Here, we introduce the design of the structure of RR（RYYAAFFARR）, an inhibitor of Aβ aggregation, using molecular docking, and compare the inhibitory ability between RR and LPFFD, which interacts with Aβ mainly de...Here, we introduce the design of the structure of RR（RYYAAFFARR）, an inhibitor of Aβ aggregation, using molecular docking, and compare the inhibitory ability between RR and LPFFD, which interacts with Aβ mainly depending on hydrophobic interaction. Our results showed that RR which can target multiple regions of Aβ with multiple weak interactions is better than those that only target a single region with the single driving force mainly.展开更多
基金financially supported by the National Natural Science Foundation of China(Nos.20634030 and 51273094)State Key Fundamental R&D Project(No.2011CB606202)PCSIRT(No.IRT1257)
文摘Here, we introduce the design of the structure of RR（RYYAAFFARR）, an inhibitor of Aβ aggregation, using molecular docking, and compare the inhibitory ability between RR and LPFFD, which interacts with Aβ mainly depending on hydrophobic interaction. Our results showed that RR which can target multiple regions of Aβ with multiple weak interactions is better than those that only target a single region with the single driving force mainly.
