Background: Studies have shown a strong correlation between the growth of E2 in serum and estrone-3-glucuronide (E1-3G) in urine during ovarian stimulation. Thus, we developed theoretical models for using urinary E1-3...Background: Studies have shown a strong correlation between the growth of E2 in serum and estrone-3-glucuronide (E1-3G) in urine during ovarian stimulation. Thus, we developed theoretical models for using urinary E1-3G in ovarian stimulation and focused on their experimental verification and analysis. Methods: A prospective, observational pilot study was conducted involving 54 patients who underwent 54 cycles of ovarian stimulation. The goal was to establish the growth rate of urinary E1-3G during the course of stimulation and to determine the daily upper and lower limits of growth rates at which stimulation is appropriate and safe. Controlled ovarian stimulation was performed using two different stimulation protocols—an antagonist protocol in 25 cases and a progestin-primed ovarian stimulation protocol (PPOS) in 29 cases, with fixed doses of gonadotropins. From the second day of stimulation, patients self-measured their daily urine E1-3G levels at home using a portable analyzer. In parallel, a standard ultrasound follow-up protocol accompanied by a determination of E2, LH, and P levels was applied to optimally control stimulation. Results: The average daily growth rates in both groups were about 50%. The daily increase in E1-3G for the antagonist protocol ranged from 14% to 79%, while they were 28% to 79% for the PPOS protocol. Conclusion: This is the first study to analyze the dynamics of E1-3G in two different protocols and to estimate the limits of its increase during the entire course of the stimulation. The results confirm our theoretical model for the viability of using urinary E1-3G for monitoring ovarian stimulation.展开更多
Visual arts refer to art experienced primarily through vision.3D visual optical art is one of them.Artists use their rich imagination and experience to combine light and objects to give viewers an unforgettable visual...Visual arts refer to art experienced primarily through vision.3D visual optical art is one of them.Artists use their rich imagination and experience to combine light and objects to give viewers an unforgettable visual experience.How-ever,the design process involves much trial and error;therefore,it is often very time-consuming.This has prompted many researchers to focus on proposing various algorithms to simplify the complicated design processes and help artists quickly realize the arts in their minds.To help computer graphics researchers interested in creating 3D visual optical art,we first classify and review relevant studies,then extract a general framework for solving 3D visual optical art design problems,and finally propose possible directions for future research.展开更多
The paper develops a passive sub-millimeter precipitation retrievals algorithm for Microwave Humidity and Temperature Sounder(MWHTS)onboard the Chinese Feng Yun 3C(FY-3C)satellite.The retrieval algorithm employs a num...The paper develops a passive sub-millimeter precipitation retrievals algorithm for Microwave Humidity and Temperature Sounder(MWHTS)onboard the Chinese Feng Yun 3C(FY-3C)satellite.The retrieval algorithm employs a number of neural network estimators trained and evaluated using the validated global reference physical model NCEP/WRF/ARTS,and works for seawater.NCEP data per 6 hours are downloaded to run the Weather Research and Forecast model WRF,and derive the typical precipitation data from the whole world.The Atmospheric Radiative Transfer Simulator ARTS is feasible for performing simulations of atmospheric radiative transfer.Rain detection algorithm has been used to generate level 2 products.Retrievals are reliable for surface precipitation rate higher than 0.1 mm/h at 15km resolution,which is in good agreement with those retrieved using the Precipitation retrieval algorithm version 1(ATMP-1)for Advanced Technology Microwave Sounder(ATMS)aboard Suomi NPP satellite.展开更多
文摘Background: Studies have shown a strong correlation between the growth of E2 in serum and estrone-3-glucuronide (E1-3G) in urine during ovarian stimulation. Thus, we developed theoretical models for using urinary E1-3G in ovarian stimulation and focused on their experimental verification and analysis. Methods: A prospective, observational pilot study was conducted involving 54 patients who underwent 54 cycles of ovarian stimulation. The goal was to establish the growth rate of urinary E1-3G during the course of stimulation and to determine the daily upper and lower limits of growth rates at which stimulation is appropriate and safe. Controlled ovarian stimulation was performed using two different stimulation protocols—an antagonist protocol in 25 cases and a progestin-primed ovarian stimulation protocol (PPOS) in 29 cases, with fixed doses of gonadotropins. From the second day of stimulation, patients self-measured their daily urine E1-3G levels at home using a portable analyzer. In parallel, a standard ultrasound follow-up protocol accompanied by a determination of E2, LH, and P levels was applied to optimally control stimulation. Results: The average daily growth rates in both groups were about 50%. The daily increase in E1-3G for the antagonist protocol ranged from 14% to 79%, while they were 28% to 79% for the PPOS protocol. Conclusion: This is the first study to analyze the dynamics of E1-3G in two different protocols and to estimate the limits of its increase during the entire course of the stimulation. The results confirm our theoretical model for the viability of using urinary E1-3G for monitoring ovarian stimulation.
基金This work is supported by the National Natural Science Foundation of China,No.62025207.
文摘Visual arts refer to art experienced primarily through vision.3D visual optical art is one of them.Artists use their rich imagination and experience to combine light and objects to give viewers an unforgettable visual experience.How-ever,the design process involves much trial and error;therefore,it is often very time-consuming.This has prompted many researchers to focus on proposing various algorithms to simplify the complicated design processes and help artists quickly realize the arts in their minds.To help computer graphics researchers interested in creating 3D visual optical art,we first classify and review relevant studies,then extract a general framework for solving 3D visual optical art design problems,and finally propose possible directions for future research.
文摘The paper develops a passive sub-millimeter precipitation retrievals algorithm for Microwave Humidity and Temperature Sounder(MWHTS)onboard the Chinese Feng Yun 3C(FY-3C)satellite.The retrieval algorithm employs a number of neural network estimators trained and evaluated using the validated global reference physical model NCEP/WRF/ARTS,and works for seawater.NCEP data per 6 hours are downloaded to run the Weather Research and Forecast model WRF,and derive the typical precipitation data from the whole world.The Atmospheric Radiative Transfer Simulator ARTS is feasible for performing simulations of atmospheric radiative transfer.Rain detection algorithm has been used to generate level 2 products.Retrievals are reliable for surface precipitation rate higher than 0.1 mm/h at 15km resolution,which is in good agreement with those retrieved using the Precipitation retrieval algorithm version 1(ATMP-1)for Advanced Technology Microwave Sounder(ATMS)aboard Suomi NPP satellite.
