Fetal rat models with neural tube defects were established by injection with retinoic acid at 10 days after conception. The immunofluorescence assay and western blot analysis showed that the number of caspase-3 positi...Fetal rat models with neural tube defects were established by injection with retinoic acid at 10 days after conception. The immunofluorescence assay and western blot analysis showed that the number of caspase-3 positive cells in myeloid tissues for spina bifida manifesta was increased. There was also increased phosphorylation of c-Jun N-terminal kinase, a member of the mitogen activated protein kinase family. The c-Jun N-terminal kinase phosphorylation level was positively correlated with caspase-3 expression in myeloid tissues for spina bifida manifesta. Experimental findings indicate that abnormal apoptosis is involved in retinoic acid-induced dominant spina bifida formation in fetal rats, and may be associated with the c-Jun N-terminal kinase signal transduction pathway.展开更多
Adrenal myelolipoma is a benign, non-secreting tumor composed of adipose and myeloid tissue that can be complicated by retroperitoneal pain or hemorrhage. Its diagnosis is carried by the computed tomography (CT) and c...Adrenal myelolipoma is a benign, non-secreting tumor composed of adipose and myeloid tissue that can be complicated by retroperitoneal pain or hemorrhage. Its diagnosis is carried by the computed tomography (CT) and confirmed histologically. Surgery may be necessary in case of large volume, symptomatic mass or complication. We report the case of a 36-year-old patient who has a combination of myelolipoma and hereditary spherocytosis, which is extremely rare in the world literature. Computed tomography guided the diagnosis and surgical excision was performed because of the volume of the mass and its symptomatic nature. The evolution at two years was without recurrences.展开更多
基金supported by the National Natural Science Foundation of China, No.30872705/HD426 and No.81070538/HD429
文摘Fetal rat models with neural tube defects were established by injection with retinoic acid at 10 days after conception. The immunofluorescence assay and western blot analysis showed that the number of caspase-3 positive cells in myeloid tissues for spina bifida manifesta was increased. There was also increased phosphorylation of c-Jun N-terminal kinase, a member of the mitogen activated protein kinase family. The c-Jun N-terminal kinase phosphorylation level was positively correlated with caspase-3 expression in myeloid tissues for spina bifida manifesta. Experimental findings indicate that abnormal apoptosis is involved in retinoic acid-induced dominant spina bifida formation in fetal rats, and may be associated with the c-Jun N-terminal kinase signal transduction pathway.
文摘Adrenal myelolipoma is a benign, non-secreting tumor composed of adipose and myeloid tissue that can be complicated by retroperitoneal pain or hemorrhage. Its diagnosis is carried by the computed tomography (CT) and confirmed histologically. Surgery may be necessary in case of large volume, symptomatic mass or complication. We report the case of a 36-year-old patient who has a combination of myelolipoma and hereditary spherocytosis, which is extremely rare in the world literature. Computed tomography guided the diagnosis and surgical excision was performed because of the volume of the mass and its symptomatic nature. The evolution at two years was without recurrences.
