Dear Editor, Hypersensitivity to mosquito bites （HMB） is primarily seen in children and adolescents in Asia and Central America. HMB may be related to the reactivation of Eps- tein-Barr virus （EBV） in infectzd nat...Dear Editor, Hypersensitivity to mosquito bites （HMB） is primarily seen in children and adolescents in Asia and Central America. HMB may be related to the reactivation of Eps- tein-Barr virus （EBV） in infectzd natural killer （NK） cells and is directly associated with chronic active EBV infection （CAEBV） and NK/T-cell leukemia/lymphoma. The median age at diagnosis of HMB is 6.7 years, and local cutaneous reactions include erythema, bullae, ne- crosis, and ulceration. In addition, systemic symptoms, including high-grade fever, malaise, lymphadenopathy, hepatosplenomegaly, hepatic dysfunction, hematuria, and proteinuria, are often present. While the etiology of HMB remains unclear, mosquito salivary gland extract may trigger EBV reactivation in latently infected NK cells. Upon reactivation, EBV oncogenes, such as latent membrane protein 1 （LMP1）, may induce immortaliza- tion of NK cells, eventually progressing to lymphoma.展开更多
文摘Dear Editor, Hypersensitivity to mosquito bites （HMB） is primarily seen in children and adolescents in Asia and Central America. HMB may be related to the reactivation of Eps- tein-Barr virus （EBV） in infectzd natural killer （NK） cells and is directly associated with chronic active EBV infection （CAEBV） and NK/T-cell leukemia/lymphoma. The median age at diagnosis of HMB is 6.7 years, and local cutaneous reactions include erythema, bullae, ne- crosis, and ulceration. In addition, systemic symptoms, including high-grade fever, malaise, lymphadenopathy, hepatosplenomegaly, hepatic dysfunction, hematuria, and proteinuria, are often present. While the etiology of HMB remains unclear, mosquito salivary gland extract may trigger EBV reactivation in latently infected NK cells. Upon reactivation, EBV oncogenes, such as latent membrane protein 1 （LMP1）, may induce immortaliza- tion of NK cells, eventually progressing to lymphoma.
