Comprehensive Summary,A new electrophilic monofluoromethylthiolating reagent N-fluoromethylthiophthalimide PhthSCH2F 1 was developed.Reagent 1 could be readily synthesized from easily available starting materials benz...Comprehensive Summary,A new electrophilic monofluoromethylthiolating reagent N-fluoromethylthiophthalimide PhthSCH2F 1 was developed.Reagent 1 could be readily synthesized from easily available starting materials benzyl mercaptan and CH_(2)FCl in three steps.N-Fluoromethylthiophthalimide 1 is a powerful electrophilic monofluoromethylthiolating reagent that allows the monofluoromethylthiolation of a wide range of nucleophiles including alkynes,aryl/vinyl boronic acids,electron-rich heteroarenes,β-ketoesters and oxindoles,as well as thiols under mild conditions.展开更多
基金the financial support from the National Key Research and Development Program of China(No.2021YFF0701700).
文摘Comprehensive Summary,A new electrophilic monofluoromethylthiolating reagent N-fluoromethylthiophthalimide PhthSCH2F 1 was developed.Reagent 1 could be readily synthesized from easily available starting materials benzyl mercaptan and CH_(2)FCl in three steps.N-Fluoromethylthiophthalimide 1 is a powerful electrophilic monofluoromethylthiolating reagent that allows the monofluoromethylthiolation of a wide range of nucleophiles including alkynes,aryl/vinyl boronic acids,electron-rich heteroarenes,β-ketoesters and oxindoles,as well as thiols under mild conditions.
