Congenital myopathies are a group of minimally progressive or non-progressive neuromuscular conditions which is present from birth. A classical type of congenital myopathy is called central core disease. This conditio...Congenital myopathies are a group of minimally progressive or non-progressive neuromuscular conditions which is present from birth. A classical type of congenital myopathy is called central core disease. This condition is often confused with muscular dystrophy. Central core disease can be associated with comorbidities which affect pregnancy and its management. In this case series, we describe two cases, who are siblings affected by the same condition but at varied levels and their management during pregnancy. We also would like to illustrate a management plan for congenital myopathy during pregnancy, for a good maternal and fetal outcome.展开更多
Phenazine-based non-fullerene acceptors(NFAs)have demonstrated great potential in improving the power conversion efficiency(PCE)of organic solar cells(OSCs).Halogenation is known to be an effective strategy for increa...Phenazine-based non-fullerene acceptors(NFAs)have demonstrated great potential in improving the power conversion efficiency(PCE)of organic solar cells(OSCs).Halogenation is known to be an effective strategy for increasing optical absorption,refining energy levels,and improving molecular packing in organic semiconductors.Herein,a series of NFAs(Pz IC-4H,Pz IC-4F,Pz IC-4Cl,Pz IC-2Br)with phenazine as the central core and with/without halogen-substituted(dicyanomethylidene)-indan-1-one(IC)as the electron-accepting end group were synthesized,and the effect of end group matched phenazine central unit on the photovoltaic performance was systematically studied.Synergetic photophysical and morphological analyses revealed that the PM6:Pz IC-4F blend involves efficient exciton dissociation,higher charge collection and transfer rates,better crystallinity,and optimal phase separation.Therefore,OSCs based on PM6:Pz IC-4F as the active layer exhibited a PCE of 16.48%with an open circuit voltage(Voc)and energy loss of 0.880 V and 0.53 e V,respectively.Accordingly,this work demonstrated a promising approach by designing phenazine-based NFAs for achieving high-performance OSCs.展开更多
Holoceneδ^18O records from various archives(ice cores,cave stalagmites,and peat sediments)from the Xinjiang region of northwestern China,in arid central Asia(ACA),are all derived ultimately from local precipitationδ...Holoceneδ^18O records from various archives(ice cores,cave stalagmites,and peat sediments)from the Xinjiang region of northwestern China,in arid central Asia(ACA),are all derived ultimately from local precipitationδ^18O(δ^18Op).Nevertheless,they have been proposed as indicators of different climatic parameters,such as wetness and temperature changes.This article summarizes previously reported records of moisture sources for the Xinjiang region and the results of modern observations conducted at an ice core site and a peat site in the Altai Mountains.The findings are used to propose that the overall positive trends in Holoceneδ^18O records from the various archives from the Xinjiang region primarily reflect the Holocene's long-term warming trend.It is concluded that more site-specific modern observations are needed to further elucidate the environmental significance of Holoceneδ^18O records from this region,especially for the separation of different seasonal temperature signals present withinδ^18O records.展开更多
The Kathmandu valley is an intermountain basin located at about 1300 and surounded by mountains around 2400m.Thick fluvio\|lacustrine sediments from late Pliocene to Quaternary are accumulated there under monsoon clim...The Kathmandu valley is an intermountain basin located at about 1300 and surounded by mountains around 2400m.Thick fluvio\|lacustrine sediments from late Pliocene to Quaternary are accumulated there under monsoon climate.We undertook palynological and sedimentological studies on 284\|m\|long drilled core that reaches the basement of the kathmandu basin,in order to clarify the paleoclimatic changes and their tectonic link with uplifting of the Himalayas..The core is lithologically divided into three members:sand predominant lower member (51m),slit and clay dominant middle member (182m) and organic silty clay predominant upper member (45m).We analyzed fossil pollens contained in muddy samples which were taken from the middle and upper member in every one meter interval.The pollen assemblage is characterized by predominance of \%Quercus,\%30%～80% of the all arboreal pollen.We inferred paleoclimatic changes on the basis of comparison between present vegetation and climate of Kathmandu valley and surrounded mountains and pollen diagram which we obtained.For the purpose of inference of paleoclimate,we used the following genera as climatic index:\%Pinus\% for cold climate, \%Quercus\% and \%Cyclobalanopsis\% for warm climate, Alnus for wet climate and Gramineae for dry climate.As the reference.we also examined amount of another eight genera,two family and all spores.The pollen diagram shows two pattern of paleoclimatic changes:oscillation pattern with seven times fluctuation of warm and cold climate in younger period (ca.115m in depth),and older less fluctuated pattern of warm climate.During the older period (209～215m in depth),one cold stage was recognized,and is characterized by predominance of Pinus and occurrence of Tsuga .展开更多
The As-level topology is a hotspot of the recent reseaches. We can understand the centralization of the network clearly by researching the evolvement trend of the Internet macroscopic topology. The massive data we use...The As-level topology is a hotspot of the recent reseaches. We can understand the centralization of the network clearly by researching the evolvement trend of the Internet macroscopic topology. The massive data we use in this paper is from CAIDA (The Cooperative Association for Internet Data Analysis) Skitter project. And the time span of the data is from July, 2001 to January, 2008. This paper introduces the background of the AS-level topology at first, then carries out the evolvement of degree, core and layer. It is believed that the influence of the top-degree nodes on the other nodes decreases and the centralization of network is going to fall off with the decrease of the core. And the nucleus status of network declines.展开更多
文摘Congenital myopathies are a group of minimally progressive or non-progressive neuromuscular conditions which is present from birth. A classical type of congenital myopathy is called central core disease. This condition is often confused with muscular dystrophy. Central core disease can be associated with comorbidities which affect pregnancy and its management. In this case series, we describe two cases, who are siblings affected by the same condition but at varied levels and their management during pregnancy. We also would like to illustrate a management plan for congenital myopathy during pregnancy, for a good maternal and fetal outcome.
基金financially supported by the National Natural Science Foundation of China (22279152,U21A20331)the National Science Fund for Distinguished Young Scholars (21925506)+1 种基金the Ningbo key scientific and technological project (2022Z117)the Ningbo Natural Science Foundation (2021J192)。
文摘Phenazine-based non-fullerene acceptors(NFAs)have demonstrated great potential in improving the power conversion efficiency(PCE)of organic solar cells(OSCs).Halogenation is known to be an effective strategy for increasing optical absorption,refining energy levels,and improving molecular packing in organic semiconductors.Herein,a series of NFAs(Pz IC-4H,Pz IC-4F,Pz IC-4Cl,Pz IC-2Br)with phenazine as the central core and with/without halogen-substituted(dicyanomethylidene)-indan-1-one(IC)as the electron-accepting end group were synthesized,and the effect of end group matched phenazine central unit on the photovoltaic performance was systematically studied.Synergetic photophysical and morphological analyses revealed that the PM6:Pz IC-4F blend involves efficient exciton dissociation,higher charge collection and transfer rates,better crystallinity,and optimal phase separation.Therefore,OSCs based on PM6:Pz IC-4F as the active layer exhibited a PCE of 16.48%with an open circuit voltage(Voc)and energy loss of 0.880 V and 0.53 e V,respectively.Accordingly,this work demonstrated a promising approach by designing phenazine-based NFAs for achieving high-performance OSCs.
基金We dedicate this paper to the memory of Prof.ZiChu Xie,who passed away in early 2020.Prof.ZiChu Xie was an inspirational mentor and friend.This work was supported by the National Science Foundation of China(41772373,41372181)the Hunan Provincial Natural Science foundation of China(2018JJ1017)+1 种基金the National Key R&D Program of China(2018YFA0606404)and the Construction Program for First-Class Disciplines(Geography)of Hunan Province,China(5010002).We thank Dr.Jan Bloemendal for improving the English language.
文摘Holoceneδ^18O records from various archives(ice cores,cave stalagmites,and peat sediments)from the Xinjiang region of northwestern China,in arid central Asia(ACA),are all derived ultimately from local precipitationδ^18O(δ^18Op).Nevertheless,they have been proposed as indicators of different climatic parameters,such as wetness and temperature changes.This article summarizes previously reported records of moisture sources for the Xinjiang region and the results of modern observations conducted at an ice core site and a peat site in the Altai Mountains.The findings are used to propose that the overall positive trends in Holoceneδ^18O records from the various archives from the Xinjiang region primarily reflect the Holocene's long-term warming trend.It is concluded that more site-specific modern observations are needed to further elucidate the environmental significance of Holoceneδ^18O records from this region,especially for the separation of different seasonal temperature signals present withinδ^18O records.
文摘The Kathmandu valley is an intermountain basin located at about 1300 and surounded by mountains around 2400m.Thick fluvio\|lacustrine sediments from late Pliocene to Quaternary are accumulated there under monsoon climate.We undertook palynological and sedimentological studies on 284\|m\|long drilled core that reaches the basement of the kathmandu basin,in order to clarify the paleoclimatic changes and their tectonic link with uplifting of the Himalayas..The core is lithologically divided into three members:sand predominant lower member (51m),slit and clay dominant middle member (182m) and organic silty clay predominant upper member (45m).We analyzed fossil pollens contained in muddy samples which were taken from the middle and upper member in every one meter interval.The pollen assemblage is characterized by predominance of \%Quercus,\%30%～80% of the all arboreal pollen.We inferred paleoclimatic changes on the basis of comparison between present vegetation and climate of Kathmandu valley and surrounded mountains and pollen diagram which we obtained.For the purpose of inference of paleoclimate,we used the following genera as climatic index:\%Pinus\% for cold climate, \%Quercus\% and \%Cyclobalanopsis\% for warm climate, Alnus for wet climate and Gramineae for dry climate.As the reference.we also examined amount of another eight genera,two family and all spores.The pollen diagram shows two pattern of paleoclimatic changes:oscillation pattern with seven times fluctuation of warm and cold climate in younger period (ca.115m in depth),and older less fluctuated pattern of warm climate.During the older period (209～215m in depth),one cold stage was recognized,and is characterized by predominance of Pinus and occurrence of Tsuga .
文摘The As-level topology is a hotspot of the recent reseaches. We can understand the centralization of the network clearly by researching the evolvement trend of the Internet macroscopic topology. The massive data we use in this paper is from CAIDA (The Cooperative Association for Internet Data Analysis) Skitter project. And the time span of the data is from July, 2001 to January, 2008. This paper introduces the background of the AS-level topology at first, then carries out the evolvement of degree, core and layer. It is believed that the influence of the top-degree nodes on the other nodes decreases and the centralization of network is going to fall off with the decrease of the core. And the nucleus status of network declines.
