In this paper,crude monkshood polysaccharide was isolated from Radix Aconiti Lateralis Preparata.The effects of crude monkshood polysaccharide on Escherichia coli and Staphylococcus aureus were investigated by microca...In this paper,crude monkshood polysaccharide was isolated from Radix Aconiti Lateralis Preparata.The effects of crude monkshood polysaccharide on Escherichia coli and Staphylococcus aureus were investigated by microcalorimetry.The power-time curves of the bacterial growth at various concentrations (c) of crude monkshood polysaccharide were plotted with a TAM air isothermal microcalorimeter at 37 °C.The growth rate constant (μ),inhibitory ratio (I),peak-height (Pm),and peak-time (tm) were calculated.From the data,the relationship between μ and c also was established.The growth rate constant μ decreased with the increasing concentrations of crude monkshood polysaccharide.Moreover,Pm reduced and tm increased with increasing concentrations.The experimental results revealed that crude monkshood polysaccharide had inhibitory activity towards S.aureus and E.coli.Results obtained from our study strongly suggest that microcalorimetry is a fast,simple,and more sensitive technology that can be easily performed to study the effect of drugs on bacteria.展开更多
目的:梳理炮制对附子成分与药理作用的影响及其历史沿革。方法:通过检索中国知网、维普、万方、PubMed、Web of Science等数据库,查阅近年国内外相关文献,对其进行整理、归纳与总结。结果:中药炮制对附子的成分与药理作用均有影响,且不...目的:梳理炮制对附子成分与药理作用的影响及其历史沿革。方法:通过检索中国知网、维普、万方、PubMed、Web of Science等数据库,查阅近年国内外相关文献,对其进行整理、归纳与总结。结果:中药炮制对附子的成分与药理作用均有影响,且不同炮制方法之间存在一定差异。结论:中药炮制作为能够使附子减毒存效的重要加工方法,其对临床辨证论治及安全使用附子发挥关键作用。展开更多
基金Project supported by the Natural Science Foundation of Shandong Province (No. Y2007C141)the Independent Innovation Foundation of Shandong University (No. 2010TS041)the Award Program for Outstanding Young Scientist of Shandong Province (No. 2007BS02002), China
文摘In this paper,crude monkshood polysaccharide was isolated from Radix Aconiti Lateralis Preparata.The effects of crude monkshood polysaccharide on Escherichia coli and Staphylococcus aureus were investigated by microcalorimetry.The power-time curves of the bacterial growth at various concentrations (c) of crude monkshood polysaccharide were plotted with a TAM air isothermal microcalorimeter at 37 °C.The growth rate constant (μ),inhibitory ratio (I),peak-height (Pm),and peak-time (tm) were calculated.From the data,the relationship between μ and c also was established.The growth rate constant μ decreased with the increasing concentrations of crude monkshood polysaccharide.Moreover,Pm reduced and tm increased with increasing concentrations.The experimental results revealed that crude monkshood polysaccharide had inhibitory activity towards S.aureus and E.coli.Results obtained from our study strongly suggest that microcalorimetry is a fast,simple,and more sensitive technology that can be easily performed to study the effect of drugs on bacteria.
文摘目的:梳理炮制对附子成分与药理作用的影响及其历史沿革。方法:通过检索中国知网、维普、万方、PubMed、Web of Science等数据库,查阅近年国内外相关文献,对其进行整理、归纳与总结。结果:中药炮制对附子的成分与药理作用均有影响,且不同炮制方法之间存在一定差异。结论:中药炮制作为能够使附子减毒存效的重要加工方法,其对临床辨证论治及安全使用附子发挥关键作用。