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Multiple Emulsions Able to Be Used for Oral Administration of Active Pharmaceutical Ingredients: Physico-Chemical Parameters Study of Different Phases
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作者 Louis Augustin Diaga Diouf Alphonse Rodrigue Djiboune +4 位作者 Mamadou Soumboundou Sidy Mouhamed Dieng Papa Mady Sy Gora Mbaye Mounibé Diarra 《Journal of Modern Physics》 2020年第10期1528-1535,共8页
Multiple emulsions are of great therapeutic interest especially in the administration of medicines which can be inactivated by digestive enzymes;moreover the researches of formulation not being often easy, a control o... Multiple emulsions are of great therapeutic interest especially in the administration of medicines which can be inactivated by digestive enzymes;moreover the researches of formulation not being often easy, a control of the different phases physicochemical parameters would be of great interest in rapid formulations and at low cost. When formulating emulsions, the preliminary tests, also known as formulation tests, constitute a step which can be long and expensive because of the quantity of reagents that can be used. A rigorous methodology could thus be of great interest, which is at the aim of our study which consists of evaluating the physico-chemical parameters of different phases used to make thus multiple emulsions. In our study, physico-chemical parameters such as conductivity, pH, density, viscosity, and surface tension have been studied by direct measurement using equipment and also by means of suitable mounting. The results showed that the pH and the surface tension have an important role in the prediction of the stability of emulsions, these latter must be of the same order of magnitude. For all phases conductivity does not have too much interest apart from helping to determine the type of the emulsion. 展开更多
关键词 Active Pharmaceutical Ingredients multiple emulsions STABILITY Physico-Chemical Parameters
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Synthesis and Characterization of Core-shell Hydroxyapatite/chitosan Biocomposite Nanospheres 被引量:2
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作者 李湘南 陈晓明 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2010年第2期252-256,共5页
Novel core-shell hydroxyapatite/chitosan biocomposite nanospheres were synthesized in a multiple emulsion. The multiple emulsion was a w/o/w emulsion, made of diammonium phosphate solution as an inner aqueous phase, c... Novel core-shell hydroxyapatite/chitosan biocomposite nanospheres were synthesized in a multiple emulsion. The multiple emulsion was a w/o/w emulsion, made of diammonium phosphate solution as an inner aqueous phase, cyclohexane as an oil phase, and calcium nitrate solution and chitosan solution as an outer aqueous. The forming mechanism of core-shell spheres and the influence of temperature on the morphology of the nanospheres were investigated. The diameter of the resulting core-shell nanospheres was 100-200 nm and the thickness of the chitosan shell was about 10 nm. And it concluded that at different reaction temperature the morphologies of the products would be changed. The core-shell nanospheres have potential applications for the development of new biomedical materials. 展开更多
关键词 multiple emulsion core-shell nanosphere CHITOSAN HYDROXYAPATITE
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Yields of projectile fragments in sulphur-emulsion interactions at 3.7 A GeV
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作者 S.Kamel W.Osman M.Fayed 《Chinese Physics C》 SCIE CAS CSCD 2017年第5期97-103,共7页
This work presents the basic characteristics of singly,doubly and heavily charged projectile fragments(PFs) emitted in inelastic interactions of ^(32)S ions with photo-emulsion nuclei at Dubna energy(3.7 A GeV).... This work presents the basic characteristics of singly,doubly and heavily charged projectile fragments(PFs) emitted in inelastic interactions of ^(32)S ions with photo-emulsion nuclei at Dubna energy(3.7 A GeV).Our experimental data are compared with the corresponding data for other projectiles at the same incident energy.The study of mean multiplicities of different charged PFs against the projectile mass shows a power-law relationship.The multiplicity distributions of singly and doubly charged PFs have been fitted well with a Gaussian distribution function.The yields of PFs broken up from the interactions of ^(32)S projectile nuclei with different target nuclei are studied.The beam energy dependence in terms of the various order moments is studied as well. 展开更多
关键词 projectile nuclei emulsion multiplicity charged doubly sulphur emitted nucleus relativistic
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