An experimental study is conducted on several retro-reflective beamforming schemes for wireless power transmission to multiple wireless power receivers(referred to herein as“targets”).The experimental results demons...An experimental study is conducted on several retro-reflective beamforming schemes for wireless power transmission to multiple wireless power receivers(referred to herein as“targets”).The experimental results demonstrate that,when multiple targets broadcast continuous-wave pilot signals at respective frequencies,a retro-reflective wireless power transmitter is capable of generating multiple wireless power beams aiming at the respective targets as long as the multiple pilot signals are explicitly separated from one another by the wireless power transmitter.However,various practical complications are identified when the pilot signals of multiple targets are not appropriately differentiated from each other by the wireless power transmitter.Specifically,when multiple pilot signals are considered to be carried by the same frequency,the wireless power transmission performance becomes heavily dependent on the interaction among the pilot signals,which is highly undesirable in practice.In conclusion,it is essential for a retro-reflective wireless power transmitter to explicitly discriminate multiple targets’pilot signals among each other.展开更多
High-voltage circuit breakers are the core equipment in power networks,and to a certain extent,are related to the safe and reliable operation of power systems.However,their core components are prone to mechanical faul...High-voltage circuit breakers are the core equipment in power networks,and to a certain extent,are related to the safe and reliable operation of power systems.However,their core components are prone to mechanical faults.This study proposes a component separation method to detect multiple mechanical faults in circuit breakers that can achieve online real-time monitoring.First,a model and strategy are presented for obtaining mechanical voiceprint signals from circuit breakers.Subsequently,the component separation method was used to decompose the voiceprint signals of multiple faults into individual component signals.Based on this,the recognition of the features of a single-fault voiceprint signal can be achieved.Finally,multiple faults in high-voltage circuit breakers were identified through an experimental simulation and verification of the circuit breaker voiceprint signals collected from the substation site.The research results indicate that the proposed method exhibits excellent performance for multiple mechanical faults,such as spring structures and loose internal components of circuit breakers.In addition,it provides a reference method for the real-time online monitoring of high-voltage circuit breakers.展开更多
Short-wavelength near infrared spectroscopy (SW-NIR) is a very rapid, versatile and precise technique, which can be used in many different situations and for very types of products and chemical compounds. Extended mul...Short-wavelength near infrared spectroscopy (SW-NIR) is a very rapid, versatile and precise technique, which can be used in many different situations and for very types of products and chemical compounds. Extended multiplicative signal correction (EMSC) is a modification of the standard MSC pre-processing method that allows the separation of physical light scattering effects from chemical (vibrational) light absorbance effects in spectra. In this paper, the EMSC is applied and compared with first derivate, second derivate, MSC and SNV in combination of PLSR to obtain robust models in terms of accuracy and predict ability with a reduced calibration data set using SW-NIR spectra of moisture in marzipan. The Extended Multiplicative Signal Correction—EMSC and combination methods provide the best results in terms of prediction ability and calibration SW-NIR spectra of moisture in marzipan. The best classification results were obtained by Extended Multiplicative Signal Correction followed by second derivates.展开更多
This paper focuses on the extraction of a harmonic signal from multiplicative and additive noises. A method is proposed in two stages: (1) to square the original discrete time series, which in- cludes both signals and...This paper focuses on the extraction of a harmonic signal from multiplicative and additive noises. A method is proposed in two stages: (1) to square the original discrete time series, which in- cludes both signals and noises, and form a new time series. By this means, the multiplicative noise is converted to additive noise; and (2) to filter out the noise by using existing noise removal schemes. With a large amount of simulation, experimental results demonstrated the efficiency and effective- ness of this newly developed method in terms of Signal-to-Noise Ratio (SNR) and other criteria. From the experiment, it is also found that: the two kinds of noises affect the SNR differently. In gen- eral, the SNR is not influenced by multiplicative Gaussian noise regardless of its variance. However, if both kinds of noise exist, the SNR decreases with the incensement of the Variance of Additive Noise to Multiplicative Noise Ratio (VAMNR). This analysis is also supported by simulation work.展开更多
BACKGROUND In traditional Chinese medicine(TCM),frankincense and myrrh are the main components of the antitumor drug Xihuang Pill.These compounds show anticancer activity in other biological systems.However,whether fr...BACKGROUND In traditional Chinese medicine(TCM),frankincense and myrrh are the main components of the antitumor drug Xihuang Pill.These compounds show anticancer activity in other biological systems.However,whether frankincense and/or myrrh can inhibit the occurrence of hepatocellular carcinoma(HCC)is unknown,and the potential molecular mechanism(s)has not yet been determined.AIM To predict and determine latent anti-HCC therapeutic targets and molecular mechanisms of frankincense and myrrh in vivo.METHODS In the present study,which was based on the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(http://tcmspw.com/tcmsp.php),Universal Protein database(http://www.uniprot.org),GeneCards:The Human Gene Database(http://www.genecards.org/)and Comparative Toxicogenomics Database(http://www.ctdbase.org/),the efficacy of and mechanism by which frankincense and myrrh act as anti-HCC compounds were predicted.The core prediction targets were screened by molecular docking.In vivo,SMMC-7721 human liver cancer cells were transplanted as xenografts into nude mice to establish a subcutaneous tumor model,and two doses of frankincense plus myrrh or one dose of an EGFR inhibitor was administered to these mice continuously for 14 d.The tumors were collected and evaluated:the tumor volume and growth rate were gauged to evaluate tumor growth;hematoxylineosin staining was performed to estimate histopathological changes;immunofluorescence(IF)was performed to detect the expression of CD31,α-SMA and collagen IV;transmission electron microscopy(TEM)was conducted to observe the morphological structure of vascular cells;enzyme-linked immunosorbent assay(ELISA)was performed to measure the levels of secreted HIF-1αand TNF-α;reverse transcription-polymerase chain reaction(RT-qPCR)was performed to measure the mRNA expression of HIF-1α,TNF-α,VEGF and MMP-9;and Western blot(WB)was performed to determine the levels of proteins expressed in the EGFR-mediated PI3K/Akt and MAPK signaling pathways.RESULTS The results of the network pharmacology analysis showed that there were 35 active components in the frankincense and myrrh extracts targeting 151 key targets.The molecular docking analysis showed that both boswellic acid and stigmasterol showed strong affinity for the targets,with the greatest affinity for EGFR.Frankincense and myrrh treatment may play a role in the treatment of HCC by regulating hypoxia responses and vascular system-related pathological processes,such as cytokine-receptor binding,and pathways,such as those involving serine/threonine protein kinase complexes and MAPK,HIF-1 and ErbB signaling cascades.The animal experiment results were verified.First,we found that,through frankincense and/or myrrh treatment,the volume of subcutaneously transplanted HCC tumors was significantly reduced,and the pathological morphology was attenuated.Then,IF and TEM showed that frankincense and/or myrrh treatment reduced CD31 and collagen IV expression,increased the coverage of perivascular cells,tightened the connection between cells,and improved the shape of blood vessels.In addition,ELISA,RT-qPCR and WB analyses showed that frankincense and/or myrrh treatment inhibited the levels of hypoxia-inducible factors,inflammatory factors and angiogenesis-related factors,namely,HIF-1α,TNF-α,VEGF and MMP-9.Furthermore,mechanistic experiments illustrated that the effect of frankincense plus myrrh treatment was similar to that of an EGFR inhibitor with regard to controlling EGFR activation,thereby inhibiting the phosphorylation activity of its downstream targets:the PI3K/Akt and MAPK(ERK,p38 and JNK)pathways.CONCLUSION In summary,frankincense and myrrh treatment targets tumor blood vessels to exert anti-HCC effects via EGFR-activated PI3K/Akt and MAPK signaling pathways,highlighting the potential of this dual TCM compound as an anti-HCC candidate.展开更多
Multiple sclerosis（MS）is a progressive inflammatory,and chronic demyelinating,neurodegenerative disease of central nervous system（CNS）.Autoimmune responses to myelin and other CNS antigens mediated by cluster of d...Multiple sclerosis（MS）is a progressive inflammatory,and chronic demyelinating,neurodegenerative disease of central nervous system（CNS）.Autoimmune responses to myelin and other CNS antigens mediated by cluster of differentiation 4（CD4＋）T cells are critical for initiation and progression of disease.Migration of autoimmune T cells from the peripheral lymph organs into CNS parenchyma leads to inflammation,demyelination and damage of axonal cytoskeleton, which manifest in decreased impulse conduction velocity of motor and sensory nerves. Myelin and axonal pathology causes motor, sensory and autonomic nerve dysfunction, including optic nerve damage leading to double or distorted vision; paresis and paralysis of extremities, painful sensations, and bladder sphincter dysfunction, manifested as bladder incontinence. Gray matter pa- thology in cortical and subcortical regions, including cerebellum and hippocampus underlies cognitive and behavioral dysfunction consisting of memory deficits, depression, and ataxic gait and tremor.展开更多
目前的脑电(EEG)情感识别模型忽略了不同时段情感状态的差异性,未能强化关键的情感信息。针对上述问题,提出一种多上下文向量优化的卷积递归神经网络(CR-MCV)。首先构造脑电信号的特征矩阵序列,通过卷积神经网络(CNN)学习多通道脑电的...目前的脑电(EEG)情感识别模型忽略了不同时段情感状态的差异性,未能强化关键的情感信息。针对上述问题,提出一种多上下文向量优化的卷积递归神经网络(CR-MCV)。首先构造脑电信号的特征矩阵序列,通过卷积神经网络(CNN)学习多通道脑电的空间特征;然后利用基于多头注意力的递归神经网络生成多上下文向量进行高层抽象特征提取;最后利用全连接层进行情感分类。在DEAP(Database for Emotion Analysis using Physiological signals)数据集上进行实验,CR-MCV在唤醒和效价维度上分类准确率分别为88.09%和89.30%。实验结果表明,CR-MCV在利用电极空间位置信息和不同时段情感状态显著性特征基础上,能够自适应地分配特征的注意力并强化情感状态显著性信息。展开更多
基金supported in part by the National Natural Science Foundation of China(61871220)the Natural Science Foundation of Jiangsu Province(BK20201293)。
文摘An experimental study is conducted on several retro-reflective beamforming schemes for wireless power transmission to multiple wireless power receivers(referred to herein as“targets”).The experimental results demonstrate that,when multiple targets broadcast continuous-wave pilot signals at respective frequencies,a retro-reflective wireless power transmitter is capable of generating multiple wireless power beams aiming at the respective targets as long as the multiple pilot signals are explicitly separated from one another by the wireless power transmitter.However,various practical complications are identified when the pilot signals of multiple targets are not appropriately differentiated from each other by the wireless power transmitter.Specifically,when multiple pilot signals are considered to be carried by the same frequency,the wireless power transmission performance becomes heavily dependent on the interaction among the pilot signals,which is highly undesirable in practice.In conclusion,it is essential for a retro-reflective wireless power transmitter to explicitly discriminate multiple targets’pilot signals among each other.
基金supported by the State Key Laboratory of Technology and Equipment for Defense against Power System Operational Risks(No.SGNR0000KJJS2302137)the National Natural Science Foundation of China(Grant No.62203248)the Natural Science Foundation of Shandong Province(Grant No.ZR2020ME194).
文摘High-voltage circuit breakers are the core equipment in power networks,and to a certain extent,are related to the safe and reliable operation of power systems.However,their core components are prone to mechanical faults.This study proposes a component separation method to detect multiple mechanical faults in circuit breakers that can achieve online real-time monitoring.First,a model and strategy are presented for obtaining mechanical voiceprint signals from circuit breakers.Subsequently,the component separation method was used to decompose the voiceprint signals of multiple faults into individual component signals.Based on this,the recognition of the features of a single-fault voiceprint signal can be achieved.Finally,multiple faults in high-voltage circuit breakers were identified through an experimental simulation and verification of the circuit breaker voiceprint signals collected from the substation site.The research results indicate that the proposed method exhibits excellent performance for multiple mechanical faults,such as spring structures and loose internal components of circuit breakers.In addition,it provides a reference method for the real-time online monitoring of high-voltage circuit breakers.
文摘Short-wavelength near infrared spectroscopy (SW-NIR) is a very rapid, versatile and precise technique, which can be used in many different situations and for very types of products and chemical compounds. Extended multiplicative signal correction (EMSC) is a modification of the standard MSC pre-processing method that allows the separation of physical light scattering effects from chemical (vibrational) light absorbance effects in spectra. In this paper, the EMSC is applied and compared with first derivate, second derivate, MSC and SNV in combination of PLSR to obtain robust models in terms of accuracy and predict ability with a reduced calibration data set using SW-NIR spectra of moisture in marzipan. The Extended Multiplicative Signal Correction—EMSC and combination methods provide the best results in terms of prediction ability and calibration SW-NIR spectra of moisture in marzipan. The best classification results were obtained by Extended Multiplicative Signal Correction followed by second derivates.
基金Supported by the Natural Science Foundation of Shaanxi Province (No.2003F40).
文摘This paper focuses on the extraction of a harmonic signal from multiplicative and additive noises. A method is proposed in two stages: (1) to square the original discrete time series, which in- cludes both signals and noises, and form a new time series. By this means, the multiplicative noise is converted to additive noise; and (2) to filter out the noise by using existing noise removal schemes. With a large amount of simulation, experimental results demonstrated the efficiency and effective- ness of this newly developed method in terms of Signal-to-Noise Ratio (SNR) and other criteria. From the experiment, it is also found that: the two kinds of noises affect the SNR differently. In gen- eral, the SNR is not influenced by multiplicative Gaussian noise regardless of its variance. However, if both kinds of noise exist, the SNR decreases with the incensement of the Variance of Additive Noise to Multiplicative Noise Ratio (VAMNR). This analysis is also supported by simulation work.
基金the National Natural Science Foundation of China,No.U20A20408(Major Program)and No.82074450(General Program)Natural Science Foundation of Hunan Province,No.2020JJ4066+2 种基金Hunan Province Research and innovation projects for Postgraduates,No.CX20190541Hunan Province"domestic firstclass cultivation discipline"Integrated Traditional Chinese and Western medicine open fund project,No.2018ZXYJH03Hunan University Undergraduate Research Learning and Innovative Experiment Project,No.201609030114.
文摘BACKGROUND In traditional Chinese medicine(TCM),frankincense and myrrh are the main components of the antitumor drug Xihuang Pill.These compounds show anticancer activity in other biological systems.However,whether frankincense and/or myrrh can inhibit the occurrence of hepatocellular carcinoma(HCC)is unknown,and the potential molecular mechanism(s)has not yet been determined.AIM To predict and determine latent anti-HCC therapeutic targets and molecular mechanisms of frankincense and myrrh in vivo.METHODS In the present study,which was based on the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(http://tcmspw.com/tcmsp.php),Universal Protein database(http://www.uniprot.org),GeneCards:The Human Gene Database(http://www.genecards.org/)and Comparative Toxicogenomics Database(http://www.ctdbase.org/),the efficacy of and mechanism by which frankincense and myrrh act as anti-HCC compounds were predicted.The core prediction targets were screened by molecular docking.In vivo,SMMC-7721 human liver cancer cells were transplanted as xenografts into nude mice to establish a subcutaneous tumor model,and two doses of frankincense plus myrrh or one dose of an EGFR inhibitor was administered to these mice continuously for 14 d.The tumors were collected and evaluated:the tumor volume and growth rate were gauged to evaluate tumor growth;hematoxylineosin staining was performed to estimate histopathological changes;immunofluorescence(IF)was performed to detect the expression of CD31,α-SMA and collagen IV;transmission electron microscopy(TEM)was conducted to observe the morphological structure of vascular cells;enzyme-linked immunosorbent assay(ELISA)was performed to measure the levels of secreted HIF-1αand TNF-α;reverse transcription-polymerase chain reaction(RT-qPCR)was performed to measure the mRNA expression of HIF-1α,TNF-α,VEGF and MMP-9;and Western blot(WB)was performed to determine the levels of proteins expressed in the EGFR-mediated PI3K/Akt and MAPK signaling pathways.RESULTS The results of the network pharmacology analysis showed that there were 35 active components in the frankincense and myrrh extracts targeting 151 key targets.The molecular docking analysis showed that both boswellic acid and stigmasterol showed strong affinity for the targets,with the greatest affinity for EGFR.Frankincense and myrrh treatment may play a role in the treatment of HCC by regulating hypoxia responses and vascular system-related pathological processes,such as cytokine-receptor binding,and pathways,such as those involving serine/threonine protein kinase complexes and MAPK,HIF-1 and ErbB signaling cascades.The animal experiment results were verified.First,we found that,through frankincense and/or myrrh treatment,the volume of subcutaneously transplanted HCC tumors was significantly reduced,and the pathological morphology was attenuated.Then,IF and TEM showed that frankincense and/or myrrh treatment reduced CD31 and collagen IV expression,increased the coverage of perivascular cells,tightened the connection between cells,and improved the shape of blood vessels.In addition,ELISA,RT-qPCR and WB analyses showed that frankincense and/or myrrh treatment inhibited the levels of hypoxia-inducible factors,inflammatory factors and angiogenesis-related factors,namely,HIF-1α,TNF-α,VEGF and MMP-9.Furthermore,mechanistic experiments illustrated that the effect of frankincense plus myrrh treatment was similar to that of an EGFR inhibitor with regard to controlling EGFR activation,thereby inhibiting the phosphorylation activity of its downstream targets:the PI3K/Akt and MAPK(ERK,p38 and JNK)pathways.CONCLUSION In summary,frankincense and myrrh treatment targets tumor blood vessels to exert anti-HCC effects via EGFR-activated PI3K/Akt and MAPK signaling pathways,highlighting the potential of this dual TCM compound as an anti-HCC candidate.
文摘Multiple sclerosis（MS）is a progressive inflammatory,and chronic demyelinating,neurodegenerative disease of central nervous system（CNS）.Autoimmune responses to myelin and other CNS antigens mediated by cluster of differentiation 4（CD4＋）T cells are critical for initiation and progression of disease.Migration of autoimmune T cells from the peripheral lymph organs into CNS parenchyma leads to inflammation,demyelination and damage of axonal cytoskeleton, which manifest in decreased impulse conduction velocity of motor and sensory nerves. Myelin and axonal pathology causes motor, sensory and autonomic nerve dysfunction, including optic nerve damage leading to double or distorted vision; paresis and paralysis of extremities, painful sensations, and bladder sphincter dysfunction, manifested as bladder incontinence. Gray matter pa- thology in cortical and subcortical regions, including cerebellum and hippocampus underlies cognitive and behavioral dysfunction consisting of memory deficits, depression, and ataxic gait and tremor.
文摘目前的脑电(EEG)情感识别模型忽略了不同时段情感状态的差异性,未能强化关键的情感信息。针对上述问题,提出一种多上下文向量优化的卷积递归神经网络(CR-MCV)。首先构造脑电信号的特征矩阵序列,通过卷积神经网络(CNN)学习多通道脑电的空间特征;然后利用基于多头注意力的递归神经网络生成多上下文向量进行高层抽象特征提取;最后利用全连接层进行情感分类。在DEAP(Database for Emotion Analysis using Physiological signals)数据集上进行实验,CR-MCV在唤醒和效价维度上分类准确率分别为88.09%和89.30%。实验结果表明,CR-MCV在利用电极空间位置信息和不同时段情感状态显著性特征基础上,能够自适应地分配特征的注意力并强化情感状态显著性信息。
