Microbial pathogens include bacteria, viruses, fungi, and parasites and together account for a significant percentage of acute and chronic human diseases. In addition to understanding the mechanisms by which various p...Microbial pathogens include bacteria, viruses, fungi, and parasites and together account for a significant percentage of acute and chronic human diseases. In addition to understanding the mechanisms by which various pathogens cause human disease, research in microbial pathogenesis also addresses mechanisms of antimicrobial resistance and the development of new antimicrobial agents and vaccines. Answering fundamental questions regarding host-microbe interactions requires an interdisciplinary approach, including microbiology, genomics, informatics, molecular and cellular biology, biochemistry, immunology, epidemiology, environment and interaction between host and microbe. Studies investigating the direct effects of pollutants on respiratory tract infections are very vast, but those interested in the role of a pre-existing disease and effects of the exposure on the response to secondary stresses are few. In an experimental study at concentrations of air pollutants found in urban environments, frank toxicological responses are rarely observed, however, exposure to secondary stress like the respiratory challenge with infectious bacteria can exacerbate the response of the experimental host. The models like experimental, mechanical, and mathematical are the most abstract, but they allow analysis and logical proofs in a way that other approaches do not permit. The present review is mostly concerned with these model representations particularly with a novel mathematical model explaining the interaction between pathogen and immunity including the equivalence point.展开更多
The People’s Army of Vietnam (PAVN) decided to use conventional warfare to unify Vietnam. The United States military operation against the Ho Chi Minh Trail traffic began in 1959. The (PAVN) connected a series of old...The People’s Army of Vietnam (PAVN) decided to use conventional warfare to unify Vietnam. The United States military operation against the Ho Chi Minh Trail traffic began in 1959. The (PAVN) connected a series of old trails leading from North Vietnam to South Vietnam via Laos and Cambodia. In the 1960s the network of trails was expanded. Trail traffic was interdicted by repeated CIA (Air America) and US Air Force (Operation Ranch Hand) tactical herbicide spraying and bombing missions. During the late 1960s, the Khmer Rouge Army slowly grew in eastern Cambodia during a time when America was spraying and bombing the Ho Chi Minh Trail. On February 22, 1969, the PAVN launched a new offensive against American forces in South Vietnam from their sanctuaries in Cambodia. President Richard Nixon and Dr. Henry Kissinger, decided to spray and bomb Cambodia, a neutral country, to eliminate the PAVN sanctuary base camps. The damage and loss of life as a result of U.S. air campaign resulted in the insurgency (Khmer Rouge) being able to recruit civilian members. This created a dual effect of strengthening the popularity of the Khmer Rouge, led by Pol Pot, enabling him to overthrow the Khmer Republic in 1975. The primary objectives of this study are to determine the political impacts and consequences of: 1) the 1959 United States secret war on the Ho Chi Minh Trail in Cambodia and 2) the 1969 President Nixon’s decision to destroy the PAVN bases hidden in the Cambodian jungles. These United States secret wars in Cambodia had long-lasting effects on Cambodian political, social, and economic stability.展开更多
The frequent rebellions in Northern Manchuria during the Third Revolutionary War occurred in the special context of the struggle between the Kuomintang(KMT)and the Communist Party of China(CPC)for Northeast China afte...The frequent rebellions in Northern Manchuria during the Third Revolutionary War occurred in the special context of the struggle between the Kuomintang(KMT)and the Communist Party of China(CPC)for Northeast China after the victory of the Anti-Japanese War.The rebellion reached its peak during the KMTs attack on Northeast China,followed by a second wave of rebellion after the defeat in the Defensive Battle of Siping.It tended to disappear after the downfall of the Jiang Pengfei Group.In addition to the blind recruitment of the CPC in traditional narratives,the instigation of the KMT,the traditional mutiny of the old army,the limitations of the early work of the Northeast Anti-Japanese United Army,the early activities of the KMT,and the regional conflicts between the local and foreign forces are also important reasons for the concentration of rebellions.展开更多
After the outbreak of World War I,the British War Office decided to dispatch female nursing personnel to the front lines due to the severe casualties among soldiers,the underdeveloped military medical services of the ...After the outbreak of World War I,the British War Office decided to dispatch female nursing personnel to the front lines due to the severe casualties among soldiers,the underdeveloped military medical services of the allied forces,and the maturity of the British Army female nursing service.Despite the harsh working conditions and the complexities of nurse-patient relationships under wartime restrictions,the female nursing staff also experienced moments of leisure that allowed them to relax and recuperate.The wartime British Army Female Nursing Service had a positive effect in reducing casualties and promoting the development of the official nurse registration movement.展开更多
Gastrointestinal problems are common during wars, and they have exerted significant adverse effects on the health of service members involved in warfare. The spectrum of digestive diseases has varied during wars of di...Gastrointestinal problems are common during wars, and they have exerted significant adverse effects on the health of service members involved in warfare. The spectrum of digestive diseases has varied during wars of different eras. At the end of the 20 th century, new frontiers of military medical research emerged due to the occurrence of high-tech wars such as the Gulf War and the Kosovo War, in which ground combat was no longer the primary method of field operations. The risk to the military personnel who face trauma has been greatly reduced, but disease and non-battle injuries(DNBIs) such as neuropsychological disorders and digestive diseases seemed to be increased. Data revealed that gastrointestinal symptoms such as constipation, diarrhea, dyspepsia, and noncardiac chest pain are common among military personnel during modern wars. In addition, a large number of deployed soldiers and veterans who participated in recent wars presented with chronic gastrointestinal complaints, which fulfilled with the Rome III criteria for functional gastrointestinal disorders(FGIDs). It was also noted that many veterans who returned from the Gulf War suffered not only from chronic digestive symptoms but also from neuropsychological dysfunction; however, they also showed symptoms of other systems. Presently, this broad range of unexplained symptoms is known as "Gulf War syndrome". The mechanism that underlies Gulf War syndrome remains unclear, but many factors have been associated with this syndrome such as war trauma, stress, infections, immune dysfunction, radiological factors, anthrax vaccination and so on. Some have questioned if the diagnosis of FGIDs can be reached given the complexity of the military situation. As a result, further studies are needed to elucidate the pathogenesis of gastrointestinal disease among military personnel.展开更多
BACKGROUND Psychosocial and physical trauma are known risk factors for irritable bowel syndrome(IBS),including in war veterans,whereas war exposure in civilians is unclear.Nicaragua experienced two wars,1970-1990:The ...BACKGROUND Psychosocial and physical trauma are known risk factors for irritable bowel syndrome(IBS),including in war veterans,whereas war exposure in civilians is unclear.Nicaragua experienced two wars,1970-1990:The Sandinistas Revolution(1970s)and The Contra War(1980s).Our aim was to investigate the role of exposure to war trauma in the subsequent development of IBS in the context of an established health surveillance system(11000 households).AIM To investigate in a civilian population the relationship between exposure to war trauma and events and the subsequent development of IBS in the context of an established public health and demographic surveillance system in western Nicaragua.METHODS We conducted a nested population-based,cross-sectional study focused on functional gastrointestinal disorders based on Rome II criteria.1617 adults were randomly selected.The Spanish Rome II Modular Questionnaire and Harvard Trauma Questionnaire were validated in Nicaragua.War exposure was assessed with 10 measures of direct and indirect war trauma and post-war effects.Multiple exposures were defined by≥3 measures.RESULTS The prevalence of IBS was 15.2%[Female(F)17.1%,Male(M)12.0%],war exposure 19.3%(F 9.3%,M 36.7%),and post-traumatic stress disorder(PTSD)5.6%(F 6.4%,M 4.3%).Significant associations with IBS in the civilian population were observed(adjusted by gender,age,socioeconomic status,education):physical and psychological abuse[adjusted odds ratio(aOR):2.25;95%confidence interval:1.1-4.5],witnessed execution(aOR:2.4;1.1-5.2),family member death(aOR:2.2;1.2-4.2),and multiple exposures(aOR:2.7;1.4-5.1).PTSD was independently associated with IBS(aOR:2.6;1.2-5.7).CONCLUSION An enduring association was observed in the Nicaragua civilian population between specific civil war-related events and subsequent IBS.Civilian populations in regions with extended armed conflict may warrant provider education and targeted interventions for patients.展开更多
War,as a social phenomenon,is studied unofficially by most disciplines of social sciences.This is due to the nature of the war itself,which is an extremely interdisciplinary phenomenon.In common thought,war is associa...War,as a social phenomenon,is studied unofficially by most disciplines of social sciences.This is due to the nature of the war itself,which is an extremely interdisciplinary phenomenon.In common thought,war is associated exclusively with the science of history,but in its essence,this phenomenon also includes economics and political sciences.War undeniably affects the political and economic processes in the state,both in a negative and positive way.Often,also the strategies of the state’s political activities and plans for economic development are conditioned by the occurrence of wars and armed conflicts.展开更多
Cutthroat competition amid subsidiary companies of IT Group Company due to immanent characteristics of IT industry and grouping management mechanism infringes upon the collective profits. Two ways to avoid cutthroat c...Cutthroat competition amid subsidiary companies of IT Group Company due to immanent characteristics of IT industry and grouping management mechanism infringes upon the collective profits. Two ways to avoid cutthroat competition of group company with game theory are studied: the assessment objective made by IT group company for subsidiary companies focuses on profits not revenue; the supervisory department of group company shall intensify law enforcement strength and give severe punishment against illegal depreciation of the subsidiary company.展开更多
SMARTPHONE companies are in battle in China, the world's largest smartphone market. While not yet the largest in terms of profit, it surpassed the United States in 2011 to register the world's highest smartphone sal...SMARTPHONE companies are in battle in China, the world's largest smartphone market. While not yet the largest in terms of profit, it surpassed the United States in 2011 to register the world's highest smartphone sales volume, according to Strategy Analytics, an international market research and consulting firm. In this fiercely competitive environment,展开更多
Gulf War Illness(GWI) encompass a spectrum of maladies specific to troops deployed during the Persian Gulf War(1990–1991). There are several hypothesized factors believed to contribute to GWI, including(but not limit...Gulf War Illness(GWI) encompass a spectrum of maladies specific to troops deployed during the Persian Gulf War(1990–1991). There are several hypothesized factors believed to contribute to GWI, including(but not limited to)exposures to chemical agents and a foreign environment(e.g., dust, pollens, insects, and microbes). Moreover, the inherent stress associated with deployment and combat has been associated with GWI. While the etiology of GWI remains uncertain, several studies have provided strong evidence that chemical exposures, especially neurotoxicants,may be underlying factors for the development of GWI. This mini style perspective article will focus on some of the major evidence linking chemical exposures to GWI development and persistence decades after exposure.展开更多
This year marks the 100th anniversary of the First World War and the 75th anniversary of the Second World War. Mauya Omauya a media editor and lecturer in international affairs at Kenya's Moi University, believes tha...This year marks the 100th anniversary of the First World War and the 75th anniversary of the Second World War. Mauya Omauya a media editor and lecturer in international affairs at Kenya's Moi University, believes that from slavery to colonialism and neocolonialism, Africa has been a victim of wars started far from its shores. His views follow:展开更多
Marxist political economy provides a perspective for grasping the root cause of the China-US trade war.The international relations of production,which stem from the international division of labor,shape the distributi...Marxist political economy provides a perspective for grasping the root cause of the China-US trade war.The international relations of production,which stem from the international division of labor,shape the distribution of international economic interests and the political status of countries.Traditionally,developing countries have been subjected to the“periphery”in the international division of labor.In the new global value chain,developing countries have remained in a subordinate position characterized by“technological-market”dependence.To achieve the goal of building a strong modern nation,China must escape the“technological-market”dependence.Yet China’s efforts and achievements in escaping dependent development are deemed as a threat to US vested interests in the international markets.To preserve the economic foundation of its hegemony,the US has resorted to a trade war to contain China’s development.展开更多
The background of this article takes place after modern China.It is an essential change in the history of the Chinese salt industry that Sichuan salt supplies to Hubei.Sichuan salt jumped out of the original sales ran...The background of this article takes place after modern China.It is an essential change in the history of the Chinese salt industry that Sichuan salt supplies to Hubei.Sichuan salt jumped out of the original sales range,sold in Hubei.Since then,Hubei has become the most essential selling place of Sichuan salt,which continues to affect the economy of Sichuan.The War of Aid to Hubei was an inter-regional war in the warlord era.In order to realize“Local governance of Hubei”,the exploiting warlord Wang Zhanyuan was expelled.Sichuan chose to send troops,which economic factors are significant.Mainly,the Sichuan salt played a crucial role in it.Through the study of this problem,we can see that the economic factors in modern times occupy an essential position in the competition of warlords and promote the progress of history.展开更多
It is important to clarify the historical facts and summarize the characteristics of the communication and cooperation between the CPC and the JCP during the War of Resistance against Japanese Aggression,as it holds h...It is important to clarify the historical facts and summarize the characteristics of the communication and cooperation between the CPC and the JCP during the War of Resistance against Japanese Aggression,as it holds historical and contemporary relevance.The research findings indicate that the Comintern played a crucial role as the key intermediary in facilitating the establishment of connections between the CPC and the JCP and in driving the deepening of their relationship.During their exchanges,both parties adhered to a flexible and multi-layered friendship based on the unified values of patriotism and internationalism.Their efforts played a significant role in the establishment of an international anti-fascist front in the East.展开更多
文摘Microbial pathogens include bacteria, viruses, fungi, and parasites and together account for a significant percentage of acute and chronic human diseases. In addition to understanding the mechanisms by which various pathogens cause human disease, research in microbial pathogenesis also addresses mechanisms of antimicrobial resistance and the development of new antimicrobial agents and vaccines. Answering fundamental questions regarding host-microbe interactions requires an interdisciplinary approach, including microbiology, genomics, informatics, molecular and cellular biology, biochemistry, immunology, epidemiology, environment and interaction between host and microbe. Studies investigating the direct effects of pollutants on respiratory tract infections are very vast, but those interested in the role of a pre-existing disease and effects of the exposure on the response to secondary stresses are few. In an experimental study at concentrations of air pollutants found in urban environments, frank toxicological responses are rarely observed, however, exposure to secondary stress like the respiratory challenge with infectious bacteria can exacerbate the response of the experimental host. The models like experimental, mechanical, and mathematical are the most abstract, but they allow analysis and logical proofs in a way that other approaches do not permit. The present review is mostly concerned with these model representations particularly with a novel mathematical model explaining the interaction between pathogen and immunity including the equivalence point.
文摘The People’s Army of Vietnam (PAVN) decided to use conventional warfare to unify Vietnam. The United States military operation against the Ho Chi Minh Trail traffic began in 1959. The (PAVN) connected a series of old trails leading from North Vietnam to South Vietnam via Laos and Cambodia. In the 1960s the network of trails was expanded. Trail traffic was interdicted by repeated CIA (Air America) and US Air Force (Operation Ranch Hand) tactical herbicide spraying and bombing missions. During the late 1960s, the Khmer Rouge Army slowly grew in eastern Cambodia during a time when America was spraying and bombing the Ho Chi Minh Trail. On February 22, 1969, the PAVN launched a new offensive against American forces in South Vietnam from their sanctuaries in Cambodia. President Richard Nixon and Dr. Henry Kissinger, decided to spray and bomb Cambodia, a neutral country, to eliminate the PAVN sanctuary base camps. The damage and loss of life as a result of U.S. air campaign resulted in the insurgency (Khmer Rouge) being able to recruit civilian members. This created a dual effect of strengthening the popularity of the Khmer Rouge, led by Pol Pot, enabling him to overthrow the Khmer Republic in 1975. The primary objectives of this study are to determine the political impacts and consequences of: 1) the 1959 United States secret war on the Ho Chi Minh Trail in Cambodia and 2) the 1969 President Nixon’s decision to destroy the PAVN bases hidden in the Cambodian jungles. These United States secret wars in Cambodia had long-lasting effects on Cambodian political, social, and economic stability.
文摘The frequent rebellions in Northern Manchuria during the Third Revolutionary War occurred in the special context of the struggle between the Kuomintang(KMT)and the Communist Party of China(CPC)for Northeast China after the victory of the Anti-Japanese War.The rebellion reached its peak during the KMTs attack on Northeast China,followed by a second wave of rebellion after the defeat in the Defensive Battle of Siping.It tended to disappear after the downfall of the Jiang Pengfei Group.In addition to the blind recruitment of the CPC in traditional narratives,the instigation of the KMT,the traditional mutiny of the old army,the limitations of the early work of the Northeast Anti-Japanese United Army,the early activities of the KMT,and the regional conflicts between the local and foreign forces are also important reasons for the concentration of rebellions.
文摘After the outbreak of World War I,the British War Office decided to dispatch female nursing personnel to the front lines due to the severe casualties among soldiers,the underdeveloped military medical services of the allied forces,and the maturity of the British Army female nursing service.Despite the harsh working conditions and the complexities of nurse-patient relationships under wartime restrictions,the female nursing staff also experienced moments of leisure that allowed them to relax and recuperate.The wartime British Army Female Nursing Service had a positive effect in reducing casualties and promoting the development of the official nurse registration movement.
文摘Gastrointestinal problems are common during wars, and they have exerted significant adverse effects on the health of service members involved in warfare. The spectrum of digestive diseases has varied during wars of different eras. At the end of the 20 th century, new frontiers of military medical research emerged due to the occurrence of high-tech wars such as the Gulf War and the Kosovo War, in which ground combat was no longer the primary method of field operations. The risk to the military personnel who face trauma has been greatly reduced, but disease and non-battle injuries(DNBIs) such as neuropsychological disorders and digestive diseases seemed to be increased. Data revealed that gastrointestinal symptoms such as constipation, diarrhea, dyspepsia, and noncardiac chest pain are common among military personnel during modern wars. In addition, a large number of deployed soldiers and veterans who participated in recent wars presented with chronic gastrointestinal complaints, which fulfilled with the Rome III criteria for functional gastrointestinal disorders(FGIDs). It was also noted that many veterans who returned from the Gulf War suffered not only from chronic digestive symptoms but also from neuropsychological dysfunction; however, they also showed symptoms of other systems. Presently, this broad range of unexplained symptoms is known as "Gulf War syndrome". The mechanism that underlies Gulf War syndrome remains unclear, but many factors have been associated with this syndrome such as war trauma, stress, infections, immune dysfunction, radiological factors, anthrax vaccination and so on. Some have questioned if the diagnosis of FGIDs can be reached given the complexity of the military situation. As a result, further studies are needed to elucidate the pathogenesis of gastrointestinal disease among military personnel.
基金Supported by the UNC UNAN FGID Epidemiology Study Project,No.54-1808958.
文摘BACKGROUND Psychosocial and physical trauma are known risk factors for irritable bowel syndrome(IBS),including in war veterans,whereas war exposure in civilians is unclear.Nicaragua experienced two wars,1970-1990:The Sandinistas Revolution(1970s)and The Contra War(1980s).Our aim was to investigate the role of exposure to war trauma in the subsequent development of IBS in the context of an established health surveillance system(11000 households).AIM To investigate in a civilian population the relationship between exposure to war trauma and events and the subsequent development of IBS in the context of an established public health and demographic surveillance system in western Nicaragua.METHODS We conducted a nested population-based,cross-sectional study focused on functional gastrointestinal disorders based on Rome II criteria.1617 adults were randomly selected.The Spanish Rome II Modular Questionnaire and Harvard Trauma Questionnaire were validated in Nicaragua.War exposure was assessed with 10 measures of direct and indirect war trauma and post-war effects.Multiple exposures were defined by≥3 measures.RESULTS The prevalence of IBS was 15.2%[Female(F)17.1%,Male(M)12.0%],war exposure 19.3%(F 9.3%,M 36.7%),and post-traumatic stress disorder(PTSD)5.6%(F 6.4%,M 4.3%).Significant associations with IBS in the civilian population were observed(adjusted by gender,age,socioeconomic status,education):physical and psychological abuse[adjusted odds ratio(aOR):2.25;95%confidence interval:1.1-4.5],witnessed execution(aOR:2.4;1.1-5.2),family member death(aOR:2.2;1.2-4.2),and multiple exposures(aOR:2.7;1.4-5.1).PTSD was independently associated with IBS(aOR:2.6;1.2-5.7).CONCLUSION An enduring association was observed in the Nicaragua civilian population between specific civil war-related events and subsequent IBS.Civilian populations in regions with extended armed conflict may warrant provider education and targeted interventions for patients.
文摘War,as a social phenomenon,is studied unofficially by most disciplines of social sciences.This is due to the nature of the war itself,which is an extremely interdisciplinary phenomenon.In common thought,war is associated exclusively with the science of history,but in its essence,this phenomenon also includes economics and political sciences.War undeniably affects the political and economic processes in the state,both in a negative and positive way.Often,also the strategies of the state’s political activities and plans for economic development are conditioned by the occurrence of wars and armed conflicts.
文摘Cutthroat competition amid subsidiary companies of IT Group Company due to immanent characteristics of IT industry and grouping management mechanism infringes upon the collective profits. Two ways to avoid cutthroat competition of group company with game theory are studied: the assessment objective made by IT group company for subsidiary companies focuses on profits not revenue; the supervisory department of group company shall intensify law enforcement strength and give severe punishment against illegal depreciation of the subsidiary company.
文摘SMARTPHONE companies are in battle in China, the world's largest smartphone market. While not yet the largest in terms of profit, it surpassed the United States in 2011 to register the world's highest smartphone sales volume, according to Strategy Analytics, an international market research and consulting firm. In this fiercely competitive environment,
基金supported in part by the VA grant(5 I21 BX003760)to JMR.
文摘Gulf War Illness(GWI) encompass a spectrum of maladies specific to troops deployed during the Persian Gulf War(1990–1991). There are several hypothesized factors believed to contribute to GWI, including(but not limited to)exposures to chemical agents and a foreign environment(e.g., dust, pollens, insects, and microbes). Moreover, the inherent stress associated with deployment and combat has been associated with GWI. While the etiology of GWI remains uncertain, several studies have provided strong evidence that chemical exposures, especially neurotoxicants,may be underlying factors for the development of GWI. This mini style perspective article will focus on some of the major evidence linking chemical exposures to GWI development and persistence decades after exposure.
文摘This year marks the 100th anniversary of the First World War and the 75th anniversary of the Second World War. Mauya Omauya a media editor and lecturer in international affairs at Kenya's Moi University, believes that from slavery to colonialism and neocolonialism, Africa has been a victim of wars started far from its shores. His views follow:
基金This study is funded by Major Research Program on Philosophy and Social Sciences of Jiangsu Education Department(The Education of Marxism International View in Colleges and Universities for a New Era,No.2022SJZDSZ001)Green Research Program of Nanjing University of Aeronautics and Astronautics(China-US Science and Technology Competition from the Perspective of Marxism,No.1023-YAH21032).
文摘Marxist political economy provides a perspective for grasping the root cause of the China-US trade war.The international relations of production,which stem from the international division of labor,shape the distribution of international economic interests and the political status of countries.Traditionally,developing countries have been subjected to the“periphery”in the international division of labor.In the new global value chain,developing countries have remained in a subordinate position characterized by“technological-market”dependence.To achieve the goal of building a strong modern nation,China must escape the“technological-market”dependence.Yet China’s efforts and achievements in escaping dependent development are deemed as a threat to US vested interests in the international markets.To preserve the economic foundation of its hegemony,the US has resorted to a trade war to contain China’s development.
文摘The background of this article takes place after modern China.It is an essential change in the history of the Chinese salt industry that Sichuan salt supplies to Hubei.Sichuan salt jumped out of the original sales range,sold in Hubei.Since then,Hubei has become the most essential selling place of Sichuan salt,which continues to affect the economy of Sichuan.The War of Aid to Hubei was an inter-regional war in the warlord era.In order to realize“Local governance of Hubei”,the exploiting warlord Wang Zhanyuan was expelled.Sichuan chose to send troops,which economic factors are significant.Mainly,the Sichuan salt played a crucial role in it.Through the study of this problem,we can see that the economic factors in modern times occupy an essential position in the competition of warlords and promote the progress of history.
基金supported by Youth Fund for Humanities and Social Sciences Research of the Ministry of Education“Research on the Translation,Sharing,and Evolution of Marxist Terminology in the Early Translation of the Communist Manifesto between China and Japan”(《共产党宣言》在中日两国早期译介过程中马克思主义术语的译出、共享与演变研究,20YJC740035).
文摘It is important to clarify the historical facts and summarize the characteristics of the communication and cooperation between the CPC and the JCP during the War of Resistance against Japanese Aggression,as it holds historical and contemporary relevance.The research findings indicate that the Comintern played a crucial role as the key intermediary in facilitating the establishment of connections between the CPC and the JCP and in driving the deepening of their relationship.During their exchanges,both parties adhered to a flexible and multi-layered friendship based on the unified values of patriotism and internationalism.Their efforts played a significant role in the establishment of an international anti-fascist front in the East.