Background: Heart dysfunction and sudden death are common complications in post-myocardial infarction. Purpose: This study aims to contribute to improving patient’s management by determining the factor...Background: Heart dysfunction and sudden death are common complications in post-myocardial infarction. Purpose: This study aims to contribute to improving patient’s management by determining the factors correlated to the occurrence of left ventricular dysfunction or post-infarction sudden death. Method: It was a transversal, descriptive and analytical study conducted from January to October 2021. Results: The variables studied covered epidemiological, therapeutic and electrocardiographic aspects. There were 102 patients admitted for a recent revascularized myocardial infarction or not who had received a 24-hour ECG Holter after the acute phase of coronary event. The study population was predominantly men 88% versus 12% women with a sex ratio of 0.15. The discharge prescription was 74% antiarrhythmic, 91% platelet antiaggregator and 14% anticoagulant. Electrical abnormalities consisted of supraventricular extrasystoles in 45% of cases, ventricular extrasystoles in 61%, atrial fibrillation in 19% and supraventricular tachycardias in 11% (p Conclusion: The prognostic factors associated with the onset of post-infarction complications were ventricular arrhythmias (p .展开更多
Background G-protein–coupled receptor kinases (GRKs) play important roles in cardiac hypertrophy and heart failure. The role of GRK4 in hypertension has been well demonstrated, but little is known in cardiac ischemic...Background G-protein–coupled receptor kinases (GRKs) play important roles in cardiac hypertrophy and heart failure. The role of GRK4 in hypertension has been well demonstrated, but little is known in cardiac ischemic injury. In the present study, we explore if and how GRK4 regulates cardiomyocyte autophagy and influence the prognosis of myocardial infarction (MI).展开更多
Background:Bone marrow mesenchymal stem cell (MSC) transplantation is a promising strategy in the treatment of myocardial infarction (MI). However, the time for transplanting cells remains controversial. The aim of th...Background:Bone marrow mesenchymal stem cell (MSC) transplantation is a promising strategy in the treatment of myocardial infarction (MI). However, the time for transplanting cells remains controversial. The aim of this study was to find an optimal time point for cell transplantation. Methods: MSCs were isolated and cultured from Sprague-Dawley (SD) rats. MI model was set up in SD rats by permanent ligation of left anterior descending coronary artery. MSCs were directly injected into the infarct border zone at 1 h, 1 week and 2 weeks after MI, respectively. Sham-operated and MI control groups received equal volume of phosphate buffered saline (PBS). At 4 weeks after MI, cardiac function was assessed by echocardiography; vessel density was analyzed on hematoxylin-eosin stained slides by light microscopy; the apoptosis of cardiomyocytes was evaluated by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay; the expressions of proteins were analyzed by Western blot. Results: MSC transplantation improved cardiac function, reduced the apoptosis of cardiomyocytes and increased vessel density. These benefits were more obvious in 1-week group than in 1-h and 2-week groups. There are more obvious in-creases in the ratio of bcl-2/bax and the expression of vascular endothelial growth factor (VEGF) and more obvious decreases in the expression of cleaved-caspase-3 in 1-week group than those in other two groups. Conclusion: MSC transplantation was beneficial for the recovery of cardiac function. MSC transplantation at 1 week post-MI exerted the best effects on increases of cardiac function, anti-apoptosis and angiogenesis.展开更多
Objective:To identify factors related to quality of life in post myocardial infarction patients.Methods:The subjects were 150 post myocardial infarction patients who were receiving follow up care at Hajar Hospital.Sel...Objective:To identify factors related to quality of life in post myocardial infarction patients.Methods:The subjects were 150 post myocardial infarction patients who were receiving follow up care at Hajar Hospital.Self-administered questionnaires consisting of physical-and mental health-quality of life(QoL)during a 14-month follow-up were designed.A χ2 test was used to determine relationships between variables.Results:There was significant correlation between demographic variables such as insurance and retirees between the subjects tested.In addition,a significant relationship between the pain intensity,fatigue,reducing or losing job performance and QoL was found.Conclusion:The role of nurses to fulfill all social,psychotically and mental requirements of the patients with myocardial infarction is highly appreciated.展开更多
Objectives To investigate the effects of adrenergic receptor antagonist (metoprol- ol or prazosin) on myocardial α1-AR density and the changes of ventricular effective refractory period disper- sion (VERP-D) in rabbi...Objectives To investigate the effects of adrenergic receptor antagonist (metoprol- ol or prazosin) on myocardial α1-AR density and the changes of ventricular effective refractory period disper- sion (VERP-D) in rabbits after myocardial infarction. Methods twenty-four adult male New Zealand rab- bits were divided into four groups at random: control group ( n = 6 ) ; MI with placebo group ( n = 6 ) ; MI with metoprolol group ( n = 6) ; MI with prazosin group ( n = 6 ). The rabbits received corresponding drugs for seven days, beginning at the first day after MI with metoprolol 5 mg · kg-1 · d-1 or prazosin 0.5 mg · kg-1 · d-1. On the seventh day after MI, VERP-D and myocardial α1-AR density were measured and meanwhile, myocardial β-AR was also measured. Results In the placebo group, the density of ventricu- lar α1-AR was increased in comparison with control group (α1-AR in normal region 36. 9 ± 0. 2 vs 27. 3 ± 0. 9 fmol mg-1 pro-1 ,P <0.01; α1-AR in ischemic region 33.0±0.9 vs 26.6±0.4 fmol mg-1 pro-1 P<0.01).In the metoprolol group, it was also increased in compari- son with control group(α1-AR in normal region 44. 7 ± 1.5 vs 27.3 ±0.9 fmol mg-1 pro-1 ,P <0. 01; α1-AR in ischemic region 33. 6 ± 0. 5 vs 26. 6 ± 0. 4 fmol mg-1 pro-1 , P <0. 01 ). Meanwhile the density of ven- tricular α1-AR in normal region in the metoprolol group was increased in comparison with placebo group (44.7 ± 1.5 vs 36. 9 ±0.2 fmol mg-1 pro-1 ,P <0. 01). While it decreased in the prazosin group in comparison withcontrol group (α1 -AR in normal region 22. 5 ± 0 . 6 vs 27.3±0.9 fmol mg-1 pro-1,P<0.01; α1-AR in ische- mic region 20.9±0.4 vs 26.6 ±0.4 fmol mg-1 pro-1 , P <0.01). VERP-D was increased after MI(P <0.01). After treatment with metoprolol or prazosin, VERP-D was decreased ( P < 0. 01 ). Conclusions After a- cute MI, α1-AR of ventricular myocardium was upregu- lated, which may be accompanied by its activitation. The density of myocardial α1-AR became upregulated more dramatically treated with metoprolol and downreg- ulated with prazosin. When treated with metoprolol or prazosin, VERP-D decreased.展开更多
Myocardial infarction(MI)is a severe heart disease requiring immediate and accurate detection for effective treatment.Deep learning(DL)algorithms have recently shown promise in enhancing MI diagnostic accuracy from el...Myocardial infarction(MI)is a severe heart disease requiring immediate and accurate detection for effective treatment.Deep learning(DL)algorithms have recently shown promise in enhancing MI diagnostic accuracy from electrocardiography(ECG)and echocardiogram(ECHO).This review presents a comprehensive literature overview focusing on recent innovative research on DL algorithms in ECG and ECHO analysis for MI identification.We examined relevant studies employing DL models,analyzing datasets,model architectures,preprocessing approaches,and performance measures.The findings reveal that DL-based algorithms substantially improve MI detection in terms of accuracy,sensitivity,specificity,and overall diagnostic performance.This is crucial for quicker,more reliable diagnoses and reducing the risk of complications.DL-based ECG and ECHO analyses emerge as pivotal tools for early and efficient MI identification.This review contributes to understanding the latest DL advancements in ECG and ECHO analysis for MI diagnosis,offering important directions for future research.展开更多
Non-exosomal non-coding RNAs(non-exo-ncRNAs)and exosomal ncRNAs(exo-ncRNAs)have been associated with the pathological development of myocardial infarction(MI).Accordingly,this analytical review provides an overview of...Non-exosomal non-coding RNAs(non-exo-ncRNAs)and exosomal ncRNAs(exo-ncRNAs)have been associated with the pathological development of myocardial infarction(MI).Accordingly,this analytical review provides an overview of current MI studies on the role of plasma non-exo/exo-ncRNAs.We summarize the features and crucial roles of ncRNAs and reveal their novel biological correlations via bioinformatics analysis.The following contributions are made:(1)we comprehensively describe the expression profile,competing endogenous RNA(ceRNA)network,and“pre-necrotic”biomarkers of non-exo/exo-ncRNAs for MI;(2)functional enrichment analysis indicates that the target genes of ncRNAs are enriched in the regulation of apoptotic signaling pathway and cellular response to chemical stress,etc.;(3)we propose an updated and comprehensive view on the mechanisms,pathophysiology,and biomarker roles of non-exo/exo-ncRNAs in MI,thereby providing a theoretical basis for the clinical management of MI.展开更多
文摘Background: Heart dysfunction and sudden death are common complications in post-myocardial infarction. Purpose: This study aims to contribute to improving patient’s management by determining the factors correlated to the occurrence of left ventricular dysfunction or post-infarction sudden death. Method: It was a transversal, descriptive and analytical study conducted from January to October 2021. Results: The variables studied covered epidemiological, therapeutic and electrocardiographic aspects. There were 102 patients admitted for a recent revascularized myocardial infarction or not who had received a 24-hour ECG Holter after the acute phase of coronary event. The study population was predominantly men 88% versus 12% women with a sex ratio of 0.15. The discharge prescription was 74% antiarrhythmic, 91% platelet antiaggregator and 14% anticoagulant. Electrical abnormalities consisted of supraventricular extrasystoles in 45% of cases, ventricular extrasystoles in 61%, atrial fibrillation in 19% and supraventricular tachycardias in 11% (p Conclusion: The prognostic factors associated with the onset of post-infarction complications were ventricular arrhythmias (p .
文摘Background G-protein–coupled receptor kinases (GRKs) play important roles in cardiac hypertrophy and heart failure. The role of GRK4 in hypertension has been well demonstrated, but little is known in cardiac ischemic injury. In the present study, we explore if and how GRK4 regulates cardiomyocyte autophagy and influence the prognosis of myocardial infarction (MI).
基金Project (No. 2004QN018) supported by the Health Bureau of Zhejiang Province, China
文摘Background:Bone marrow mesenchymal stem cell (MSC) transplantation is a promising strategy in the treatment of myocardial infarction (MI). However, the time for transplanting cells remains controversial. The aim of this study was to find an optimal time point for cell transplantation. Methods: MSCs were isolated and cultured from Sprague-Dawley (SD) rats. MI model was set up in SD rats by permanent ligation of left anterior descending coronary artery. MSCs were directly injected into the infarct border zone at 1 h, 1 week and 2 weeks after MI, respectively. Sham-operated and MI control groups received equal volume of phosphate buffered saline (PBS). At 4 weeks after MI, cardiac function was assessed by echocardiography; vessel density was analyzed on hematoxylin-eosin stained slides by light microscopy; the apoptosis of cardiomyocytes was evaluated by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay; the expressions of proteins were analyzed by Western blot. Results: MSC transplantation improved cardiac function, reduced the apoptosis of cardiomyocytes and increased vessel density. These benefits were more obvious in 1-week group than in 1-h and 2-week groups. There are more obvious in-creases in the ratio of bcl-2/bax and the expression of vascular endothelial growth factor (VEGF) and more obvious decreases in the expression of cleaved-caspase-3 in 1-week group than those in other two groups. Conclusion: MSC transplantation was beneficial for the recovery of cardiac function. MSC transplantation at 1 week post-MI exerted the best effects on increases of cardiac function, anti-apoptosis and angiogenesis.
文摘Objective:To identify factors related to quality of life in post myocardial infarction patients.Methods:The subjects were 150 post myocardial infarction patients who were receiving follow up care at Hajar Hospital.Self-administered questionnaires consisting of physical-and mental health-quality of life(QoL)during a 14-month follow-up were designed.A χ2 test was used to determine relationships between variables.Results:There was significant correlation between demographic variables such as insurance and retirees between the subjects tested.In addition,a significant relationship between the pain intensity,fatigue,reducing or losing job performance and QoL was found.Conclusion:The role of nurses to fulfill all social,psychotically and mental requirements of the patients with myocardial infarction is highly appreciated.
文摘Objectives To investigate the effects of adrenergic receptor antagonist (metoprol- ol or prazosin) on myocardial α1-AR density and the changes of ventricular effective refractory period disper- sion (VERP-D) in rabbits after myocardial infarction. Methods twenty-four adult male New Zealand rab- bits were divided into four groups at random: control group ( n = 6 ) ; MI with placebo group ( n = 6 ) ; MI with metoprolol group ( n = 6) ; MI with prazosin group ( n = 6 ). The rabbits received corresponding drugs for seven days, beginning at the first day after MI with metoprolol 5 mg · kg-1 · d-1 or prazosin 0.5 mg · kg-1 · d-1. On the seventh day after MI, VERP-D and myocardial α1-AR density were measured and meanwhile, myocardial β-AR was also measured. Results In the placebo group, the density of ventricu- lar α1-AR was increased in comparison with control group (α1-AR in normal region 36. 9 ± 0. 2 vs 27. 3 ± 0. 9 fmol mg-1 pro-1 ,P <0.01; α1-AR in ischemic region 33.0±0.9 vs 26.6±0.4 fmol mg-1 pro-1 P<0.01).In the metoprolol group, it was also increased in compari- son with control group(α1-AR in normal region 44. 7 ± 1.5 vs 27.3 ±0.9 fmol mg-1 pro-1 ,P <0. 01; α1-AR in ischemic region 33. 6 ± 0. 5 vs 26. 6 ± 0. 4 fmol mg-1 pro-1 , P <0. 01 ). Meanwhile the density of ven- tricular α1-AR in normal region in the metoprolol group was increased in comparison with placebo group (44.7 ± 1.5 vs 36. 9 ±0.2 fmol mg-1 pro-1 ,P <0. 01). While it decreased in the prazosin group in comparison withcontrol group (α1 -AR in normal region 22. 5 ± 0 . 6 vs 27.3±0.9 fmol mg-1 pro-1,P<0.01; α1-AR in ische- mic region 20.9±0.4 vs 26.6 ±0.4 fmol mg-1 pro-1 , P <0.01). VERP-D was increased after MI(P <0.01). After treatment with metoprolol or prazosin, VERP-D was decreased ( P < 0. 01 ). Conclusions After a- cute MI, α1-AR of ventricular myocardium was upregu- lated, which may be accompanied by its activitation. The density of myocardial α1-AR became upregulated more dramatically treated with metoprolol and downreg- ulated with prazosin. When treated with metoprolol or prazosin, VERP-D decreased.
文摘Myocardial infarction(MI)is a severe heart disease requiring immediate and accurate detection for effective treatment.Deep learning(DL)algorithms have recently shown promise in enhancing MI diagnostic accuracy from electrocardiography(ECG)and echocardiogram(ECHO).This review presents a comprehensive literature overview focusing on recent innovative research on DL algorithms in ECG and ECHO analysis for MI identification.We examined relevant studies employing DL models,analyzing datasets,model architectures,preprocessing approaches,and performance measures.The findings reveal that DL-based algorithms substantially improve MI detection in terms of accuracy,sensitivity,specificity,and overall diagnostic performance.This is crucial for quicker,more reliable diagnoses and reducing the risk of complications.DL-based ECG and ECHO analyses emerge as pivotal tools for early and efficient MI identification.This review contributes to understanding the latest DL advancements in ECG and ECHO analysis for MI diagnosis,offering important directions for future research.
基金National Natural Science Foundation of China(Nos.81860073,81760074,and 82160439)Yunnan Provincial Department of Science and Technology(No.202001AT070039)+10 种基金the Yunnan Health Training Project of High-Level Talents(No.H-2018032)the 100 Young and Middle-aged Academic and Technical Backbones of Kunming Medical University(No.60118260106)the Young Talents of Yunnan Thousand Talents Plan(Nos.YNQR-QNRC-2019-006 and RLQN20200002)the Graduate Student Innovation Fund of Kunming Medical University(No.2022S035)the National Natural Science Foundation of China(Nos.81860073,81760074,and 82160439)Yunnan Provincial Department of Science and Technology(No.202001AT070039)Yunnan Health Training Project of High-Level Talents(No.H-2018032)100 Young and Middle-aged Academic and Technical Backbones of Kunming Medical University(No.60118260106)Young Talents of Yunnan Thousand Talents Plan(Nos.YNQR-QNRC-2019-006 and RLQN20200002)Graduate Student Innovation Fund of Kunming Medical University(No.2022S035)Clinical Medical Center for Cardiovascular and Cerebrovascular Disease of Yunnan Province(No.ZX2019-03-01),China.
文摘Non-exosomal non-coding RNAs(non-exo-ncRNAs)and exosomal ncRNAs(exo-ncRNAs)have been associated with the pathological development of myocardial infarction(MI).Accordingly,this analytical review provides an overview of current MI studies on the role of plasma non-exo/exo-ncRNAs.We summarize the features and crucial roles of ncRNAs and reveal their novel biological correlations via bioinformatics analysis.The following contributions are made:(1)we comprehensively describe the expression profile,competing endogenous RNA(ceRNA)network,and“pre-necrotic”biomarkers of non-exo/exo-ncRNAs for MI;(2)functional enrichment analysis indicates that the target genes of ncRNAs are enriched in the regulation of apoptotic signaling pathway and cellular response to chemical stress,etc.;(3)we propose an updated and comprehensive view on the mechanisms,pathophysiology,and biomarker roles of non-exo/exo-ncRNAs in MI,thereby providing a theoretical basis for the clinical management of MI.
