Organ-on-a-chip technology aims to reproduce the key physiological features of human organs and tissues,even complex actions of multi-organ interaction.While organ-on-a-chips at single-organ level has made notable ach...Organ-on-a-chip technology aims to reproduce the key physiological features of human organs and tissues,even complex actions of multi-organ interaction.While organ-on-a-chips at single-organ level has made notable achievement during the last decade,multi-organ-on-a-chips,which manifests unique advantages,has started gathering attention only recently.In this viewpoint,we discuss the current status of organ-on-a-chip technology,with a specific emphasis on multi-organ-on-a-chip.Key technological advances contributing to the maturation of the field,and challenges that need to be addressed before wider adoption in relevant fields are discussed.We will share our perspectives on how the multi-organ-on-a-chip can improve the drug development process.展开更多
基金This work was supported by National Research Foundation of Korea,under Grant(Basic Research Lab,2019R1A4A1025958)by the Ministry of Trade,Industry&Energy(MOTIE),Republic of Korea,under the Technology Innovation Program,Grant 20008414(Development of intestine-liver-kidney multiorgan tissue chip mimicking absorption distribution metabolism excretion of drug),Hongik University Research Fund.
文摘Organ-on-a-chip technology aims to reproduce the key physiological features of human organs and tissues,even complex actions of multi-organ interaction.While organ-on-a-chips at single-organ level has made notable achievement during the last decade,multi-organ-on-a-chips,which manifests unique advantages,has started gathering attention only recently.In this viewpoint,we discuss the current status of organ-on-a-chip technology,with a specific emphasis on multi-organ-on-a-chip.Key technological advances contributing to the maturation of the field,and challenges that need to be addressed before wider adoption in relevant fields are discussed.We will share our perspectives on how the multi-organ-on-a-chip can improve the drug development process.
