Objective To observe the injury of spatial memory in the rat of continuative illumination and the protection of catgut implantation at Nèiguān （内关 PC6） from the injury. Methods After training for 7 days in M...Objective To observe the injury of spatial memory in the rat of continuative illumination and the protection of catgut implantation at Nèiguān （内关 PC6） from the injury. Methods After training for 7 days in Morris＇s water maze of 4 quadrants, on the 8th day, 48 male Wistar rats of clear grade were randomly divided into a normal group, a model group, a melatonin （MT） group and a catgut implantation group, 12 rats each group. The spatial injury in the rats was induced by continuative and long-term （24 h and 42 days） illumination, and at the same time, they were treated with catgut implantation at Nèiguān （内关 PC6） and intraperitoneal injection of MT; changes of spatial memory ability and ultrastructures of the neurons of the hippocampus were detected by Morris＇s water maze and transmission electron microscope, respectively. Results The searching platform latency （SPL） in the Morris＇s water maze in the model group significantly prolonged as compared with that before modeling （P〈0.05）, and after treatment it was significantly shortened in the MT group and the catgut implantation group as compared with the model group （both P 〈 0.05）, but with no significant differences as compared with that before treatment （both P 〉0.05）. Mitochondria, synapses, axes and vascular endothelium in the hippocampus in the model group were injured in varying degrees, but a less injury was found in the MT group and the catgut implantation group which was similar to that in the normal group. Conclusion Catgut Implantation at Nèiguān （1内关 PC6） can protect from the injury of spatial memory in the rat of continuative illumination.展开更多
文摘Objective To observe the injury of spatial memory in the rat of continuative illumination and the protection of catgut implantation at Nèiguān （内关 PC6） from the injury. Methods After training for 7 days in Morris＇s water maze of 4 quadrants, on the 8th day, 48 male Wistar rats of clear grade were randomly divided into a normal group, a model group, a melatonin （MT） group and a catgut implantation group, 12 rats each group. The spatial injury in the rats was induced by continuative and long-term （24 h and 42 days） illumination, and at the same time, they were treated with catgut implantation at Nèiguān （内关 PC6） and intraperitoneal injection of MT; changes of spatial memory ability and ultrastructures of the neurons of the hippocampus were detected by Morris＇s water maze and transmission electron microscope, respectively. Results The searching platform latency （SPL） in the Morris＇s water maze in the model group significantly prolonged as compared with that before modeling （P〈0.05）, and after treatment it was significantly shortened in the MT group and the catgut implantation group as compared with the model group （both P 〈 0.05）, but with no significant differences as compared with that before treatment （both P 〉0.05）. Mitochondria, synapses, axes and vascular endothelium in the hippocampus in the model group were injured in varying degrees, but a less injury was found in the MT group and the catgut implantation group which was similar to that in the normal group. Conclusion Catgut Implantation at Nèiguān （1内关 PC6） can protect from the injury of spatial memory in the rat of continuative illumination.
