Efficacy evaluation and survival analysis of the combination of oxaliplatin plus Teysuno (SOX) with immune checkpoint inhibitors in the conversion therapy of locally advanced gastric cancer

Background:The efficacy of combining immune checkpoint inhibitors(ICIs)with chemotherapy in neoadjuvant therapy for locally advanced gastric cancer has been explored.However,limited research exists on its effectiveness in conversion therapy,and its superiority over standalone chemotherapy remains to be elucidated.This study aims to investigate the efficacy and survival outcomes of patients treated with ICIs in combination with conversion therapy for locally advanced gastric cancer.Methods:Retrospective data from patients with locally advanced gastric cancer treated with either oxaliplatin+S-1(SOX)alone or in combination with ICIs in conversion therapywere collected.Clinical andpathological characteristics,disease-free survival,andefficacy assessments in nonoperable patients were compared between the 2 treatment groups.Efficacy was further evaluated through dynamic changes in serum markers,and patients’quality of life was assessed using the QLQ-STO22(Gastric Cancer–Specific Quality of Life Questionnaire)quality-of-life measurement scale.Results:A total of 140 patients underwent conversion therapy:80 in the SOX alone group and 60 in the SOX combined with the ICIs group.There were no significant differences in baseline characteristics between the 2 groups.Compared with the SOX alone group,the SOX combined with ICIs group exhibited a higher conversion rate(83.3%vs 75%,P=0.23),R0 resection rate(90.0%vs 83.3%,P=0.31),pathological complete response(pCR)rate(18%vs 5%,P=0.02),median disease-free survival(21.4 vs 16.9 months,P=0.007),the objective response rate in nonoperable patients(60%vs 40%,P=0.301),and median progression-free survival time(7.9 vs 5.7 months,P=0.009).The QLQ-STO22 quality-of-life assessment revealed statistically significant improvements in pain,swallowing difficulties,and dietary restrictions in the combination therapy group compared with those in the monotherapy group.The enhanced efficacy of immune combination with SOX is evident,as demonstrated by the significantly prolonged surgical duration in operated patients(206.6±26.6 min vs 197.8±19.8 min,P=0.35)and intraoperative blood loss(158.9±21.2 mL vs 148.9±25.1 mL,P=0.59).No significant differences were observed in postoperative complications.Conclusions:Compared with the SOX conversion therapy regimen,SOX combined with ICIs demonstrated higher conversion rates,R0 resection rates,pathological response rates,and disease-free survival without increasing surgical difficulty or complications.Nonoperable patients also experienced longer progression-free survival and objective response rates.

Evaluation of Energy Efficiency and Analysis of Influencing Factors of Company CW’s Manufacturing Workshops

In this work,the Slacks-Based Measure(SBM)model within Data Envelopment Analysis was employed to establish a set of indicators for evaluating the energy efficiency of manufacturing workshops.The energy efficiency of 12 Company CW’s manufacturing workshops from 2016 to 2022 was assessed.The findings indicated that aside from a few workshops operating at the production frontier,the rest exhibit significant fluctuations in energy efficiency and generally low energy efficiency.Subsequently,a combined GRA-Tobit analysis model was introduced to identify factors influencing the energy efficiency of Company CW’s manufacturing workshops.Regression analysis revealed that technological investments,employee quality,workshop production scale,investment in clean energy,and the level of pollution control all significantly impact the energy efficiency of Company CW’s manufacturing workshops.By evaluating the energy efficiency of Company CW’s manufacturing workshops and studying their influencing factors,this research aids company managers in understanding the energy efficiency of the manufacturing process.It optimizes the combination of various production elements,thereby offering effective guidance for improving the energy efficiency issues of the company’s manufacturing workshops,which can contribute to enhancing the corporation’s overall energy efficiency.

A Brief Analysis and Evaluation of the Frequently Used College English Course Book——Listening and Speaking Course

This paper does some research and exploration of one of the most commonly used Chinese college English course book:Listening and Speaking Course(Second Edition 2010)compiled by Yu Shumei and Li Huiqin.It introduces the aims of the textbookand its structure.By evaluating the teaching functions of differnt parts,it can be safely concluded that this textbook is well quali-fied to be used.However,being inadequate in teaching listening strategies and lacking in teaching speaking strategies can affectstudents'listening and speaking in the long run.Therefore,it is strongly recommended that teachers should add more practicalstrategies and useful materials in their teaching procedures to make the textbook more applicable.

Study on effectiveness evaluation of weapon systems based on grey relational analysis and TOPSIS

To evaluate the effectiveness of weapon systems, the advantages and disadvantages of grey relational analysis and TOPSIS for multiattribute decision-making is pointed out, and an effectiveness evaluation model of weapon systems by combining grey relational analysis and TOPSIS is proposed. The model aggregates the grey relational grade and the distance to a new integrated closeness and reflects not only the trend but also the situation of the alternative. The example illuminates that the model is effective for the effectiveness evaluation of weapon systems.

Analysis and Evaluation of Nutritional Quality in Chinese Radish (Raphanus sativus L.)

Radish （Raphanus sativus L.） is an important vegetable crop worldwide. High nutritional quality was critical in its genetic improvement and production. The nutritional quality of 42 Chinese radish cultivars was analyzed in this study. The contents of six nutritional facts, dry matter （DM）, crude fiber （CF）, total soluble sugar （TSS）, vitamin C （Vc）, protein, and nitrate, ranged from 29.7 to 88.2, 4.507 to 18.546, 2.233 to 15.457, 0.1416 to 0.3341, 0.34 to 1.15, and 1.81 to 5.89 g·kg^-1 fresh weight （FW）, respectively. Significant differences among the 42 radish cultivars were detected in the contents of nutritional facts. The data were subjected to cross-correlation analysis and principal component analysis （PCA）. It was found that DM content was positively correlated with the content of TSS （r=0.7104）, Vc （r=0.4011） and protein （r=0.4120）. Vitamin C （Vc） content of radish showed a positive correlation （r = 0.3300） with the protein content. According to the principal component analysis, out of the 42 radish cultivars, Nau-17, Nau-28, Nau-6, Nau-11, Nau-10, Nau-27, and Nau-31 were detected with very high scores in comprehensive evaluation. It could be concluded that abundant diversity of nutritional fact content occurred in different radish genotypes, and PCA analysis was effective for selecting radish germplasm with high quality. The results could contribute useful knowledge of nutritional quality, and provide important germplasms for the elite cultivar development and the inheritance study of nutritional facts in radish.

Cytological Evaluation and Karyotype Analysis in Plant Germplasms of Elytrigia Desv.

Elytrigia Desv. is widely distributed throughout the world and is represented with species of various levels of ploidy including diploids, tetraploids, hexaploids, octaploids, and decaploids. The distribution pattern of these ploidy levels, however, is not well-defined. In this study, the levels of ploidy for 64 accessions of Elytrigia from 25 countries were determined with microscopic procedures. The results showed that accessions of E. intermedia and E. repens were grouped into three distinct levels of ploidy including diploids, tetraploids and hexaploids. For E. elongata, E. pontica, and E. caespitosa, it was found that two ploidy levels presented, and only one ploidy level was in those of E. hybrid, E. pycnantha, E. pungens, E. juncea, and E. alatavica. Karyotype analysis indicated that the karyotype formula of diploid, tetraploid and hexaploid of E. intermedia was 2n = 2x = 14 = 6m ＋ 6sm ＋ 2st, 2n = 4x = 28 = 2M ＋ 10m ＋ 16sm and 2n = 6x = 42 = 4M ＋ 18m ＋ 20sin, respectively. Furthermore, the karyotype formula of three germplasms in tetraploid of E. intermedia was 2n=4x=28 =2M＋ 10m＋ 16sm, 2n=4x=28=4M＋22m （sat）＋2sm and 2n=4x=28 =4M＋ 12m＋ 12sm （sat）, which were not completely uniform. Therefore, it could be suggested that the studies about chromosome constitution would be helpful for the detail understanding of the diversity of germplasm resource in Elytrigia and promoting the utilization in the crop molecular breeding.

Comprehensive Evaluation on the Irrigation Water Quality in Turpan City Based on Matter Element Analysis Method

Matter-element analysis method was used to construct the comprehensive matter-element model for the evaluation of the quality of various kinds of irrigation water in Turpan City to evaluate the quality of irrigation water（such as river water,spring water, Karez well water, pumped well water） in Turpan City, Xinjiang. The results showed that the quality of the irrigation water was the best in October,which was in Grade I or Grade 2; in May, the quality of some of the irrigation water became poorer to Grade II, which was easy to soil salinization; in March, the detected qualities of the water samples water from the Meiyaogou basin were all in Grade IV, which was not suitable for farmland irrigation. The comparison on the evaluation results of matter-element analysis and fuzzy evaluation method showed that the results of the 2 methods were almost consistent with each other, and showed good uniformity.

Risk analysis of extended reach wells in the Liuhua Oilfield,South China Sea,based on comprehensive fuzzy evaluation method

Drilling engineering has great uncertainty and it always involves huge investment and high risk. Risk analysis of extended reach drilling （ERD） is very important to prevent complex failures and to improve drilling efficiency. Nowadays there are few reports on how to analyze quantitatively the drilling risk for extended reach wells （ERWs）. Based on the fuzzy set theory, a comprehensive fuzzy evaluation model for analyzing risks of ERD is proposed in this paper. Well B6ERW07 is a planned 8,000-meter ERW with a high ratio of horizontal displacement （HD） to vertical depth （VD） in the Liuhua Oilfield, the South China Sea, China. On the basis of the evaluation model developed in this study, the risk for drilling Well B6ERW07 was evaluated before drilling. The evaluation result shows that the success rate of drilling this well is predicted to be 51.9%, providing important rational and scientific information for the decisionmakers.

Chromatographic fingerprinting and quantitative analysis for the quality evaluation of Xinkeshu tablet

A simple, sensitive and accurate method based on high performance liquid chromato- graphy （HPLC） with diode array detector （DAD） was developed and validated for systematic quality evaluation of one type of traditional Chinese medicine preparations named Xinkeshu （XKS） tablet. In this study, the chromatographic fingerprints of XKS tablet were developed first, 23 peaks were selected as the common peaks to evaluate the similarities among different batches of XKS samples, which were manufactured in a long time span of three years. Additionally, simultaneous quantification of six markers in XKS tablet, including Danshensu, Protocatechuic aldehyde, Puerarin, Daidzin, Salvianolic acid B and Daidzein, was performed. The validation results showed that the developed method was specific, accurate, precise and robust. The preliminary explanation on why a close similarity between fingerprints did not exactly mean similar contents of chemical components in samples was given. The contribution of each chromatographic peak to similarity was also evaluated. The developed method offers an efficient, reliable and practical approach for systematic quality evaluation of XKS tablet.

Mining Weights of Land Evaluation Factors Based on Cloud Model and Correlation Analysis

The veracity of land evaluation is tightly related to the reasonable weights of land evaluation fac- tors. By mapping qualitative linguistic words into a fine-changeable cloud drops and translating the uncertain factor conditions into quantitative values with the uncertain illation based on cloud model, and then, inte- grating correlation analysis, a new way of figuring out the weight of land evaluation factors is proposed. It may solve the limitations of the conventional ways.

Spatial analysis and evaluation of a coal deposit by coupling AHP & GIS techniques

Nowadays,the evaluation of coal deposits becomes crucial,due to many uncontrollable factors,which affect the energy sector.A comparative evaluation of coal deposits is essential for their hierarchical classification regarding their sustainable exploitation,when compared to other coal deposits or competitive fuels,which may be used as alternative solutions for electricity generation.In this paper,a method for spatial analysis and evaluation of a lignite deposit is proposed,by creating four spatial key indicators via GIS analysis,which are then aggregated by applying a weighted linear combination.The analytical hierarchy process is applied to estimate the relative weights of the indicators,in order to perform a weighted cartographic overlay.Through the synthesis of the indicators,an overall,total spatial quality indicator is calculated.The weighted analysis was shown to be more effective compared to the unweighted one,because it can provide more reliable results regarding the exploitation of the examined lignite deposit.The implementation of GIS-based analytical hierarchy process in spatial analysis and evaluation of lignite deposits,in terms of sustainable exploitation,demonstrates that this method can be extensively applied for evaluating the economic potential of mineral deposits.

Evaluation on monthly sea surface wind speed of four reanalysis data sets over the China seas after 1988

This study investigates the long-term changes of monthly sea surface wind speeds over the China seas from 1988 to 2015. The 10-meter wind speeds products from four major global reanalysis datasets with high resolution are used: Cross-Calibrated Multi-Platform data set(CCMP), NCEP climate forecast system reanalysis data set(CFSR),ERA-interim reanalysis data set(ERA-int) and Japanese 55-year reanalysis data set(JRA55). The monthly sea surface wind speeds of four major reanalysis data sets have been investigated through comparisons with the longterm and homogeneous observation wind speeds data recorded at ten stations. The results reveal that(1) the wind speeds bias of CCMP, CFSR, ERA-int and JRA55 are 0.91 m/s, 1.22 m/s, 0.62 m/s and 0.22 m/s, respectively.The wind speeds RMSE of CCMP, CFSR, ERA-int and JRA55 are 1.38 m/s, 1.59 m/s, 1.01 m/s and 0.96 m/s,respectively;(2) JRA55 and ERA-int provides a realistic representation of monthly wind speeds, while CCMP and CFSR tend to overestimate observed wind speeds. And all the four data sets tend to underestimate observed wind speeds in Bohai Sea and Yellow Sea;(3) Comparing the annual wind speeds trends between observation and the four data sets at ten stations for 1988-1997, 1988–2007 and 1988–2015, the result show that ERA-int is superior to represent homogeneity monthly wind speeds over the China seaes.

Ecological Safety Evaluation of Land Use in Ji'an City Based on the Principal Component Analysis

According to the ecological safety evaluation index data of land-use change in Ji'an City from 1999 to 2008,positive treatment on selected reverse indices is conducted by Reciprocal Method.Meanwhile,Index Method is used to standardize the selected indices,and Principal Component Analysis is applied by using year as a unit.FB is obtained,which is related with the ecological safety of land-use change from 1999 to 2008.According to the scientific,integrative,hierarchical,practical and dynamic principles,ecological safety evaluation index system of land-use change in Ji'an City is established.Principal Component Analysis and evaluation model are used to calculate four parameters,including the natural resources safety index of land use,the socio-economic safety indicators of land use,the eco-environmental safety index of land use,and the ecological safety degree of land use in Ji'an City.Result indicates that the ecological safety degree of land use in Ji'an City shows a slow upward trend as a whole.At the same time,ecological safety degree of land-use change is relatively low in Ji'an City with the safety value of 0.645,which is at a weak safety zone and needs further monitoring and maintenance.

Fuzzy Synthetic Evaluation of Water Quality of Naoli River Using Parameter Correlation Analysis

In order to improve the effectiveness of Fuzzy Synthetic Evaluation (FSE) models, a Parameter Correlation Analysis (PCA) was introduced into the FSE and a case study was carried out in the Naoli River in the Sanjiang Plain, Northeast China. The basic principle of the PCA is that the pairs of parameters which are highly correlated and linear with each other would contribute the same information to an assessment and one of them should be eliminated. The method of the PCA is that a correlation relationship among candidate parameters is examined before the FSE. If there is an apparent nonlinear or curvilinear relationship between two parameters, then both will be retained; if the correlation is significant (p<0.01), and the scatter plot suggests a linear relationship, then one of them will be deleted. However, which one will be deleted? For solving this problem, a sensitivity test was conducted and the higher sensitivity parameters remained. The results indicate that the original data should be preprocessed through the PCA for redundancy and variability. The study shows that introducing the PCA into the FSE can simplify the FSE calculation process greatly, while the results have not been changed much.

Application of Principal Component Analysis(PCA)to the Evaluation and Screening of Multiactivity Fungi

Continued innovation in screening methodologies remains important for the discovery of high-quality multiactive fungi,which have been of great significance to the development of new drugs.Mangrove-derived fungi,which are well recognized as prolific sources of natural products,are worth sustained attention and further study.In this study,118 fungi,which mainly included Aspergillus spp.(34.62%)and Penicillium spp.(15.38%),were isolated from the mangrove ecosystem of the Maowei Sea,and 83.1%of the cultured fungi showed at least one bioactivity in four antibacterial and three antioxidant assays.To accurately evaluate the fungal bioactivities,the fungi with multiple bioactivities were successfully evaluated and screened by principal component analysis(PCA),and this analysis provided a dataset for comparing and selecting multibioactive fungi.Among the 118 mangrove-derived fungi tested in this study,Aspergillus spp.showed the best comprehensive activity.Fungi such as A.clavatonanicus,A.flavipes and A.citrinoterreus,which exhibited high comprehensive bioactivity as determined by the PCA,have great potential in the exploitation of natural products and the development of new drugs.This study demonstrated the first use of PCA as a time-saving,scientific method with a strong ability to evaluate and screen multiactive fungi,which indicated that this method can affect the discovery and development of new drugs.

Performance Analysis and Evaluation of Geometric Parameters in Stereo Deflectometry

This paper presents a novel geometric parameters analysis to improve the measurement accuracy of stereo deflectometry.Stereo deflectometry can be used to obtain form information for freeform specular surfaces.A measurement system based on stereo deflectometry typically consists of a fringe-displaying screen,a main camera,and a reference camera.The arrangement of the components of a stereo deflectometry system is important for achieving high-accuracy measurements.In this paper,four geometric parameters of a stereo deflectometry system are analyzed and evaluated:the distance between the main camera and the measured object surface,the angle between the main camera ray and the surface normal,the distance between the fringe-displaying screen and the object,and the angle between the main camera and the reference camera.The influence of the geometric parameters on the measurement accuracy is evaluated.Experiments are performed using simulated and experimental data.The experimental results confirm the impact of these parameters on the measurement accuracy.A measurement system based on the proposed analysis has been set up to measure a stock concave mirror.Through a comparison of the given surface parameters of the concave mirror,a global measurement accuracy of 154.2 nm was achieved.

Evaluation and Selection of Sealants and Fillers Using Principal Component Analysis for Cracks in Asphalt Concrete Pavements

The objective of this paper was to develop a comprehensive evaluation method and index to evaluate the performance of sealants and fillers for cracks in asphalt concrete pavements using the method of principal component analysis. The performance experiments including cone penetration, softening point, flow, resilience and tension at low temperature respectively were conducted by reference of ASTM D5329 for eight sealants and fillers often used in China. There by a principal component model was developed and weight of every index was calculated. The experimental results show that there are significantly different performances for sealants and fillers often used in China. Principal component analysis is an objective method that evaluates and selects the performance of sealants and fillers for cracks in asphalt concrete pavements.

Energy efficiency evaluation based on DEA integrated factor analysis in ethylene production

Energy efficiency evaluation plays an important role in energy efficiency improvement of the ethylene production. It is observed from the actual production data that the ethylene production energy efficiency often varies with the complex production working conditions. In the favored methods for energy efficiency evaluation,DEA models may show poor resolution when directly used to evaluate the efficiency values. Therefore, a new energy efficiency evaluation method for ethylene production is proposed based on DEA integrated factor analysis with respect to operation classification. Three key factors, including raw material composition, cracking depth and load rate, are taken into account in determining the production working conditions by means of k-means algorithm. Based on the multi-working conditions mode the energy efficiency evaluation of the ethylene production is made by using DEA model, where the most related energy data are screened by factor analysis.Furthermore, the supporting decision of energy efficiency improvement is provided to the operators. The accuracy and effectiveness of the proposed method are illustrated by applying in a practical ethylene production,which gives more effective energy efficiency evaluation in the complicated working conditions of ethylene production with declined dimension of input indicators.

THE EVALUATION AND ANALYSIS OF THE TOURISM RESOURCES IN JILIN PROVINCE

This paper comprehensively evaluates and analyzes the tourism resources in Jilin Province, China. And it consists of three parts. The first two parts are on the resources evaluation and analysis. Based on the results of evaluation about the structural and spatial distribution of the tourism resources, it is found that, the natural resources play fundamental roles in Jilin, while the human and cultural resources are important complementary parts as well. In the spatial distribution analysis, the resources show the characteristic of "six clusters"and "three belts"spatial relations. Four clusters are centered on the cities, which are Changchun, Jilin, Baicheng, Tonghua and Ji′an; one cluster is around the Changbai Moutains and one cluster nears the frontier at Tumen between China, Russia and P.D. R. Korea. And the three belts are: 1) The west belt. It contains Xianghai and Momoge natural protection region. The evident of this zone is its ecological and ethical tourism resources. 2)The middle belt characterized by urban traveling and recreation, including Jilin and Changchun, together with their nearby Nong′an and Siping. 3) The last belt is also the most important one, which is the east zone. It covers the Changbai Mountains, the golden triangles of Tonghua and the Tumen River. This zone is remarkable for its abundant natural landscapes and unique folk customs. In the last part the concept planning is briefly constructed for the tourism resources in Jilin Province according to the above evaluation and analysis.

Genetic background analysis and breed evaluation of Yiling yellow cattle

Traditionally, Chinese indigenous cattle is geographically widespread. The present study analyzed based on genome-wide variants to evaluate the genetic background among 157 individuals from four representative indigenous cattle breeds of Hubei Province of China： Yiling yellow cattle （YL）, Bashan cattle （BS）, Wuling cattle （WL）, Zaobei cattle （ZB）, and 21 indi- viduals of Qinchuan cattle （QC） from the nearby Shanxi Province of China. Linkage disequilibrium （LD） analysis showed the LD of YL was the lowest （~=0.32） when the distance between markers was approximately 2 kb. Principle component analysis （PCA）, and neighbor-joining （NJ）-tree revealed a separation of Yiling yellow cattle from other geographic nearby local cattle breeds. In PCA plot, the YL and QC groups were segregated as expected; moreover, YL individuals clustered together more obviously. In the N J-tree, the YL group formed an independent branch and BS, WL, ZB groups were mixed. We then used the FST statistic approach to reveal long-term selection sweep of YL and other 4 cattle breeds. According to the selective sweep, we identified the unique pathways of YL, associated with production traits. Based on the results, it can be proposed that YL has its unique genetic characteristics of excellence resource, and it is an indispensable cattle breed in China.