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Unveiling Promising Neuroimaging Biomarkers for Schizophrenia Through Clinical and Genetic Perspectives
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作者 Jing Guo Changyi He +4 位作者 Huimiao Song Huiwu Gao Shi Yao Shan-Shan Dong Tie-Lin Yang 《Neuroscience Bulletin》 SCIE CAS CSCD 2024年第9期1333-1352,共20页
Schizophrenia is a complex and serious brain disorder.Neuroscientists have become increasingly interested in using magnetic resonance-based brain imaging-derived phenotypes(IDPs)to investigate the etiology of psychiat... Schizophrenia is a complex and serious brain disorder.Neuroscientists have become increasingly interested in using magnetic resonance-based brain imaging-derived phenotypes(IDPs)to investigate the etiology of psychiatric disorders.IDPs capture valuable clinical advantages and hold biological significance in identifying brain abnormalities.In this review,we aim to discuss current and prospective approaches to identify potential biomarkers for schizophrenia using clinical multimodal neuroimaging and imaging genetics.We first described IDPs through their phenotypic classification and neuroimaging genomics.Secondly,we discussed the applications of multimodal neuroimaging by clinical evidence in observational studies and randomized controlled trials.Thirdly,considering the genetic evidence of IDPs,we discussed how can utilize neuroimaging data as an intermediate phenotype to make association inferences by polygenic risk scores and Mendelian randomization.Finally,we discussed machine learning as an optimum approach for validating biomarkers.Together,future research efforts focused on neuroimaging biomarkers aim to enhance our understanding of schizophrenia. 展开更多
关键词 SCHIZOPHRENIA Biomarkers Brain imaging-derived phenotypes multimodal neuroimaging Imaging genomics
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Relationship between circadian rhythm and brain cognitive functions 被引量:1
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作者 Shiyang XU Miriam AKIOMA Zhen YUAN 《Frontiers of Optoelectronics》 EI CSCD 2021年第3期278-287,共10页
Circadian rhythms are considered a masterstroke of natural selection,which gradually increase the adaptability of species to the Earth’s rotation.Importantly,the nervous system plays a key role in allowing organisms ... Circadian rhythms are considered a masterstroke of natural selection,which gradually increase the adaptability of species to the Earth’s rotation.Importantly,the nervous system plays a key role in allowing organisms to maintain circadian rhythmicity.Circadian rhythms affect multiple aspects of cognitive functions(mainly via arousal),particularly those needed for effort-intensive cognitive tasks,which require considerable top-down executive control.These include inhibitory control,working memory,task switching,and psychomotor vigilance.This mini review highlights the recent advances in cognitive functioning in the optical and multimodal neuroimaging fields;it discusses the processing of brain cognitive functions during the circadian rhythm phase and the effects of the circadian rhythm on the cognitive component of the brain and the brain circuit supporting cognition. 展开更多
关键词 circadian rhythm COGNITION optical neuroimaging multimodal neuroimaging
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