Background: Many patients with irritable bowel syndrome (IBS) try the approach of complementary or herbal medicines, as western medications do not treat IBS. The current case report presents the combine effect of four...Background: Many patients with irritable bowel syndrome (IBS) try the approach of complementary or herbal medicines, as western medications do not treat IBS. The current case report presents the combine effect of four herbal components as a traditional treatment of IBS. Method: The herbal components were purchased from the local market. The components including Lipidium sativum L., Trigonella foenum-graceum L., Myristica fragrance Hoyutt. and Apium graveolens Linn were ground and mixed well (dry weight), and took orally for two days as advised by the local healer. Results: The symptoms included loose bowel movements accompanied by prolonged flatulence abdominal cramping, faecal urgency as well as mucus discharge were improved and remain suppressed for 5 to 6 months afterthe treatment with multi-herbal formula. Conclusion: The current case report showed that the multi-herbal formula might be a promising treatment for IBS-diarrhoea.展开更多
Xiaoer-Feire-Kechuan(XFK) is an 11-herb Chinese medicine formula to treat cough and pulmonary inflammation.The complicated composition rendered its chemical analysis and effective-component elucidation.In this study,w...Xiaoer-Feire-Kechuan(XFK) is an 11-herb Chinese medicine formula to treat cough and pulmonary inflammation.The complicated composition rendered its chemical analysis and effective-component elucidation.In this study,we combined quantitative analysis and bioactivity test to reveal the antiinflammatory constituents of XFK.First,UPLC-DAD and UHPLC/Q-Orbitrap-MS methods were established and validated to quantify 35 analytes(covering 9 out of 11 herbs) in different XFK formulations.Parallel reaction monitoring mode built in Q-Orbitrap-MS was used to improve the sensitivity and selectivity.Then,anti-inflammatory activities of the 35 analytes were analyzed using in vitro COX-2 inhibition assay.Finally,major analytes forsythosides H,I,A(8-10),and baicalin(15)(total contents varied from 21.79 to 91.20 mg/dose in different formulations) with significant activities(inhibitory rate ≥ 80%) were proposed as the anti-inflammatory constituents of XFK.The present study provided an effective strategy to discover effective constituents of multi-herb formulas.展开更多
Recently reports showed that the pathobiology of acne vulgaris was arising from the exploration of sebaceous gland biology, hormonal factors, hyper-keratinization, and the role of bacteria, sebum, nutrition, cytokines...Recently reports showed that the pathobiology of acne vulgaris was arising from the exploration of sebaceous gland biology, hormonal factors, hyper-keratinization, and the role of bacteria, sebum, nutrition, cytokines and toll-like receptors (TLRs). Propionibacterium acnes (P.acnes) has a strong proinflammatory activity and targets molecules involved in the innate cutaneous immunity on keratinocytes by acting on TLR-2, leads to the development of comedones. GMP, a multi-herb extraction, targeted most of the major pathogenic features of acne with desired physicochemical traits. It strongly suppressed P.acnes growth, and reduced inflammation by suppressing the TLR-2/NF- kB pathway in SZ-95 sebocytes and HaCaT keratinocytes. GMP exhibited a marginal effect on cell viability and may have modulated hyper-keratinization of the epidermis. These results demonstrate the clinical feasibility of applying GMP for the treatment of acne.展开更多
目的:探讨手部动力支具在多区肌腱修复术后的临床应用效果。方法:选取2016年6月~2018年2月我院收治的81例肌腱损伤患者作为研究对象,采用随机数字表法分为支具组45例和对照组36例。支具组安装手部动力支具进行功能锻炼,并配合中药熏洗;...目的:探讨手部动力支具在多区肌腱修复术后的临床应用效果。方法:选取2016年6月~2018年2月我院收治的81例肌腱损伤患者作为研究对象,采用随机数字表法分为支具组45例和对照组36例。支具组安装手部动力支具进行功能锻炼,并配合中药熏洗;对照组给予常规治疗,并配合中药熏洗。治疗后,用总主动活动度测定法(total active movement,TAM)评定患指肌腱修复后的功能。结果:随访3个月,支具组的综合优良率为87.9%,高于对照组的63.9%,差异有统计学意义,P<0.05;支具组的二次松解手术发生率明显低于对照组,差异有统计学意义,χ2=3.854,P=0.048<0.05;两组均未发生不良反应。结论:手部动力支具能较明显地降低肌腱修复术后粘连的发生率和二次松解手术发生率,安全有效。展开更多
文摘Background: Many patients with irritable bowel syndrome (IBS) try the approach of complementary or herbal medicines, as western medications do not treat IBS. The current case report presents the combine effect of four herbal components as a traditional treatment of IBS. Method: The herbal components were purchased from the local market. The components including Lipidium sativum L., Trigonella foenum-graceum L., Myristica fragrance Hoyutt. and Apium graveolens Linn were ground and mixed well (dry weight), and took orally for two days as advised by the local healer. Results: The symptoms included loose bowel movements accompanied by prolonged flatulence abdominal cramping, faecal urgency as well as mucus discharge were improved and remain suppressed for 5 to 6 months afterthe treatment with multi-herbal formula. Conclusion: The current case report showed that the multi-herbal formula might be a promising treatment for IBS-diarrhoea.
基金supported by the National Key Research and Development Program of China (Grant No.: 2018YFC1707304, 2018YFC1707301)Beijing Natural Science Foundation (Grant No.: JQ18027)National Natural Science Foundation of China (Grant No.: 81725023)。
文摘Xiaoer-Feire-Kechuan(XFK) is an 11-herb Chinese medicine formula to treat cough and pulmonary inflammation.The complicated composition rendered its chemical analysis and effective-component elucidation.In this study,we combined quantitative analysis and bioactivity test to reveal the antiinflammatory constituents of XFK.First,UPLC-DAD and UHPLC/Q-Orbitrap-MS methods were established and validated to quantify 35 analytes(covering 9 out of 11 herbs) in different XFK formulations.Parallel reaction monitoring mode built in Q-Orbitrap-MS was used to improve the sensitivity and selectivity.Then,anti-inflammatory activities of the 35 analytes were analyzed using in vitro COX-2 inhibition assay.Finally,major analytes forsythosides H,I,A(8-10),and baicalin(15)(total contents varied from 21.79 to 91.20 mg/dose in different formulations) with significant activities(inhibitory rate ≥ 80%) were proposed as the anti-inflammatory constituents of XFK.The present study provided an effective strategy to discover effective constituents of multi-herb formulas.
文摘Recently reports showed that the pathobiology of acne vulgaris was arising from the exploration of sebaceous gland biology, hormonal factors, hyper-keratinization, and the role of bacteria, sebum, nutrition, cytokines and toll-like receptors (TLRs). Propionibacterium acnes (P.acnes) has a strong proinflammatory activity and targets molecules involved in the innate cutaneous immunity on keratinocytes by acting on TLR-2, leads to the development of comedones. GMP, a multi-herb extraction, targeted most of the major pathogenic features of acne with desired physicochemical traits. It strongly suppressed P.acnes growth, and reduced inflammation by suppressing the TLR-2/NF- kB pathway in SZ-95 sebocytes and HaCaT keratinocytes. GMP exhibited a marginal effect on cell viability and may have modulated hyper-keratinization of the epidermis. These results demonstrate the clinical feasibility of applying GMP for the treatment of acne.
文摘目的:探讨手部动力支具在多区肌腱修复术后的临床应用效果。方法:选取2016年6月~2018年2月我院收治的81例肌腱损伤患者作为研究对象,采用随机数字表法分为支具组45例和对照组36例。支具组安装手部动力支具进行功能锻炼,并配合中药熏洗;对照组给予常规治疗,并配合中药熏洗。治疗后,用总主动活动度测定法(total active movement,TAM)评定患指肌腱修复后的功能。结果:随访3个月,支具组的综合优良率为87.9%,高于对照组的63.9%,差异有统计学意义,P<0.05;支具组的二次松解手术发生率明显低于对照组,差异有统计学意义,χ2=3.854,P=0.048<0.05;两组均未发生不良反应。结论:手部动力支具能较明显地降低肌腱修复术后粘连的发生率和二次松解手术发生率,安全有效。
