The objective of this multicentric study was to assess the prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma génitalium and Trichomonas vaginalis infections in Brazzaville, in the Republic of...The objective of this multicentric study was to assess the prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma génitalium and Trichomonas vaginalis infections in Brazzaville, in the Republic of Congo, using molecular methods. From January to December 2021, the sexually transmitted disease risk participants were recruited from six centers: The Association of Young HIV-Positive People of Congo, The Congolese Association for Family Welfare, The Association for Support to Vulnerable Groups, Talangaï hospital, Brazzaville university hospital (outpatient service) and the private clinic COGEMO (outpatient service). The real-time multiplex PCR was carried out to detect these pathogens. Each patient had at least one specimen (urine, urethral, anal and/or vaginal samples). The patients were considered infected when one of their samples was positive. 287 participants made of 227 women and 60 men were tested. The general prevalence of these infections was: Chlamydia trachomatis 2.79%, Neisseria gonorrhoeae 3.14%, Mycoplasma génitalium 3.45% and Trichomonas vaginalis 2.97. The prevalence rates according to sex were: C. trachomatis, M. génitalium, N. gonorrhea and T. vaginalis were 1.32%, 2.05%, 1.32% and 3.42% in women and 8.33%, 7.02%, 10% and 1.75% in men, respectively. Most infected patients were asymptomatic. Prevalence rates were higher in bisexual individuals, with the exception of T. vaginalis which showed higher prevalence in heterosexual patients. The bisexual and homosexual individuals represent a major public health problem in sexually active young adults, particularly among men having sex with men. These sexually transmitted infections are mainly asymptomatic, their diagnosis and management remain difficult in developing countries.展开更多
目的探讨儿童支原体肺炎患儿降钙素原(PCT)、C反应蛋白(CRP)、T淋巴细胞亚群、免疫球蛋白的变化及临床意义,为患者的临床诊疗提供参考。方法选取2017年2月至2018年2月在西安交通大学附属红会医院就诊的90例支原体肺炎患儿作为观察组,其...目的探讨儿童支原体肺炎患儿降钙素原(PCT)、C反应蛋白(CRP)、T淋巴细胞亚群、免疫球蛋白的变化及临床意义,为患者的临床诊疗提供参考。方法选取2017年2月至2018年2月在西安交通大学附属红会医院就诊的90例支原体肺炎患儿作为观察组,其中大叶性肺炎40例,支气管肺炎50例;选择同期健康体检者90例作为对照组。测定并比较观察组和对照组以及观察组中大叶性肺炎与支气管肺炎患儿间的T淋巴细胞、免疫球蛋白A (IgA)、免疫球蛋白G (IgG)、免疫球蛋白M (IgM)、PCT、CRP水平。结果观察组和对照组受检者的CD4^+[(34.12±4.02)%vs (42.23±3.45)%]和CD8^+[(21.78±2.25)%vs (32.12±2.28)%]水平比较,观察组明显低于对照组,而CD4^+/CD8^+[(3.27±0.42) vs (1.82±0.39)]比较,观察组明显高于对照组,差异均有统计学意义(P<0.05);观察组和对照组受检者的IgA [(1.12±0.21) g/L vs (1.69±0.32) g/L]比较,观察组明显低于对照组;IgG [(14.78±2.45) g/L vs (10.21±1.21) g/L]、IgM [(2.45±0.37) g/L vs (1.62±0.29) g/L]比较,观察组明显高于对照组,差异均有统计学意义(P<0.05);观察组和对照组受检者的PCT [(0.56±0.12) ng/m L vs (0.23±0.06) ng/m L]和CRP [(25.12±5.11)μg/m L vs (6.12±1.26)μg/m L]水平比较,观察组明显高于对照组,差异均有统计学意义(P<0.05);大叶性肺炎患儿CD8^+、IgG、IgM、PCT、CRP的表达水平均明显高于支气管肺炎患儿,而CD4^+、CD4^+/CD8^+、IgA明显低于支气管肺炎患儿,差异均有统计学意义(P<0.05)。结论 T淋巴细胞亚群、免疫功能、PCT及CRP表达水平可准确了解患儿病情动态变化,在支原体肺炎患儿疾病的诊断、鉴别中有重要意义。展开更多
文摘The objective of this multicentric study was to assess the prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma génitalium and Trichomonas vaginalis infections in Brazzaville, in the Republic of Congo, using molecular methods. From January to December 2021, the sexually transmitted disease risk participants were recruited from six centers: The Association of Young HIV-Positive People of Congo, The Congolese Association for Family Welfare, The Association for Support to Vulnerable Groups, Talangaï hospital, Brazzaville university hospital (outpatient service) and the private clinic COGEMO (outpatient service). The real-time multiplex PCR was carried out to detect these pathogens. Each patient had at least one specimen (urine, urethral, anal and/or vaginal samples). The patients were considered infected when one of their samples was positive. 287 participants made of 227 women and 60 men were tested. The general prevalence of these infections was: Chlamydia trachomatis 2.79%, Neisseria gonorrhoeae 3.14%, Mycoplasma génitalium 3.45% and Trichomonas vaginalis 2.97. The prevalence rates according to sex were: C. trachomatis, M. génitalium, N. gonorrhea and T. vaginalis were 1.32%, 2.05%, 1.32% and 3.42% in women and 8.33%, 7.02%, 10% and 1.75% in men, respectively. Most infected patients were asymptomatic. Prevalence rates were higher in bisexual individuals, with the exception of T. vaginalis which showed higher prevalence in heterosexual patients. The bisexual and homosexual individuals represent a major public health problem in sexually active young adults, particularly among men having sex with men. These sexually transmitted infections are mainly asymptomatic, their diagnosis and management remain difficult in developing countries.
文摘目的探讨儿童支原体肺炎患儿降钙素原(PCT)、C反应蛋白(CRP)、T淋巴细胞亚群、免疫球蛋白的变化及临床意义,为患者的临床诊疗提供参考。方法选取2017年2月至2018年2月在西安交通大学附属红会医院就诊的90例支原体肺炎患儿作为观察组,其中大叶性肺炎40例,支气管肺炎50例;选择同期健康体检者90例作为对照组。测定并比较观察组和对照组以及观察组中大叶性肺炎与支气管肺炎患儿间的T淋巴细胞、免疫球蛋白A (IgA)、免疫球蛋白G (IgG)、免疫球蛋白M (IgM)、PCT、CRP水平。结果观察组和对照组受检者的CD4^+[(34.12±4.02)%vs (42.23±3.45)%]和CD8^+[(21.78±2.25)%vs (32.12±2.28)%]水平比较,观察组明显低于对照组,而CD4^+/CD8^+[(3.27±0.42) vs (1.82±0.39)]比较,观察组明显高于对照组,差异均有统计学意义(P<0.05);观察组和对照组受检者的IgA [(1.12±0.21) g/L vs (1.69±0.32) g/L]比较,观察组明显低于对照组;IgG [(14.78±2.45) g/L vs (10.21±1.21) g/L]、IgM [(2.45±0.37) g/L vs (1.62±0.29) g/L]比较,观察组明显高于对照组,差异均有统计学意义(P<0.05);观察组和对照组受检者的PCT [(0.56±0.12) ng/m L vs (0.23±0.06) ng/m L]和CRP [(25.12±5.11)μg/m L vs (6.12±1.26)μg/m L]水平比较,观察组明显高于对照组,差异均有统计学意义(P<0.05);大叶性肺炎患儿CD8^+、IgG、IgM、PCT、CRP的表达水平均明显高于支气管肺炎患儿,而CD4^+、CD4^+/CD8^+、IgA明显低于支气管肺炎患儿,差异均有统计学意义(P<0.05)。结论 T淋巴细胞亚群、免疫功能、PCT及CRP表达水平可准确了解患儿病情动态变化,在支原体肺炎患儿疾病的诊断、鉴别中有重要意义。
