期刊文献+
共找到10,216篇文章
< 1 2 250 >
每页显示 20 50 100
One-step spraying method to construct superhydrophobic magnesium surface with extraordinary robustness and multi-functions 被引量:5
1
作者 Lingjie Li Xia Li +5 位作者 Jinlong Chen Lei Liu Jinglei Lei Nianbing Li Gao Liu Fusheng Pan 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2021年第2期668-675,共8页
The robust magnesium surfaces with multi-functions are highly desirable,and the simple and scalable methods to construct such surfaces are urgently indispensable.Herein,we conducted a one-step spraying method to facil... The robust magnesium surfaces with multi-functions are highly desirable,and the simple and scalable methods to construct such surfaces are urgently indispensable.Herein,we conducted a one-step spraying method to facilely fabricate the robust coating with multi-functions on magnesium alloys.The as-sprayed magnesium alloys surface is superhydrophobic with a static water contact angle(WCA)of 157.0°and a roll-off angle of 6.0°.Such surface has excellent mechanical,chemical and thermal stabilities,even undergoing various physical and chemical damages,including sand impact(10 gmin^(-1),≥20 min),water impact(2 impacts s^(-1),≥180 min),abrasion(1.00 kPa,≥25 cycles),peeling(≥2.15 kPa),high temperature(200°C,≥24 h),strong acidic/salty/basic media(p H=113)and organic-solvent immersion(ethanol and n-hexane,≥24 h),demonstrating brilliant robustness.Notably,the surface displays multi-functions of corrosion protection,anti-fouling and heat insulation,which will undoubtedly promote the much wider applications of magnesium alloys. 展开更多
关键词 Magnesium alloy Spraying method SUPERHYDROPHOBICITY ROBUSTNESS multi-functions
下载PDF
A Study on Chengdu Museum’s Endeavor to Expand Its International Influence
2
作者 Zhou Lijuan 《Contemporary Social Sciences》 2024年第5期143-155,共13页
Expanding a city’s cultural influence through museums is a growing trend in local efforts to promote cultural advancement and communication in China in the context of international engagement in the new era.Chengdu M... Expanding a city’s cultural influence through museums is a growing trend in local efforts to promote cultural advancement and communication in China in the context of international engagement in the new era.Chengdu Museum,which opened its new venue to the public in 2016,has emphasized the importance of engagement with foreign visitors as a key focus of its recent development.This aligns with Chengdu’s goal of establishing itself as a world-renowned cultural and creative city during the 14th Five-Year Plan period(2021–2025).This paper summarizes the approaches of renowned Chinese and foreign museums to expanding their international influence,citing examples such as the British Museum,the Louvre Museum,and the National Museum of China.Based on a case study of Chengdu Museum’s efforts to enhance its international communication capacity since 2016,several suggestions are put forward for urban museums regarding how to increase research capability,create a media matrix,and develop cloud exhibition platforms.This study aims to provide some insights for museums to effectively integrate resources to preserve urban culture urban culture and enhance the global influence of Chinese culture. 展开更多
关键词 museum international influence Chengdu museum cultural communication
下载PDF
Multi-functional photonic spin Hall effect sensor controlled by phase transition
3
作者 程杰 李瑞昭 +3 位作者 程骋 张亚林 刘胜利 董鹏 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第7期336-342,共7页
Photonic spin Hall effect(PSHE), as a novel physical effect in light–matter interaction, provides an effective metrological method for characterizing the tiny variation in refractive index(RI). In this work, we propo... Photonic spin Hall effect(PSHE), as a novel physical effect in light–matter interaction, provides an effective metrological method for characterizing the tiny variation in refractive index(RI). In this work, we propose a multi-functional PSHE sensor based on VO_(2), a material that can reveal the phase transition behavior. By applying thermal control, the mutual transformation into different phase states of VO_(2) can be realized, which contributes to the flexible switching between multiple RI sensing tasks. When VO_(2) is insulating, the ultrasensitive detection of glucose concentrations in human blood is achieved. When VO_(2) is in a mixed phase, the structure can be designed to distinguish between the normal cells and cancer cells through no-label and real-time monitoring. When VO_(2) is metallic, the proposed PSHE sensor can act as an RI indicator for gas analytes. Compared with other multi-functional sensing devices with the complex structures, our design consists of only one analyte and two VO_(2) layers, which is very simple and elegant. Therefore, the proposed VO_(2)-based PSHE sensor has outstanding advantages such as small size, high sensitivity, no-label, and real-time detection, providing a new approach for investigating tunable multi-functional sensors. 展开更多
关键词 photonic spin Hall effect multi-functional sensors phase transition sensing performance
下载PDF
Seismic effectiveness evaluation and optimized design of tie up method for securing museum collections
4
作者 Wang Meng Yan Yi +3 位作者 Yang Weiguo Liu Pei Ge Jiaqi Ma Botao 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2024年第3期741-763,共23页
To quantify the seismic effectiveness of the most commonly used fishing line tie up method for securing museum collections and optimize fixed strategies for exhibitions,shaking table tests of the seismic systems used ... To quantify the seismic effectiveness of the most commonly used fishing line tie up method for securing museum collections and optimize fixed strategies for exhibitions,shaking table tests of the seismic systems used for typical museum collection replicas have been carried out.The influence of body shape and fixed measure parameters on the seismic responses of replicas and the interaction behavior between replicas and fixed measures have been explored.Based on the results,seismic effectiveness evaluation indexes of the tie up method are proposed.Reasonable suggestions for fixed strategies are given,which provide a basis for the exhibition of delicate museum collections considering the principle of minimizing seismic responses and intervention.The analysis results show that a larger ratio of height of mass center to bottom diameter led to more intense rocking responses.Increasing the initial pretension of fishing lines was conducive to reducing the seismic responses and stress variation of the lines.Through comprehensive consideration of the interaction forces and effective securement,it is recommended to apply 20%of breaking stress as the initial pretension.For specific museum collections that cannot be effectively protected by the independent tie up method,an optimized strategy of a combination of fishing lines and fasteners is recommended. 展开更多
关键词 tie up method museum collections shaking table test seismic effectiveness optimized design
下载PDF
The Educational Adaptive-optics Solar Telescope at the Shanghai Astronomy Museum
5
作者 Zhimao Du Qing Lin +6 位作者 Xuejun Rao Yue Zhong Jiawen Yao Hua Bao Libo Zhong Yu Liang Hui Zhang 《Astronomical Techniques and Instruments》 CSCD 2024年第3期171-178,共8页
The Educational Adaptive-optics Solar Telescope(EAST)at the Shanghai Astronomy Museum has been running routine astronomical observations since 2021.It is a 65-cm-aperture Gregorian solar telescope for scientific educa... The Educational Adaptive-optics Solar Telescope(EAST)at the Shanghai Astronomy Museum has been running routine astronomical observations since 2021.It is a 65-cm-aperture Gregorian solar telescope for scientific education,outreach,and research.The telescope system is designed in an“open”format so that the solar tower architecture can be integrated with it,and visitors can watch the observations live from inside the tower.Equipped with adaptive optics,a high-resolution imaging system,and an integral field unit spectro-imaging system,this telescope can obtain high-resolution solar images in the TiO and Hαbands,and perform spectral image reconstruction using 400 optical fibers at selected wavelengths.It can be used not only in public education and scientific outreach but also in solar physics research. 展开更多
关键词 Astronomy museum Sun observation Adaptive optics Integral field unit
下载PDF
Tourism Mode of Tea Culture Museum in Guizhou:A Case Study of Meitan Modern Tea Culture Museum Settlement
6
作者 Yiran HU Min WANG +3 位作者 Kaixun ZHOU Qijin WANG Xue MO Xiaoxia LIU 《Asian Agricultural Research》 2024年第10期16-20,共5页
Since the 14 th Five-Year Plan,tea culture has become very popular.However,due to the lack of brand awareness and overall planning,and the mechanical application of the model outside the province and other tourism pro... Since the 14 th Five-Year Plan,tea culture has become very popular.However,due to the lack of brand awareness and overall planning,and the mechanical application of the model outside the province and other tourism products,Guizhou Tea Culture Tourism presents a"strong tea,light culture,weak tourism".In view of this,in order to realize the positioning goal of"building a national demonstration zone for the integration of tea culture and tourism"in the 14 th Five-Year Plan of Guizhou tea industry,and explore the development mode of integration of tea culture and tourism with Guizhou characteristics,this study takes museum tourism as the breakthrough point,Meitan Tea Museum settlement as the research object,and collects Meitan Tea Museum tourism resources.This paper uses SWOT analysis to evaluate the Meitan Tea Culture Museum Tourism model,and provides some recommendations for the development of tea culture museum tourism in Guizhou Province. 展开更多
关键词 Tea culture museum tourism Meitan in Guizhou Province Tea culture museum settlement
下载PDF
Research on Improving Artistry of Exhibitions in History Museums in China
7
作者 Yang Yuli Yang Xiannong 《Contemporary Social Sciences》 2024年第2期85-96,共12页
Chinese civilization,with its long and continuous history and rich cultural heritage,plays a central role in China’s dialogue with other civilizations.Therefore,it is necessary to collect and refine the defining symb... Chinese civilization,with its long and continuous history and rich cultural heritage,plays a central role in China’s dialogue with other civilizations.Therefore,it is necessary to collect and refine the defining symbols and best elements of Chinese culture and showcase them to the world;develop discourse and narrative systems with Chinese characteristics,better tell China’s stories,and make China’s voice heard.This effort can help Chinese civilization shine globally,interact with other civilizations,and promote its communication and influence worldwide.In China,history museums,as physical carriers of Chinese civilization,are an important component in developing Chinese discourse and narrative systems and an important channel to better tell China’s stories and make China’s voice heard.Improving the artistry of museum exhibitions caters to the public’s growing demand for a more enriching cultural experience and substantially promotes Chinese culture on a global scale.With the communication of Chinese civilization as the main focal point,this study investigated the current issues related to the artistry of history museum exhibitions in China and defined the artistry of history museum exhibitions and their connotations.Based on an in-depth analysis of the artistry of historical museum exhibitions within China,this paper enumerated the areas where improvements could be made to enhance exhibition artistry,intending to promote the communication of Chinese civilization. 展开更多
关键词 history museums ARTISTRY AESTHETICS communication of Chinese culture Chinese civilization
下载PDF
Beauty in the Gathering:Exhibition of Precious Collection from Art Museums Around China
8
《China & The World Cultural Exchange》 2024年第4期38-43,共6页
"Beauty in the Gathering:Exhibition of Precious Collection from Art Museums around China"opens at the National Art Museum of China(NAMOC)on February 1 and lasts until April 1.The exhibition provides a glimps... "Beauty in the Gathering:Exhibition of Precious Collection from Art Museums around China"opens at the National Art Museum of China(NAMOC)on February 1 and lasts until April 1.The exhibition provides a glimpse of the great variety of art collected by 15 museums,and distinctive features that vary from region to region,which has witnessed the further prosperity and development of the art museum industry since the new era.The exhibition showcases over 500 pieces of traditional Chinese painting,oil painting,printmaking,watercolor painting,lacquer painting,sculpture,folk art,mixed media art,calligraphy and other collections provided by these museums. 展开更多
关键词 museum EXHIBITION PAINTING
下载PDF
Analysis on the Development Model of Relic and Museum Tourism Products Based on ERP Analysis:A Case Study on Shandong Province
9
作者 WANG Xia 《Journal of Landscape Research》 2024年第1期77-82,共6页
In recent years, the trend of people choosing relic and museum tourism during their vacationand leisure time is growing day by day, mainly because it touches people's feelings about historical relicsand cultural h... In recent years, the trend of people choosing relic and museum tourism during their vacationand leisure time is growing day by day, mainly because it touches people's feelings about historical relicsand cultural heritage. The development of relic and museum tourism products is not only the inheritanceof culture and the protection of cultural relics, but also the promotion of tourism consumption under thebackground of cultural tourism integration, which has promoted the development of regional economy.With the relic and museum tourism resources in Shandong Province as the research object, through theanalysis of its resources, market and products, this paper put forward three applicable modes of relic andmuseum tourism product development, including independent development, joint development, and artauthorization, and proposed specific suggestions around the three modes. 展开更多
关键词 ERP analysis Relic and museum tourism Product development Shandong Province
下载PDF
“Luminous Conflicts:Navigating Architecture,Light,and Visitor Experience in Museums”:The Case of Yale Center for British Art
10
作者 Charalampia N.Dimitropoulou Andreas Giacumacatos 《Journal of Civil Engineering and Architecture》 2024年第9期415-422,共8页
The architectural design of the YCBA(Yale Center for British Art)exemplifies Kahn’s exploration of light as a transformative element.However,preserving sensitive materials within the museum challenges the building’s... The architectural design of the YCBA(Yale Center for British Art)exemplifies Kahn’s exploration of light as a transformative element.However,preserving sensitive materials within the museum challenges the building’s original intent.The potential harm caused by light necessitates control measures,potentially compromising the intended luminous ambiance envisioned by Kahn.A comprehensive survey revealed a strong preference for natural light in the museum environment.Visitors appreciated the ethereal qualities and heightened engagement with exhibits facilitated by natural light.This research critically examines the balance between architectural vision,preservation imperatives,and visitor expectations,highlighting the museum space as a dynamic field of action.The architectural elements,interior configuration,lighting,and movement are in constant harmony and conflict.This investigation contributes to a deeper understanding of the relationship between architecture,light,the museum experience,and knowledge.It underscores the importance of considering preservation,design,and visitor preferences when balancing these elements in museums. 展开更多
关键词 ARCHITECTURE LIGHT VISITORS museum experience
下载PDF
Integration of Environmental and Social Values in Cultural Spaces:Sustainable and Inclusive Wayfinding Materials for Museums
11
作者 Cristiana Cellucci Teresa Villani 《Journal of Civil Engineering and Architecture》 2024年第5期207-217,共11页
In the context of use of large museum centers,numerous national and international methodological experiments show that the wayfinding project must consider the needs of both habitual users(user-centered design)and loc... In the context of use of large museum centers,numerous national and international methodological experiments show that the wayfinding project must consider the needs of both habitual users(user-centered design)and local communities(design for communities)and the importance of environmental protection(eco-design)as a priority interest of the community.This“double target”,“user-centered”and“environment-centered”can be applied during the selection process of materials to be used in the project.With respect to these possibilities,this contribution intends to present the results of research focused on material characterization of the reception and distribution spaces of large museum centers.This characterization is based on use of sensory materials and aims to evaluate their impact on the usability and sustainability of wayfinding systems.The paper directed towards a proposal for organization of integrated information on new generation so-called smart materials;within the design of a wayfinding system,these can balance the aesthetic-perceptual and performance and environmental impact,in order to allow designers to make informed decisions oriented towards inclusion and sustainability.The study was addressed by conducting two phases of systematic literature and library review of materials.The investigations conducted led to achievement of a first research result which consists in the identification of a“standard sheet”for the mapping and cataloging of the materials used for wayfinding.The“standard sheet”allows organizing the information on smart,sensorial,and eco-friendly materials,balancing the aesthetic-perceptive component with the performance on the environmental impact along the entire life cycle in a circular perspective.This tool could guide designers towards an environmental communication project oriented towards sustainability and is effective for usability and wayfinding. 展开更多
关键词 WAYFINDING eco-friendly materials sensory materials user-centered design ECO-DESIGN innovative museum
下载PDF
A Discussion on the Structure and Spatial Composition of Long Museum West Bund
12
作者 Guanyan Xiao 《Journal of World Architecture》 2024年第3期1-8,共8页
The Long Museum,with its distinctive T-shaped“umbrella-vault”structure,offers a rich array of spatial experiences.This article delves into space from both structural and compositional perspectives.As the constructio... The Long Museum,with its distinctive T-shaped“umbrella-vault”structure,offers a rich array of spatial experiences.This article delves into space from both structural and compositional perspectives.As the construction mediator,the umbrella vault embodies the consistency of construction and implies the causality of the surface.Presented as an element,the space flows freely,showing diverse fields and order.In terms of the liberation of its meaning,the space offers static perception and dynamic experience,creating a rich exhibition atmosphere.As a distinct entity,the umbrella-vault presents the physical nature,and the dialogue between the Long Museum and the city makes it a museum of art for the people. 展开更多
关键词 Long museum STRUCTURE Spatial composition Umbrella-vault
下载PDF
Development Strategy of Sichuan Sports Museum under the Background of Cultural and Tourism Integration
13
作者 Junxian Feng 《Proceedings of Business and Economic Studies》 2024年第3期173-178,共6页
Through conducting a SWOT analysis of the Chengdu Sports Institute Museum,and utilizing the 4M management,5W display,and 4P marketing theoretical models,this study explores effective strategies suitable for Sichuan sp... Through conducting a SWOT analysis of the Chengdu Sports Institute Museum,and utilizing the 4M management,5W display,and 4P marketing theoretical models,this study explores effective strategies suitable for Sichuan sports museums in terms of functionality,display,and marketing. 展开更多
关键词 Integration of culture and tourism Sports museum Development strategy
下载PDF
Dilemma and Exploration of Resource Sharing in University Museums of Natural History——using Natural History Museum of Zhengzhou Normal University as an example
14
作者 李长看 《Agricultural Science & Technology》 CAS 2013年第7期1064-1068,F0003,共6页
A natural history museum is a museum for collection, researching and presenting natural environment and natural heritages about natural history. In the research, based on the analysis on necessity of university museum... A natural history museum is a museum for collection, researching and presenting natural environment and natural heritages about natural history. In the research, based on the analysis on necessity of university museums’ services to society in resources sharing, the difficulties and dilemmas were summarized in sharing resources of museums and the approaches for resources sharing were explored with the case of Natural History Museum of Zhengzhou Normal University in order to investigate the way for better services of university museum to the public. 展开更多
关键词 University museum of natural history Social services Resource sharing METHODS
下载PDF
Catalogue of the Type Specimens of Amphibians and Reptiles in the Herpetological Museum of the Chengdu Institute of Biology,Chinese Academy of Sciences:Ⅱ.Hynobiidae (Amphibia,Urodela) 被引量:2
15
作者 Jianli XIONG Yueying CHEN Xiaomao ZENG 《Asian Herpetological Research》 SCIE 2012年第4期327-333,共7页
In order to facilitate herpetological research for herpetologists in and outside of China,we will report all the type specimens of Amphibia and Reptilia deposited in the Herpetological Museum of the Chengdu Institute ... In order to facilitate herpetological research for herpetologists in and outside of China,we will report all the type specimens of Amphibia and Reptilia deposited in the Herpetological Museum of the Chengdu Institute of Biology(CIB),Chinese Academy of Sciences(CAS) in series. This report focuses on the type specimens of the family Hynobiidae of Urodela in Amphibia,which comprises seven species. Each entry provides the genus name,species name,information of the original description,the catalog number of holotype,sex,type locality,information of allotype(if any) and paratype,number and distribution of deposited specimens,and comments where they are appropriate. 展开更多
关键词 type specimen CATALOGUE hynobiid salamander museum
下载PDF
The Pterosaur Collection at the Natural History Museum,London,UK:an Overview and List of Specimens,with Description of Recent Curatorial Developments 被引量:1
16
作者 Lorna STEEL 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2012年第6期1340-1355,共16页
The pterosaur collection at the Natural History Museum is of great historical importance. Most of the material is figured or cited, and several specimens are types or casts of types. Pterosaurs from UK localities are ... The pterosaur collection at the Natural History Museum is of great historical importance. Most of the material is figured or cited, and several specimens are types or casts of types. Pterosaurs from UK localities are well represented, but foreign material is also present as original specimens and as high quality casts. The entire collection has been recorded in a database and curatorial improvements have been made, which has improved physical and virtual access to the collection. Although many of the specimens were collected as long ago as the early 1800s, they are still useful today. A full list of Natural History Museum pterosaur specimens is published, for the first time since 1888. 展开更多
关键词 PTEROSAURIA CURATION museum
下载PDF
基于Citespace软件的国际museum learning研究现状与趋势分析 被引量:7
17
作者 朱家华 陈怡 +1 位作者 孟凡龙 崔鸿 《中国博物馆》 北大核心 2020年第1期47-53,共7页
Museum learning是国内博物馆教育研究领域的热点,把握和追踪museum learning的国际研究热点与趋势,有助于教育研究者更好的审视国内博物馆教育现状,更有效地提供理论与实践支持。研究中、通过对web of science数据库807篇museum learn... Museum learning是国内博物馆教育研究领域的热点,把握和追踪museum learning的国际研究热点与趋势,有助于教育研究者更好的审视国内博物馆教育现状,更有效地提供理论与实践支持。研究中、通过对web of science数据库807篇museum learning研究文献的梳理. 展开更多
关键词 museum LEARNING 场馆学习 博物馆学习 馆校合作 CITESPACE
下载PDF
Design of Drilling and Riveting Multi-functional End Effector for CFRP and Aluminum Components in Robotic Aircraft Assembly 被引量:6
18
作者 Zhang Lin Tian Wei +4 位作者 Li Dawei Hong Peng Li Zhenyu Zhou Weixue Liao Wenhe 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI CSCD 2018年第3期529-538,共10页
To fulfill the demands for higher quality,efficiency and flexibility in aviation industry,a multi-functional end effector is designed to automate the drilling and riveting processes in assembling carbon fiber reinforc... To fulfill the demands for higher quality,efficiency and flexibility in aviation industry,a multi-functional end effector is designed to automate the drilling and riveting processes in assembling carbon fiber reinforced polymer(CFRP)and aluminum components for a robotic aircraft assembly system.To meet the specific functional requirements for blind rivet installation on CFRP and aluminum materials,additional modules are incorporated on the end effector aside of the basic processing modules for drilling.And all of these processing modules allow for a onestep-drilling-countersinking process,hole inspection,automatic rivet feed,rivet geometry check,sealant application,rivet insertion and installation.Besides,to guarantee the better quality of the hole drilled and joints riveted,several online detection and adjustment measures are applied to this end effector,including the reference detection and perpendicular calibration,which could effectively ensure the positioning precision and perpendicular accuracy as demanded.Finally,the test result shows that this end effector is capable of producing each hole to a positioning precision within ±0.5 mm,aperpendicular accuracy within 0.3°,a diameter tolerance of H8,and a countersink depth tolerance of±0.01 mm.Moreover,it could drill and rivet up to three joints per minute,with acceptable shearing and tensile strength. 展开更多
关键词 robotic aircraft assembly CFRP and aluminum components automatic drilling and riveting multi-functional end effector online detection and adjustment
下载PDF
An Evaluation of Light Distribution in the Exhibition Areas of the Mimesis Art Museum Designed by Alvaro Siza 被引量:1
19
作者 Chang Sung Kim 《Journal of Building Construction and Planning Research》 2014年第4期227-243,共17页
The works of Alvaro Siza have been referred that they were not the theoretical architecture but the sensual and experiential one. His works were designed on the base of their locality that each of them located. For th... The works of Alvaro Siza have been referred that they were not the theoretical architecture but the sensual and experiential one. His works were designed on the base of their locality that each of them located. For the study, I selected a work of him, which was the Mimesis Art Museum at Paju in South Korea, and reviewed existing literatures to understand how he controlled the light and created the architectural spaces and forms in relation with the light, and I measured the illumination levels of the inside areas of the Mimesis Art Museum, and then, I surveyed the visitors’ responses on the lighting conditions of the Mimesis Art Museum. The results of the measurements showed that the illumination levels of the Mimesis Art museum on the first floor were effectively controlled to display the art works. The illumination levels on the third floor, however, were much higher than recommended illumination values for museum because of less controlled natural light. Therefore, more considerations to control the natural light are needed to secure stable environment in the exhibition spaces. Meanwhile, the answers of questionnaires concerning the quality of lighting conditions in the Mimesis Art Museum showed that the natural light was so effective to light the museum although the natural light illuminated some areas of the museum with high illumination levels. 展开更多
关键词 Alvaro Siza The Memesis ART museum NATURAL LIGHT
下载PDF
Development of a novel multi-functional integrated bioconjugate effectively targeting K-Ras mutant pancreatic cancer 被引量:1
20
作者 Yang-Yang Wang Liang Li +4 位作者 Xiu-Jun Liu Qing-Fang Miao Yi Li Meng-Ran Zhang Yong-Su Zhen 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2022年第2期232-242,共11页
Folate receptor(FR)overexpression occurs in a variety of cancers,including pancreatic cancer.In addition,enhanced macropinocytosis exists in K-Ras mutant pancreatic cancer.Furthermore,the occurrence of intensive desmo... Folate receptor(FR)overexpression occurs in a variety of cancers,including pancreatic cancer.In addition,enhanced macropinocytosis exists in K-Ras mutant pancreatic cancer.Furthermore,the occurrence of intensive desmoplasia causes a hypoxic microenvironment in pancreatic cancer.In this study,a novel FR-directed,macropinocytosis-enhanced,and highly cytotoxic bioconjugate folate(F)-human serum albumin(HSA)-apoprotein of lidamycin(LDP)-active enediyne(AE)derived from lidamycin was designed and prepared.F-HSA-LDP-AE consisted of four moieties:F,HSA,LDP,and AE.F-HSA-LDP presented high binding efficiency with the FR and pancreatic cancer cells.Its uptake in wild-type cells was more extensive than in K-Ras mutant-type cells.By in vivo optical imaging,F-HSA-LDP displayed prominent tumor-specific biodistribution in pancreatic cancer xenograft-bearing mice,showing clear and lasting tumor localization for 360 h.In the MTT assay,F-HSA-LDP-AE demonstrated potent cytotoxicity in three types of pancreatic cancer cell lines.It also induced apoptosis and caused G2/M cell cycle arrest.F-HSALDP-AE markedly suppressed the tumor growth of AsPc-1 pancreatic cancer xenografts in athymic mice.At well-tolerated doses of 0.5 and 1 mg/kg,(i.v.,twice),the inhibition rates were 91.2%and 94.8%,respectively(P<0.01).The results of this study indicate that the F-HSA-LDP multi-functional bioconjugate might be effective for treating K-Ras mutant pancreatic cancer. 展开更多
关键词 Pancreatic cancer Folate receptor multi-functional Macropinocytosis-enhanced BIOCONJUGATE K-RAS PEGYLATION
下载PDF
上一页 1 2 250 下一页 到第
使用帮助 返回顶部