An experimental animal model of malignant soft-tissue tumor was established to investigate the applied value of multi-slice spiral CT perfusion imaging preliminarily. Ten New Zealand white rabbits which were implanted...An experimental animal model of malignant soft-tissue tumor was established to investigate the applied value of multi-slice spiral CT perfusion imaging preliminarily. Ten New Zealand white rabbits which were implanted with VX2 tumor in either proximal thigh were subjected to CT plain scan and perfusion scan two weeks later respectively, then the original perfusion images were transmitted to AW4.0 Workstation. The functional maps and perfusion parameters including blood flow （BF）, blood volume （BV）, mean transit time （MTT） and permeability surface （PS） were computed and analyzed. All the values of BF, BV and PS in VX2 soft-tissue tumors were obviously higher while the MTT-values were lower than those in the normal muscular tissues significantly. It was suggested that multi-slice spiral CT perfusion imaging is an accurate, convenient and relatively safe functional imaging technique, and can give a quantitative assessment to angiogenesis and blood perfusion of soft-tissue tumors.展开更多
目的用13N－NH3 PET门控心肌灌注显像（GMPI）评价局部心肌血流灌注及整体和局部心功能参数在监测放射性心脏损伤（RIHD）动态变化方面的价值。方法取6只雄性Beagle犬于照射前1周及照射（单次20 Gy）后3、6、12个月分别行13N－NH3 PET G...目的用13N－NH3 PET门控心肌灌注显像（GMPI）评价局部心肌血流灌注及整体和局部心功能参数在监测放射性心脏损伤（RIHD）动态变化方面的价值。方法取6只雄性Beagle犬于照射前1周及照射（单次20 Gy）后3、6、12个月分别行13N－NH3 PET GMPI。比较照射前后整体心功能参数[左心室射血分数（LVEF）、舒张末期容积（EDV）、收缩末期容积（ESV）]和局部心功能参数[室壁运动、室壁增厚、舒张末期心肌灌注（EDP）、收缩末期心肌灌注（ESP）]的差异。采用重复测量方差分析和配对t检验处理数据。结果与照射前相比，EDV和ESV、LVEF在照射后3个月未见明显变化；照射后6个月ESV增大，LVEF减小，EDV未见明显变化；照射后12个月ESV进一步扩大，LVEF进一步减小，EDV开始增大（F值：20.974～177.846，均P〈0.05）。与照射前相比，部分心肌节段室壁运动（10%，2/20）、室壁增厚（20%，4/20）、EDP（10%，2/20）及ESP（15%，3/20）在照射后3个月即出现变化且表现为功能增强（t值：14.446～672.315，均P〈0.05）；照射后6个月室壁运动（15%，3/20）、室壁增厚（20%，4/20）、EDP（15%，3/20）及ESP（25%，5/20）出现下降（t值：18.171～723.156，均P〈0.05）；照射后12个月室壁运动（35%，7/20）、室壁增厚（45%，9/20）、EDP（40%，8/20）及ESP（60%，12/20）下降更为明显（t值：14.783～711.259，均P〈0.05）。结论13N－NH3 PET GMPI可用于早期发现RIHD并监测RIHD的动态发展。与整体心功能参数相比，局部心功能参数（室壁运动、室壁增厚、EDP及ESP）更加灵敏，或可作为RIHD的早期监测指标。展开更多
文摘An experimental animal model of malignant soft-tissue tumor was established to investigate the applied value of multi-slice spiral CT perfusion imaging preliminarily. Ten New Zealand white rabbits which were implanted with VX2 tumor in either proximal thigh were subjected to CT plain scan and perfusion scan two weeks later respectively, then the original perfusion images were transmitted to AW4.0 Workstation. The functional maps and perfusion parameters including blood flow （BF）, blood volume （BV）, mean transit time （MTT） and permeability surface （PS） were computed and analyzed. All the values of BF, BV and PS in VX2 soft-tissue tumors were obviously higher while the MTT-values were lower than those in the normal muscular tissues significantly. It was suggested that multi-slice spiral CT perfusion imaging is an accurate, convenient and relatively safe functional imaging technique, and can give a quantitative assessment to angiogenesis and blood perfusion of soft-tissue tumors.
文摘目的用13N－NH3 PET门控心肌灌注显像（GMPI）评价局部心肌血流灌注及整体和局部心功能参数在监测放射性心脏损伤（RIHD）动态变化方面的价值。方法取6只雄性Beagle犬于照射前1周及照射（单次20 Gy）后3、6、12个月分别行13N－NH3 PET GMPI。比较照射前后整体心功能参数[左心室射血分数（LVEF）、舒张末期容积（EDV）、收缩末期容积（ESV）]和局部心功能参数[室壁运动、室壁增厚、舒张末期心肌灌注（EDP）、收缩末期心肌灌注（ESP）]的差异。采用重复测量方差分析和配对t检验处理数据。结果与照射前相比，EDV和ESV、LVEF在照射后3个月未见明显变化；照射后6个月ESV增大，LVEF减小，EDV未见明显变化；照射后12个月ESV进一步扩大，LVEF进一步减小，EDV开始增大（F值：20.974～177.846，均P〈0.05）。与照射前相比，部分心肌节段室壁运动（10%，2/20）、室壁增厚（20%，4/20）、EDP（10%，2/20）及ESP（15%，3/20）在照射后3个月即出现变化且表现为功能增强（t值：14.446～672.315，均P〈0.05）；照射后6个月室壁运动（15%，3/20）、室壁增厚（20%，4/20）、EDP（15%，3/20）及ESP（25%，5/20）出现下降（t值：18.171～723.156，均P〈0.05）；照射后12个月室壁运动（35%，7/20）、室壁增厚（45%，9/20）、EDP（40%，8/20）及ESP（60%，12/20）下降更为明显（t值：14.783～711.259，均P〈0.05）。结论13N－NH3 PET GMPI可用于早期发现RIHD并监测RIHD的动态发展。与整体心功能参数相比，局部心功能参数（室壁运动、室壁增厚、EDP及ESP）更加灵敏，或可作为RIHD的早期监测指标。
