Myoepithelioma/myoepithelial carcinomas are not commonly found in soft tissues and are especially rare at visceral sites.This report describes a case of a rare low-grade myoepithelial carcinoma of the stomach.A61-year...Myoepithelioma/myoepithelial carcinomas are not commonly found in soft tissues and are especially rare at visceral sites.This report describes a case of a rare low-grade myoepithelial carcinoma of the stomach.A61-year-old female patient presented with postprandial abdominal discomfort.Endoscopy revealed a 1.1 cm submucosal lesion.Local excision was performed after malignancy was confirmed by biopsy.The resection margin is free of tumor and she received no adjuvant therapy.The tumor was characterized by multinodular growth with biphasic epithelioid and spindle components.Infiltrative margin and nuclear pleomorphism are seen.Tumor cells were positive for both epithelial and myoepithelial markers.Evidence of epithelial differentiation was confirmed by electron microscopy.No EWSR1 rearrangement was detected.The final diagnosis was low-grade myoepithelial gastric carcinoma.The patient is currently well, and no evidence of recurrence or metastasis was found after ten-month of follow-up.Myoepithelial carcinoma should be considered in the differential diagnosis of a biphasic gastric tumor.展开更多
BACKGROUND Myoepithelial carcinoma(MC)is a rare malignant neoplasm that mainly occurs in the salivary gland.MC can be confused with many other tumors when arising outside the salivary glands because it presents with a...BACKGROUND Myoepithelial carcinoma(MC)is a rare malignant neoplasm that mainly occurs in the salivary gland.MC can be confused with many other tumors when arising outside the salivary glands because it presents with a wide spectrum of cytomorphological and immunohistochemical features.To the best of our knowledge,esophageal MC has not been previously reported.The purpose of this study was to describe the imaging and clinicopathological features of esophageal MC to improve the understanding of the disease.CASE SUMMARY Three men and one woman diagnosed with esophageal MC were enrolled in this study.The primary clinical symptom was dysphagia.The mass was mainly located in the middle esophagus.Laboratory tests revealed that two patients who underwent tumor abnormal protein were positive.Radical resection was performed for all patients with no adjuvant therapy.Hematoxylin-eosin staining showed infiltrative growth of epithelial cells with hyperchromatic and pleomorphic nuclei toward the periphery.Immunohistochemistry showed that all patients were positive for P63,and most patients were positive for SOX-10,AE1/AE3,P40,and calponin.The Ki-67 values were all higher than 60%.Patient one died one month after discharge from an unknown cause.Patient two lost to follow-up.At patient three’s four-month review,enhanced computed tomography(CT)showed anastomosis recurrence and bilateral lung metastases.He abandoned treatment and lost to follow-up.Patient four attended review appointments regularly and remained in a good general condition.CONCLUSION Here,we present the first report of esophageal MC and review the relevant literature.Esophageal MC is more likely to occur in the middle esophagus in older patients with male dominance.A fungating type observed on CT scanning may help narrow down the differential diagnosis.Cystic change or necrosis may occur in larger lesions.The final diagnosis should be made according to the pathological examination.The treatment for MC is surgical resection,and the efficacy of chemotherapy needs to be determined with future studies.展开更多
BACKGROUND Myoepithelial carcinoma(MC)is a clinically rare malignancy,there is controversy regarding its etiology and its biological behavior is not fully elucidated.Extensive surgical resection is the main treatment ...BACKGROUND Myoepithelial carcinoma(MC)is a clinically rare malignancy,there is controversy regarding its etiology and its biological behavior is not fully elucidated.Extensive surgical resection is the main treatment method.We describe a case of pleomorphic adenoma(PA)with multiple postoperative recurrences after malignant transformation,and the history of the disease in this patient was more than 20 years.Complete resection during the first surgery of PA and long-term postoperative follow-up is necessary.CASE SUMMARY A 34-year-old male with PA and a history of 5 postoperative recurrences over 21 years,each surgically removed,presented 15 d ago with headache,nasal congestion,protrusion of the right eyeball and loss of vision in the right eye,with progressively worsening symptoms.The patient underwent surgery,and MC was confirmed by pathology examination.A small PA component was locally visible under light microscope.The patient had a recurrence of the tumor 2 mo after surgery and underwent surgical resection.CONCLUSION During the first operation for PA,care should be taken not to rupture the envelope to prevent tumor cell implantation,and when complete resection is not possible due to the anatomical site,postoperative radiotherapy is necessary to control the lesion and prevent infiltration and malignant transformation of the tumor to MC.Computed tomography and magnetic resonance imaging is important for establishing diagnosis and developing a treatment plan.展开更多
Objective: Objective of this study is to highlight the importance of considering clinical and radiological findings in parotid tumors before operating tumors with high suspicion of malignancy though reported as benign...Objective: Objective of this study is to highlight the importance of considering clinical and radiological findings in parotid tumors before operating tumors with high suspicion of malignancy though reported as benign on histopathology. Material and Methods: 20 years old female patient underwent radical parotidectomy for epithelial-myoepithelial carcinoma of the left parotid gland which was diagnosed on FNAC. Contrast CT and contrast MRI also showed a tumor involving left parotid gland with destruction of ramus of mandible and loss of tissue planes medially & laterally. Facial nerve was infiltrated by tumor, thus sacrificed. Post operatively, patient had left facial palsy and was discharged after 7 days without any other sequelae. Postoperative histopathology showed pleomorphic adenoma with positive resection margins medially, superiorly & posteriorly. No further treatment was given in view of the benign nature of the tumor. Results: Patient was kept on monthly follow up and was disease free at one year follow up. Conclusion: Aggressive surgical treatment should be planned for malignant parotid tumors to give a better tumor free survival. Misdiagnosis can occur on FNAC as it can hit only one part of the tumor thus missing a malignant tumor or can interpret pleomorphic adenoma as epithelial-myoepithelial carcinoma.展开更多
Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm with unknown malignant potential that has been described in most organ systems. We herein present a case of a young female who presented with macroscopic hem...Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm with unknown malignant potential that has been described in most organ systems. We herein present a case of a young female who presented with macroscopic hematuria. An IMT of the urinary bladder which was not suspected after clinical, radiological and surgical work-up was diagnosed microscopically and confirmed by immunohistochemistry. A close clinical follow-up is recommended because of the unknown biological behavior of this tumor. A brief review of literature is also presented here.展开更多
文摘Myoepithelioma/myoepithelial carcinomas are not commonly found in soft tissues and are especially rare at visceral sites.This report describes a case of a rare low-grade myoepithelial carcinoma of the stomach.A61-year-old female patient presented with postprandial abdominal discomfort.Endoscopy revealed a 1.1 cm submucosal lesion.Local excision was performed after malignancy was confirmed by biopsy.The resection margin is free of tumor and she received no adjuvant therapy.The tumor was characterized by multinodular growth with biphasic epithelioid and spindle components.Infiltrative margin and nuclear pleomorphism are seen.Tumor cells were positive for both epithelial and myoepithelial markers.Evidence of epithelial differentiation was confirmed by electron microscopy.No EWSR1 rearrangement was detected.The final diagnosis was low-grade myoepithelial gastric carcinoma.The patient is currently well, and no evidence of recurrence or metastasis was found after ten-month of follow-up.Myoepithelial carcinoma should be considered in the differential diagnosis of a biphasic gastric tumor.
文摘BACKGROUND Myoepithelial carcinoma(MC)is a rare malignant neoplasm that mainly occurs in the salivary gland.MC can be confused with many other tumors when arising outside the salivary glands because it presents with a wide spectrum of cytomorphological and immunohistochemical features.To the best of our knowledge,esophageal MC has not been previously reported.The purpose of this study was to describe the imaging and clinicopathological features of esophageal MC to improve the understanding of the disease.CASE SUMMARY Three men and one woman diagnosed with esophageal MC were enrolled in this study.The primary clinical symptom was dysphagia.The mass was mainly located in the middle esophagus.Laboratory tests revealed that two patients who underwent tumor abnormal protein were positive.Radical resection was performed for all patients with no adjuvant therapy.Hematoxylin-eosin staining showed infiltrative growth of epithelial cells with hyperchromatic and pleomorphic nuclei toward the periphery.Immunohistochemistry showed that all patients were positive for P63,and most patients were positive for SOX-10,AE1/AE3,P40,and calponin.The Ki-67 values were all higher than 60%.Patient one died one month after discharge from an unknown cause.Patient two lost to follow-up.At patient three’s four-month review,enhanced computed tomography(CT)showed anastomosis recurrence and bilateral lung metastases.He abandoned treatment and lost to follow-up.Patient four attended review appointments regularly and remained in a good general condition.CONCLUSION Here,we present the first report of esophageal MC and review the relevant literature.Esophageal MC is more likely to occur in the middle esophagus in older patients with male dominance.A fungating type observed on CT scanning may help narrow down the differential diagnosis.Cystic change or necrosis may occur in larger lesions.The final diagnosis should be made according to the pathological examination.The treatment for MC is surgical resection,and the efficacy of chemotherapy needs to be determined with future studies.
文摘BACKGROUND Myoepithelial carcinoma(MC)is a clinically rare malignancy,there is controversy regarding its etiology and its biological behavior is not fully elucidated.Extensive surgical resection is the main treatment method.We describe a case of pleomorphic adenoma(PA)with multiple postoperative recurrences after malignant transformation,and the history of the disease in this patient was more than 20 years.Complete resection during the first surgery of PA and long-term postoperative follow-up is necessary.CASE SUMMARY A 34-year-old male with PA and a history of 5 postoperative recurrences over 21 years,each surgically removed,presented 15 d ago with headache,nasal congestion,protrusion of the right eyeball and loss of vision in the right eye,with progressively worsening symptoms.The patient underwent surgery,and MC was confirmed by pathology examination.A small PA component was locally visible under light microscope.The patient had a recurrence of the tumor 2 mo after surgery and underwent surgical resection.CONCLUSION During the first operation for PA,care should be taken not to rupture the envelope to prevent tumor cell implantation,and when complete resection is not possible due to the anatomical site,postoperative radiotherapy is necessary to control the lesion and prevent infiltration and malignant transformation of the tumor to MC.Computed tomography and magnetic resonance imaging is important for establishing diagnosis and developing a treatment plan.
文摘Objective: Objective of this study is to highlight the importance of considering clinical and radiological findings in parotid tumors before operating tumors with high suspicion of malignancy though reported as benign on histopathology. Material and Methods: 20 years old female patient underwent radical parotidectomy for epithelial-myoepithelial carcinoma of the left parotid gland which was diagnosed on FNAC. Contrast CT and contrast MRI also showed a tumor involving left parotid gland with destruction of ramus of mandible and loss of tissue planes medially & laterally. Facial nerve was infiltrated by tumor, thus sacrificed. Post operatively, patient had left facial palsy and was discharged after 7 days without any other sequelae. Postoperative histopathology showed pleomorphic adenoma with positive resection margins medially, superiorly & posteriorly. No further treatment was given in view of the benign nature of the tumor. Results: Patient was kept on monthly follow up and was disease free at one year follow up. Conclusion: Aggressive surgical treatment should be planned for malignant parotid tumors to give a better tumor free survival. Misdiagnosis can occur on FNAC as it can hit only one part of the tumor thus missing a malignant tumor or can interpret pleomorphic adenoma as epithelial-myoepithelial carcinoma.
文摘Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm with unknown malignant potential that has been described in most organ systems. We herein present a case of a young female who presented with macroscopic hematuria. An IMT of the urinary bladder which was not suspected after clinical, radiological and surgical work-up was diagnosed microscopically and confirmed by immunohistochemistry. A close clinical follow-up is recommended because of the unknown biological behavior of this tumor. A brief review of literature is also presented here.
