in the reliability of the grid. The need to ensure that they can be accomplished together demands a much richer ICT monitoring and control network than the current system. In this paper we particularly investigate the design and deployment of the ICT system in the urban environment, specifically in a university campus that is embedded in a city, thus it represents the Neighbourhood Area Network (NAN) level of the Smart Grid. In order to design an ICT infrastructure, we have introduced two related architectures: namely communications network architecture and a software architecture. Having access to the characteristics of a real NAN guides us to choose appropriate communication technologies and identify the actual requirements of the system. To implement these architectures at this level we need to gather and process information from environmental sensors (monitoring e.g. temperature, movement of people and vehicles) that can provide useful information about changes in the loading of the NAN, with information from instrumentation of the Power Grid itself. Energy constraints are one of the major limitations of the communication network in the Smart Grid, especially where wireless networking is proposed. Thus we analyse the most energy efficient method of collecting and sending data. The main contribution of this research is that we propose and implement an energy efficient ICT network and describe our software architecture at the NAN level, currently very underdeveloped. We also discuss our experimental results. To our knowledge, no such architectures have yet been implemented for collecting data which can provide the basis of Decision Support Tools (DSTs).

Wireless Sensor Network for Monitoring Maturity Stage of Fruit

In this letter, we present a wireless sensor network for monitoring the maturity stage of fruit. A dual-polari- zation coupled patch sensor, which is robust to environmental changes, was designed to operate at 2.45 GHz. It was attached to a Durian fruit for a period of days to measure the magnitude of mutual coupling corresponding mainly to the starch concentration of its pulp. Signal was transmitted from a sensor node, via tree nodes, to a master node that displays the variations occurring in the period. The maximum mutual coupling occurred at the maturity stage of 60% whereas the minimum occurred at 70%. These results demonstrate that this wireless sensor network can enable fruit growers to harvest their Durians at an appropriate time, providing a reliable quality control for export.

Special Marking of 3D Networks＇ Points for the Monitoring of Modern Constructions

In order to monitor the deformations of modern constructions a local 3D network was usually being established at the surrounding area. The centering error, of both the instrument and targets, causes significant uncertainties in the determination of the x, y, z coordinates of the network＇s points. In order to assure precise centering for both the instrument and targets, not only for the accessible but also for the inaccessible network＇s points, a prototype way of marking is being implied. A special semi-permanent portable metallic stand （Photo 1） was manufactured for marking the accessible points. The stand provides forced instrument centering of the order of_＋0, lmm. It is light enough to carry, it accelerates and facilitates the centering and leveling of the instrument as well as it eliminates the time needed for the measurements. The applied laboratory checks in order to certify the suitability of its use and the provided accuracy are being described. For the inaccessible points special targets were used. The targets were put in permanent attachments （Photos 7-8）, which were also manufactured. Useful conclusions were drawn when these special accessories were used in to a 3D network, which was established for the monitoring of a new football stadium. Two measurement phases were carried out. The first one is with the stadium empty and the second one is when it was crowded （about 32000 people） during a significant football match.

加热炉炉温智能控制系统设计与实现

加热炉作为钢铁工业生产的重要设备,对钢坯等物料加热质量有重要的影响,能够将金属物料加热到轧制所需的温度。目前,加热炉已经应用到冶金、机械、建材、轻工等多个领域。加热炉属于高耗能窖炉,资源耗费较大,在加热过程中会随着烟气损耗大量的热量,随着科技的快速发展,智能控制技术已经运用工业生产中,通过智能控制系统对加热炉炉温进行控制,可以有效对温度进行调节,符合锻造需求。综合分析加热炉的构成以及工作原理,并介绍加热炉的炉温控制重点,并提出一种加热炉的炉温智能控制系统设计方案,希望能够提升加热炉的生产效率,改善产品质量,节约资源减少环境污染问题。

无模型自适应滑模控制的微波加热过程温度控制

微波加热模型具有无限维、非线性和时变等特点,导致控制器难于设计和实现。针对此问题,提出了一种适用于微波加热过程的无模型自适应滑模控制方法。首先,对微波加热过程传热数学模型进行分析,建立了微波加热过程输入功率与温度之间的全格式动态线性化数据模型。然后,根据该数据模型设计了无模型自适应滑模控制器,并给出了数据模型中相关未知时变参数和未知干扰的估计算法。最后,利用COMSOL和MATLAB进行仿真,仿真结果验证了所提控制方法的有效性。