Chronic diseases have drawn much attention as the primary cause of death and disability. In exploring novel sideeffect-free agents against chronic diseases, significant efforts have been devoted to mushroom polysaccha...Chronic diseases have drawn much attention as the primary cause of death and disability. In exploring novel sideeffect-free agents against chronic diseases, significant efforts have been devoted to mushroom polysaccharides due to their diverse biological activities. This work reviewed the structural features, biological performances and molecular mechanisms of mushroom polysaccharides in managing cancers, diabetes mellitus and cardiovascular diseases. The potentials of mushroom polysaccharides against chronic diseases highly depend on their structural features, including monosaccharide composition, molecular weight, the type and configuration of glycosidic bonds, degree of branching, the type of substituent pattern and chain conformation. Regarding their working mechanisms, shared and diseasespecific pathways were found. The three chronic diseases shared the regulation of specific signalling pathways and the adjustment of gut microbiota. In addition, the roles of transcription factors, receptors, enzymes, hormones and other functional proteins involved in the molecular mechanisms of mushroom polysaccharides against chronic diseases are first elaborated herein. The present review describes the state of the art of mushroom polysaccharides in treating chronic diseases and addresses the perspectives, and will further promote research on this topic.展开更多
Edible mushroom polysaccharides,as one of the main biological activities of mushrooms,have anti-tumour,anti-inflammatory,antioxidant,immune regulation and other functions.Especially because of its anti-tumour and immu...Edible mushroom polysaccharides,as one of the main biological activities of mushrooms,have anti-tumour,anti-inflammatory,antioxidant,immune regulation and other functions.Especially because of its anti-tumour and immunomodulatory activity,it has been used in the clinical treatment of various diseases.Recent studies have focused on mushroom polysaccharides'functional properties,which may be related to their chemical structures.This review aims to clarify the biological activity of edible mushroom polysaccharides and their medicinal potential in human health and to reveal the relationship between chemical structure and the biological activity of edible mushroom polysaccharides.展开更多
基金supported by the National Key Research and Development Program of China(2016YFD0400204-2)。
文摘Chronic diseases have drawn much attention as the primary cause of death and disability. In exploring novel sideeffect-free agents against chronic diseases, significant efforts have been devoted to mushroom polysaccharides due to their diverse biological activities. This work reviewed the structural features, biological performances and molecular mechanisms of mushroom polysaccharides in managing cancers, diabetes mellitus and cardiovascular diseases. The potentials of mushroom polysaccharides against chronic diseases highly depend on their structural features, including monosaccharide composition, molecular weight, the type and configuration of glycosidic bonds, degree of branching, the type of substituent pattern and chain conformation. Regarding their working mechanisms, shared and diseasespecific pathways were found. The three chronic diseases shared the regulation of specific signalling pathways and the adjustment of gut microbiota. In addition, the roles of transcription factors, receptors, enzymes, hormones and other functional proteins involved in the molecular mechanisms of mushroom polysaccharides against chronic diseases are first elaborated herein. The present review describes the state of the art of mushroom polysaccharides in treating chronic diseases and addresses the perspectives, and will further promote research on this topic.
基金We gratefully acknowledge financial support from the Taishan Industry Leading Talents Project(tscy20200221)the Key Research and Develop Program of Shandong Province(2020CXGC010601).
文摘Edible mushroom polysaccharides,as one of the main biological activities of mushrooms,have anti-tumour,anti-inflammatory,antioxidant,immune regulation and other functions.Especially because of its anti-tumour and immunomodulatory activity,it has been used in the clinical treatment of various diseases.Recent studies have focused on mushroom polysaccharides'functional properties,which may be related to their chemical structures.This review aims to clarify the biological activity of edible mushroom polysaccharides and their medicinal potential in human health and to reveal the relationship between chemical structure and the biological activity of edible mushroom polysaccharides.
