Artemisinins tested against W-2 strains of malaria falciparum are investigated with molecular electrostatic potential (MEP), in an attempt to identify key features of the compounds that are necessary for their activit...Artemisinins tested against W-2 strains of malaria falciparum are investigated with molecular electrostatic potential (MEP), in an attempt to identify key features of the compounds that are necessary for their activities, as well as to investigate likely interactions with the receptor in a biological process and to use that information to propose new molecules. In order to discover the best geometry involving the ligand-receptor complexes (heme) studied and help in the proposition of the new derivatives, molecular simulations of interactions between the most negative charged region around the peroxide and heme locates (the ones around the Fe2+ ion) were carried out. In addition, PCA (principal components analysis), HCA (hierarchical cluster analysis), SDA (stepwise discriminant analysis), and KNN (K-nearest neighbor) multivariate models were employed to investigate which descriptors are responsible for the classification between the higher and lower antimalarial activity of the compounds, and also this information was used to propose new potentially active molecules. The information accumulated in studies of MEP, molecular docking, and multivariate analysis supported the proposal of new structures with potential antimalarial activities. The multivariate models constructed were applied to the new structures and indicated numbers 19 and 20 as the most prominent for syntheses and biological assays.展开更多
BACKGROUNDSpontaneous bacterial peritonitis (SBP) is a detrimental infection of the asciticfluid in liver cirrhosis patients, with high mortality and morbidity. Earlydiagnosis and timely antibiotic administration have...BACKGROUNDSpontaneous bacterial peritonitis (SBP) is a detrimental infection of the asciticfluid in liver cirrhosis patients, with high mortality and morbidity. Earlydiagnosis and timely antibiotic administration have successfully decreased themortality rate to 20%-25%. However, many patients cannot be diagnosed in theearly stages due to the absence of classical SBP symptoms. Early diagnosis ofasymptomatic SBP remains a great challenge in the clinic.AIMTo establish a multivariate predictive model for early diagnosis of asymptomaticSBP using positive microbial cultures from liver cirrhosis patients with ascites.METHODSA total of 98 asymptomatic SBP patients and 98 ascites liver cirrhosis patients withnegative microbial cultures were included in the case and control groups,respectively. Multiple linear stepwise regression analysis was performed toidentify potential indicators for asymptomatic SBP diagnosis. The diagnosticperformance of the model was estimated using the receiver operatingcharacteristic curve.RESULTSPatients in the case group were more likely to have advanced disease stages,cirrhosis related-complications, worsened hematology and ascites, and higher mortality. Based on multivariate analysis, the predictive model was as follows: y (P) = 0.018 + 0.312 × MELD (model of end-stage liver disease) + 0.263 × PMN(ascites polymorphonuclear) + 0.184 × N (blood neutrophil percentage) + 0.233 ×HCC (hepatocellular carcinoma) + 0.189 × renal dysfunction. The area under thecurve value of the established model was 0.872, revealing its high diagnosticpotential. The diagnostic sensitivity was 73.5% (72/98), the specificity was 86.7%(85/98), and the diagnostic efficacy was 80.1%.CONCLUSIONOur predictive model is based on the MELD score, polymorphonuclear cells,blood N, hepatocellular carcinoma, and renal dysfunction. This model mayimprove the early diagnosis of asymptomatic SBP.展开更多
Background: Leaf Area Index(LAI) is an important parameter used in monitoring and modeling of forest ecosystems. The aim of this study was to evaluate performance of the artificial neural network(ANN) models to predic...Background: Leaf Area Index(LAI) is an important parameter used in monitoring and modeling of forest ecosystems. The aim of this study was to evaluate performance of the artificial neural network(ANN) models to predict the LAI by comparing the regression analysis models as the classical method in these pure and even-aged Crimean pine forest stands.Methods: One hundred eight temporary sample plots were collected from Crimean pine forest stands to estimate stand parameters. Each sample plot was imaged with hemispherical photographs to detect the LAI. The partial correlation analysis was used to assess the relationships between the stand LAI values and stand parameters, and the multivariate linear regression analysis was used to predict the LAI from stand parameters. Different artificial neural network models comprising different number of neuron and transfer functions were trained and used to predict the LAI of forest stands.Results: The correlation coefficients between LAI and stand parameters(stand number of trees, basal area, the quadratic mean diameter, stand density and stand age) were significant at the level of 0.01. The stand age, number of trees, site index, and basal area were independent parameters in the most successful regression model predicted LAI values using stand parameters(R_(adj)~2=0.5431). As corresponding method to predict the interactions between the stand LAI values and stand parameters, the neural network architecture based on the RBF 4-19-1 with Gaussian activation function in hidden layer and the identity activation function in output layer performed better in predicting LAI(SSE(12.1040), MSE(0.1223), RMSE(0.3497), AIC(0.1040), BIC(-77.7310) and R^2(0.6392)) compared to the other studied techniques.Conclusion: The ANN outperformed the multivariate regression techniques in predicting LAI from stand parameters. The ANN models, developed in this study, may aid in making forest management planning in study forest stands.展开更多
The reservoir volumetric approach represents a widely accepted, but flawed method of petroleum play resource calculation. In this paper, we propose a combination of techniques that can improve the applicability and qu...The reservoir volumetric approach represents a widely accepted, but flawed method of petroleum play resource calculation. In this paper, we propose a combination of techniques that can improve the applicability and quality of the resource estimation. These techniques include: 1) the use of the Multivariate Discovery Process model (MDP) to derive unbiased distribution parameters of reservoir volumetric variables and to reveal correlations among the variables; 2) the use of the Geo-anchored method to estimate simultaneously the number of oil and gas pools in the same play; and 3) the crossvalidation of assessment results from different methods. These techniques are illustrated by using an example of crude oil and natural gas resource assessment of the Sverdrup Basin, Canadian Archipelago. The example shows that when direct volumetric measurements of the untested prospects are not available, the MDP model can help derive unbiased estimates of the distribution parameters by using information from the discovered oil and gas accumulations. It also shows that an estimation of the number of oil and gas accumulations and associated size ranges from a discovery process model can provide an alternative and efficient approach when inadequate geological data hinder the estimation. Cross-examination of assessment results derived using different methods allows one to focus on and analyze the causes for the major differences, thus providing a more reliable assessment outcome.展开更多
For multivariate linear model Y=XΘ+ε, ~N(0, σ 2ΣV), this paper is concerned with the admissibility of linear estimators of estimable function SXΘ in the class of all estimators. All admissible linear estimators ...For multivariate linear model Y=XΘ+ε, ~N(0, σ 2ΣV), this paper is concerned with the admissibility of linear estimators of estimable function SXΘ in the class of all estimators. All admissible linear estimators of SXΘ are given under each of four definitions of admissibility.展开更多
Considering the problems that should be solved in the synthetic earthquake prediction at present, a new model is proposed in the paper. It is called joint multivariate statistical model combined by principal component...Considering the problems that should be solved in the synthetic earthquake prediction at present, a new model is proposed in the paper. It is called joint multivariate statistical model combined by principal component analysis with discriminatory analysis. Principal component analysis and discriminatory analysis are very important theories in multivariate statistical analysis that has developed quickly in the late thirty years. By means of maximization information method, we choose several earthquake prediction factors whose cumulative proportions of total sam-ple variances are beyond 90% from numerous earthquake prediction factors. The paper applies regression analysis and Mahalanobis discrimination to extrapolating synthetic prediction. Furthermore, we use this model to charac-terize and predict earthquakes in North China (30~42N, 108~125E) and better prediction results are obtained.展开更多
In this paper, compression LS estimate (k) of the regression coefficient B isconsidered when the design matrix present ill-condition in multivariate linear model.The MSE (mean square error)of the estimate(k)=Ve...In this paper, compression LS estimate (k) of the regression coefficient B isconsidered when the design matrix present ill-condition in multivariate linear model.The MSE (mean square error)of the estimate(k)=Vec( (k))is less than theMSE of LS estimate β ̄* of the regression coefficient β= Vec(B) by choosing the pa-rameter k. Admissibility , numerical stability and relative efficiency of (k)are proved. The method of determining k value for practical use is also suggested展开更多
Current univariate approach to predict the probability of well construction time has limited accuracy due to the fact that it ignores key factors affecting the time.In this study,we propose a multivariate probabilisti...Current univariate approach to predict the probability of well construction time has limited accuracy due to the fact that it ignores key factors affecting the time.In this study,we propose a multivariate probabilistic approach to predict the risks of well construction time.It takes advantage of an extended multi-dimensional Bernacchia–Pigolotti kernel density estimation technique and combines probability distributions by means of Monte-Carlo simulations to establish a depth-dependent probabilistic model.This method is applied to predict the durations of drilling phases of 192 wells,most of which are located in the AustraliaAsia region.Despite the challenge of gappy records,our model shows an excellent statistical agreement with the observed data.Our results suggested that the total time is longer than the trouble-free time by at least 4 days,and at most 12 days within the 10%–90% confidence interval.This model allows us to derive the likelihoods of duration for each phase at a certain depth and to generate inputs for training data-driven models,facilitating evaluation and prediction of the risks of an entire drilling operation.展开更多
It is important to consider the changing states in hedging.The Markov regime-switching dynamic correlation multivariate stochastic volatility( MRS-DC-MSV) model was proposed to solve this issue. DC-MSV model and MRS-D...It is important to consider the changing states in hedging.The Markov regime-switching dynamic correlation multivariate stochastic volatility( MRS-DC-MSV) model was proposed to solve this issue. DC-MSV model and MRS-DC-MSV model were used to calculate the time-varying hedging ratios and compare the hedging performance. The Markov chain Monte Carlo( MCMC) method was used to estimate the parameters. The results showed that,there were obviously two economic states in Chinese financial market. Two models all did well in hedging,but the performance of MRS-DCMSV model was better. It could reduce risk by nearly 90%. Thus,in the hedging period,changing states is a factor that cannot be neglected.展开更多
AIM The purpose of this study was to evaluate the diagnostic value of trefoil factor family 3(TFF3) for the early detection of colorectal cancer(CC). METHODS Serum TFF3 and carcino-embryonic antigen(CEA) were detected...AIM The purpose of this study was to evaluate the diagnostic value of trefoil factor family 3(TFF3) for the early detection of colorectal cancer(CC). METHODS Serum TFF3 and carcino-embryonic antigen(CEA) were detected in 527 individuals, including 115 healthy control(HC), 198 colorectal adenoma(CA), and 214 CC individuals in the training group. RESULTS Serum TFF3 showed no significant correlation with age, gender, or tumor location but showed significant correlation with the tumor stage. Serum TFF3 in the CC group was significantly higher than in the HC or CA group. The AUC values of TFF3 for discriminating between HC and CC and between CA and CC were 0.930(0.903, 0.958) and 0.834(0.796, 0.873). A multivariate model combining TFF3 and CEA was built. Compared to TFF3 or CEA alone, the multivariate model showed significant improvement(P < 0.001). For discriminating between HC and CC, HC and early stage CC, HC and advanced stage CC, CA and CC, CA and early stage CC, and CA and advanced stage CC in the training group, the sensitivities were 92.99%, 91.46%, 93.18%, 73.83%, 76.83%, and 81.82%, and the specificities were 91.30%, 91.30%, 93.91%, 88.38%, 77.27%, and 88.38%, respectively. After validation, the sensitivities were 89.39%, 85.71%, 90.79%, 72.73%, 71.43%, and 78.95%, and the specificities were 87.85%, 87.85%, 2.52%, 87.85%, 80.77%, and 87.50%, respectively. CONCLUSION The multivariate diagnostic model that included TFF3 and CEA showed significant improvement over the conventional biomarker CEA and might provide a potential method for the early detection of CC.展开更多
Heavy metal pollution in soil-plant system is of major environmental concern on a world scale and in China in particular with the rapid development of industry. The heavy metal pollution status in soil-plant system in...Heavy metal pollution in soil-plant system is of major environmental concern on a world scale and in China in particular with the rapid development of industry. The heavy metal pollution status in soil-plant system in China, the research progress on the bioavailability of heavy metals (affecting factors, extraction methods, free-ion activity model, adsorption model, multivariate regression model, Q-I relationship, and compound pollution), and soil remediation are reviewed in the paper. Future research and monitoring is also discussed.展开更多
In this article, the Bayes linear unbiased estimator (BALUE) of parameters is derived for the multivariate linear models. The superiorities of the BALUE over the least square estimator (LSE) is studied in terms of...In this article, the Bayes linear unbiased estimator (BALUE) of parameters is derived for the multivariate linear models. The superiorities of the BALUE over the least square estimator (LSE) is studied in terms of the mean square error matrix (MSEM) criterion and Bayesian Pitman closeness (PC) criterion.展开更多
Most of the existing multivariable grey models are based on the 1-order derivative and 1-order accumulation, which makes the parameters unable to be adjusted according to the data characteristics of the actual problem...Most of the existing multivariable grey models are based on the 1-order derivative and 1-order accumulation, which makes the parameters unable to be adjusted according to the data characteristics of the actual problems. The results about fractional derivative multivariable grey models are very few at present. In this paper, a multivariable Caputo fractional derivative grey model with convolution integral CFGMC(q, N) is proposed. First, the Caputo fractional difference is used to discretize the model, and the least square method is used to solve the parameters. The orders of accumulations and differential equations are determined by using particle swarm optimization(PSO). Then, the analytical solution of the model is obtained by using the Laplace transform, and the convergence and divergence of series in analytical solutions are also discussed. Finally, the CFGMC(q, N) model is used to predict the municipal solid waste(MSW). Compared with other competition models, the model has the best prediction effect. This study enriches the model form of the multivariable grey model, expands the scope of application, and provides a new idea for the development of fractional derivative grey model.展开更多
Von Rosen (1989) proposed the MLE of parameters in multivariate linear normal model MLNM(sumfromn= lto ∞AiBiCi). This paper discusses some properties of Rosen's MLE for general distributions which includs invaria...Von Rosen (1989) proposed the MLE of parameters in multivariate linear normal model MLNM(sumfromn= lto ∞AiBiCi). This paper discusses some properties of Rosen's MLE for general distributions which includs invariant, equivariant, strong consistency and asymptotic normality. Furthermore, we can construct the consistent confidence region for the parameter of experctation in MLNM(sumfromn=1to∞, AiBiCi) and obtain asymptotic distribu- tion and consistent confidence region of the linear discrimination function for canonical correlation by Kahtri (1988).展开更多
Multivariate mixtures are encountered in situations where the data are repeated or clustered measurements in the presence of heterogeneity among the observations with unknown proportions.In such situations,the main in...Multivariate mixtures are encountered in situations where the data are repeated or clustered measurements in the presence of heterogeneity among the observations with unknown proportions.In such situations,the main interest may be not only in estimating the component parameters,but also in obtaining reliable estimates of the mixing proportions.In this paper,we propose an empirical likelihood approach combined with a novel dimension reduction procedure for estimating parameters of a two-component multivariate mixture model.The performance of the new method is compared to fully parametric as well as almost nonparametric methods used in the literature.展开更多
This article presented a new data fusion approach for reasonably predicting dynamic serviceability reliability of the long-span bridge girder.Firstly,multivariate Bayesian dynamic linear model(MBDLM)considering dynami...This article presented a new data fusion approach for reasonably predicting dynamic serviceability reliability of the long-span bridge girder.Firstly,multivariate Bayesian dynamic linear model(MBDLM)considering dynamic correlation among the multiple variables is provided to predict dynamic extreme deflections;secondly,with the proposed MBDLM,the dynamic correlation coefficients between any two performance functions can be predicted;finally,based on MBDLM and Gaussian copula technique,a new data fusion method is given to predict the serviceability reliability of the long-span bridge girder,and the monitoring extreme deflection data from an actual bridge is provided to illustrated the feasibility and application of the proposed method.展开更多
Let{X_(ni),F_(ni);1≤i≤n,n≥1}be an array of R^(d)martingale difference random vectors and{A_(ni),1≤i≤n,n≥1}be an array of m×d matrices of real numbers.In this paper,the Marcinkiewicz-Zygmund type weak law of...Let{X_(ni),F_(ni);1≤i≤n,n≥1}be an array of R^(d)martingale difference random vectors and{A_(ni),1≤i≤n,n≥1}be an array of m×d matrices of real numbers.In this paper,the Marcinkiewicz-Zygmund type weak law of large numbers for maximal weighted sums of martingale difference random vectors is obtained with not necessarily finite p-th(1<p<2)moments.Moreover,the complete convergence and strong law of large numbers are established under some mild conditions.An application to multivariate simple linear regression model is also provided.展开更多
As the use of Cannabis products as natural medicines burgeons,it is also appearing as a food ingredient.It is important to screen Cannabis samples as ingredients by profiling their chemical compositions,which is refer...As the use of Cannabis products as natural medicines burgeons,it is also appearing as a food ingredient.It is important to screen Cannabis samples as ingredients by profiling their chemical compositions,which is referred to as chemotyping.Two sets of botanical extracts were studied.The first set is referred to as Cannabis contained plant materials from 15 samples of the sativa,indica,and hybrids of the two species.The second set contained 20 extracts from the variety of Cannabis sativa with low tetrahydrocannabinol(THC)concentrations,i.e.,below 0.3%,and,henceforth,will be referred to as hemp.An ultraviolet(UV)microplate reader provides a cost-effective and high-throughput method for identifying chemotypes of plant extracts by their spectra.The microplate reader affords rapid measurements of small volumes,e.g.,50μL,which demonstrates a potential to significantly reduce the analysis time and cost for Cannabis and hemp chemotyping or chemi-cal profiling.Replicate samples were measured on different days to demonstrate the robustness of the method.Projected difference resolution(PDR)maps were used to visualize the separations among the classes.Five multivariate classifiers,fuzzy rule-building expert system(FuRES),super partial least squares-discriminant analysis(sPLS-DA),support vector machine(SVM),and two tree-based support vector machines(SVMtreeG and SVMtreeH)were evaluated.The classifiers were validated with ten bootstrapped Latin partitions(BLPs).For the Cannabis extracts,the SVMtreeG yielded the best performance and the classification accuracy was 99.1±0.4%for spectra collected in the nonlinear absorbance range.For the hemp extracts,the SVM classifier performed the best with a 97.4±0.6%classification accuracy.These results demonstrate that the UV microplate reader coupled with multivariate classifiers can be used as a high-throughput and cost-effective approach for chemotyping Cannabis.展开更多
One of the major tasks of monitoring production well operations is to determine bottom-hole flowing pressure.The overwhelming majority of wells in the Perm Krai are serviced using borehole pumps,which makes it difficu...One of the major tasks of monitoring production well operations is to determine bottom-hole flowing pressure.The overwhelming majority of wells in the Perm Krai are serviced using borehole pumps,which makes it difficult to take direct bottom-hole flowing pressure measurements.The bottomhole filtration pressure(BHFP)in these wells is very often determined by recalculating the parameters measured at the well mouth(annulus pressure,dynamic fluid level depth).The recalculation is done by procedures based on analytically determining the characteristics of the gas-liquid mixture in the wellbore,which is very inconsistent to perform due to the mixture's complex behavior.This article proposes an essentially different approach to BHFP measurements that relies on the mathematical processing of the findings of more than 4000 parallel mouth and deep investigations of the oil production wells of a large oil-production region.As a result,multivariate mathematical models are elaborated that allow reliably determining the BHFP of oil-production wells in operation.展开更多
For aircraft manufacturing industries, the analyses and prediction of part machining error during machining process are very important to control and improve part machining quality. In order to effectively control mac...For aircraft manufacturing industries, the analyses and prediction of part machining error during machining process are very important to control and improve part machining quality. In order to effectively control machining error, the method of integrating multivariate statistical process control (MSPC) and stream of variations (SoV) is proposed. Firstly, machining error is modeled by multi-operation approaches for part machining process. SoV is adopted to establish the mathematic model of the relationship between the error of upstream operations and the error of downstream operations. Here error sources not only include the influence of upstream operations but also include many of other error sources. The standard model and the predicted model about SoV are built respectively by whether the operation is done or not to satisfy different requests during part machining process. Secondly, the method of one-step ahead forecast error (OSFE) is used to eliminate autocorrelativity of the sample data from the SoV model, and the T2 control chart in MSPC is built to realize machining error detection according to the data characteristics of the above error model, which can judge whether the operation is out of control or not. If it is, then feedback is sent to the operations. The error model is modified by adjusting the operation out of control, and continually it is used to monitor operations. Finally, a machining instance containing two operations demonstrates the effectiveness of the machining error control method presented in this paper.展开更多
文摘Artemisinins tested against W-2 strains of malaria falciparum are investigated with molecular electrostatic potential (MEP), in an attempt to identify key features of the compounds that are necessary for their activities, as well as to investigate likely interactions with the receptor in a biological process and to use that information to propose new molecules. In order to discover the best geometry involving the ligand-receptor complexes (heme) studied and help in the proposition of the new derivatives, molecular simulations of interactions between the most negative charged region around the peroxide and heme locates (the ones around the Fe2+ ion) were carried out. In addition, PCA (principal components analysis), HCA (hierarchical cluster analysis), SDA (stepwise discriminant analysis), and KNN (K-nearest neighbor) multivariate models were employed to investigate which descriptors are responsible for the classification between the higher and lower antimalarial activity of the compounds, and also this information was used to propose new potentially active molecules. The information accumulated in studies of MEP, molecular docking, and multivariate analysis supported the proposal of new structures with potential antimalarial activities. The multivariate models constructed were applied to the new structures and indicated numbers 19 and 20 as the most prominent for syntheses and biological assays.
基金Supported by the Digestive Medical Coordinated Development Center of Beijing Municipal Administration,No.XXZ0403.
文摘BACKGROUNDSpontaneous bacterial peritonitis (SBP) is a detrimental infection of the asciticfluid in liver cirrhosis patients, with high mortality and morbidity. Earlydiagnosis and timely antibiotic administration have successfully decreased themortality rate to 20%-25%. However, many patients cannot be diagnosed in theearly stages due to the absence of classical SBP symptoms. Early diagnosis ofasymptomatic SBP remains a great challenge in the clinic.AIMTo establish a multivariate predictive model for early diagnosis of asymptomaticSBP using positive microbial cultures from liver cirrhosis patients with ascites.METHODSA total of 98 asymptomatic SBP patients and 98 ascites liver cirrhosis patients withnegative microbial cultures were included in the case and control groups,respectively. Multiple linear stepwise regression analysis was performed toidentify potential indicators for asymptomatic SBP diagnosis. The diagnosticperformance of the model was estimated using the receiver operatingcharacteristic curve.RESULTSPatients in the case group were more likely to have advanced disease stages,cirrhosis related-complications, worsened hematology and ascites, and higher mortality. Based on multivariate analysis, the predictive model was as follows: y (P) = 0.018 + 0.312 × MELD (model of end-stage liver disease) + 0.263 × PMN(ascites polymorphonuclear) + 0.184 × N (blood neutrophil percentage) + 0.233 ×HCC (hepatocellular carcinoma) + 0.189 × renal dysfunction. The area under thecurve value of the established model was 0.872, revealing its high diagnosticpotential. The diagnostic sensitivity was 73.5% (72/98), the specificity was 86.7%(85/98), and the diagnostic efficacy was 80.1%.CONCLUSIONOur predictive model is based on the MELD score, polymorphonuclear cells,blood N, hepatocellular carcinoma, and renal dysfunction. This model mayimprove the early diagnosis of asymptomatic SBP.
基金Funding from The Scientific and Technological Research Council of Turkey(Project No:2130026)is gratefully acknowledged
文摘Background: Leaf Area Index(LAI) is an important parameter used in monitoring and modeling of forest ecosystems. The aim of this study was to evaluate performance of the artificial neural network(ANN) models to predict the LAI by comparing the regression analysis models as the classical method in these pure and even-aged Crimean pine forest stands.Methods: One hundred eight temporary sample plots were collected from Crimean pine forest stands to estimate stand parameters. Each sample plot was imaged with hemispherical photographs to detect the LAI. The partial correlation analysis was used to assess the relationships between the stand LAI values and stand parameters, and the multivariate linear regression analysis was used to predict the LAI from stand parameters. Different artificial neural network models comprising different number of neuron and transfer functions were trained and used to predict the LAI of forest stands.Results: The correlation coefficients between LAI and stand parameters(stand number of trees, basal area, the quadratic mean diameter, stand density and stand age) were significant at the level of 0.01. The stand age, number of trees, site index, and basal area were independent parameters in the most successful regression model predicted LAI values using stand parameters(R_(adj)~2=0.5431). As corresponding method to predict the interactions between the stand LAI values and stand parameters, the neural network architecture based on the RBF 4-19-1 with Gaussian activation function in hidden layer and the identity activation function in output layer performed better in predicting LAI(SSE(12.1040), MSE(0.1223), RMSE(0.3497), AIC(0.1040), BIC(-77.7310) and R^2(0.6392)) compared to the other studied techniques.Conclusion: The ANN outperformed the multivariate regression techniques in predicting LAI from stand parameters. The ANN models, developed in this study, may aid in making forest management planning in study forest stands.
文摘The reservoir volumetric approach represents a widely accepted, but flawed method of petroleum play resource calculation. In this paper, we propose a combination of techniques that can improve the applicability and quality of the resource estimation. These techniques include: 1) the use of the Multivariate Discovery Process model (MDP) to derive unbiased distribution parameters of reservoir volumetric variables and to reveal correlations among the variables; 2) the use of the Geo-anchored method to estimate simultaneously the number of oil and gas pools in the same play; and 3) the crossvalidation of assessment results from different methods. These techniques are illustrated by using an example of crude oil and natural gas resource assessment of the Sverdrup Basin, Canadian Archipelago. The example shows that when direct volumetric measurements of the untested prospects are not available, the MDP model can help derive unbiased estimates of the distribution parameters by using information from the discovered oil and gas accumulations. It also shows that an estimation of the number of oil and gas accumulations and associated size ranges from a discovery process model can provide an alternative and efficient approach when inadequate geological data hinder the estimation. Cross-examination of assessment results derived using different methods allows one to focus on and analyze the causes for the major differences, thus providing a more reliable assessment outcome.
文摘For multivariate linear model Y=XΘ+ε, ~N(0, σ 2ΣV), this paper is concerned with the admissibility of linear estimators of estimable function SXΘ in the class of all estimators. All admissible linear estimators of SXΘ are given under each of four definitions of admissibility.
文摘Considering the problems that should be solved in the synthetic earthquake prediction at present, a new model is proposed in the paper. It is called joint multivariate statistical model combined by principal component analysis with discriminatory analysis. Principal component analysis and discriminatory analysis are very important theories in multivariate statistical analysis that has developed quickly in the late thirty years. By means of maximization information method, we choose several earthquake prediction factors whose cumulative proportions of total sam-ple variances are beyond 90% from numerous earthquake prediction factors. The paper applies regression analysis and Mahalanobis discrimination to extrapolating synthetic prediction. Furthermore, we use this model to charac-terize and predict earthquakes in North China (30~42N, 108~125E) and better prediction results are obtained.
文摘In this paper, compression LS estimate (k) of the regression coefficient B isconsidered when the design matrix present ill-condition in multivariate linear model.The MSE (mean square error)of the estimate(k)=Vec( (k))is less than theMSE of LS estimate β ̄* of the regression coefficient β= Vec(B) by choosing the pa-rameter k. Admissibility , numerical stability and relative efficiency of (k)are proved. The method of determining k value for practical use is also suggested
文摘Current univariate approach to predict the probability of well construction time has limited accuracy due to the fact that it ignores key factors affecting the time.In this study,we propose a multivariate probabilistic approach to predict the risks of well construction time.It takes advantage of an extended multi-dimensional Bernacchia–Pigolotti kernel density estimation technique and combines probability distributions by means of Monte-Carlo simulations to establish a depth-dependent probabilistic model.This method is applied to predict the durations of drilling phases of 192 wells,most of which are located in the AustraliaAsia region.Despite the challenge of gappy records,our model shows an excellent statistical agreement with the observed data.Our results suggested that the total time is longer than the trouble-free time by at least 4 days,and at most 12 days within the 10%–90% confidence interval.This model allows us to derive the likelihoods of duration for each phase at a certain depth and to generate inputs for training data-driven models,facilitating evaluation and prediction of the risks of an entire drilling operation.
基金National Natural Science Foundation of China(No.71401144)
文摘It is important to consider the changing states in hedging.The Markov regime-switching dynamic correlation multivariate stochastic volatility( MRS-DC-MSV) model was proposed to solve this issue. DC-MSV model and MRS-DC-MSV model were used to calculate the time-varying hedging ratios and compare the hedging performance. The Markov chain Monte Carlo( MCMC) method was used to estimate the parameters. The results showed that,there were obviously two economic states in Chinese financial market. Two models all did well in hedging,but the performance of MRS-DCMSV model was better. It could reduce risk by nearly 90%. Thus,in the hedging period,changing states is a factor that cannot be neglected.
基金Supported by The Capital Health Development Special Scientific Research Projects,No.2014-2-2154National Natural Science Foundation of China,No.81471761 and No.81501568
文摘AIM The purpose of this study was to evaluate the diagnostic value of trefoil factor family 3(TFF3) for the early detection of colorectal cancer(CC). METHODS Serum TFF3 and carcino-embryonic antigen(CEA) were detected in 527 individuals, including 115 healthy control(HC), 198 colorectal adenoma(CA), and 214 CC individuals in the training group. RESULTS Serum TFF3 showed no significant correlation with age, gender, or tumor location but showed significant correlation with the tumor stage. Serum TFF3 in the CC group was significantly higher than in the HC or CA group. The AUC values of TFF3 for discriminating between HC and CC and between CA and CC were 0.930(0.903, 0.958) and 0.834(0.796, 0.873). A multivariate model combining TFF3 and CEA was built. Compared to TFF3 or CEA alone, the multivariate model showed significant improvement(P < 0.001). For discriminating between HC and CC, HC and early stage CC, HC and advanced stage CC, CA and CC, CA and early stage CC, and CA and advanced stage CC in the training group, the sensitivities were 92.99%, 91.46%, 93.18%, 73.83%, 76.83%, and 81.82%, and the specificities were 91.30%, 91.30%, 93.91%, 88.38%, 77.27%, and 88.38%, respectively. After validation, the sensitivities were 89.39%, 85.71%, 90.79%, 72.73%, 71.43%, and 78.95%, and the specificities were 87.85%, 87.85%, 2.52%, 87.85%, 80.77%, and 87.50%, respectively. CONCLUSION The multivariate diagnostic model that included TFF3 and CEA showed significant improvement over the conventional biomarker CEA and might provide a potential method for the early detection of CC.
文摘Heavy metal pollution in soil-plant system is of major environmental concern on a world scale and in China in particular with the rapid development of industry. The heavy metal pollution status in soil-plant system in China, the research progress on the bioavailability of heavy metals (affecting factors, extraction methods, free-ion activity model, adsorption model, multivariate regression model, Q-I relationship, and compound pollution), and soil remediation are reviewed in the paper. Future research and monitoring is also discussed.
基金Supported by the National Natural Science Foundation of China (No.10801123,10801124,10771204)the Knowledge Innovation Program of the Chinese Academy of Sciences (Grant No. KJCX3-SYW-S02)
文摘In this article, the Bayes linear unbiased estimator (BALUE) of parameters is derived for the multivariate linear models. The superiorities of the BALUE over the least square estimator (LSE) is studied in terms of the mean square error matrix (MSEM) criterion and Bayesian Pitman closeness (PC) criterion.
基金supported by the National Natural Science Foundation of China (51479151,61403288)。
文摘Most of the existing multivariable grey models are based on the 1-order derivative and 1-order accumulation, which makes the parameters unable to be adjusted according to the data characteristics of the actual problems. The results about fractional derivative multivariable grey models are very few at present. In this paper, a multivariable Caputo fractional derivative grey model with convolution integral CFGMC(q, N) is proposed. First, the Caputo fractional difference is used to discretize the model, and the least square method is used to solve the parameters. The orders of accumulations and differential equations are determined by using particle swarm optimization(PSO). Then, the analytical solution of the model is obtained by using the Laplace transform, and the convergence and divergence of series in analytical solutions are also discussed. Finally, the CFGMC(q, N) model is used to predict the municipal solid waste(MSW). Compared with other competition models, the model has the best prediction effect. This study enriches the model form of the multivariable grey model, expands the scope of application, and provides a new idea for the development of fractional derivative grey model.
文摘Von Rosen (1989) proposed the MLE of parameters in multivariate linear normal model MLNM(sumfromn= lto ∞AiBiCi). This paper discusses some properties of Rosen's MLE for general distributions which includs invariant, equivariant, strong consistency and asymptotic normality. Furthermore, we can construct the consistent confidence region for the parameter of experctation in MLNM(sumfromn=1to∞, AiBiCi) and obtain asymptotic distribu- tion and consistent confidence region of the linear discrimination function for canonical correlation by Kahtri (1988).
基金partially supported by the Natural Sciences and Engineering Research Council of Canada(NSERC)Discovery Grants(RGPIN-2018-05846,RGPIN-2018-05981)the National Natural Science Foundation of China(Grant Numbers 11771144,11501354 and 11501208)the Chinese 111 Project(B14019).
文摘Multivariate mixtures are encountered in situations where the data are repeated or clustered measurements in the presence of heterogeneity among the observations with unknown proportions.In such situations,the main interest may be not only in estimating the component parameters,but also in obtaining reliable estimates of the mixing proportions.In this paper,we propose an empirical likelihood approach combined with a novel dimension reduction procedure for estimating parameters of a two-component multivariate mixture model.The performance of the new method is compared to fully parametric as well as almost nonparametric methods used in the literature.
基金This work was supported by Natural Science Foundation of Gansu Province of China(20JR10RA625,20JR10RA623)National Key Research and Development Project of China(Project No.2019YFC1511005)+1 种基金Fundamental Research Funds for the Central Universities(Grant No.lzujbky-2020-55)National Natural Science Foundation of China(Grant No.51608243).
文摘This article presented a new data fusion approach for reasonably predicting dynamic serviceability reliability of the long-span bridge girder.Firstly,multivariate Bayesian dynamic linear model(MBDLM)considering dynamic correlation among the multiple variables is provided to predict dynamic extreme deflections;secondly,with the proposed MBDLM,the dynamic correlation coefficients between any two performance functions can be predicted;finally,based on MBDLM and Gaussian copula technique,a new data fusion method is given to predict the serviceability reliability of the long-span bridge girder,and the monitoring extreme deflection data from an actual bridge is provided to illustrated the feasibility and application of the proposed method.
基金Supported by the Outstanding Youth Research Project of Anhui Colleges(Grant No.2022AH030156)。
文摘Let{X_(ni),F_(ni);1≤i≤n,n≥1}be an array of R^(d)martingale difference random vectors and{A_(ni),1≤i≤n,n≥1}be an array of m×d matrices of real numbers.In this paper,the Marcinkiewicz-Zygmund type weak law of large numbers for maximal weighted sums of martingale difference random vectors is obtained with not necessarily finite p-th(1<p<2)moments.Moreover,the complete convergence and strong law of large numbers are established under some mild conditions.An application to multivariate simple linear regression model is also provided.
文摘As the use of Cannabis products as natural medicines burgeons,it is also appearing as a food ingredient.It is important to screen Cannabis samples as ingredients by profiling their chemical compositions,which is referred to as chemotyping.Two sets of botanical extracts were studied.The first set is referred to as Cannabis contained plant materials from 15 samples of the sativa,indica,and hybrids of the two species.The second set contained 20 extracts from the variety of Cannabis sativa with low tetrahydrocannabinol(THC)concentrations,i.e.,below 0.3%,and,henceforth,will be referred to as hemp.An ultraviolet(UV)microplate reader provides a cost-effective and high-throughput method for identifying chemotypes of plant extracts by their spectra.The microplate reader affords rapid measurements of small volumes,e.g.,50μL,which demonstrates a potential to significantly reduce the analysis time and cost for Cannabis and hemp chemotyping or chemi-cal profiling.Replicate samples were measured on different days to demonstrate the robustness of the method.Projected difference resolution(PDR)maps were used to visualize the separations among the classes.Five multivariate classifiers,fuzzy rule-building expert system(FuRES),super partial least squares-discriminant analysis(sPLS-DA),support vector machine(SVM),and two tree-based support vector machines(SVMtreeG and SVMtreeH)were evaluated.The classifiers were validated with ten bootstrapped Latin partitions(BLPs).For the Cannabis extracts,the SVMtreeG yielded the best performance and the classification accuracy was 99.1±0.4%for spectra collected in the nonlinear absorbance range.For the hemp extracts,the SVM classifier performed the best with a 97.4±0.6%classification accuracy.These results demonstrate that the UV microplate reader coupled with multivariate classifiers can be used as a high-throughput and cost-effective approach for chemotyping Cannabis.
文摘One of the major tasks of monitoring production well operations is to determine bottom-hole flowing pressure.The overwhelming majority of wells in the Perm Krai are serviced using borehole pumps,which makes it difficult to take direct bottom-hole flowing pressure measurements.The bottomhole filtration pressure(BHFP)in these wells is very often determined by recalculating the parameters measured at the well mouth(annulus pressure,dynamic fluid level depth).The recalculation is done by procedures based on analytically determining the characteristics of the gas-liquid mixture in the wellbore,which is very inconsistent to perform due to the mixture's complex behavior.This article proposes an essentially different approach to BHFP measurements that relies on the mathematical processing of the findings of more than 4000 parallel mouth and deep investigations of the oil production wells of a large oil-production region.As a result,multivariate mathematical models are elaborated that allow reliably determining the BHFP of oil-production wells in operation.
基金National Natural Science Foundation of China (70931004)
文摘For aircraft manufacturing industries, the analyses and prediction of part machining error during machining process are very important to control and improve part machining quality. In order to effectively control machining error, the method of integrating multivariate statistical process control (MSPC) and stream of variations (SoV) is proposed. Firstly, machining error is modeled by multi-operation approaches for part machining process. SoV is adopted to establish the mathematic model of the relationship between the error of upstream operations and the error of downstream operations. Here error sources not only include the influence of upstream operations but also include many of other error sources. The standard model and the predicted model about SoV are built respectively by whether the operation is done or not to satisfy different requests during part machining process. Secondly, the method of one-step ahead forecast error (OSFE) is used to eliminate autocorrelativity of the sample data from the SoV model, and the T2 control chart in MSPC is built to realize machining error detection according to the data characteristics of the above error model, which can judge whether the operation is out of control or not. If it is, then feedback is sent to the operations. The error model is modified by adjusting the operation out of control, and continually it is used to monitor operations. Finally, a machining instance containing two operations demonstrates the effectiveness of the machining error control method presented in this paper.