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Effect of Danzhijiangtang capsule on monocyte chemoattractant protein-1 mRNA expression in newly diagnosed diabetes subclinical vascular lesions 被引量:9
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作者 Zhao-Hui Fang Yan Liu +6 位作者 Tao-Tao Bao Ying-Qun Ni Jian Liu Guo-Bin Shi Ji-Ping Wu Jun-Ping Yang Hong Zhang 《World Journal of Gastroenterology》 SCIE CAS 2013年第19期2963-2968,共6页
AIM:To investigate the effect of Danzhijiangtang capsule(DJC) on monocyte chemoattractant protein-1(MCP-1) mRNA expression in newly diagnosed type 2 diabetes mellitus(T2DM) subclinical vascular lesions.METHODS:Sixty-t... AIM:To investigate the effect of Danzhijiangtang capsule(DJC) on monocyte chemoattractant protein-1(MCP-1) mRNA expression in newly diagnosed type 2 diabetes mellitus(T2DM) subclinical vascular lesions.METHODS:Sixty-two patients with newly diagnosed T2DM subclinical vascular lesions were randomly divided into a control group and treatment group of 31 cases each.Oral antidiabetic therapy with routine western medicine was conducted in both groups,and the treatment group was additionally treated with DJCs.The treatment course for both groups was 12 wk.Before and after treatment,the total efficiency and traditional Chinese medicine(TCM) syndrome score were calculated.The fasting plasma glucose(FPG),2-h plasma glucose(2hPG),fasting insulin(FINS),insulin resistance index(IRI),hemoglobin(Hb)A1c,blood lipids,and hemorheology indices were determined.In addition,the levels of vascular endothelial growth factors including thrombomodulin(TM),von Willebrand factor(vWF),P-selectin and MCP-1 mRNA were determined.RESULTS:After 12 wk of treatment,the TCM syndrome score was significantly decreased compared to before treatment in both groups.After treatment,FPG,2hPG,HbA1c,FINS,IRI,total cholesterol,triglycerides,low-density lipoprotein,high-density lipoprotein,whole blood low shear specific viscosity,plasma specific viscosity,TM,vWF,P-selectin and MCP-1 mRNA were significantly improved compared to before treatment in both groups.After treatment,the total efficiency and TCM syndrome score in the treatment group were better than in the control group.FINS,IRI,whole blood high shear specific viscosity,plasma specific viscosity,TM,vWF,P-selectin and MCP-1 mRNA level in the treatment group were significantly reduced after treatment compared with control group.CONCLUSION:DJCs are efficacious in supplementing qi,nourishing yin and invigorating blood circulation,and upregulate MCP-1 mRNA expression in patients with T2DM subclinical vascular lesions. 展开更多
关键词 Danzhijiangtang CAPSULE Type 2 DIABETES MELLITUS SUBCLINICAL vascular lesions monocyte CHEMOATTRACTANT protein-1
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Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis 被引量:7
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作者 Erwin Gbele Marcus Mhlbauer +7 位作者 Hartwig Paulo Monika Johann Christin Meltzer Franz Leidl Norbert Wodarz Reiner Wiest Jrgen Schlmerich Claus Hellerbrand 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第44期5558-5562,共5页
AIM:To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (MCP-1 ) gene in patients with spontaneous bacterial peritonitis (SBP).METHODS:MCP-1 genotyping was performed in 23 patients with SBP and... AIM:To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (MCP-1 ) gene in patients with spontaneous bacterial peritonitis (SBP).METHODS:MCP-1 genotyping was performed in 23 patients with SBP and 83 cirrhotic control patients with non-infected ascites.RESULTS:The frequency of carriers of the G-allele was lower in SBP patients but this difference did not reach statistical significance. However,in the subgroup of patients with alcoholic cirrhosis (n=80),carriers of the G-allele were significantly less frequent in SBP-patients (38.1%) than in cirrhotic controls (67.8%,P=0.021). CONCLUSION:In patients with alcoholic liver cirrhosis,the-2518 MCP-1 genotype AA is a risk factor for the development of SBP. 展开更多
关键词 monocyte chemotactic protein-1 CHEMOKINES Spontaneous bacterial peritonitis POLYMORPHISM LIVERCIRRHOSIS
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Molecular detection of monocyte chemotactic protein-1 polymorphism in spontaneous bacterial peritonitis patients 被引量:7
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作者 Maysa Kamal Salama Dina Sabry +8 位作者 Mohamed AS Al-Ghussein Rasha Ahmed Sayed AbdAllah Fatma Mohamed Taha Wael Fathy Miriam Safwat Wadie Mona Nabih Amr Abul-Fotouh Tarneem Darwish 《World Journal of Gastroenterology》 SCIE CAS 2014年第33期11793-11799,共7页
AIM: To investigate the association of the functional monocyte chemotactic protein-1 (MCP-1) promoter polymorphism (A-2518G) with spontaneous bacterial peritonitis (SBP).
关键词 monocyte chemotactic protein-1 GENOTYPE Spontaneous bacterial peritonitis Liver cirrhosis As-cites Gene expression INTERLEUKIN-10
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Effects of Simvastatin on NF-κB-DNA Binding Activity and Monocyte Chemoattractant Protein-1 Expression in a Rabbit Model of Atherosclerosis 被引量:4
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作者 杨晓云 王琳 +3 位作者 曾和松 DUBEY Laxman 周宁 卜军 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2006年第2期194-198,共5页
To observe the effects of simvastatin on nuclear factor kappaB (NF-kB)-DNA binding activity and on the expression of monocyte chemoattractant protein-1 (MCP-1) in atherosclerotic plaque in rabbits and to explore t... To observe the effects of simvastatin on nuclear factor kappaB (NF-kB)-DNA binding activity and on the expression of monocyte chemoattractant protein-1 (MCP-1) in atherosclerotic plaque in rabbits and to explore the anti-atherosclerotic properties beyond its lipid-lowering effects. Thirty-six New Zealand male rabbits were randomly divided into low-cholesterol group (LC), high- cholesterol group (HC), high-cholesterol+ simvastatin group (HC+S) and then were fed for 12 weeks. At the end of the experiment, standard enzymatic assays, electrophoretic mobility shift as- say (EMSA), immunohistochemical staining, and morphometry were performed to observe serum lipids, NF-kB-DNA binding activity, MCP-1 protein expression, intirna thickness and plaque area of aorta respectively in all three groups. Our results showed that the serum lipids, NF-kB-DNA binding activity, expression of MCP-1 protein, intima thickness, and plaque area of aorta in the LC and HC+S groups were significantly lower than those in the HC group (P〈0.05). There was no significant difference in the serum lipids between the LC and HC+S groups (P〉0.05), but the NF-kB-DNA binding activity, the expression of MCP-1 protein and the intirna thickness and plaque area of aorta in the HC+S group were significantly decreased as compared to the LC group (P〈0. 05). This study demonstrated that simvastatin could decrease atherosclerosis by inhibiting the NF-kB-DNA binding activity and by reducing the expression of MCP-1 protein. 展开更多
关键词 SIMVASTATIN nuclear factor kappaB monocyte chemoattractant protein-1 ATHEROSCLEROSIS
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Expression of monocyte chemotactic protein-1/CCL2 in gastric cancer and its relationship with tumor hypoxia 被引量:3
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作者 Lei-Lei Tao Shu-Jing Shi +1 位作者 Long-Bang Chen Gui-Chun Huang 《World Journal of Gastroenterology》 SCIE CAS 2014年第15期4421-4427,共7页
AIM: To investigate the expression and prognostic value of CCL2 in gastric cancer, as well as its relationship with tumor hypoxia.
关键词 CHEMOKINES monocyte chemotactic protein-1/CCL2 Gastric cancer Prognostic marker IMMUNOHISTOCHEMISTRY
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Plasma monocyte chemotactic protein-1 remains elevated after minimally invasive colorectal cancer resection 被引量:2
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作者 HMC Shantha Kumara Elizabeth A Myers +7 位作者 Sonali AC Herath Joon Ho Jang Linda Njoh Xiaohong Yan Daniel Kirchoff Vesna Cekic Martin Luchtefeld Richard L Whelan 《World Journal of Gastrointestinal Oncology》 SCIE CAS 2014年第10期413-419,共7页
AIM: To investigate plasma Monocyte Chemotactic Protein-1 levels preoperatively in colorectal cancer(CRC) and benign patients and postoperatively after CRC resection.METHODS: A plasma bank was screened for minimally i... AIM: To investigate plasma Monocyte Chemotactic Protein-1 levels preoperatively in colorectal cancer(CRC) and benign patients and postoperatively after CRC resection.METHODS: A plasma bank was screened for minimally invasive colorectal cancer resection(MICR) for CRC and benign disease(BEN) patients for whom preoperative, early postoperative, and 1 or more late postoperative samples(postoperative day 7-27) were available. Monocyte chemotactic protein-1(MCP-1) levels(pg/mL) were determined via enzyme linked immuno-absorbent assay. RESULTS: One hundred and two CRC and 86 BEN patients were studied. The CRC patient's median preoperative MCP-1 level(283.1, CI: 256.0, 294.3) was higher than the BEN group level(227.5, CI: 200.2, 245.2; P = 0.0004). Vs CRC preoperative levels, elevated MCP-1 plasma levels were found on postoperative day 1(446.3, CI: 418.0, 520.1), postoperative day 3(342.7, CI: 320.4, 377.4), postoperative day 7-13(326.5, CI: 299.4, 354.1), postoperative day 14-20(361.6, CI: 287.8, 407.9), and postoperative day 21-27(318.1, CI: 287.2, 371.6; P < 0.001 for all). CONCLUSION: Preoperative MCP-1 levels were higher in CRC patients(vs BEN). After MICR for CRC, MCP-1 levels were elevated for 1 mo and may promote angiogenesis, cancer recurrence and metastasis. 展开更多
关键词 COLORECTAL cancer monocyte chemotactic protein-1 MINIMALLY invasive COLORECTAL RESECTION angio-genesis
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Malarial pigment enhances heat shock protein-27 in THP-1 cells:new perspectives for in vitro studies on monocyte apoptosis prevention 被引量:1
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作者 Mauro Prato Valentina Gallo +3 位作者 Elena Valente Amina Khadjavi Giorgia Mandili Giuliana Giribaldi 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2010年第12期934-938,共5页
Objective:To investigate the effect of malarial pigment(hemozoin,HZ) on expression of heat shock proteins(HSPs) and cell viability in human monocytes by using a stable cell line(THP-1 cells).Methods:THP-1 cells were f... Objective:To investigate the effect of malarial pigment(hemozoin,HZ) on expression of heat shock proteins(HSPs) and cell viability in human monocytes by using a stable cell line(THP-1 cells).Methods:THP-1 cells were fed with native HZ or treated with pro-apoptotic molecule gliotoxin for 9 h.Thereafter,the protein expression of HSP-27 and HSP-70 was evaluated by western blotting.Alternatively,HZ-fed cells were cultured up to 72 h and cell viability parameters(survival,apoptosis and necrosis rates) were measured by flow cytometric analysis. Results:HZ increased basal protein levels of HSP-27 without altering those of HSP-70 in THP-1 cells,and promoted long-term cell survival without inducing apoptosis.As expected,gliotoxin inhibited HSP-27 protein expression and promoted long-term cell apoptosis.Conclusions: Present data show that HZ prevents cell apoptosis and enhances the expression of anli-apoptotic HSP-27 in THP-1 cells,confirming the previous evidences obtained from HZ-fed immunopurified monocytes.Since the use of a stable cell line is pivotal to perform HSP-27 silencing experiments, monocytic THP-1 cells could be a good candidate line for such an approach,which is heavily required to clarify the role of HSP-27 in survival of impaired HZ-fed monocytes during falciparum malaria. 展开更多
关键词 HEMOZOIN PLASMODIUM FALCIPARUM Malaria monocyte THP-1 cells Phagocytosis APOPTOSIS Heat shock protein-27
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Expression of Monocyte Chemoattractant Protein-1 in Monocytes and Effects of Native and Oxidized Very Low Density Lipoproteins 被引量:1
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作者 王国平 邓仲端 倪娟 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 1997年第4期203-205,共3页
Monocyte chemoattractant protein-1(MCP-1), a potent chemoattractant, is thought to play an important role in migration of monocytes into atherosclerotic lesions. The present study was designed to investigate the capac... Monocyte chemoattractant protein-1(MCP-1), a potent chemoattractant, is thought to play an important role in migration of monocytes into atherosclerotic lesions. The present study was designed to investigate the capacity of human peripheral blood monocytes to express MCP-1 and effects of native very low density lipoprotein (VLDL) and oxidized VLDL(OX-VLDL) on the expression. The total RNA was extracted from cultured monocytes, which were exposed to VLDL and OX-VLDL, and the media conditioned by monocytes were collected. MCP-1 mRNA expression was examined by Northern blot analysis. MCP-1 protein in conditioned media was determined by using sandwich ELISA. The results showed that monocytes can express MCP-1 after a 24 h incubation at 37℃,and the expression was markedly increased by a exposure to OX-VLDL, whereas the expression was slightly increased when exposed to VLDL. It suggests that the capacity of monocytes to produce MCP-1 that recruits and activates circulating monocytes may be of considerable importance in atherogenesis, and oxidation of VLDL enhances its potential to promote atherogenesis. 展开更多
关键词 monocyte chemoattractant protein-1 very low density lipoprotein OXIDIZATION monocyteS ATHEROSCLEROSIS
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Monocyte chemotactic protein-1 gene polymorphism and spontaneous bacterial peritonitis 被引量:1
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作者 Levent Filik 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第7期914-914,共1页
I read with great interest the article by Gbele et al published in issue 44 of World J Gastroenterol 2009.The results of their study indicate that-2518 Monocyte chemotactic protein-1(MCP-1)genotype AA is a risk fact... I read with great interest the article by Gbele et al published in issue 44 of World J Gastroenterol 2009.The results of their study indicate that-2518 Monocyte chemotactic protein-1(MCP-1)genotype AA is a risk factor for spontaneous bacterial peritonitis in patients with alcoholic cirrhosis.However,there are some items that need to be discussed. 展开更多
关键词 Spontaneous bacterial peritonitis monocyte chemotactic protein-1 POLYMORPHISM
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Monocyte chemotactic protein-1 and soluble adhesion molecules as possible prognostic markers of the efficacy of antiviral treatment in chronic hepatitis C 被引量:1
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作者 AnatolPanasiuk DanutaProkopowicz BozenaPanasiuk 《World Journal of Gastroenterology》 SCIE CAS CSCD 2004年第24期3639-3642,共4页
AIM:To explain the role of Monocyte chemotactic protein-1 (MCP-1) and soluble adhesion molecules in chronic hepatitis C during the treatment of interferon alpha (IFNα) 2 b and ribavirin (RBV). METHODS:Concentrations ... AIM:To explain the role of Monocyte chemotactic protein-1 (MCP-1) and soluble adhesion molecules in chronic hepatitis C during the treatment of interferon alpha (IFNα) 2 b and ribavirin (RBV). METHODS:Concentrations of MCP-1,soluble adhesion molecules intercellular adhesion molecule-1 (sICAM-1),sP- selectin,interleukin (IL) 6,and IL10 in serum were estimated in the group of 40 patients with chronic hepatitis C treated with IFNalpha2 b and RBV in 0,16,32,48 wk of the therapy, RESULTS:In chronic hepatitis C,before and during the treatment,the serum levels of MCP-1 and sP-selectin in responders were similar to those of healthy subjects.In non- responders (NR),MCP-1 increased in the course of IFNc^+RBV treatment,differences were statistically significant as compared to responders.MCP-1 correlated statistically with the activity of periportal inflammation (r=0.35,P<0.05) but not with staging of liver fibrosis,sICAM-1 positively correlated with inflammatory activity and fibrosis in NR.sP-selectin did not correlate with histological findings in the liver.The MCP-1 correlated with the soluble form of sP-selectin concentrations (r= 6,P<0.001) and with IL-10 level in NR (r=0.4,P<0.05).There was no correlation observed between the concentration of MCP-1 and sICAM-1,IL-6 during the treatment. CONCLUSION:MCP-1 concentration may be a prognostic marker of the efficacy of IFN+RBV therapy in patients with chronic hepatitis C. 展开更多
关键词 Adult Antiviral Agents DOSAGE Biological Markers Female Hepatitis C Chronic Humans Intercellular Adhesion Molecule-1 INTERLEUKIN-10 INTERLEUKIN-6 Male Middle Aged monocyte Chemoattractant protein-1 P-SELECTIN Prognosis SOLUBILITY
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Correlation of serum cyclophilin A and monocyte chemoattractant protein-1 levels with carotid atherosclerosis in patients with acute cerebral infarction 被引量:1
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作者 Jun Jia Liang Huang Zhan-Hua Zhang 《Journal of Hainan Medical University》 2017年第11期150-153,共4页
Objective:To study the correlation of serum cyclophilin A (CyPA) and monocyte chemoattractant protein-1 (MCP-1) levels with carotid atherosclerosis in patients with acute cerebral infarction.Methods: 106 patients with... Objective:To study the correlation of serum cyclophilin A (CyPA) and monocyte chemoattractant protein-1 (MCP-1) levels with carotid atherosclerosis in patients with acute cerebral infarction.Methods: 106 patients with acute cerebral infarction who were hospitalized in our hospital between July 2011 and August 2015 were selected as observation group, and 50 cases of healthy persons who received physical examination in our hospital during the same period were selected as normal control group. The serum CyPA and MCP-1 contnets in two groups were determined. According to the median of CyPA and MCP-1 contents in observation group, they were divided into high CyPA group and low CyPA group as well as high MCP-1 group and low MCP-1 group, 53 cases in each group. Contents of lipid metabolism indexes and carotid atherosclerosis illness-related indicators were compared between acute cerebral infarction patients with different CyPA and MCP-1 contents.Results:Serum CyPA and MCP-1 contents in observation group were significantly higher than those in control group. Serum TC, LP(a) and LDL-C contents in high CyPA group and high MCP-1 group were higher than those in low CyPA group and low MCP-1 group while HDL-C contents were lower than those in low CyPA group and low MCP-1 group. Serum CysC, Hcy and UA contents in high CyPA group and high MCP-1 group were higher than those in low CyPA group and low MCP-1 group.Conclusion: Serum CyPA and MCP-1 contents in patients with acute cerebral infarction are higher than those in normal population, and the contents of CyPA and MCP-1 are positively correlated with the degree of carotid atherosclerosis. 展开更多
关键词 Acute cerebral INFARCTION CYCLOPHILIN A monocyte CHEMOATTRACTANT protein-1 CAROTID ATHEROSCLEROSIS
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The enhancement of astrocytic-derived monocyte chemoattractant protein-1 induced by the interaction of opiate and HIV tat in HIV-associated dementia
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作者 Xiao Han Biomedical Experimentation,School of Basic Medical Sciences,Peking University Health Science Center,Beijing 100191,China 《Journal of Pharmaceutical Analysis》 SCIE CAS 2009年第4期277-281,共5页
HIV-associated dementia(HAD)is a public health problem and is particularly prevalent in drug abusers.The neuropathogenesis of human immunodeficiency virus(HIV)infection involves a complex cascade of inflammatory event... HIV-associated dementia(HAD)is a public health problem and is particularly prevalent in drug abusers.The neuropathogenesis of human immunodeficiency virus(HIV)infection involves a complex cascade of inflammatory events,including monocyte/macrophage infiltration in the brain,glial immune activation and release of neurotoxic substances.In these events,astrocytic-derived monocyte chemoattractant protein-1(MCP-1)plays an important role,whose release is elevated by HIV transactivator of transcription(HIV tat)and could be further elevated by opiates.This review will also consider some critical factors and events in MCP-1 enhancement induced by the interactions of opiate and HIV tat,including the mediating role of mu opioid receptor(MOR)and CCR2 as well as the possible signal transduction pathways within the cells.Finally,it will make some future perspectives on the exact pathways,new receptors and target cells,and the vulnerability to neurodegeneration with HIV and opiates. 展开更多
关键词 DEMENTIA HIV transactivator of transcription ASTROCYTE MORPHINE monocyte chemoattractant protein-1
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Variation of Serum Monocyte Chemoattractant Protein-1 in Patients with Diabetes and Metabolic Syndrome
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作者 黎慧清 邓秀玲 +3 位作者 李贞琼 罗长青 刘建社 王玉梅 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2011年第3期312-316,共5页
This study investigated the variation of serum monocyte chemoattractant protein-1(MCP-1) in patients with both diabetes mellitus(DM) and metabolic syndrome(MS).Based on the International Diabetes Federation(IDF... This study investigated the variation of serum monocyte chemoattractant protein-1(MCP-1) in patients with both diabetes mellitus(DM) and metabolic syndrome(MS).Based on the International Diabetes Federation(IDF) diagnostic criteria,93 patients enrolled in this study were divided into four groups:normal control(NC),simple DM,simple MS,and DM plus MS(DM-MS) groups.The main measures included height,weight,waist circumference(WC),hip circumference,blood pressure,fasting blood glucose,insulin resistance index(HOMA-IR),serum triglyceride(TG),HDL-ch,LDL-ch,and MCP-1.The results showed that the serum levels of MCP-1 in the DM-MS group were significantly increased as compared with those in the DM and MS groups(P0.05),and the increase in the MCP-1 level in the DM group was much higher than in the MS group(P0.05).The DM-MS group had the highest HOMA-IR levels,followed by MS,DM and NC groups(P0.05).Correlation tests showed that the association of MCP-1 with age,HDL-ch,or LDL-ch was insignificant,whereas that of MCP-1 with body mass index(BMI),waist hip rate(WHR),WC,systolic blood pressure(SBP),diastolic blood pressure(DBP),TG,and HOMA-IR was significantly positive.It was concluded that circulating MCP-1 was substantially increased in patients with both DM and MS as compared with that in the patients with DM or MS alone,and the central obese state may contribute to a more vicious proinflammatory condition and insulin resistance in patients with diabetes. 展开更多
关键词 monocyte chemoattractant protein-1 DIABETES metabolic syndrome
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Effect of monocyte chemoattractant protein-1 on chemotactic gene expression by macrophage cell line U937
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作者 卞广兴 郭葆玉 +4 位作者 苗红 邱磊 曹冬梅 道书艳 张冉 《Journal of Medical Colleges of PLA(China)》 CAS 2004年第3期135-138,共4页
Objective: To study the chemotactic superfamily genes expression profiling of macrophage line U937 treated with monocyte chemoattractant protein-1 (MCP-1) using gene chip technique. Methods: Total RNA from macrophage ... Objective: To study the chemotactic superfamily genes expression profiling of macrophage line U937 treated with monocyte chemoattractant protein-1 (MCP-1) using gene chip technique. Methods: Total RNA from macrophage line U937 (as control) and U937 with MCP-1 was extracted, made reverse transcript to cDNA and tested with gene expression chip HO2 human. Results: Some chemotactic-related gene expressions were changed in all analyzed genes. Regulated upon activation, normal T cell expressed and secreted (RANTES) was up-regulated over 2-fold and 7 chemotactic-related genes (CCR2, CCR5, CCL16, GROβ, GROγ, IL-8 and granulocyte chemotactic protein 2) were down-regulated over 2-fold in MCP-1 treated U937 cells at mRNA level. Conclusion: MCP-1 can influence some chemokines and receptors expression in macrophage in vitro, in which MCP-1 mainly down-regulates the chemotactic genes expression of those influencing neutrophilic granulocyte (GROβ, GROγ, IL-8 and granulocyte chemotactic protein 2). Another novel finding is that it can also down-regulate the mRNA level of CCR5, which plays a critical role in many disorders and illnesses. 展开更多
关键词 monocyte chemoattractant protein-1 gene chip macrophage line U937
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Role of p38 Mitogen-activated Protein Kinase in Mediating Monocyte Chemoattractant Protein-1 in Human Umbilical Vein Endothelial Cells
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作者 李艳波 邓华聪 +1 位作者 郑丹 李呼伦 《Chinese Medical Sciences Journal》 CAS CSCD 2004年第1期71-71,共1页
关键词 Cells Cultured Endothelial Cells Humans Mitogen-Activated Protein Kinases monocyte Chemoattractant protein-1 RNA Messenger Research Support Non-U.S. Gov't Umbilical Veins p38 Mitogen-Activated Protein Kinases
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Monocyte chemoattractant protein-1 plays a key role in type 1 diabetes
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作者 DongLi GuoliangLiu 《Journal of Nanjing Medical University》 2005年第2期60-62,共3页
Type 1 diabetes is an autoimmune dise as e resulting from the selective destruction of β cells in the pa ncreatic islets. In both human and rodent models of type 1 diabetes, the clinica l disease is preceded by a pro... Type 1 diabetes is an autoimmune dise as e resulting from the selective destruction of β cells in the pa ncreatic islets. In both human and rodent models of type 1 diabetes, the clinica l disease is preceded by a progressive mononuclear cell invasion of the pancreat ic islets (insulitis). In the early stage of insulitis,the major components are monocyte/macrophages, and the recruitment of mononuclear cells is a critical st ep in the pathogenesis of the type 1 diabetes. Studies have revealed that Monocy te chemoattractant protein-1(MCP-1) specifically recruits monocytes/ macrophag es into pancreas and plays an important role in the development of insulitis and diabetes. 展开更多
关键词 monocyte chemoattractant protein-1 insulits type 1 diabetes
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Effect of Llinagliptin on tumor necrosis factor receptor and monocyte chemoattractant protein-1 in patients with diabetic nephropathy
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作者 Li-Yan Jia Xiao-Hui Cao +2 位作者 Yan-Yun Hu Yu Bai Jun Wang 《Journal of Hainan Medical University》 2019年第8期49-52,共4页
Objective:To explore the effect of Linagliptin on tumor necrosis factor receptor and monocyte chemoattractant protein-1 in patients with diabetic nephropathy.Methods: A total of 98 patients with diabetic nephropathy a... Objective:To explore the effect of Linagliptin on tumor necrosis factor receptor and monocyte chemoattractant protein-1 in patients with diabetic nephropathy.Methods: A total of 98 patients with diabetic nephropathy admitted to the Hospital from January 2017 to September 2018 were enrolled. The patients were divided into two groups according to the random double-blind method, with 49 cases in each group. The control group was treated with Metformin, whereas the experimental group was treated with Linagliptin plus Metformin. After 3 months of continuous treatment, the renal function [urinary albumin excretion rate, 24 h urine protein quantitation and serum creatinine], glycolipids metabolic levels [glycated hemoglobin, fasting blood glucose, total cholesterol and triglycerides], monocyte chemoattractant protein-1, tumor necrosis factor receptor, high-sensitivity C-reactive protein, and adverse reactions were compared between the two groups.Results:After 3 months of treatment, the levels of UAER, 24 h Upor and Scr in the experimental group were shown to be lower than those in the control group, and the difference was statistically significant. After 3 months of treatment, the levels of HbA1c, FPG, TC and TG in the experimental group were shown to be lower than the control group, and the difference was statistically significant. After 3 months of treatment, the levels of MCP-1, sTNFR1 and hs-CRP in the experimental group were lower than those in the control group, and the difference was statistically significant. There was no significant difference in incidence of adverse reactions between the two groups.Conclusion: For patients with diabetic nephropathy, Linagliptin is with higher safety, which can help improve their glycolipids metabolic levels and renal function, reduce the inflammatory response and the levels of MCP-1 and sTNFR1, and yet incur fewer adverse reactions. 展开更多
关键词 Diabetic NEPHROPATHY LINAGLIPTIN METFORMIN Tumor NECROSIS factor receptor monocyte CHEMOATTRACTANT protein-1
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Expression of macrophage inflammatory protein-1αin Kupffer cells following liver ischemia or reperfusion injury in rats 被引量:5
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作者 Wei Ma Zuo-Ren Wang +1 位作者 Lei Shi Yue Yuan 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第24期3854-3858,共5页
AIM: To explore the expression of macrophage inflammatory protein-1α (MIP-1α) in Kupffer cells (KCs) following liver ischemia/reperfusion injury IRI in rats. METHODS: Forty male SD rats were divided randomly i... AIM: To explore the expression of macrophage inflammatory protein-1α (MIP-1α) in Kupffer cells (KCs) following liver ischemia/reperfusion injury IRI in rats. METHODS: Forty male SD rats were divided randomly into five groups. A model of partial warm ischemia/ reperfusion injury in the rat liver was established. KCs were isolated and incubated one hour, six hours, 12 h, and 24 h after the reperfusion. Tumor necrosis factor alpha (TNF-α) and interleukin-lbeta (IL-1β) in the supernatants were measured by ELISA. MIP-1α in KCs was detected by immunocytochemical and RT-PCR. RESULTS: No or few MIP-1α protein and mRNA were expressed in the KCs of the control group. Its expression in the IRI group had a significant increase after the reperfusion (P 〈 0.05), which was contrary to the control group. CONCLUSION: The active behavior of the MIP-1α gene in KCs following liver ischemia/reperfusion injury is assumed to be one of the major causes for the hepatic ischemia/reperfusion injury. 展开更多
关键词 LIVER ISCHEMIA/REPERFUSION Kupffer cell Macrophage inflammatory protein-1α
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血清MCP-1和MIP-1β水平与老年脓毒症患者心肌损伤的相关性
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作者 万林 樊媛 张瑞 《心脏杂志》 CAS 2024年第4期412-416,共5页
目的探讨血清单核细胞趋化因子蛋白1(MCP-1)和巨噬细胞炎性蛋白-1β(MIP-1β)水平与老年脓毒症患者心肌损伤的相关性。方法前瞻纳入2021年3月~2022年3月医院50例出现心肌损伤的老年脓毒症患者,纳入心肌损伤组,同期50例未出现心肌损伤的... 目的探讨血清单核细胞趋化因子蛋白1(MCP-1)和巨噬细胞炎性蛋白-1β(MIP-1β)水平与老年脓毒症患者心肌损伤的相关性。方法前瞻纳入2021年3月~2022年3月医院50例出现心肌损伤的老年脓毒症患者,纳入心肌损伤组,同期50例未出现心肌损伤的老年脓毒症患者,纳入非心肌损伤组,测定并比较两组入院时血清MCP-1和MIP-1β水平,分析血清MCP-1和MIP-1β水平与老年脓毒症患者心肌损伤的关系。结果心肌损伤组血清心肌肌钙蛋白T(cTnT)、B型钠尿肽前体(Pro-BNP)、肌酸激酶同工酶(CK-MB)、MCP-1和MIP-1β表达水平高于非心肌损伤组,差异有统计学意义(均P<0.01);经单项Logistic回归分析后建立多元回归模型行多因素分析,结果显示,血清c TnT、Pro-BNP、CK-MB、MCP-1、MIP-1β表达与老年脓毒症患者心肌损伤有关,可能是老年脓毒症患者心肌损伤的预测因素(OR>1,P<0.05);绘制ROC曲线发现,血清MCP-1、MIP-1β表达单独及联合预测老年脓毒症患者心肌损伤的AUC均>0.850,均有一定预测价值。结论血清MCP-1、MIP-1β过表达可能与老年脓毒症患者心肌损伤有关,增加心肌损伤,联合检测老年脓毒症早期血清MCP-1和MIP-1β水平可预测心肌损伤风险。 展开更多
关键词 脓毒症 老年 心肌损伤 单核细胞趋化因子蛋白1 巨噬细胞炎性蛋白-1β 相关性
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ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn's disease patients 被引量:2
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作者 Simone CS Wolfkamp Caroline Verseyden +5 位作者 Esther WM Vogels Sander Meisner Kirsten Boonstra Charlotte P Peters Pieter CF Stokkers Anje A te Velde 《World Journal of Gastroenterology》 SCIE CAS 2014年第10期2664-2672,共9页
AIM: To investigate if the presence of relevant genetic polymorphisms has effect on the effectual clearance of bacteria by monocytes and granulocytes in patients with Crohn&#x02019;s disease (CD).
关键词 inflammatory bowel disease PHAGOCYTOSIS Polymorphism monocyteS GRANULOCYTES Nucleotide-binding ligomerization domain-containing protein 2 Immunity-related guanosine triphosphatase gene Autophagy related like 1
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