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A CNN-Based Single-Stage Occlusion Real-Time Target Detection Method
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作者 Liang Liu Nan Yang +4 位作者 Saifei Liu Yuanyuan Cao Shuowen Tian Tiancheng Liu Xun Zhao 《Journal of Intelligent Learning Systems and Applications》 2024年第1期1-11,共11页
Aiming at the problem of low accuracy of traditional target detection methods for target detection in endoscopes in substation environments, a CNN-based real-time detection method for masked targets is proposed. The m... Aiming at the problem of low accuracy of traditional target detection methods for target detection in endoscopes in substation environments, a CNN-based real-time detection method for masked targets is proposed. The method adopts the overall design of backbone network, detection network and algorithmic parameter optimisation method, completes the model training on the self-constructed occlusion target dataset, and adopts the multi-scale perception method for target detection. The HNM algorithm is used to screen positive and negative samples during the training process, and the NMS algorithm is used to post-process the prediction results during the detection process to improve the detection efficiency. After experimental validation, the obtained model has the multi-class average predicted value (mAP) of the dataset. It has general advantages over traditional target detection methods. The detection time of a single target on FDDB dataset is 39 ms, which can meet the need of real-time target detection. In addition, the project team has successfully deployed the method into substations and put it into use in many places in Beijing, which is important for achieving the anomaly of occlusion target detection. 展开更多
关键词 Real-Time Mask target CNN (Convolutional Neural Network) Single-Stage Detection multi-Scale Feature Perception
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Modeling of the Multi-Target Locating and Tracking in the Field Artillery System 被引量:1
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作者 杨国胜 窦丽华 +1 位作者 陈杰 侯朝桢 《Journal of Beijing Institute of Technology》 EI CAS 2002年第1期14-18,共5页
A method for the multi target locating and tracking with the multi sensor in a field artillery system is studied. A general modeling structure of the system is established. Based on concepts of cluster and closed ba... A method for the multi target locating and tracking with the multi sensor in a field artillery system is studied. A general modeling structure of the system is established. Based on concepts of cluster and closed ball, an algorithm is put forward for multi sensor multi target data fusion and an optimal solution for state estimation is presented. The simulation results prove the algorithm works well for the multi stationary target locating and the multi moving target tracking under the condition of the sparse target environment. Therefore, this method can be directly applied to the field artillery C 3I system. 展开更多
关键词 field artillery system data fusion closed ball cluster single sensor multi target multi sensor multi target
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Obstacle Avoidance and Multitarget Tracking of a Super Redundant Modular Manipulator Based on Bezier Curve and Particle Swarm Optimization 被引量:6
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作者 Li Chen Ying Ma +1 位作者 Yu Zhang Jinguo Liu 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2020年第5期101-119,共19页
A super redundant serpentine manipulator has slender structure and multiple degrees of freedom.It can travel through narrow spaces and move in complex spaces.This manipulator is composed of many modules that can form ... A super redundant serpentine manipulator has slender structure and multiple degrees of freedom.It can travel through narrow spaces and move in complex spaces.This manipulator is composed of many modules that can form different lengths of robot arms for different application sites.The increase in degrees of freedom causes the inverse kinematics of redundant manipulator to be typical and immensely increases the calculation load in the joint space.This paper presents an integrated optimization method to solve the path planning for obstacle avoidance and discrete trajectory tracking of a super redundant manipulator.In this integrated optimization,path planning is established on a Bezier curve,and particle swarm optimization is adopted to adjust the control points of the Bezier curve with the kinematic constraints of manipulator.A feasible obstacle avoidance path is obtained along with a discrete trajectory tracking by using a follow-the-leader strategy.The relative distance between each two discrete path points is limited to reduce the fitting error of the connecting rigid links to the smooth curve.Simulation results show that this integrated optimization method can rapidly search for the appropriate trajectory to guide the manipulator in obtaining the target while achieving obstacle avoidance and meeting joint constraints.The proposed algorithm is suitable for 3D space obstacle avoidance and multitarget path tracking. 展开更多
关键词 Super redundant manipulator multi target tracking Follow-the-leader Obstacle avoidance Bezier curve PSO
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Modified joint probabilistic data association with classification-aided for multitarget tracking 被引量:8
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作者 Ba Hongxin Cao Lei +1 位作者 He Xinyi Cheng Qun 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2008年第3期434-439,共6页
Joint probabilistic data association is an effective method for tracking multiple targets in clutter, but only the target kinematic information is used in measure-to-track association. If the kinematic likelihoods are... Joint probabilistic data association is an effective method for tracking multiple targets in clutter, but only the target kinematic information is used in measure-to-track association. If the kinematic likelihoods are similar for different closely spaced targets, there is ambiguity in using the kinematic information alone; the correct association probability will decrease in conventional joint probabilistic data association algorithm and track coalescence will occur easily. A modified algorithm of joint probabilistic data association with classification-aided is presented, which avoids track coalescence when tracking multiple neighboring targets. Firstly, an identification matrix is defined, which is used to simplify validation matrix to decrease computational complexity. Then, target class information is integrated into the data association process. Performance comparisons with and without the use of class information in JPDA are presented on multiple closely spaced maneuvering targets tracking problem. Simulation results quantify the benefits of classification-aided JPDA for improved multiple targets tracking, especially in the presence of association uncertainty in the kinematic measurement and target maneuvering. Simulation results indicate that the algorithm is valid. 展开更多
关键词 multi-target tracking data association joint probabilistic data association classification information track coalescence maneuvering target.
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FGAs-Based Data Association Algorithm for Multi-sensor Multi-target Tracking 被引量:4
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作者 朱力立 张焕春 经亚枝 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2003年第3期177-181,共5页
A novel data association algorithm is developed based on fuzzy geneticalgorithms (FGAs). The static part of data association uses one FGA to determine both the lists ofcomposite measurements and the solutions of m-bes... A novel data association algorithm is developed based on fuzzy geneticalgorithms (FGAs). The static part of data association uses one FGA to determine both the lists ofcomposite measurements and the solutions of m-best S-D assignment. In the dynamic part of dataassociation, the results of the m-best S-D assignment are then used in turn, with a Kalman filterstate estimator, in a multi-population FGA-based dynamic 2D assignment algorithm to estimate thestates of the moving targets over time. Such an assignment-based data association algorithm isdemonstrated on a simulated passive sensor track formation and maintenance problem. The simulationresults show its feasibility in multi-sensor multi-target tracking. Moreover, algorithm developmentand real-time problems are briefly discussed. 展开更多
关键词 multi-target tracking data association FGA assignment problem kalmanfilter
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Performance analysis of multi-channel order statistics detector for range-spread target 被引量:5
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作者 Shuwen Xu Penglang Shui 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2012年第5期689-699,共11页
The problem of two order statistics detection schemes for the detection of a spatially distributed target in white Gaussian noise are studied.When the number of strong scattering cells is known,we first show an optima... The problem of two order statistics detection schemes for the detection of a spatially distributed target in white Gaussian noise are studied.When the number of strong scattering cells is known,we first show an optimal detector,which requires many processing channels.The structure of such optimal detector is complex.Therefore,a simpler quasi-optimal detector is then introduced.The quasi-optimal detector,called the strong scattering cells’ number dependent order statistics(SND-OS) detector,takes the form of an average of maximum strong scattering cells with a known number.If the number of strong scattering cells is unknown in real situation,the multi-channel order statistics(MC-OS) detector is used.In each channel,a various number of maximums scattered from target are averaged.Then,the false alarm probability analysis and thresholds sets for each channel are given,following the detection results presented by means of Monte Carlo simulation strategy based on simulated target model and three measured targets.In particular,the theoretical analysis and simulation results highlight that the MC-OS detector can efficiently detect range-spread targets in white Gaussian noise. 展开更多
关键词 order statistics strong scattering cell multi-CHANNEL range-spread target
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Target Tracking and Obstacle Avoidance for Multi-agent Systems 被引量:4
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作者 Jing Yan Xin-Ping Guan Fu-Xiao Tan 《International Journal of Automation and computing》 EI 2010年第4期550-556,共7页
This paper considers the problems of target tracking and obstacle avoidance for multi-agent systems. To solve the problem that multiple agents cannot effectively track the target while avoiding obstacle in dynamic env... This paper considers the problems of target tracking and obstacle avoidance for multi-agent systems. To solve the problem that multiple agents cannot effectively track the target while avoiding obstacle in dynamic environment, a novel control algorithm based on potential function and behavior rules is proposed. Meanwhile, the interactions among agents are also considered. According to the state whether an agent is within the area of its neighbors' influence, two kinds of potential functions are presented. Meanwhile, the distributed control input of each agent is determined by relative velocities as well as relative positions among agents, target and obstacle. The maximum linear speed of the agents is also discussed. Finally, simulation studies are given to demonstrate the performance of the proposed algorithm. 展开更多
关键词 target tracking obstacle avoidance potential function multi-agent systems
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Multi-target Collaborative Combat Decision-Making by Improved Particle Swarm Optimizer 被引量:5
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作者 Ding Yongfei Yang Liuqing +2 位作者 Hou Jianyong Jin Guting Zhen Ziyang 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI CSCD 2018年第1期181-187,共7页
A decision-making problem of missile-target assignment with a novel particle swarm optimization algorithm is proposed when it comes to a multiple target collaborative combat situation.The threat function is establishe... A decision-making problem of missile-target assignment with a novel particle swarm optimization algorithm is proposed when it comes to a multiple target collaborative combat situation.The threat function is established to describe air combat situation.Optimization function is used to find an optimal missile-target assignment.An improved particle swarm optimization algorithm is utilized to figure out the optimization function with less parameters,which is based on the adaptive random learning approach.According to the coordinated attack tactics,there are some adjustments to the assignment.Simulation example results show that it is an effective algorithm to handle with the decision-making problem of the missile-target assignment(MTA)in air combat. 展开更多
关键词 collaborative combat multi-target decision-making improved particle swarm optimization(IPSO)
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A new algorithm of bearings-only multi-target tracking of bistatic system 被引量:2
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作者 Benlian XU Zhiquan WANG 《控制理论与应用(英文版)》 EI 2006年第4期331-337,共7页
Much research mainly focuses on the batch processing method (e.g. maximum likelihood method) when bearings-only multiple targets tracking of bistatic sonar system is considered. In this paper, the idea of recursive ... Much research mainly focuses on the batch processing method (e.g. maximum likelihood method) when bearings-only multiple targets tracking of bistatic sonar system is considered. In this paper, the idea of recursive processing method is presented and employed, and corresponding data association algorithms, i.e. a multi-objective ant-colony-based optimization algorithm and an easy fast assignment algorithm are developed to solve the measurements-to-measurements and measurements-to-tracks data association problems of bistatic sonar system, respectively. Monte-Carlo simulations are induced to evaluate the effectiveness of the proposed methods. 展开更多
关键词 BEARINGS-ONLY multi-target tracking Data association Ant colony optimization
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Long-term acupuncture treatment has a multitargeting regulation on multiple brain regions in rats with Alzheimer's disease:a positron emission tomography study 被引量:3
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作者 Yang-jia Lu Xiao-wen Cai +9 位作者 Gui-feng Zhang Yong Huang Chun-zhi Tang Bao-ci Shan Shao-yang Cui Jun-qi Chen Shan-shan Qu Zheng Zhong Xin-sheng Lai Genevieve Zara Steiner 《Neural Regeneration Research》 SCIE CAS CSCD 2017年第7期1159-1165,共7页
The acute effect of acupuncture on Alzheimer's disease,i.e.,on brain activation during treatment,has been reported.However,the effect of long-term acupuncture on brain activation in Alzheimer's disease is unclear.Th... The acute effect of acupuncture on Alzheimer's disease,i.e.,on brain activation during treatment,has been reported.However,the effect of long-term acupuncture on brain activation in Alzheimer's disease is unclear.Therefore,in this study,we performed long-term needling at Zusanli(ST36)or a sham point(1.5 mm lateral to ST36)in a rat Alzheimer's disease model,for 30 minutes,once per day,for 30 days.The rats underwent 18F-fluorodeoxyglucose positron emission tomography scanning.Positron emission tomography images were processed with SPM2.The brain areas activated after needling at ST36 included the left hippocampus,the left orbital cortex,the left infralimbic cortex,the left olfactory cortex,the left cerebellum and the left pons.In the sham-point group,the activated regions were similar to those in the ST36 group.However,the ST36 group showed greater activation in the cerebellum and pons than the sham-point group.These findings suggest that long-term acupuncture treatment has targeted regulatory effects on multiple brain regions in rats with Alzheimer's disease. 展开更多
关键词 nerve regeneration NEURODEGENERATION ACUPUNCTURE Zusanli (ST36) Alzheimer's disease long-term treatment positron emissiontomography rat mechanism targeting effect compensation multi-target regulation neural regeneration
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Target Tracking and Obstacle Avoidance for Multi-agent Networks with Input Constraints 被引量:2
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作者 Jing Yan Xin-Ping Guan +1 位作者 Xiao-Yuan Luo Fu-Xiao Tan 《International Journal of Automation and computing》 EI 2011年第1期46-53,共8页
In this paper, the problems of target tracking and obstacle avoidance for multi-agent networks with input constraints are investigated. When there is a moving obstacle, the control objectives are to make the agents tr... In this paper, the problems of target tracking and obstacle avoidance for multi-agent networks with input constraints are investigated. When there is a moving obstacle, the control objectives are to make the agents track a moving target and to avoid collisions among agents. First, without considering the input constraints, a novel distributed controller can be obtained based on the potential function. Second, at each sampling time, the control algorithm is optimized. Furthermore, to solve the problem that agents cannot effectively avoid the obstacles in dynamic environment where the obstacles are moving, a new velocity repulsive potential is designed. One advantage of the designed control algorithm is that each agent only requires local knowledge of its neighboring agents. Finally, simulation results are provided to verify the effectiveness of the proposed approach. 展开更多
关键词 target tracking obstacle avoidance multi-agent networks potential function optimal control.
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METHOD OF MULTI-TARGET TRACKING IN WIDE AREA SURVEILLANCE AIRBORNE RADAR SYSTEM BASING ON CLUSTERING ANALYSIS 被引量:3
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作者 Wu Kun Zhao Fengjun +2 位作者 Hui Zhou Zheng Shichao Zheng Mingjie 《Journal of Electronics(China)》 2014年第3期208-213,共6页
This paper proposed a robust method based on the definition of Mahalanobis distance to track ground moving target. The feature and the geometry of airborne ground moving target tracking systems are studied at first. B... This paper proposed a robust method based on the definition of Mahalanobis distance to track ground moving target. The feature and the geometry of airborne ground moving target tracking systems are studied at first. Based on this feature, the assignment relation of time-nearby target is calculated via Mahalanobis distance, and then the corresponding transformation formula is deduced. The simulation results show the correctness and effectiveness of the proposed method. 展开更多
关键词 Airborne radar Wide Area Surveillance(WAS) Moving target detect multi-target Tracking(MTT)
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Highly maneuvering target tracking using multi-parameter fusion Singer model 被引量:2
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作者 Shuyi Jia Yun Zhang Guohong Wang 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2017年第5期841-850,共10页
An algorithm of highly maneuvering target tracking is proposed to solve the problem of large tracking error caused by strong maneuver. In this algorithm, a new estimator, named as multi-parameter fusion Singer (MF-Sin... An algorithm of highly maneuvering target tracking is proposed to solve the problem of large tracking error caused by strong maneuver. In this algorithm, a new estimator, named as multi-parameter fusion Singer (MF-Singer) model is derived based on the Singer model and the fuzzy reasoning method by using radial acceleration and velocity of the target, and applied to the problem of maneuvering target tracking in strong maneuvering environment and operating environment. The tracking performance of the MF-Singer model is evaluated and compared with other manuevering tracking models. It is shown that the MF-Singer model outperforms these algorithms in several examples. 展开更多
关键词 maneuvering target multi-parameter fusion Singer (MF-Singer) fuzzy reasoning Singer model
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MULTI-TARGET VISUAL TRACKING AND OCCLUSION DETECTION BY COMBINING BHATTACHARYYA COEFFICIENT AND KALMAN FILTER INNOVATION 被引量:1
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作者 Chen Ken Chul Gyu Jhun 《Journal of Electronics(China)》 2013年第3期275-282,共8页
This paper introduces an approach for visual tracking of multi-target with occlusion occurrence. Based on the author's previous work in which the Overlap Coefficient (OC) is used to detect the occlusion, in this p... This paper introduces an approach for visual tracking of multi-target with occlusion occurrence. Based on the author's previous work in which the Overlap Coefficient (OC) is used to detect the occlusion, in this paper a method of combining Bhattacharyya Coefficient (BC) and Kalman filter innovation term is proposed as the criteria for jointly detecting the occlusion occurrence. Fragmentation of target is introduced in order to closely monitor the occlusion development. In the course of occlusion, the Kalman predictor is applied to determine the location of the occluded target, and the criterion for checking the re-appearance of the occluded target is also presented. The proposed approach is put to test on a standard video sequence, suggesting the satisfactory performance in multi-target tracking. 展开更多
关键词 Visual tracking multi-target occlusion Bhattacharyya Coefficient (BC) Kalman filter
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Research and Application of Multi-Target Tracking Based on GM-PHD Filter 被引量:2
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作者 Yanyi Li Limin Guo Xiangsong Huang 《Optics and Photonics Journal》 2020年第6期125-133,共9页
<div style="text-align:justify;"> In recent years, multi-target tracking technology based on Gaussian Mixture- Probability Hypothesis Density (GM-PHD) filtering has become a hot field of information fu... <div style="text-align:justify;"> In recent years, multi-target tracking technology based on Gaussian Mixture- Probability Hypothesis Density (GM-PHD) filtering has become a hot field of information fusion research. This article outlines the generation and development of multi-target tracking methods based on GM-PHD filtering, and the principle and implementation method of GM-PHD filtering are explained, and the application status based on GM-PHD filtering is summarized, and the key issues of the development of GM-PHD filtering technology are analyzed. </div> 展开更多
关键词 GM-PHD multi-target Tracking Random Finite Set
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Target estimation using MIMO radar with multiple subcarriers 被引量:2
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作者 Min Jiang Jianguo Huang +1 位作者 Yong Jin Jing Han 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2012年第1期57-62,共6页
This paper analyzes the effect of waveform parame- ters on the joint target location and velocity estimation by a non- coherent multiple input multiple output (MIMO) radar transmitting multiple subcarriers signals. ... This paper analyzes the effect of waveform parame- ters on the joint target location and velocity estimation by a non- coherent multiple input multiple output (MIMO) radar transmitting multiple subcarriers signals. How the number of subcarriers in- fluences the estimation accuracy is illustrated by considering the joint Cramer-Rao bound and the mean square error of the maxi- mum likelihood estimate. The non-coherent MIMO radar ambiguity function with multiple subcarriers is developed and investigated by changing the number of subcarriers, the pulse width and the frequency spacing between adjacent subcarriers. The numerical results show that more subcarriers mean more accurate estimates, higher localization resolution, and larger pulse width results in a worse performance of target location estimation, while the fre- quency spacing affects target location estimation little. 展开更多
关键词 target estimation non-coherent multiple input multi- ple output (MIMO) radar multiple subcarrier waveform parameter ambiguity function (AF).
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Augmented input estimation in multiple maneuvering target tracking 被引量:1
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作者 HADAEGH Mahmoudreza KHALOOZADEH Hamid BEHESHTI Mohammadtaghi 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2019年第5期841-851,共11页
This paper presents augmented input estimation(AIE)for multiple maneuvering target tracking.Multi-target tracking(MTT)is based on two main parts,data association and estimation.In data association(DA),the best observa... This paper presents augmented input estimation(AIE)for multiple maneuvering target tracking.Multi-target tracking(MTT)is based on two main parts,data association and estimation.In data association(DA),the best observations are assigned to the considered tracks.In real conditions,the number of observations is more than targets and also locations of observations are often so scattered that the association between targets and observations cannot be done simply.In this case,for general MTT problems with unknown numbers of targets,we present a Markov chain Monte-Carlo DA(MCMCDA)algorithm that approximates the optimal Bayesian filter with low complexity in computations.After DA,estimation and tracking should be done.Since in general cases,many targets can have maneuvering motions,then AIE is proposed to cover both the non-maneuvering and maneuvering parts of motion and the maneuver detection procedure is eliminated.This model with an input estimation(IE)approach is a special augmentation in the state space model which considers both the state vector and the unknown input vector as a new augmented state vector.Some comparisons based on the Monte-Carlo simulations are also made to evaluate the performances of the proposed method and other older methods in MTT. 展开更多
关键词 multi-target tracking (MTT) MARKOV chain Monte-Carlodata ASSOCIATION (MCMCDA) DATA ASSOCIATION (DA) augmentedinput estimation (AIE)
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Hybrid hierarchical trajectory planning for a fixed-wing UCAV performing air-to-surface multi-target attack 被引量:5
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作者 Yu Zhang Jing Chen Lincheng Shen 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2012年第4期536-552,共17页
This paper considers the problem of generating a flight trajectory for a single fixed-wing unmanned combat aerial vehicle (UCAV) performing an air-to-surface multi-target attack (A/SMTA) mission using satellite-gu... This paper considers the problem of generating a flight trajectory for a single fixed-wing unmanned combat aerial vehicle (UCAV) performing an air-to-surface multi-target attack (A/SMTA) mission using satellite-guided bombs. First, this problem is formulated as a variant of the traveling salesman problem (TSP), called the dynamic-constrained TSP with neighborhoods (DCT- SPN). Then, a hierarchical hybrid approach, which partitions the planning algorithm into a roadmap planning layer and an optimal control layer, is proposed to solve the DCTSPN. In the roadmap planning layer, a novel algorithm based on an updatable proba- bilistic roadmap (PRM) is presented, which operates by randomly sampling a finite set of vehicle states from continuous state space in order to reduce the complicated trajectory planning problem to planning on a finite directed graph. In the optimal control layer, a collision-free state-to-state trajectory planner based on the Gauss pseudospectral method is developed, which can generate both dynamically feasible and optimal flight trajectories. The entire process of solving a DCTSPN consists of two phases. First, in the offline preprocessing phase, the algorithm constructs a PRM, and then converts the original problem into a standard asymmet- ric TSP (ATSP). Second, in the online querying phase, the costs of directed edges in PRM are updated first, and a fast heuristic searching algorithm is then used to solve the ATSP. Numerical experiments indicate that the algorithm proposed in this paper can generate both feasible and near-optimal solutions quickly for online purposes. 展开更多
关键词 hierarchical trajectory planning air-to-surface multi-target attack (A/SMTA) traveling salesman problem (TSP) proba-bilistic roadmap Gauss pseudospectral method unmanned com-bat aerial vehicle (UCAV).
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Inverse Synthetic Aperture Radar Imaging of Multi-Targets Based on Image Processing Technique
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作者 Yong Wang Shuai Feng Qingxiang Zhang 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2018年第6期46-58,共13页
This paper presents a newmulti-targets inverse synthetic aperture radar (ISAR) imaging approach via the image segmentation processing. This method can separate multi-targets with similar velocities,and there is no str... This paper presents a newmulti-targets inverse synthetic aperture radar (ISAR) imaging approach via the image segmentation processing. This method can separate multi-targets with similar velocities,and there is no strict limit on the rotational state of the targets. Firstly,the motion compensation for the completely multi-targets echo is carried out and the coarse image can be achieved with the Range-Doppler (RD) technique. Then a series of image processing methods and image segmentation processing are used to separate the echo data of each mono-target. At last,the image with high quality of each target can be achieved with the RD technique and the Range-Instantaneous-Doppler (RID) technique. ISAR imaging results of simulated and measured data validate the validity of the proposed approach. 展开更多
关键词 ISAR multi-targets image segmentation
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Multi-targets antidepressant mechanism of the bis-benzylisoquinoline 7-O-ethylfangchinoline:Involvement of noradrenergic,dopaminergic and AMPAergic systems
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作者 Zhao-fuSHENG Xiang-yuCUI +11 位作者 Su-yingCUI BinYU Xue-qiongZHANG Sheng-jieLI QingCAO Yuan-liHUANG Ya-pingXU Jin-zhiSONG HuiDING Zhi-geLIN GuangYANG Yong-heZHANG 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2015年第S1期44-44,共1页
OBJECTIVE Bisbenzylisoquinoline(BBI)alkaloids have extensive pharmacological functions.The aim of this study was to investigate the mechanisms underlying the antidepressant-like action of 7-O-ethylfangchinoline(YH-200... OBJECTIVE Bisbenzylisoquinoline(BBI)alkaloids have extensive pharmacological functions.The aim of this study was to investigate the mechanisms underlying the antidepressant-like action of 7-O-ethylfangchinoline(YH-200)in mice.METHODS Male ICR mice were used in the forced swimming(FST)and tail suspension tests(TST).RESULTS YH-200(60mg·kg-1,ig)decreased the immobility time in FST and TST,and prolonged the latency to immobility in FST.YH-200 revealed more potent anti-immobility activity than its BBI derivative tetrandrine.In addition,the pretreatment of mice with prazosin(1mg·kg-1,ip,anα1-adrenoceptor antagonist),propranolol(2 mg·kg-1,ip,a nonselectiveβ-adrenoceptor antagonist),SCH23390(0.05mg·kg-1,ip,a dopamine D1/D5 receptor antagonist),haloperidol(0.2mg·kg-1,ip,a dopamine D2/D3 receptor antagonist)and NBQX(10mg·kg-1,ip,an AMPA receptor antagonist)prevented the antidepressant-like effect of YH-200(60mg·kg-1,ig)in FST.Besides that,the pretreatment of mice with yohimbine(1mg·kg-1,ip,an α2 adrenoceptor antagonist)augmented the antidepressant-like effect of YH-200(30mg·kg-1,ig)in FST.After 14 dadministration,YH-200(30 and 60mg·kg-1,ig)did not develop drug resistance,but the potency was strengthened,meanwhile,it did not influence the changes in mice body weight.CONCLUSION YH-200 may possess the therapeutic potential for the treatment of depression via the multi-targets including the noradrenergic(α1,α2 and β-adrenoceptors),dopaminergic(D1/D5 and D2/D3receptors)and AMPAergic systems. 展开更多
关键词 depression YH-200 multi-targets FORCED SWIMMING te
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