Attention deficit hyperactivity disorder(ADHD)is a common,highly heritable psychiatric disorder charac-terized by hyperactivity,inattention and increased im-pulsivity.In recent years,a large number of genetic studies ...Attention deficit hyperactivity disorder(ADHD)is a common,highly heritable psychiatric disorder charac-terized by hyperactivity,inattention and increased im-pulsivity.In recent years,a large number of genetic studies for ADHD have been published and related ge-netic data has been accumulated dramatically.To pro-vide researchers a comprehensive ADHD genetic re-source,we previously developed the first genetic data-base for ADHD(ADHDgene).The abundant genetic data provides novel candidates for further study.Meanwhile,it also brings new challenge for selecting promising candidate genes for replication and verification research.In this study,we surveyed the computational tools for candidate gene prioritization and selected five tools,which integrate multiple data sources for gene prioritiza-tion,to prioritize ADHD candidate genes in ADHDgene.The prioritization analysis resulted in 16 prioritized can-didate genes,which are mainly involved in several major neurotransmitter systems or in nervous system development pathways.Among these genes,nervous system development related genes,especially SNAP25,STX1A and the gene-gene interactions related with each of them deserve further investigations.Our results may provide new insight for further verification study and facilitate the exploration of pathogenesis mechanism of ADHD.展开更多
基金supported by Key Laboratory of Mental Health,Insti-tute of Psychology,Chinese Academy of Sciences.
文摘Attention deficit hyperactivity disorder(ADHD)is a common,highly heritable psychiatric disorder charac-terized by hyperactivity,inattention and increased im-pulsivity.In recent years,a large number of genetic studies for ADHD have been published and related ge-netic data has been accumulated dramatically.To pro-vide researchers a comprehensive ADHD genetic re-source,we previously developed the first genetic data-base for ADHD(ADHDgene).The abundant genetic data provides novel candidates for further study.Meanwhile,it also brings new challenge for selecting promising candidate genes for replication and verification research.In this study,we surveyed the computational tools for candidate gene prioritization and selected five tools,which integrate multiple data sources for gene prioritiza-tion,to prioritize ADHD candidate genes in ADHDgene.The prioritization analysis resulted in 16 prioritized can-didate genes,which are mainly involved in several major neurotransmitter systems or in nervous system development pathways.Among these genes,nervous system development related genes,especially SNAP25,STX1A and the gene-gene interactions related with each of them deserve further investigations.Our results may provide new insight for further verification study and facilitate the exploration of pathogenesis mechanism of ADHD.
