The glutathione-S-transferase genes mainly the GSTM1 and GSTT1 alleles are responsible for the synthesis of detoxication enzymes that can remove toxic substances. The objective of this study is to seek changes in the ...The glutathione-S-transferase genes mainly the GSTM1 and GSTT1 alleles are responsible for the synthesis of detoxication enzymes that can remove toxic substances. The objective of this study is to seek changes in the genetic polymorphism of glutathione-S-transferase GSTM1 and GSTT1 in motorcycle drivers exposed to BTEX. Our study group consists of 60 motorcycle drivers including 30 professional and 30 non-professional. Blood samples were preleveled from the study population in the EDTA tubes and DNA was extracted by the phenol/chloroform method. The PCR technique was used to determine the presence or absence of genes. Our results showed that the percentage of GSTM1 null genotype has a statistically significant difference (P = 0.02), while the percentage of GSTT1 null genotype was non-significant (P = 0.76) between the two groups. The percentage of deletion of both genes is higher in professional than non-professional motorcycle drivers. Air pollution in Cotonou by BTEX seems to influence the deletion of the GSTM1 and GSTT1 genes at a higher percentage among professional than non-professional motorcycle drivers.展开更多
Motorcycle taxi drivers are workers who use motorcycle to carry passengers. Objectives: to identify the sociodemographic profile and evaluate the physical and mental quality of life of motorcycle taxi drivers. Methods...Motorcycle taxi drivers are workers who use motorcycle to carry passengers. Objectives: to identify the sociodemographic profile and evaluate the physical and mental quality of life of motorcycle taxi drivers. Methods: Cross-sectional study, held in Campo Grande, Mato Grosso do Sul-Brazil, from May to July 2015 with 301 participants. To calculate the sample size, the margin of error was 5%, confidence level, 95%;and the drivers were randomly selected. For data collection, two instruments were used: the demographic questionnaire and the SF-36 Health Status Questionnaire. Results: Among the 301 respondents, predominance fell on males (98.7%, n = 297), married or in a stable relationship (63.5%, n = 191), with completed high school education (44.9%, n = 135). More than half felt discomfort while working (52.8%, n = 159). Of those with diagnosed disease the predominant type of disease was hypertension (55.5%, n = 30). When male and female were compared, men had lower average in the mental health aspect (63.39 ± 13.22);and women, in the emotional aspect (41.66 ± 31.91). There were significant differences in the scores of physical functioning (p = 0.002), bodily pain (0.043) and general health perceptions (p = 0.003) of the drivers reporting disease, compared to those who did not reported it. Conclusion: The studied motorcycle taxi drivers are mostly male, married, with high school education. Regarding quality of life, men had lower perception in the general mental health aspect whereas women showed lower perception in the emotional aspects. The individuals with disease had lower perceived quality of life in the physical functioning, bodily pain and general health concepts.展开更多
文摘The glutathione-S-transferase genes mainly the GSTM1 and GSTT1 alleles are responsible for the synthesis of detoxication enzymes that can remove toxic substances. The objective of this study is to seek changes in the genetic polymorphism of glutathione-S-transferase GSTM1 and GSTT1 in motorcycle drivers exposed to BTEX. Our study group consists of 60 motorcycle drivers including 30 professional and 30 non-professional. Blood samples were preleveled from the study population in the EDTA tubes and DNA was extracted by the phenol/chloroform method. The PCR technique was used to determine the presence or absence of genes. Our results showed that the percentage of GSTM1 null genotype has a statistically significant difference (P = 0.02), while the percentage of GSTT1 null genotype was non-significant (P = 0.76) between the two groups. The percentage of deletion of both genes is higher in professional than non-professional motorcycle drivers. Air pollution in Cotonou by BTEX seems to influence the deletion of the GSTM1 and GSTT1 genes at a higher percentage among professional than non-professional motorcycle drivers.
文摘Motorcycle taxi drivers are workers who use motorcycle to carry passengers. Objectives: to identify the sociodemographic profile and evaluate the physical and mental quality of life of motorcycle taxi drivers. Methods: Cross-sectional study, held in Campo Grande, Mato Grosso do Sul-Brazil, from May to July 2015 with 301 participants. To calculate the sample size, the margin of error was 5%, confidence level, 95%;and the drivers were randomly selected. For data collection, two instruments were used: the demographic questionnaire and the SF-36 Health Status Questionnaire. Results: Among the 301 respondents, predominance fell on males (98.7%, n = 297), married or in a stable relationship (63.5%, n = 191), with completed high school education (44.9%, n = 135). More than half felt discomfort while working (52.8%, n = 159). Of those with diagnosed disease the predominant type of disease was hypertension (55.5%, n = 30). When male and female were compared, men had lower average in the mental health aspect (63.39 ± 13.22);and women, in the emotional aspect (41.66 ± 31.91). There were significant differences in the scores of physical functioning (p = 0.002), bodily pain (0.043) and general health perceptions (p = 0.003) of the drivers reporting disease, compared to those who did not reported it. Conclusion: The studied motorcycle taxi drivers are mostly male, married, with high school education. Regarding quality of life, men had lower perception in the general mental health aspect whereas women showed lower perception in the emotional aspects. The individuals with disease had lower perceived quality of life in the physical functioning, bodily pain and general health concepts.
