Dynamic microphysiological system chip platform for high-throughput,customizable,and multi-dimensional drug screening

Spheroids and organoids have attracted significant attention as innovative models for disease modeling and drug screening.By employing diverse types of spheroids or organoids,it is feasible to establish microphysiological systems that enhance the precision of disease modeling and offer more dependable and comprehensive drug screening.High-throughput microphysiological systems that support optional,parallel testing of multiple drugs have promising applications in personalized medical treatment and drug research.However,establishing such a system is highly challenging and requires a multidisciplinary approach.This study introduces a dynamic Microphysiological System Chip Platform(MSCP)with multiple functional microstructures that encompass the mentioned advantages.We developed a high-throughput lung cancer spheroids model and an intestine-liverheart-lung cancer microphysiological system for conducting parallel testing on four anti-lung cancer drugs,demonstrating the feasibility of the MSCP.This microphysiological system combines microscale and macroscale biomimetics to enable a comprehensive assessment of drug efficacy and side effects.Moreover,the microphysiological system enables evaluation of the real pharmacological effect of drug molecules reaching the target lesion after absorption by normal organs through fluid-based physiological communication.The MSCP could serves as a valuable platform for microphysiological system research,making significant contributions to disease modeling,drug development,and personalized medical treatment.

Effect of preload forces on multidimensional signal dynamic behaviours for battery early safety warning

Providing early safety warning for batteries in real-world applications is challenging.In this study,comprehensive thermal abuse experiments are conducted to clarify the multidimensional signal evolution of battery failure under various preload forces.The time-sequence relationship among expansion force,voltage,and temperature during thermal abuse under five categorised stages is revealed.Three characteristic peaks are identified for the expansion force,which correspond to venting,internal short-circuiting,and thermal runaway.In particular,an abnormal expansion force signal can be detected at temperatures as low as 42.4°C,followed by battery thermal runaway in approximately 6.5 min.Moreover,reducing the preload force can improve the effectiveness of the early-warning method via the expansion force.Specifically,reducing the preload force from 6000 to 1000 N prolongs the warning time(i.e.,227 to 398 s)before thermal runaway is triggered.Based on the results,a notable expansion force early-warning method is proposed that can successfully enable early safety warning approximately 375 s ahead of battery thermal runaway and effectively prevent failure propagation with module validation.This study provides a practical reference for the development of timely and accurate early-warning strategies as well as guidance for the design of safer battery systems.

Improving the utility of locally differentially private protocols for longitudinal and multidimensional frequency estimates

This paper investigates the problem of collecting multidimensional data throughout time(i.e.,longitudinal studies)for the fundamental task of frequency estimation under Local Differential Privacy(LDP)guarantees.Contrary to frequency estimation of a single attribute,the multidimensional aspect demands particular attention to the privacy budget.Besides,when collecting user statistics longitudinally,privacy progressively degrades.Indeed,the“multiple”settings in combination(i.e.,many attributes and several collections throughout time)impose several challenges,for which this paper proposes the first solution for frequency estimates under LDP.To tackle these issues,we extend the analysis of three state-of-the-art LDP protocols(Generalized Randomized Response–GRR,Optimized Unary Encoding–OUE,and Symmetric Unary Encoding–SUE)for both longitudinal and multidimensional data collections.While the known literature uses OUE and SUE for two rounds of sanitization(a.k.a.memoization),i.e.,L-OUE and L-SUE,respectively,we analytically and experimentally show that starting with OUE and then with SUE provides higher data utility(i.e.,L-OSUE).Also,for attributes with small domain sizes,we propose Longitudinal GRR(L-GRR),which provides higher utility than the other protocols based on unary encoding.Last,we also propose a new solution named Adaptive LDP for LOngitudinal and Multidimensional FREquency Estimates(ALLOMFREE),which randomly samples a single attribute to be sent with the whole privacy budget and adaptively selects the optimal protocol,i.e.,either L-GRR or L-OSUE.As shown in the results,ALLOMFREE consistently and considerably outperforms the state-of-the-art L-SUE and L-OUE protocols in the quality of the frequency estimates.

The Static Stability Region of an Integrated Electricity-Gas System Considering Voltage and Gas Pressure

In an integrated electricity-gas system(IEGS),load fluctuations affect not only the voltage in the power system but also the gas pressure in the natural gas system.The static voltage stability region(SVSR)method is a tool for analyzing the overall static voltage stability in a power system.However,in an IEGS,the SVSR boundary may be overly optimistic because the gas pressure may collapse before the voltage collapses.Thus,the SVSR method cannot be directly applied to an IEGS.In this paper,the concept of the SVSR is extended to the IEGS-static stability region(SSR)while considering voltage and gas pressure.First,criteria for static gas pressure stability in a natural gas system are proposed,based on the static voltage stability criteria in a power system.Then,the IEGS-SSR is defined as a set of active power injections that satisfies multi-energy flow(MEF)equations and static voltage and gas pressure stability constraints in the active power injection space of natural gas-fired generator units(NGUs).To determine the IEGSSSR,a continuation MEF(CMEF)method is employed to trace the boundary point in one specific NGU scheduling direction.A multidimensional hyperplane sampling method is also proposed to sample the NGU scheduling directions evenly.The obtained boundary points are further used to form the IEGSSSR in three-dimensional(3D)space via a Delaunay triangulation hypersurface fitting method.Finally,the numerical results of typical case studies are presented to demonstrate that the proposed method can effectively form the IEGS-SSR,providing a tool for IEGS online monitoring and dispatching.

RFFsNet-SEI:a multidimensional balanced-RFFs deep neural network framework for specific emitter identification

Existing specific emitter identification(SEI)methods based on hand-crafted features have drawbacks of losing feature information and involving multiple processing stages,which reduce the identification accuracy of emitters and complicate the procedures of identification.In this paper,we propose a deep SEI approach via multidimensional feature extraction for radio frequency fingerprints(RFFs),namely,RFFsNet-SEI.Particularly,we extract multidimensional physical RFFs from the received signal by virtue of variational mode decomposition(VMD)and Hilbert transform(HT).The physical RFFs and I-Q data are formed into the balanced-RFFs,which are then used to train RFFsNet-SEI.As introducing model-aided RFFs into neural network,the hybrid-driven scheme including physical features and I-Q data is constructed.It improves physical interpretability of RFFsNet-SEI.Meanwhile,since RFFsNet-SEI identifies individual of emitters from received raw data in end-to-end,it accelerates SEI implementation and simplifies procedures of identification.Moreover,as the temporal features and spectral features of the received signal are both extracted by RFFsNet-SEI,identification accuracy is improved.Finally,we compare RFFsNet-SEI with the counterparts in terms of identification accuracy,computational complexity,and prediction speed.Experimental results illustrate that the proposed method outperforms the counterparts on the basis of simulation dataset and real dataset collected in the anechoic chamber.

AAK Theorem and a Design of Multidimensional BIBO Stable Filters

Rational approximation theory occupies a significant place in signal processing and systems theory. This research paper proposes an optimal design of BIBO stable multidimensional Infinite Impulse Response filters with a realizable (rational) transfer function thanks to the Adamjan, Arov and Krein (AAK) theorem. It is well known that the one dimensional AAK results give the best approximation of a polynomial as a rational function in the Hankel semi norm. We suppose that the Hankel matrix associated to the transfer function has a finite rank.

Multidimensional Perspectives on the Teaching and Practice of Typography Design

With the deepening of the curriculum teaching reform in colleges and universities,the teaching reform of art design professional courses is imperative.The study found that the current art design professional font design course teaching there are more solidified teaching methods,students operating ability is relatively homogenised,the teaching content to the"westernised"based,resulting in poor adaptability of students and other prominent problems.This paper starts from the"three effects"of"effect","efficiency"and"effectiveness",and adopts a multi-dimensional and emotional thinking perspective to carry out the curriculum of typeface design.This paper starts from the"three effects"of"effect","efficiency"and"effectiveness",and adopts a multi-dimensional and emotional perspective of thinking to carry out the teaching and practice of typeface design in order to strengthen the visual information of Chinese culture,and at the same time,to explore the creative potential of the students,so as to improve the students'innovation and creativity.

A Corpus-Based Comparative Multidimensional Analysis of the Two English Translations of Luoyang Jialan Ji

By using the MD approach, this study aims at making a comparison between the lexical features in W. J. F. Jenner’s and Wang Yitong’s translations of Luoyang Jialan Ji (547 AD) from a multidimensional perspective. Statistics show that both the two translations belong to the General Narrative Exposition Register. However, there are significant discrepancies between the two versions in Dimension 1 “Involved versus Informational Production”, Dimension 4 “Overt Expression of Persuasion” and Dimension 5 “Abstract versus Non-Abstract Information”. The differences in Dimension 2 “Narrative versus Non-Narrative Concerns” and Dimension 3 “Explicit versus Situation-Dependent Reference” are not that significant. It is found that in Dimension 1, the information density of Wang’s version is much higher than that of Jenner’s. In Dimension 4, Wang’s version contains more overt persuasive effort than Jenner’s. In Dimension 5, the positive and negative contrast between the two versions indicates that Wang’s version provides information in a more abstract way, whereas Jenner’s in a relatively non-abstract way. Combined with typical examples in the two translation versions, this study is hoped to help better understand the translations of Luoyang Jialan Ji and conduct future studies on the translation styles of the two translators.

Multidimensional System of Ferro-magnetic Chain Type~*

The global solvability of homogeneous boundary problem for a class of multidimensional generalized system of ferro-magnetic chain type is considered.

EXISTENCE AND NONEXISTENCE FOR THE INITIAL BOUNDARY VALUE PROBLEM OF ONE CLASS OF SYSTEM OF MULTIDIMENSIONAL NONLINEAR SCHRDINGER EQUATIONS WITH OPERATOR AND THEIR SOLITON SOLUTIONS

The nonlinear interactions between the monochromatic wave have been considered by K. Matsunchi, who also proposed one class of the nonlinear Schrdinger equation system with wave operator. We also obtain the same type of equations, which are satisfied by transverse velocity of higher frequency electron, as we study soliton in plasma physics. In this paper, under some condition we study the existence and nonexistence for this equations in the cases possessing different signs in nonlinear term.

LONG TIME BEHAVIOR FOR SOLUTION OF INITIAL-BOUNDARY VALUE PROBLEM OF ONE CLASS OF SYSTEMS WITH MULTIDIMENSIONAL INHOMOGENEOUS GBBM EQUATIONS

The following initial-boundary value problem for the systems with multidimensional inhomogeneous generalized Benjamin-Bona-Mahony ( GBBM ) equations is reviewed. The existence of global attractors of this problem was proved by means of a uniform priori estimate for time.

Multidimensional Design Paradigms for Data Warehouses: A Systematic Mapping Study

Data warehouses (DW) must integrate information from the different areas and sources of an organization in order to extract knowledge relevant to decision-making. The DW development is not an easy task, which is why various design approaches have been put forward. These approaches can be classified in three different paradigms according to the origin of the information requirements: supply-driven, demand-driven, and hybrids of these. This article compares the methodologies for the multidimensional design of DW through a systematic mapping as research methodology. The study is presented for each paradigm, the main characteristics of the methodologies, their notations and problem areas exhibited in each one of them. The results indicate that there is no follow-up to the complete process of implementing a DW in either an academic or industrial environment;however, there is also no evidence that the attempt is made to address the design and development of a DW by applying and comparing different methodologies existing in the field.

INTERACTION OF STRONG AND WEAK SINGULARITIES FOR HYPERBOLIC SYSTEM OF CONSERVATION LAWS IN MULTIDIMENSIONAL SPACE

In this paper we study the interaction of strong and weak singularities for hyperbolic system of conservation laws in multidimensional space. Under the assumption of transversal intersect of the shock front with the bicharacteristics bearing weak singularities we proved a theorem on regularity propagation across the shock front.

A multidimensional examination of performances of HSR (High-Speed Rail) systems

This paper deals with a multidimensional examination of the infrastructural, technical/technological, operational, economic, social, and environmental performances of high-speed rail （HSR） systems, including their overview, analysis of some real-life cases, and limited （analytical） modeling. The infrastructural performances reflect design and geometrical characteristics of the HSR lines and stations. The technical/technological performances relate to the characteristics of rolling stock, i.e., high-speed trains, and supportive facilities and equipment, i.e., the power supply, signaling, and traffic control and management system（s）. The operational performances include the capacity and productivity of HSR lines and rolling stock, and quality of services. The economic per- formances refer to the HSR systems＇ costs, revenues, and their relationship. The social performances relate to the impacts of HSR systems on the society such as congestion, noise, and safety, and their externalities, and the effects in terms of contribution to the local and global/country social- economic development. Finally, the environmental performances of the HSR systems reflect their energy consumption and related emissions of green house gases, land use, and corresponding externalities.

Multidimensional defects tailoring local electron and Mg^(2+) diffusion channels for boosting magnesium storage performance of WO_(3)/MoO_(2)

Defect engineering presents great promise in addressing lower specific capacity,sluggish diffusion kinetics and poor cycling life issues in energy storage devices.Herein,multidimensional(0D/2D/3D) structural defects are constructed in WO_(3)/MoO_(2) simultaneously via competing for and sharing with O atoms during simple hydrothermal process.OD and 2D defects tailor local electron,activating more sites and generating built-in electric fields to yield ion reservoir,meanwhile,3D defect owning lower anisotropic property tailors Mg^(2+) diffusion channels to fully exploit Mg^(2+) adsorbed sites induced by OD and 2D defects,enhance the kinetics and maintain structural stability.Benefitted from synergistic effect of 0D/2D/3D structural defects,the designed WO_(3)/MoO_(2) shows the higher specific capacity(112.8 mA h g^(-1) at 50 mA g^(-1) with average attenuation rate per cycle of 0.068%),superior rate capability and excellent cycling stability(specific capacity retention of 80% after 1500 cycles at 1000 mA g^(-1)).This strategy provides design ideas of introducing multidimensional structural defects for tailoring local electron and microstructure to improve energy storage property.

Soil water content and nitrogen differentially correlate with multidimensional leaf traits of two temperate broadleaf species

The variation and correlation of leaf economics and vein traits are crucial for predicting plant ecological strategies under different environmental changes.However,correlations between these two suites of traits and abiotic factors such as soil water and nitrogen content remain ambiguous.We measured leaf economics and vein traits as well as soil water and nitrogen content for two different shade-tolerant species(Betula platyphylla and Acer mono)in four mixed broadleaved-Korean pine(Pinus koraiensis)forests along a latitudinal gradient in Northeast China.We found that leaf economics traits and vein traits were decoupled in shade-intolerant species,Betula platphylla,but significantly coupled in a shadetolerant species,A.mono.We found stronger correlations among leaf traits in the shade tolerant species than in the shade intolerant species.Furthermore,leaf economic traits were positively correlated with the soil water gradient for both species,whereas vein traits were positively correlated with soil water gradient for the shade intolerant species but negatively correlated in the shade tolerant species.Although economic traits were positively correlated with soil nitrogen gradient in shade intolerant species but not correlated in shade tolerant species,vein traits were negatively correlated with soil nitrogen gradient in shade tolerant species but not correlated in shade intolerant species.Our study provides evidence for distinct correlations between leaf economics and vein traits and local abiotic factors of species differing in light demands.We recommend that the ecological significance of shade tolerance be considered for species when evaluating ecosystem functions and predicting plant responses to environmental changes.

Psychometric Properties among Japanese Women Based on the Multidimensional Assessment of Women’s Experience of Childbirth

Aims/Background: Perceived experiences of childbirth are important for mothers as they affect their self-esteem, mother-child interactions, subsequent mother-child bonding, and their desire for another child. This study examined the factor structure and construct validity of Salmon and Drew’s Multidimensional Assessment of Women’s Experience of Childbirth (MAWEC) in Japanese. Design/Methods: This study conducted a questionnaire survey using the Japanese version of the MAWEC and other variables with 759 women with infants in Japan. The participants’ mean (standard deviation [SD], range) age was 31.9 (5.3, 18 - 46) years. A total of 353 (46.5%) participants were primiparous and 384 (50.6%) were multiparous, and 22 (2.9%) did not answer. The data were randomly divided into two groups for exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) and separately analyzed the positive- and negative-worded items. I conducted EFA using the maximum-likelihood method with PROMAX rotation from one-through two- and three-factor structures. Different factor structure models were compared in terms of CFAs using, as indicator of goodness-of-fit, chi-square/df, comparative fit index (CFI), and root mean square of error approximation (RMSEA). Results: This study showed that a bifactor model for the MAWEC with four subscales (positive emotion, positive coping, negative emotion, and negative coping) fit the data the best. These four subscales were associated with demographic, obstetric, neonatal, and feeding characteristics. For example, primiparas were more vulnerable to coping aspects of perceived childbirth experiences, including sense of mastery over the delivery process and ability to enjoy the delivery. Gestational age at birth was associated with emotional aspects of perceived childbirth experiences. Conclusion: The Japanese version of the MAWEC consists of four aspects regarding perceived childbirth experience. Perinatal health professionals may examine women’s childbirth experiences from these four perspectives. .

On the Role of Security in the System of Personal Values:Are Conservatives Prioritizing Security?

Security is a value contained in most theories of personal values.Yet,while the relations among the most basic values are clear and reliable,the role of security in the system of values remains ambiguous.People striving for security are often also striving for tradition and conformity but sometimes they are focusing more on other values(such as health values,for example).Based on eight representative surveys(N=24,000)in several German cities between 1998 and 2022,the author shows that when measuring security without suggesting a particular meaning of this notion,security takes a relatively central position within the system of values and their components(shown by multidimensional scaling,MDS).People striving for security also emphasize the importance of law and order,working hard,and having a good family life as guiding principles in their lives.Conformity is not that important for them,and having an exciting life is even negatively correlated.Age has little impact on the MDS structure of values and their components,even though people exhibit substantial changes in the relative weights they assign to many values as they get older.

Robust H_∞ Filter Design for 2D Discrete Systems in Roesser Model

This paper investigates the robust H ∞ filtering problem for uncertain two-dimensional (2D) systems described by the Roesser model. The parameter uncertainties considered in this paper are assumed to be of polytopic type. A new structured polynomially parameter-dependent method is utilized, which is based on homogeneous polynomially parameter-dependent matrices of arbitrary degree. The proposed method includes results in the quadratic framework and the linearly parameter-dependent framework as special cases for zeroth degree and first degree, respectively. A numerical example illustrates the feasibility and advantage of the proposed filter design methods.

Big Data Application Simulation Platform Design for Onboard Distributed Processing of LEO Mega-Constellation Networks

Due to the restricted satellite payloads in LEO mega-constellation networks(LMCNs),remote sensing image analysis,online learning and other big data services desirably need onboard distributed processing(OBDP).In existing technologies,the efficiency of big data applications(BDAs)in distributed systems hinges on the stable-state and low-latency links between worker nodes.However,LMCNs with high-dynamic nodes and long-distance links can not provide the above conditions,which makes the performance of OBDP hard to be intuitively measured.To bridge this gap,a multidimensional simulation platform is indispensable that can simulate the network environment of LMCNs and put BDAs in it for performance testing.Using STK's APIs and parallel computing framework,we achieve real-time simulation for thousands of satellite nodes,which are mapped as application nodes through software defined network(SDN)and container technologies.We elaborate the architecture and mechanism of the simulation platform,and take the Starlink and Hadoop as realistic examples for simulations.The results indicate that LMCNs have dynamic end-to-end latency which fluctuates periodically with the constellation movement.Compared to ground data center networks(GDCNs),LMCNs deteriorate the computing and storage job throughput,which can be alleviated by the utilization of erasure codes and data flow scheduling of worker nodes.