Musculoskeletal manifestations of atypical Mycobacterium are very rare and they can be easily missed by the junior doctors. We are presenting two cases of atypical Mycobacterium: the first one was infected by cleaning...Musculoskeletal manifestations of atypical Mycobacterium are very rare and they can be easily missed by the junior doctors. We are presenting two cases of atypical Mycobacterium: the first one was infected by cleaning a fish tank and the other was immune-compromised patients. Both the cases were treated with broad spectrum antiboitics initially, with no results, unless the specimen cultures were obtained surgically and the specific cultures were asked. The treatment was started after obtaining the culture results. Both the patients were started on antituberculous treatment for 3 - 6 months with good functional results.展开更多
This case report presents an unusual and challenging diagnostic scenario involving a 72-year-old man who recently returned from a trip to Maui, Hawaii. While in Maui, the patient presented with a fever and fatigue tha...This case report presents an unusual and challenging diagnostic scenario involving a 72-year-old man who recently returned from a trip to Maui, Hawaii. While in Maui, the patient presented with a fever and fatigue that resolved spontaneously. However, he had an observable rash on his head and was given a steroid injection to resolve the rash. Later on his trip, the patient experienced a dry, nonproductive cough which resolved with a five-day course of prednisone. While visiting Michigan, the patient began to experience neck pain and visited Troy Beaumont Hospital for further treatment. Meningitis tests were negative. Vancomycin was given due to the detection of gram positive coccidioidomycosis in the culture, but this was later proven to be a contaminant. Coccidiomycosis does not initially have specific symptoms. Despite negative coccidioidomycosis antigen tests, the patient exhibited features more consistent with blastomycosis and cryptococcus, highlighting the complexities of diagnosing fungal infections with atypical presentations. The case emphasizes the importance of considering alternative fungal pathogens native to endemic regions and pursuing comprehensive diagnostic measures to establish an accurate diagnosis. Lastly, the discussion about recommendations for antifungal therapy and preventative measures for individuals at risk of respiratory fungal infections is critically important for the advancement of early detection of fungal infections.展开更多
BACKGROUND Infections by non-tuberculous mycobacteria(NTM)have become more common in recent years.Mycobacterium canariasense(M.canariasense)was first reported as an opportunistic pathogen in 2004,but there have been v...BACKGROUND Infections by non-tuberculous mycobacteria(NTM)have become more common in recent years.Mycobacterium canariasense(M.canariasense)was first reported as an opportunistic pathogen in 2004,but there have been very few case reports since then.Nocardia is a genus of aerobic and Gram-positive bacilli,and these species are also opportunistic pathogens and in the Mycobacteriales order.Conventional methods for diagnosis of NTM are inefficient.Metagenomic next-generation sequencing(mNGS)can rapidly detect many pathogenic microorganisms,even rare species.Most NTM and Nocardia infections occur in immunocompromised patients with atypical clinical symptoms.There are no previous reports of infection by M.canariasense and Nocardia farcinica(N.farcinica),especially in immunocompetent patients.This case report describes an immunocompetent 52-year-old woman who had overlapping infections of M.canariasense,N.farcinica,and Candida parapsilosis(C.parapsilosis)based on mNGS.CASE SUMMARY A 52-year-old woman presented with a productive cough and chest pain for 2 wk,and recurrent episodes of moderate-grade fever for 1 wk.She received antibiotics for 1 wk at a local hospital,and experienced defervescence,but the productive cough and chest pain persisted.We collected samples of a lung lesion and alveolar lavage fluid for mNGS.The lung tissue was positive for M.canariasense,N.farcinica,and C.parapsilosis,and the alveolar lavage fluid was positive for M.canariasense.The diagnosis was pneumonia,and application of appropriate antibiotic therapy cured the patient.CONCLUSION Etiological diagnosis is critical for patients with infectious diseases.mNGS can identify rare and novel pathogens,and does not require a priori knowledge.展开更多
Atypical cutaneous lymphoproliferative disorder (ACLD) is a rare condition that has been associated with HIV infection. Patients with ACLD present with diffuse, erythematous and pruritic skin lesions accompanied by ge...Atypical cutaneous lymphoproliferative disorder (ACLD) is a rare condition that has been associated with HIV infection. Patients with ACLD present with diffuse, erythematous and pruritic skin lesions accompanied by generalized lymphadenopathy. The clinical characteristics of ACLD overlap most notably with several other conditions including Mycosis Fungoides/Sézary Syndrome (MF/SS), a cutaneous lymphoma of T-cell lineage. Unlike Mycosis Fungoides, the noxious infiltrates of ACLD are not monoclonal but polyclonal and consist of cytotoxic CD8+ T-cells instead of CD4+ T-cells or B-cells. Highly active antiretroviral therapy (HAART) has been reported to improve ACLD. We describe the case of a Caucasian man with longstanding HIV infection who presented with severe erythroderma. Skin and lymph node biopsies showed polyclonal CD8+ T-cell infiltrates. Gene rearrangement studies did not reveal an obvious clonal disorder. Hallmark peripheral blood findings consisting of a severe depletion of CD4+ T-lymphocytes and markedly elevated CD8+ cells provided an important diagnostic clue. Despite the purported benefits of HAART in ameliorating this disorder, erythroderma and extreme pruritus improved only after the patient began taking mycophenolate mofetil and hydroxyurea. Unfortunately, he succumbed to complications of methicillin-resistant Staphylococcus aureus septicemia. We alert readers to this rare HIV-associated condition which may mimic other benign and malignant skin conditions and briefly discuss diagnostic and therapeutic options.展开更多
Objective:To investigate the distribution characteristics of atypical pathogen infection in Hainan.Methods:A descriptive research was used to collect the data of 800 patients with atypical pathogen infection in Hainan...Objective:To investigate the distribution characteristics of atypical pathogen infection in Hainan.Methods:A descriptive research was used to collect the data of 800 patients with atypical pathogen infection in Hainan,(including Burkholderia pseudomallei,Aspergillus,Mycobacterium nontuberculosis,Nocardia,Penicillium marneffei,Cryptococcus,Candida albicans,Mycoplasma,Rickettsia).To study the epidemiological characteristics of the above pathogen infection.Results:In the distribution of population infected with atypical pathogens,the female composition ratio of Aspergillus,Nocardia and Penicillium marneffei was higher than that of male,while the male composition ratio of Burkholderia melioidis,non-tuberculous Mycobacterium,Cryptococcus,Candida albicans,Mycoplasma and Rickettsia was higher than that of female.In terms of age,melioidosis,Aspergillus,non-tuberculous Mycobacterium,Penicillium Marneffei and Rickettsia were the highest in the middle-aged group,the highest in the young group infected with Cryptococcus,the highest in the elderly group infected with Candida albicans,and the highest in the children infected with Mycoplasma.Children and farmers were more common,accounting for 35%and 29.25%respectively.Coastal area is the highest incidence area,as high as 89%;The onset time was mostly concentrated in the third quarter,accounting for the largest proportion.According to the statistics of the sources of samples that could be isolated,sputum culture was the most common.Hypertension was the most common complication of underlying diseases,and more than 55%of patients had fever before or on admission.Conclusion:Atypical pathogens in hainan area differences in the population distribution,the pathogen infection all have good sex and age,occupational distribution occurs in children and farmers,coastal areas and in the third quarter for the high incidence area and season,in addition,the atypical pathogen infection,often accompanied by fever and hypertension patients with suspected atypical pathogen infection,clinical to improve the diagnosis and treatment of these diseases,we should actively search for pathogens from multiple specimen sources.展开更多
Objective: To investigate the relationship between serum procalcitonin (PCT) and C-reactive protein (CRP) combined with the proportion of atypical lymphocytes and severity of respiratory virus infection. Methods: A to...Objective: To investigate the relationship between serum procalcitonin (PCT) and C-reactive protein (CRP) combined with the proportion of atypical lymphocytes and severity of respiratory virus infection. Methods: A total of 113 children with respiratory infection in our hospital from January 2018 to August 2018 were enrolled. According to the type of infection, they were divided into bacterial infection group (n=38) and virus infection group (n=52), 60 healthy children were selected as the control group. Serum PCT, CRP and atypical lymphocyte ratios were measured in each group, and the relationship between them and the severity of the disease was analyzed. Results: The serum CRP and PCT in the bacterial infection group were significantly higher than those in the virus-infected group and the control group. While The ratio of atypical lymphocytes in the virus-infected group was significantly higher than that in the bacterial-infected group and the control group;The serum PCR, CRP and atypical lymphocyte ratio gradually increased with the severity of the disease, the difference was statistically significant. Pearson correlation analysis showed that serum PCT, CRP content and atypical lymphocyte ratio were significantly positively correlated with the severity of the disease. The positive rate of PCR and CRP in the bacterial infection group was significantly higher than that in the virus infection group. The positive rate of heterotypic lymphocyte ratio was significantly lower than that in the virus infection group. Conclusion: The detection of serum PCT and CRP levels has a good diagnostic value for bacterial respiratory infections. The ratio of atypical lymphocytes can be used as a preliminary aid in the diagnosis of respiratory virus infection-related diseases. The combination of the two is of great significance for the clinical diagnosis of children with respiratory infections.展开更多
Objective:The purpose of this study is to identify existing literature on recurrent atypical mycobacterial cervicofacial lymphadenitis to augment our understanding of a unique patient who presented to our tertiary‐ca...Objective:The purpose of this study is to identify existing literature on recurrent atypical mycobacterial cervicofacial lymphadenitis to augment our understanding of a unique patient who presented to our tertiary‐care center 5‐years posttreatment with recurrence following curettage.Data Sources:OVID Medline,Scopus,and Web of Science.Methods:A literature search was conducted yielding 49 original articles which were screened twice by two independent reviewers resulting in 14 studies meeting inclusion criteria for data extraction using Covidence software.Two independent reviewers extracted data on recurrence of atypical mycobacterial cervicofacial lymphadenitis and consensus was reached on data points from all included studies.Results:This study illuminated the paucity of recurrence reporting in the literature regarding atypical mycobacterial lymphadenitis.Sixteen studies identified in our review included discussions on recurrence with few elaborating beyond the rate of recurrence to describe their management.Fourteen out of sixteen studies provided recurrence rates for their cohort,11 out of 14 specified the initial treatment modality,and only five out of eight studies that described initial treatment with surgery differentiated recurrence rates between complete and incomplete excision.The mean length of follow‐up in the included studies was 20 months.There was one previously reported case of late recurrence at 5‐years.Conclusions:We identified few reports that discussed the management of recurrence of atypical mycobacterial cervicofacial lymphadenitis.There was minimal data on recurrence rates between surgical treatment modalities.The case discussed in our study showcases that treatment with curettage has the potential to present with late recurrence.展开更多
BACKGROUND An epidemic of Mycobacterium chimaera (M. chimaera) infections following cardiac surgery is ongoing worldwide. The outbreak was first discovered in 2011, and it has been traced to a point source contaminati...BACKGROUND An epidemic of Mycobacterium chimaera (M. chimaera) infections following cardiac surgery is ongoing worldwide. The outbreak was first discovered in 2011, and it has been traced to a point source contamination of the LivaNova 3T heater-cooler unit, which is used also in Italy. International data are advocated to clarify the spectrum of clinical features of the disease as well as treatment options and outcome. We report a series of M. chimaera infections diagnosed in Treviso Hospital, including the first cases notified in Italy in 2016. CASE SUMMARY Since June 2016, we diagnosed a M. chimaera infection in nine patient who had undergone cardiac valve surgery between February 2011 and November 2016. The time between cardiac surgery and developing symptoms ranged from 6 to 97 mo. Unexplained fever, psychophysical decay, weight loss, and neurological symptoms were common complaints. The median duration of symptoms was 32 wk, and the longest was almost two years. A new cardiac murmur, splenomegaly, choroidoretinitis, anaemia or lymphopenia, abnormal liver function tests and hyponatremia were common findings. All the patients presented a prosthetic valve endocarditis, frequently associated to an ascending aortic pseudoneurysm or spondylodiscitis. M. chimaera was cultured from blood, bioprosthetic tissue, pericardial abscess, vertebral tissue, and bone marrow. Mortality is high in our series, reflecting the poor outcome observed in other reports. Three patients have undergone repeat cardiac surgery. Five patients are being treated with a targeted multidrug antimycobacterial regimen. CONCLUSION Patients who have undergone cardiac surgery in Italy and presenting with signs and symptoms of endocarditis must be tested for M. chimaera.展开更多
BACKGROUND Mycobacterium abscessus(M.abscessus)is a rapidly growing mycobacterium and ubiquitous in the environment,which infrequently causes disease in humans.However,it can cause cutaneous or respiratory infections ...BACKGROUND Mycobacterium abscessus(M.abscessus)is a rapidly growing mycobacterium and ubiquitous in the environment,which infrequently causes disease in humans.However,it can cause cutaneous or respiratory infections among immunocompromised hosts.Due to the resistance to most antibiotics,the pathogen is formidable and difficult-to-treat.CASE SUMMARY Here,we present a case of catheter-related M.abscessus infections in a patient with motor neurone disease.Catheter and peripheral blood cultures of the patient showed positive results during Gram staining and acid-fast staining.The alarm time of catheter blood culture was 10.6 h earlier than that of peripheral blood.After removal of the peripherally inserted central catheter,secretion and catheter blood culture were positive.M.abscessus was identified by matrix-assisted laser desorption ionization-time of flight mass spectrometry and 16S rDNA sequencing.CONCLUSION For catheter-related M.abscessus infection,rapid diagnosis and timely and adequate antimicrobial therapy are crucial.展开更多
文摘Musculoskeletal manifestations of atypical Mycobacterium are very rare and they can be easily missed by the junior doctors. We are presenting two cases of atypical Mycobacterium: the first one was infected by cleaning a fish tank and the other was immune-compromised patients. Both the cases were treated with broad spectrum antiboitics initially, with no results, unless the specimen cultures were obtained surgically and the specific cultures were asked. The treatment was started after obtaining the culture results. Both the patients were started on antituberculous treatment for 3 - 6 months with good functional results.
文摘This case report presents an unusual and challenging diagnostic scenario involving a 72-year-old man who recently returned from a trip to Maui, Hawaii. While in Maui, the patient presented with a fever and fatigue that resolved spontaneously. However, he had an observable rash on his head and was given a steroid injection to resolve the rash. Later on his trip, the patient experienced a dry, nonproductive cough which resolved with a five-day course of prednisone. While visiting Michigan, the patient began to experience neck pain and visited Troy Beaumont Hospital for further treatment. Meningitis tests were negative. Vancomycin was given due to the detection of gram positive coccidioidomycosis in the culture, but this was later proven to be a contaminant. Coccidiomycosis does not initially have specific symptoms. Despite negative coccidioidomycosis antigen tests, the patient exhibited features more consistent with blastomycosis and cryptococcus, highlighting the complexities of diagnosing fungal infections with atypical presentations. The case emphasizes the importance of considering alternative fungal pathogens native to endemic regions and pursuing comprehensive diagnostic measures to establish an accurate diagnosis. Lastly, the discussion about recommendations for antifungal therapy and preventative measures for individuals at risk of respiratory fungal infections is critically important for the advancement of early detection of fungal infections.
基金Supported by The Guangxi TCM Suitable Technology Development and Promotion Project,No.GZSY20-20.
文摘BACKGROUND Infections by non-tuberculous mycobacteria(NTM)have become more common in recent years.Mycobacterium canariasense(M.canariasense)was first reported as an opportunistic pathogen in 2004,but there have been very few case reports since then.Nocardia is a genus of aerobic and Gram-positive bacilli,and these species are also opportunistic pathogens and in the Mycobacteriales order.Conventional methods for diagnosis of NTM are inefficient.Metagenomic next-generation sequencing(mNGS)can rapidly detect many pathogenic microorganisms,even rare species.Most NTM and Nocardia infections occur in immunocompromised patients with atypical clinical symptoms.There are no previous reports of infection by M.canariasense and Nocardia farcinica(N.farcinica),especially in immunocompetent patients.This case report describes an immunocompetent 52-year-old woman who had overlapping infections of M.canariasense,N.farcinica,and Candida parapsilosis(C.parapsilosis)based on mNGS.CASE SUMMARY A 52-year-old woman presented with a productive cough and chest pain for 2 wk,and recurrent episodes of moderate-grade fever for 1 wk.She received antibiotics for 1 wk at a local hospital,and experienced defervescence,but the productive cough and chest pain persisted.We collected samples of a lung lesion and alveolar lavage fluid for mNGS.The lung tissue was positive for M.canariasense,N.farcinica,and C.parapsilosis,and the alveolar lavage fluid was positive for M.canariasense.The diagnosis was pneumonia,and application of appropriate antibiotic therapy cured the patient.CONCLUSION Etiological diagnosis is critical for patients with infectious diseases.mNGS can identify rare and novel pathogens,and does not require a priori knowledge.
文摘Atypical cutaneous lymphoproliferative disorder (ACLD) is a rare condition that has been associated with HIV infection. Patients with ACLD present with diffuse, erythematous and pruritic skin lesions accompanied by generalized lymphadenopathy. The clinical characteristics of ACLD overlap most notably with several other conditions including Mycosis Fungoides/Sézary Syndrome (MF/SS), a cutaneous lymphoma of T-cell lineage. Unlike Mycosis Fungoides, the noxious infiltrates of ACLD are not monoclonal but polyclonal and consist of cytotoxic CD8+ T-cells instead of CD4+ T-cells or B-cells. Highly active antiretroviral therapy (HAART) has been reported to improve ACLD. We describe the case of a Caucasian man with longstanding HIV infection who presented with severe erythroderma. Skin and lymph node biopsies showed polyclonal CD8+ T-cell infiltrates. Gene rearrangement studies did not reveal an obvious clonal disorder. Hallmark peripheral blood findings consisting of a severe depletion of CD4+ T-lymphocytes and markedly elevated CD8+ cells provided an important diagnostic clue. Despite the purported benefits of HAART in ameliorating this disorder, erythroderma and extreme pruritus improved only after the patient began taking mycophenolate mofetil and hydroxyurea. Unfortunately, he succumbed to complications of methicillin-resistant Staphylococcus aureus septicemia. We alert readers to this rare HIV-associated condition which may mimic other benign and malignant skin conditions and briefly discuss diagnostic and therapeutic options.
基金Hainan Provincial Key Research and Development Science and Technology Cooperation(No.ZDYF2020223)Innovative Research Team of Hainan Natural Science Foundation(No.820CXTD448)National Natural Science Foundation of China(No.82011530049,81860001)。
文摘Objective:To investigate the distribution characteristics of atypical pathogen infection in Hainan.Methods:A descriptive research was used to collect the data of 800 patients with atypical pathogen infection in Hainan,(including Burkholderia pseudomallei,Aspergillus,Mycobacterium nontuberculosis,Nocardia,Penicillium marneffei,Cryptococcus,Candida albicans,Mycoplasma,Rickettsia).To study the epidemiological characteristics of the above pathogen infection.Results:In the distribution of population infected with atypical pathogens,the female composition ratio of Aspergillus,Nocardia and Penicillium marneffei was higher than that of male,while the male composition ratio of Burkholderia melioidis,non-tuberculous Mycobacterium,Cryptococcus,Candida albicans,Mycoplasma and Rickettsia was higher than that of female.In terms of age,melioidosis,Aspergillus,non-tuberculous Mycobacterium,Penicillium Marneffei and Rickettsia were the highest in the middle-aged group,the highest in the young group infected with Cryptococcus,the highest in the elderly group infected with Candida albicans,and the highest in the children infected with Mycoplasma.Children and farmers were more common,accounting for 35%and 29.25%respectively.Coastal area is the highest incidence area,as high as 89%;The onset time was mostly concentrated in the third quarter,accounting for the largest proportion.According to the statistics of the sources of samples that could be isolated,sputum culture was the most common.Hypertension was the most common complication of underlying diseases,and more than 55%of patients had fever before or on admission.Conclusion:Atypical pathogens in hainan area differences in the population distribution,the pathogen infection all have good sex and age,occupational distribution occurs in children and farmers,coastal areas and in the third quarter for the high incidence area and season,in addition,the atypical pathogen infection,often accompanied by fever and hypertension patients with suspected atypical pathogen infection,clinical to improve the diagnosis and treatment of these diseases,we should actively search for pathogens from multiple specimen sources.
文摘Objective: To investigate the relationship between serum procalcitonin (PCT) and C-reactive protein (CRP) combined with the proportion of atypical lymphocytes and severity of respiratory virus infection. Methods: A total of 113 children with respiratory infection in our hospital from January 2018 to August 2018 were enrolled. According to the type of infection, they were divided into bacterial infection group (n=38) and virus infection group (n=52), 60 healthy children were selected as the control group. Serum PCT, CRP and atypical lymphocyte ratios were measured in each group, and the relationship between them and the severity of the disease was analyzed. Results: The serum CRP and PCT in the bacterial infection group were significantly higher than those in the virus-infected group and the control group. While The ratio of atypical lymphocytes in the virus-infected group was significantly higher than that in the bacterial-infected group and the control group;The serum PCR, CRP and atypical lymphocyte ratio gradually increased with the severity of the disease, the difference was statistically significant. Pearson correlation analysis showed that serum PCT, CRP content and atypical lymphocyte ratio were significantly positively correlated with the severity of the disease. The positive rate of PCR and CRP in the bacterial infection group was significantly higher than that in the virus infection group. The positive rate of heterotypic lymphocyte ratio was significantly lower than that in the virus infection group. Conclusion: The detection of serum PCT and CRP levels has a good diagnostic value for bacterial respiratory infections. The ratio of atypical lymphocytes can be used as a preliminary aid in the diagnosis of respiratory virus infection-related diseases. The combination of the two is of great significance for the clinical diagnosis of children with respiratory infections.
文摘Objective:The purpose of this study is to identify existing literature on recurrent atypical mycobacterial cervicofacial lymphadenitis to augment our understanding of a unique patient who presented to our tertiary‐care center 5‐years posttreatment with recurrence following curettage.Data Sources:OVID Medline,Scopus,and Web of Science.Methods:A literature search was conducted yielding 49 original articles which were screened twice by two independent reviewers resulting in 14 studies meeting inclusion criteria for data extraction using Covidence software.Two independent reviewers extracted data on recurrence of atypical mycobacterial cervicofacial lymphadenitis and consensus was reached on data points from all included studies.Results:This study illuminated the paucity of recurrence reporting in the literature regarding atypical mycobacterial lymphadenitis.Sixteen studies identified in our review included discussions on recurrence with few elaborating beyond the rate of recurrence to describe their management.Fourteen out of sixteen studies provided recurrence rates for their cohort,11 out of 14 specified the initial treatment modality,and only five out of eight studies that described initial treatment with surgery differentiated recurrence rates between complete and incomplete excision.The mean length of follow‐up in the included studies was 20 months.There was one previously reported case of late recurrence at 5‐years.Conclusions:We identified few reports that discussed the management of recurrence of atypical mycobacterial cervicofacial lymphadenitis.There was minimal data on recurrence rates between surgical treatment modalities.The case discussed in our study showcases that treatment with curettage has the potential to present with late recurrence.
文摘BACKGROUND An epidemic of Mycobacterium chimaera (M. chimaera) infections following cardiac surgery is ongoing worldwide. The outbreak was first discovered in 2011, and it has been traced to a point source contamination of the LivaNova 3T heater-cooler unit, which is used also in Italy. International data are advocated to clarify the spectrum of clinical features of the disease as well as treatment options and outcome. We report a series of M. chimaera infections diagnosed in Treviso Hospital, including the first cases notified in Italy in 2016. CASE SUMMARY Since June 2016, we diagnosed a M. chimaera infection in nine patient who had undergone cardiac valve surgery between February 2011 and November 2016. The time between cardiac surgery and developing symptoms ranged from 6 to 97 mo. Unexplained fever, psychophysical decay, weight loss, and neurological symptoms were common complaints. The median duration of symptoms was 32 wk, and the longest was almost two years. A new cardiac murmur, splenomegaly, choroidoretinitis, anaemia or lymphopenia, abnormal liver function tests and hyponatremia were common findings. All the patients presented a prosthetic valve endocarditis, frequently associated to an ascending aortic pseudoneurysm or spondylodiscitis. M. chimaera was cultured from blood, bioprosthetic tissue, pericardial abscess, vertebral tissue, and bone marrow. Mortality is high in our series, reflecting the poor outcome observed in other reports. Three patients have undergone repeat cardiac surgery. Five patients are being treated with a targeted multidrug antimycobacterial regimen. CONCLUSION Patients who have undergone cardiac surgery in Italy and presenting with signs and symptoms of endocarditis must be tested for M. chimaera.
文摘BACKGROUND Mycobacterium abscessus(M.abscessus)is a rapidly growing mycobacterium and ubiquitous in the environment,which infrequently causes disease in humans.However,it can cause cutaneous or respiratory infections among immunocompromised hosts.Due to the resistance to most antibiotics,the pathogen is formidable and difficult-to-treat.CASE SUMMARY Here,we present a case of catheter-related M.abscessus infections in a patient with motor neurone disease.Catheter and peripheral blood cultures of the patient showed positive results during Gram staining and acid-fast staining.The alarm time of catheter blood culture was 10.6 h earlier than that of peripheral blood.After removal of the peripherally inserted central catheter,secretion and catheter blood culture were positive.M.abscessus was identified by matrix-assisted laser desorption ionization-time of flight mass spectrometry and 16S rDNA sequencing.CONCLUSION For catheter-related M.abscessus infection,rapid diagnosis and timely and adequate antimicrobial therapy are crucial.
