The Suzuki-Miyaura reaction of methyl-5-bromo-8-（tosyloxy）-1,6-naphthyridine-7-carboxylate（5）,with 2 equiv. of arylboronic acids gave diarylated product, 5,8–diaryl-1,6-naphthyridine-7-carboxylate（7）, whereas 1...The Suzuki-Miyaura reaction of methyl-5-bromo-8-（tosyloxy）-1,6-naphthyridine-7-carboxylate（5）,with 2 equiv. of arylboronic acids gave diarylated product, 5,8–diaryl-1,6-naphthyridine-7-carboxylate（7）, whereas 1 equiv. of arylboronic acid resulted in site-selective formation of 5-aryl-8-（tosyloxy）-1,6-naphthyridine-7-carboxylate（8）. The reactions proceeded with excellent chemo-selectivity in favor of the bromide group. Likewise, one-pot reaction with completely different boronic acids by sequential addition produced 1,6-naphthyridine-7-carboxylates,（10） containing two different aryl groups at 5 and 8 positions.展开更多
基金the VIT University Vellore for the support and facilitiesSIF-VIT for their support of NMR(DST-FIST Fund)
文摘The Suzuki-Miyaura reaction of methyl-5-bromo-8-（tosyloxy）-1,6-naphthyridine-7-carboxylate（5）,with 2 equiv. of arylboronic acids gave diarylated product, 5,8–diaryl-1,6-naphthyridine-7-carboxylate（7）, whereas 1 equiv. of arylboronic acid resulted in site-selective formation of 5-aryl-8-（tosyloxy）-1,6-naphthyridine-7-carboxylate（8）. The reactions proceeded with excellent chemo-selectivity in favor of the bromide group. Likewise, one-pot reaction with completely different boronic acids by sequential addition produced 1,6-naphthyridine-7-carboxylates,（10） containing two different aryl groups at 5 and 8 positions.
