Bacillus Calmette-Guerin(BCG) intravesical instillation has been adopted in the treatment of patients with superficial bladder cancer.BCG-induced disseminated infection,though rare,has been associated with the histolo...Bacillus Calmette-Guerin(BCG) intravesical instillation has been adopted in the treatment of patients with superficial bladder cancer.BCG-induced disseminated infection,though rare,has been associated with the histological finding of epithelioid granulomas in different organs,including the liver.We report the case of an adult patient with multi-organ failure,who developed sepsis,acute respiratory failure and acute hepatic failure with encephalopathy whose liver biopsy confirmed the presence of atypical,granulomatous-like lesions.Recovery was observed only after empirical therapy for Mycobacterium bovis with isoniazid,rifampicin,ethambutol and steroids was introduced.This case highlights the importance of a thorough patient assessment in order to exclude other more common causes of hepatic granulomas and to confirm diagnosis.Histological findings may be non-specific when the liver is involved in BCGinduced disseminated infection.展开更多
Dormancy represents a fascinating adaptive strategy for organisms to survive in unforgiving environments.After a period of dormancy,organisms often exhibit exceptional resilience.This period is typically divided into ...Dormancy represents a fascinating adaptive strategy for organisms to survive in unforgiving environments.After a period of dormancy,organisms often exhibit exceptional resilience.This period is typically divided into hibernation and aestivation based on seasonal patterns.However,the mechanisms by which organisms adapt to their environments during dormancy,as well as the potential relationships between different states of dormancy,deserve further exploration.Here,we selected Perccottus glenii and Protopterus annectens as the primary subjects to study hibernation and aestivation,respectively.Based on histological and transcriptomic analysis of multiple organs,we discovered that dormancy involved a coordinated functional response across organs.Enrichment analyses revealed noteworthy disparities between the two dormant species in their responses to extreme temperatures.Notably,similarities in gene expression patterns pertaining to energy metabolism,neural activity,and biosynthesis were noted during hibernation,suggesting a potential correlation between hibernation and aestivation.To further explore the relationship between these two phenomena,we analyzed other dormancy-capable species using data from publicly available databases.This comparative analysis revealed that most orthologous genes involved in metabolism,cell proliferation,and neural function exhibited consistent expression patterns during dormancy,indicating that the observed similarity between hibernation and aestivation may be attributable to convergent evolution.In conclusion,this study enhances our comprehension of the dormancy phenomenon and offers new insights into the molecular mechanisms underpinning vertebrate dormancy.展开更多
With the support of the National Natural Science Foundation of China and the Ministry of Science and Technology of China,the research teams led by Prof.Gao Hua(高华)from Tongji University,and Prof.Filippo Giancotti at...With the support of the National Natural Science Foundation of China and the Ministry of Science and Technology of China,the research teams led by Prof.Gao Hua(高华)from Tongji University,and Prof.Filippo Giancotti at Memorial Sloan Kettering Cancer Center,reported recently on the mechanism of multiorgan site metastatic creactivation,which was published in Cell(2016,166:47—62).展开更多
钢铁材料微观组织决定了钢的力学性能,因此对钢材微观组织的识别十分重要。钢铁材料显微组织图片放大倍数差异大,同种微观组织在不同放大倍数下的形貌也有很大差别,对持续扩充的多尺度钢材微观组织数据集进行分类的难度很大。因此,结合V...钢铁材料微观组织决定了钢的力学性能,因此对钢材微观组织的识别十分重要。钢铁材料显微组织图片放大倍数差异大,同种微观组织在不同放大倍数下的形貌也有很大差别,对持续扩充的多尺度钢材微观组织数据集进行分类的难度很大。因此,结合VGG16网络和自组织增量神经网络(Self Organizing Incremental Neural Network,SOINN),构建基于增量学习的多尺度钢材微观组织图像分类模型;同时,提出基于中心距离的交叉熵损失(Cross Entropy Loss based on Center Distance,CELCD)和交叉训练策略,并融合交叉训练、CELCD和Anchor loss克服“灾难性遗忘”问题,实现对钢材微观组织图片数据的持续学习和高效分类。实验比较了不同增量学习方法在旧数据上的分类精度和“遗忘程度”,结果表明,在增量学习后所提方法的预测精度较增量学习前仅下降14.02%的前提下,在旧数据上的分类精度最高可达80.49%,与上限精度仅相差5.49%,优于其他增量学习方法。展开更多
文摘Bacillus Calmette-Guerin(BCG) intravesical instillation has been adopted in the treatment of patients with superficial bladder cancer.BCG-induced disseminated infection,though rare,has been associated with the histological finding of epithelioid granulomas in different organs,including the liver.We report the case of an adult patient with multi-organ failure,who developed sepsis,acute respiratory failure and acute hepatic failure with encephalopathy whose liver biopsy confirmed the presence of atypical,granulomatous-like lesions.Recovery was observed only after empirical therapy for Mycobacterium bovis with isoniazid,rifampicin,ethambutol and steroids was introduced.This case highlights the importance of a thorough patient assessment in order to exclude other more common causes of hepatic granulomas and to confirm diagnosis.Histological findings may be non-specific when the liver is involved in BCGinduced disseminated infection.
基金supported by the National Natural Science Foundation of China (32170480,31972866)Youth Innovation Promotion Association,Chinese Academy of Sciences (http://www.yicas.cn)+1 种基金Young Top-notch Talent Cultivation Program of Hubei ProvinceWuhan Branch,Supercomputing Center,Chinese Academy of Sciences,China。
文摘Dormancy represents a fascinating adaptive strategy for organisms to survive in unforgiving environments.After a period of dormancy,organisms often exhibit exceptional resilience.This period is typically divided into hibernation and aestivation based on seasonal patterns.However,the mechanisms by which organisms adapt to their environments during dormancy,as well as the potential relationships between different states of dormancy,deserve further exploration.Here,we selected Perccottus glenii and Protopterus annectens as the primary subjects to study hibernation and aestivation,respectively.Based on histological and transcriptomic analysis of multiple organs,we discovered that dormancy involved a coordinated functional response across organs.Enrichment analyses revealed noteworthy disparities between the two dormant species in their responses to extreme temperatures.Notably,similarities in gene expression patterns pertaining to energy metabolism,neural activity,and biosynthesis were noted during hibernation,suggesting a potential correlation between hibernation and aestivation.To further explore the relationship between these two phenomena,we analyzed other dormancy-capable species using data from publicly available databases.This comparative analysis revealed that most orthologous genes involved in metabolism,cell proliferation,and neural function exhibited consistent expression patterns during dormancy,indicating that the observed similarity between hibernation and aestivation may be attributable to convergent evolution.In conclusion,this study enhances our comprehension of the dormancy phenomenon and offers new insights into the molecular mechanisms underpinning vertebrate dormancy.
文摘With the support of the National Natural Science Foundation of China and the Ministry of Science and Technology of China,the research teams led by Prof.Gao Hua(高华)from Tongji University,and Prof.Filippo Giancotti at Memorial Sloan Kettering Cancer Center,reported recently on the mechanism of multiorgan site metastatic creactivation,which was published in Cell(2016,166:47—62).
文摘钢铁材料微观组织决定了钢的力学性能,因此对钢材微观组织的识别十分重要。钢铁材料显微组织图片放大倍数差异大,同种微观组织在不同放大倍数下的形貌也有很大差别,对持续扩充的多尺度钢材微观组织数据集进行分类的难度很大。因此,结合VGG16网络和自组织增量神经网络(Self Organizing Incremental Neural Network,SOINN),构建基于增量学习的多尺度钢材微观组织图像分类模型;同时,提出基于中心距离的交叉熵损失(Cross Entropy Loss based on Center Distance,CELCD)和交叉训练策略,并融合交叉训练、CELCD和Anchor loss克服“灾难性遗忘”问题,实现对钢材微观组织图片数据的持续学习和高效分类。实验比较了不同增量学习方法在旧数据上的分类精度和“遗忘程度”,结果表明,在增量学习后所提方法的预测精度较增量学习前仅下降14.02%的前提下,在旧数据上的分类精度最高可达80.49%,与上限精度仅相差5.49%,优于其他增量学习方法。
